Acute sensory irritation from exposure to isopropanol (2-propanol) at TLV in workers and controls: Objective versus subjective effects

Annals of Occupational Hygiene

Volumn 46, Issue 4, 2002, Pages 359-373

  Smeets, Monique A M ^a,b   Mauté, Christopher ^a   Dalton, Pamela H ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Exposure assessment; Isopropanol; Nasal congestion; Nasal secretion; Occupational exposure; Ocular hyperemia; Phlebotomy; Respiration; Sensory irritation; Threshold limit value

Indexed keywords

ALCOHOLS; OCCUPATIONAL RISKS; ODORS; ENVIRONMENTAL CHAMBERS; HEALTH; PHYSIOLOGICAL MODELS; PHYSIOLOGY; POINT CONTACTS; PSYCHOPHYSIOLOGY; RESPIRATORY MECHANICS; SENSORY PERCEPTION;

SENSORY IRRITATION;

HEALTH RISKS; ODOR CONTROL;

2 PROPANOL; PHENETHYL ALCOHOL; SOLVENT;

ADULT; AIR; ANNOYANCE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BREATHING RATE; CLINICAL ARTICLE; COGNITION; CONJUNCTIVAL HYPEREMIA; CONTROLLED STUDY; EYE IRRITATION; FEMALE; HUMAN; MALE; MAXIMUM ALLOWABLE CONCENTRATION; NOSE CONGESTION; NOSE SECRETION; OCCUPATIONAL EXPOSURE; ODOR; PHLEBOTOMY; PRIORITY JOURNAL; RATING SCALE; SELF REPORT; SYMPTOM; UPPER RESPIRATORY TRACT; BREATHING; CHEMICALLY INDUCED DISORDER; EYE; HYPEREMIA; MIDDLE AGED; NOSE MUCOSA; PARAMEDICAL PERSONNEL; SECRETION;

2-PROPANOL; ADULT; ALLIED HEALTH PERSONNEL; EYE; FEMALE; HUMANS; HYPEREMIA; MALE; MIDDLE AGED; NASAL MUCOSA; OCCUPATIONAL EXPOSURE; ODORS; PHLEBOTOMY; RESPIRATION; SOLVENTS; THRESHOLD LIMIT VALUES;

EXPOSURE ASSESSMENT; ISO-PROPANOLS; NASAL CONGESTION; NASAL SECRETION; OCCUPATIONAL EXPOSURE; OCULAR HYPEREMIA; PHLEBOTOMY; RESPIRATION; SENSORY IRRITATION; THRESHOLD LIMIT VALUES;

EID: 0036593323     PISSN: 00034878     EISSN: None     Source Type: Journal    
DOI: 10.1093/annhyg/mef054     Document Type: Article

References (37)

1. Alarie Y. (1966) Irritating properties of airborne materials to the upper respiratory tract. Arch Environ Health; 13: 433-49.
2. American Conference of Governmental Industrial Hygienists. (1998) Threshold limit values for chemical substances and physical agents. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.
3. Cain WS, See LC, Tosun T. (1986) Irritation and odor from formaldehyde: chamber studies. ASHRAE Proc; 14: 126-37.
4. Cometto-Muniz J, Cain W. (1993) Efficacy of volatile organic compounds in evoking nasal pungency and odor. Arch Environ Health; 48: 309-14.
5. Dalton P, Wysocki CJ, Brody MJ, Lawley HJ. (1997) Perceived odor, irritation and health symptoms following short-term exposure to acetone. Am J Ind Med; 31: 558-69.
6. Dalton P, Lees PSJ, Cowart BJ et al. (2002) Olfactory function in workers exposed to styrene in the reinforced-plastics industry. Am J Ind Med (in press).
7. Dalton P, Dilks DD, Banton MI. (2000) Evaluation of odor and sensory irritation thresholds for methyl iso-butyl ketone (MiBK) in humans. Am Ind Hyg Assoc J; 61: 340-50.
8. Devos M, Patte F, Rouault J, Laffort P, Van Gemert LJ. (1990) Standardized human olfactory thresholds, Vol. 1. New York, NY: IRL Press at Oxford University Press. ISBN 0 19 963146 8.
9. Dick RB, Setzer JV, Taylor BJ, Shukla R. (1989) Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone. Br J Ind Med; 46: 111-21.
10. Doty RL, Brugger WE, Jurs PC, Orndorff MA, Snyder PJ, Lowry LD. (1978) Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol Behav; 20: 175-85.
11. Edling C, Hellquist H, Odkvist LM. (1988) Occupational exposure to formaldehyde and histopathological changes in the nasal mucosa. Br J Ind Med; 45: 761-5.
12. Fisher E. (1997) Acoustic rhinometry. Clin Otolaryngol; 22: 307-17.
13. Green BG, Dalton P, Cowart BJ, Shaffer G, Rankin KR, Higgins J, (1996) Evaluating the 'Labeled Magnitude Scale' for measuring sensations of taste and smell. Chem Senses; 21: 323-34.
14. Hempel-Jorgenson A, Kjaergaard S, Molhave L. (1998) Cytological changes and conjunctival hyperemia in relation to sensory eye irritation. Int Arch Occup Environ Health; 71: 225-35.
15. Hiipakka D, Samimi B. (1987) Exposure of acrylic fingernail sculptors to organic vapors and methylacrylate dusts. Am Ind Hyg Assoc J; 48: 230-7.
16. Kapp RW Jr, Bevan C, Gardiner TH, Banton MI, Tyler TR, Wright GA. (1996) Isopropanol: summary of TSCA test rule studies and relevance to hazard identification. Regul Toxicol Pharmacol; 23: 183-92.
17. Kesavanathan J, Swift DL, Fitzgerald TK, Permutt T, Bascom R. (1996) Evaluation of acoustic rhinometry and posterior rhinomanometry as tools for inhalation challenge studies. J Toxicol Environ Health; 48: 295-307.
18. Kjaergaard S, Pedersen OF. (1989) Dust exposure, eye redness, eye cytology and mucous membrane irritation in tobacco industry. Int Arch Occup Environ Health; 61: 519-25.
19. Kjaergaard SK, Pedersen BV, Taudorf E, Molhave L. (1990) Assessment of changes in eye redness by a photographic method and the relation to sensory eye irritation. Int Arch Occup Environ Health; 62: 133-7.
20. Kjaergaard S, Pedersen OF, Molhave L. (1992) Sensitivity of the eyes to airborne irritant stimuli: influence of individual characteristics. Arch Environ Health; 47: 45-50.
21. Maizlish NA, Langolf GD, Whitehead LW et al. (1985) Behavioural evaluation of workers exposed to mixtures of organic solvents. Br J Ind Med; 42: 579-90.
22. Maizlish NA, Fine LJ, Albers JW, Whitehead LW, Langolf GD. (1987) A neurological evaluation of workers exposed to mixtures of organic solvents. Br J Ind Med; 44: 14-25.
23. Matsushita T, Yoshumune A, Inoue T, Yamada S, Suzuki H. (1969) Experimental studies for determining the MAC value of acetone. I. Biologic reactions in the one-day exposure to acetone. Jap J Ind Health; 11: 477-85.
24. Nelson KW, Ege JF Jr, Morwick R. (1943) Sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol; 25: 282-5.
25. Nihlen A, Lof A, Johanson G. (1998a) Controlled ethyl-butyl ether (ETBE) exposure of male volunteers II. Acute effects. Toxicol Sci; 46: 143-50.
26. Nihlen A, Walinder R, Lof A, Johanson G. (1998b) Experimental exposure to methyl tertiary-butyl ether II. Acute effects on humans. Toxicol Appl Pharmacol; 148: 281-7.
27. Ogle JW, Cohen KL. (1996) External ocular hyperemia: a quantifiable indicator of spacecraft air quality. Aviation Space Environ Med; 67: 423-8.
28. Otto DA, Hudnell HK, House DE, Molhave L, Counts W. (1992) Exposure of humans to a volatile organic mixture. I. Behavioral assessment. Arch Environ Health; 47: 23-30.
29. Paustenbach D, Alarie Y, Kulle T et al. (1997) A recommended occupational exposure limit for formadehyde based on irritation. J Toxicol Environ Health; 50: 217-63.
30. Prah JD, Benignus VA. (1984) Trigeminal sensitivity to contact chemical stimulation: a new method and some results. Percept Psychophys; 35: 65-8.
31. Rasmussen TR, Brauer M, Kjaergaard S. (1995) Effects of nitrous acid exposure on human mucus membranes. Am J Respir Crit Care Med; 151: 1504-11.
32. Roithmann R, Shpirer I, Cole P, Chapnick J, Szalai J, Zamel N. (1997) The role of acoustic rhinometry in nasal provocation testing. Ear Nose Throat; 76: 747-52.
33. Samet JM, Cheng P-W. (1994) The role of airway mucus in pulmonary toxicology. Environ Health Perspect; 102: 89-103.
34. Sethre T, Laubli T, Berode M, Krueger H. (2000) Neurobehavioural effects of experimental isopropanol exposure. Int Arch Occup Environ Health; 73: 105-12.
35. Silkoff P, Chakravorty S, Chapnik J, Cole P, Zamel N. (1999) Reproducibility of acoustic rhinometry and rhinomanometry in normal subjects. Am J Rhinol; 13: 131-5.
36. Ukai H, Takada S, Inui S, Imai Y, Kawai T, Shimbo S, Ikeda M. (1994) Occupational exposure to solvent mixtures: effects on health and metabolism. Occup Environ Med; 51: 523-9.
37. Wysocki CJ, Dalton P, Brody MJ, Lawley HJ. (1997) Acetone odor and irritation thresholds obtained from acetone-exposed factory workers and from control (occupationally non-exposed) subjects. Am Ind Hyg Assoc J; 58: 704-12.