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Volumn 319, Issue 2, 2006, Pages 864-870

Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; DEXAMETHASONE; DIGOXIGENIN; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A4; RIFAMPICIN; UNCLASSIFIED DRUG;

EID: 33751160865     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.108282     Document Type: Article
Times cited : (35)

References (29)
  • 1
    • 0018606615 scopus 로고
    • Noncompartmental determination of the steady-state volume of distribution
    • Benet LZ and Galeazzi RL (1979) Noncompartmental determination of the steady-state volume of distribution. J Pharm Sci 68:1071-1074.
    • (1979) J Pharm Sci , vol.68 , pp. 1071-1074
    • Benet, L.Z.1    Galeazzi, R.L.2
  • 4
    • 0034235341 scopus 로고    scopus 로고
    • Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2
    • Fattinger K, Cattori V, Hagenbuch B, Meier PJ, and Stieger B (2000) Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology 32:82-86.
    • (2000) Hepatology , vol.32 , pp. 82-86
    • Fattinger, K.1    Cattori, V.2    Hagenbuch, B.3    Meier, P.J.4    Stieger, B.5
  • 5
    • 0036138199 scopus 로고    scopus 로고
    • Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways
    • Guo GL, Choudhuri S, and Klaassen CD (2002) Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. J Pharmacol Exp Ther 300:206-212.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 206-212
    • Guo, G.L.1    Choudhuri, S.2    Klaassen, C.D.3
  • 8
    • 0345731376 scopus 로고    scopus 로고
    • Regulation of drug and bile salt transporters in liver and intestine
    • Kullak-Ublick GA and Becker MB (2003) Regulation of drug and bile salt transporters in liver and intestine. Drug Metab Rev 35:305-317.
    • (2003) Drug Metab Rev , vol.35 , pp. 305-317
    • Kullak-Ublick, G.A.1    Becker, M.B.2
  • 9
    • 6944219986 scopus 로고    scopus 로고
    • Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: Studies of Dg3 metabolism in primary rat hepatocytes versus microsomes
    • Lam JL and Benet LZ (2004) Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of Dg3 metabolism in primary rat hepatocytes versus microsomes. Drug Metab Dispos 32:1311-1316.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1311-1316
    • Lam, J.L.1    Benet, L.Z.2
  • 10
    • 33746089203 scopus 로고    scopus 로고
    • In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: Characterizing the importance of transporter-enzyme interplay
    • Lam JL, Okochi H, Huang Y, and Benet LZ (2006) In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Drug Metab Dispos 34:1336-1344.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1336-1344
    • Lam, J.L.1    Okochi, H.2    Huang, Y.3    Benet, L.Z.4
  • 11
    • 33751179538 scopus 로고    scopus 로고
    • Effects of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers
    • in press
    • Lau YY, Huang Y, Frassetto L, and Benet LZ (2006a) Effects of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clin Pharmacol Ther, in press.
    • (2006) Clin Pharmacol Ther
    • Lau, Y.Y.1    Huang, Y.2    Frassetto, L.3    Benet, L.Z.4
  • 12
    • 31144438802 scopus 로고    scopus 로고
    • Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: Application of in vitro and ex situ systems
    • Lau YY, Okochi H, Huang Y, and Benet LZ (2006b) Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther 316:762-771.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 762-771
    • Lau, Y.Y.1    Okochi, H.2    Huang, Y.3    Benet, L.Z.4
  • 13
    • 33745230031 scopus 로고    scopus 로고
    • Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: Relevance of first-pass effect from hepatic uptake transporters, intestinal and hepatic metabolism
    • Lau YY, Okochi H, Huang Y, and Benet LZ (2006c) Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, intestinal and hepatic metabolism. Drug Metab Dispos 34:1175-1181.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1175-1181
    • Lau, Y.Y.1    Okochi, H.2    Huang, Y.3    Benet, L.Z.4
  • 14
    • 1342302110 scopus 로고    scopus 로고
    • Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: Hepatic enzyme-transporter interplay
    • Lau YY, Wu CY, Okochi H, and Benet LZ (2004) Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther 308:1040-1045.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1040-1045
    • Lau, Y.Y.1    Wu, C.Y.2    Okochi, H.3    Benet, L.Z.4
  • 15
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Investig 102:1016-1023.
    • (1998) J Clin Investig , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Willson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 16
    • 33645806523 scopus 로고    scopus 로고
    • Molecular characterization and inhibition of amanitin uptake into human hepatocytes
    • Letschert K, Faulstich H, Keller D, and Keppler D (2006) Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci 91:140-149.
    • (2006) Toxicol Sci , vol.91 , pp. 140-149
    • Letschert, K.1    Faulstich, H.2    Keller, D.3    Keppler, D.4
  • 17
    • 0036851821 scopus 로고    scopus 로고
    • Enantioselective covalent binding of 2-phenylpropionic acid to protein in vitro in rat hepatocytes
    • Li C, Benet LZ, and Grillo MP (2002) Enantioselective covalent binding of 2-phenylpropionic acid to protein in vitro in rat hepatocytes. Chem Res Toxicol 15:1480-1487.
    • (2002) Chem Res Toxicol , vol.15 , pp. 1480-1487
    • Li, C.1    Benet, L.Z.2    Grillo, M.P.3
  • 18
    • 0033943874 scopus 로고    scopus 로고
    • Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione
    • Li L, Meier PJ, and Ballatori N (2000) Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione. Mol Pharmacol 58:335-340.
    • (2000) Mol Pharmacol , vol.58 , pp. 335-340
    • Li, L.1    Meier, P.J.2    Ballatori, N.3
  • 20
    • 0032519643 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers
    • Salphati L and Benet LZ (1998) Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem Pharmacol 55:387-395.
    • (1998) Biochem Pharmacol , vol.55 , pp. 387-395
    • Salphati, L.1    Benet, L.Z.2
  • 21
    • 0032910725 scopus 로고    scopus 로고
    • Metabolism of Dg3 and digoxigenin digitoxosides in rat liver microsomes: Involvement of cytochrome P4503A
    • Salphati L and Benet LZ (1999) Metabolism of Dg3 and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A. Xenobiotica 29:171-185.
    • (1999) Xenobiotica , vol.29 , pp. 171-185
    • Salphati, L.1    Benet, L.Z.2
  • 23
    • 0034976320 scopus 로고    scopus 로고
    • Induction of cytochromes P450
    • Schuetz EG (2001) Induction of cytochromes P450. Curr Drug Metab 2:139-147.
    • (2001) Curr Drug Metab , vol.2 , pp. 139-147
    • Schuetz, E.G.1
  • 24
    • 0037310871 scopus 로고    scopus 로고
    • Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A
    • Shitara Y, Itoh T, Sato H, Li AP, and Sugiyama Y (2003) Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A. J Pharmacol Exp Ther 304:610-616.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 610-616
    • Shitara, Y.1    Itoh, T.2    Sato, H.3    Li, A.P.4    Sugiyama, Y.5
  • 25
    • 0036175452 scopus 로고    scopus 로고
    • Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport
    • Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, and Sugiyama Y (2002) Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res (NY) 19:147-153.
    • (2002) Pharm Res (NY) , vol.19 , pp. 147-153
    • Shitara, Y.1    Sugiyama, D.2    Kusuhara, H.3    Kato, Y.4    Abe, T.5    Meier, P.J.6    Itoh, T.7    Sugiyama, Y.8
  • 28
    • 0037216648 scopus 로고    scopus 로고
    • Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation
    • Tirona RG, Leake BF, Wolkoff AW, and Kim RB (2003) Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther 304:223-228.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 223-228
    • Tirona, R.G.1    Leake, B.F.2    Wolkoff, A.W.3    Kim, R.B.4
  • 29
    • 0036293982 scopus 로고    scopus 로고
    • Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
    • Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, and Fattinger K (2002) Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology 36:164-172.
    • (2002) Hepatology , vol.36 , pp. 164-172
    • Vavricka, S.R.1    Van Montfoort, J.2    Ha, H.R.3    Meier, P.J.4    Fattinger, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.