Exposure reconstruction for reducing uncertainty in risk assessment: Example using MTBE biomarkers and a simple pharmacokinetic model

Biomarkers

Volumn 12, Issue 4, 2007, Pages 331-348

  Pleil, J D ^a,b   Kim, D ^c,d   Prah, J D ^d   Rappaport, S M ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b University of North Carolina   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Blood sample; Classical pharmacokinetic model; Environmental health risk; Exhaled breath sample; Exposure assessment; Exposure reconstruction

Indexed keywords

2HYDROXYISOBUTYRIC ACID; BIOLOGICAL MARKER; ENVIRONMENTAL CHEMICAL; ISOBUTYRIC ACID; TERT BUTYL ALCOHOL; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD SAMPLING; BREATHING; CALCULATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; HEALTH HAZARD; HUMAN; HUMAN EXPERIMENT; KINETICS; MALE; NORMAL HUMAN; POLLUTANT; PREDICTION; RISK ASSESSMENT; URINALYSIS;

BIOLOGICAL MARKERS; BREATH TESTS; ENVIRONMENTAL EXPOSURE; HUMANS; HYDROXYBUTYRATES; METHYL ETHERS; MODELS, BIOLOGICAL; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT; TERT-BUTYL ALCOHOL;

EID: 34250722175     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.1080/13547500701246334     Document Type: Article

References (37)

1. Amberg, A., Rosner, E. and Dekant, W. (1999) Biotransformation and kinetics of excretion of methyl-tert-butyl ether in rats and humans. Toxicological Science, 51, pp. 1-8.
2. Amberg, A., Rosner, E. and Dekant, W. (2001) Toxicokinetics of methyl tert-butyl ether and its metabolites in humans after oral exposure. Toxicological Science, 61, pp. 62-67.
3. Ashley, D., Bonin, M., Cardinali, F., McCraw, J., Holler, J., Needham, L. and Patterson, D. (1992) Determining volatile organic compounds in human blood from a large sample population by using purge and trap gas chromatography/mass spectrometry. Analytical Chemistry, 64, pp. 1021-1029.
4. (2006) Agency for Toxic Substances and Disease Registry.
5. Boroujerdi, M. (2002) Pharmacokinetics: Principle and Applications, McGraw Hill, New York
6. Buckley, TJ, Prah, JD, Ashley, D., Zweidinger, RA and Wallace, LA (1997) Body burden measurements and models to assess inhalation exposure to methyl tertiary-butyl ether (MTBE). Journal of the Air and Waste Management Association, 47, pp. 739-752.
7. (1998) Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, CA
8. (1997) Air Resources Board, Stationary Source Division, California Environmental Protection Agency, Sacramento, CA
9. Castell, JV, Donato, MT and Gomez-Lechon, MJ (2005) Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach. Experimental and Toxicological Pathology, 57, pp. 189-204.
10. Clewell, HJ, Gentry, PR, Kester, JE and Andersen, ME (2005) Evaluation of physiologically based pharmacokinetic models in risk assessment: An example with perchloroethylene. Critical Reviews in Toxicology, 35, pp. 413-433.
11. (2001)
12. Dekant, W., Bernauer, U., Rosner, E. and Amberg, A. (2001) Toxicokinetics of ethers used as fuel oxygenates. Toxicology Letters, 124, pp. 37-45.
13. Ding, X. and Kaminski, LS (2003) Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual Reviews in Pharmacological Toxicology, 43, pp. 149-173.
14. (2001) Methyl Tertiary Butyl Ether.
15. Furtaw, EJ (2001) An overview of human exposure modeling activities at the USEPAs National Exposure Laboratory. Toxicology and Environmental Health, 17, pp. 302-314.
16. Hakkola, M. and Saarinen, L. (2000) Exposure of tanker drivers to gasoline and some of its components. Annals of Occupational Hygiene, 40, pp. 1-10.
17. (2004) Health Effects Institute, Cambridge, MA
18. Imbriani, M. and Ghittori, S. (2005) Gases and organic solvents in urine as biomarkers of occupational exposure: A review. International Archives of Environmental Health, 78, pp. 1-19.
19. Johnson, ML (1998) Exposure of humans to MTBE from drinking water.
20. Jones, K. and Cocker, J. (2003) A human exposure study to investigate biological monitoring methods for 2-butoxyethanol. Biomarkers, 8, pp. 360-370.
21. Licata, AC, Dekant, W., Smith, CE and Borghoff, SJ (2001) A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: Implementing sensitivity and variability analyses. Toxicological Science, 62, pp. 191-204.
22. Lindstrom, AB and Pleil, JD (1996) Alveolar breath sampling and analysis to assess exposures to methyl tertiary butyl ether (MTBE) during motor vehicle refueling. Journal of the Air and Waste Management Association, 46, pp. 676-682.
23. Lindstrom, AB and Pleil, JD (2002) A review of the USEPAs single breath canister (SBC) method for exhaled volatile organic biomarkers. Biomarkers, 7, pp. 189-208.
24. McKone, TE (1987) Human exposure to volatile organic compounds in household tap water: The indoor pollution pathway. Environmental Science and Technology, 21, pp. 1194-1201.
25. Pleil, JD and Lindstrom, AB (1995) Collection of a single alveolar exhaled breath for volatile organic compounds analysis Journal of Industrial Medicine, 28, pp. 109-121.
26. Pleil, JD and Lindstrom, AB (1995) Measurement of volatile organic compounds in exhaled breath as collected in SUMMA canisters. Journal of Chromatography B, 665, pp. 271-279.
27. Pleil, JD and Lindstrom, AB (1998) Sample timing and mathematical considerations for modeling breath elimination of volatile organic compounds. Risk Analysis, 18, pp. 585-602.
28. Pleil, JD, Kim, D., Prah, JD, Ashley, DL and Rappaport, SM (2005) Breath Gas Analysis for Medical Diagnostics, pp. 347-360. World Scientific Publishers, Singapore
29. Prah, JD, Ashley, DA, Blount, B., Case, M., Leavens, T., Pleil, JD and Cardinali, F. (2004) Dermal, oral and inhalation pharmacokinetics of methyl tertiary butyl ether (MTBE) in human volunteers. Toxicological Sciences, 77, pp. 195-205.
30. Prah, JD, Goldstein, GM, Devlin, R., Otto, D., Ashley, D., House, D., Willingham, F., Cohen, KL and Gerrity, T. (1994) Sensory, symptomatic, inflammatory, and ocular responses to and the metabolism of methyl tertiary butyl ether in a controlled human exposure experiment. Inhalation Toxicology, 6, pp. 521-538.
31. Rappaport, SM (1985) Smoothing of exposure variability at the receptor: implication for health standards. Annals of Occupational Hygiene, 29, pp. 201-214.
32. Rappaport, SM and Spear, RC (1988) Physiological damping of exposure variability during brief periods. Annals of Occupational Hygiene, 32, pp. 21-33.
33. Rappaport, SM, Symanski, E., Yager, JW and Kupper, LL (1995) The relationship between environmental monitoring and biological markers in exposure assessment. Environmental Health Perspectives, 103, pp. 49-53.
34. Tsai, PJ, Lee, CC, Chen, MR, Shih, TS, Lai, CH and Liou, HH (2002) Predicting the contents of BTEX and MTBE for the three types of tollbooth at a highway toll station via the direct and indirect approaches. Atmospheric Environment, 36, pp. 5961-5969.
35. (2001) National Survey of MTBE and other VOCs in Community Drinking Water Sources.
36. Wallace, LA, Nelson, WC, Pellizzari, ED and Raymer, JH (1997) Uptake and decay of volatile organic compounds at environmental concentrations: application of a four compartment model to a chamber study of five human subjects. Journal of Exposure Analysis and Environmental Epidemiology, 7, pp. 141-163.
37. Watson, WP and Mutti, A. (2004) Role of biomarkers in monitoring exposures to chemicals: Present position, future prospects. Biomarkers, 9, pp. 211-242.