Air pollution exposure-DNA adduct dosimetry in humans and rodents: Evidence for non-linearity at high doses

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 378, Issue 1-2, 1997, Pages 51-63

  Lewtas, J ^a   Walsh, D ^a   Williams, R ^a   Dobias L ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b Regional Institute of Hygiene   (Czech Republic)

Author keywords

32P postlabeling; Air pollution; DNA adduct; Dose extrapolation; Dose reponse; Human exposure; PAH; Personal exposure monitoring; Polycyclic aromatic hydrocarbon; Polycyclic organic matter; Respirable particulate matter; Risk assessment

Indexed keywords

ALUMINUM; CARCINOGEN; COAL; COKE; DNA; FUEL; ORGANIC MATTER; PETROLEUM; PHOSPHORUS 32; POLYCYCLIC AROMATIC HYDROCARBON;

AIR POLLUTION; AIRBORNE PARTICLE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; CHINA; CONTROLLED STUDY; COVALENT BOND; CZECH REPUBLIC; DNA ADDUCT; DOSE RESPONSE; DOSIMETRY; DRUG MEGADOSE; ENVIRONMENTAL EXPOSURE; FEMALE; GEOGRAPHIC DISTRIBUTION; HUMAN; HUMAN CELL; ISOTOPE LABELING; LEUKOCYTE; LUNG ALVEOLUS CELL; LUNG LAVAGE; LUNG PARENCHYMA; NONHUMAN; NONLINEAR SYSTEM; OCCUPATIONAL EXPOSURE; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; RURAL AREA; UNITED STATES; URBAN AREA; WORKER;

AIR POLLUTANTS; AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; BENZO(A)PYRENE; CARCINOGENS; COAL TAR; CZECH REPUBLIC; DNA ADDUCTS; ENDONUCLEASES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; LEUKOCYTES; OCCUPATIONAL EXPOSURE; PHOSPHORUS RADIOISOTOPES; POLYCYCLIC HYDROCARBONS, AROMATIC; RATS; RATS, WISTAR; SMOKING;

ANIMALIA; RODENTIA;

EID: 0030859279     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00097-3     Document Type: Article

References (28)

1. W.K. Lutz, Dose-response relationship and low dose extrapolation in chemical carcinogenesis, Carcinogenesis 11 (1990) 1243-1247.
2. G.N. Wogan, Molecular epidemiology in cancer risk assessment and prevention: recent progress and avenues for future research, Environ. Health Perspect. 98 (1992) 167-178.
3. K. Hemminki, E. Grzybowska, M. Chorazy, K. Twardovska-Saucha, J.W. Sroczynski, K.L. Putman, K. Randerath, D.H. Phillips, A. Hewer, R.M. Santella, T.L. Young, F.P. Perera, DNA adducts in humans environmentally exposed to aromatic compounds in an industrial area of Poland, Carcinogenesis 11 (1990) 1229-1231.
4. F.P. Perera, K. Hemminki, E. Gryzbowska, G. Motykiewicz, J. Michalska, R.M. Santella, T.L. Young, C. Dickey, P. Brandt-Rauf, I. DeVivo, W. Blaner, W.Y. Tsai, M. Chorazy, Molecular and genetic damage in humans from environmental pollution in Poland, Nature 360 (1992) 256-258.
5. E. Grzybowska, K. Hemminiki, J. Szeliga, M. Chorazy, Seasonal variation of aromatic adducts in human lymphocytes and granulocytes, Carcinogenesis 14 (1993) 2523-2526.
6. US EPA, The Air Toxics Problem in the United States: an Analysis of Cancer Risks for Selected Pollutants, EPA-450/1-85-001, May 1985.
7. 32P-postlabeling in the study of human exposure to carcinogens, in: J.D. Groopman and P.L. Skipper (Eds.), Molecular Dosimetry and Human Cancer, CRC Press, Boca Raton, FL, 1991, pp. 151-171.
8. B. Binková, J. Lewtas, I. Míšková, J. Leníček, R.J. srám, DNA adducts and personal air monitoring of carcinogenic polycyclic aromatic hydrocarbons in an environmentally exposed population, Carcinogenesis 16 (1995) 1037-1046.
9. R. Williams, L. Brooks, R. Stevens, V. Marple, J. Lewtas, Field test and laboratory evaluation of a lightweight modular designed, personal sampler for human biomarker studies, in: Measurement of Toxic and Related Air Pollutants, A and WMA, Philadelphia, 1992, pp. 188-194.
10. R. Watts, J. Lewtas, R. Stevens, T. Hartlage, J. Pinto, R. Williams, K. Hattaway, I. Míšková, I. Beneš, F. Kotěšovec, R.J. Šrám, Czech-U.S. EPA health study: assessment of personal and ambient air exposures to PAH and organic mutagens in the Teplice district of Northern Bohemia, Int. J. Environ. Anal. Chem. 56 (1994) 271-287.
11. R. Williams, A. Collier, J. Lewtas, Environmental tobacco smoke exposure of young children as assessed using a passive diffusion device for nicotine, Indoor Environ. 2 (1993) 98-104.
12. R. Williams, J. Meares, L. Brooks, R. Watts, P. Lemieux, Priority pollutant PAH analysis of incinerator emission particles using HPLC and optimized fluorescence detection, Int. J. Environ. Anal. Chem. 54 (1994) 299-314.
13. 32P-postlabeling analysis of aromatic carcinogen adducts, Cancer Res. 45 (1985) 5656-5662.
14. 32P-postlabeling analysis of nonradioactive aromatic carcinogen DNA adducts, Carcinogenesis 3 (1982) 1081-1082.
15. J.L. Mumford, X.Z. He, R.S. Chapman, S.R. Cao, D.B. Harris, X.M. Li, Y.L. Xian, W.Z. Jiang, C.W. Xu, J.C. Chuang, W.E. Wilson, M. Cook, Lung cancer and indoor air pollution in Xuan Wei, China, Science 235 (1987) 217-220.
16. J.L. Mumford, X. Lee, J. Lewtas, T.L. Young, R.M. Santella, DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality, Environ. Health Perspect. 99 (1993) 83-87.
17. J. Lewtas, J. Mumford, R.B. Everson, B. Hulka, T. Wilcosky, W. Kozumbo, C. Thompson, M. George, L. Dobias, R.J. Šrám, X. Li, J. Gallagher, Comparison of DNA adducts from complex mixture exposures in various human tissues and experimental systems, Environ. Health Perspect. 99 (1993) 89-97.
18. J. Gallagher, J. Mumford, X. Li, T. Shank, D. Manchester, J. Lewtas, DNA adduct profiles and levels in placenta, blood and lung in relation to cigarette smoking and smoky coal emissions, in: D.H. Phillips, M. Castegnaro, H. Bartsch (Eds.), Postlabelling Methods for Detection of DNA Adducts, International Agency for Research on Cancer, Lyon, 1993, pp. 283-292.
19. W.K. Lutz, Quantitative evaluation of DNA-binding data in vivo for low-dose extrapolations, Arch. Toxicol. 11 (1987) 66-74.
20. M.C. Poirier, F.A. Beland, DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models - implications for DNA adduct-based human cancer risk assessment, Chem. Res. Toxicol. 5 (1992) 749-755.
21. J.A. Swenberg, F.C. Richardson, J.A. Boucheron, F.H. Deal, S.A. Belinsky, M. Charbonneau, B.G. Short, High to low dose extrapolation: critical determinants involved in the dose response of carcinogenic substances, Environ. Health Perspect. 76 (1987) 57-63.
22. W.K. Lutz, D. Gaylor, Significance of DNA adducts at low dose: shortening the time to spontaneous tumor occurrence, Regul. Toxicol. Pharmacol. 23 (1996) 29-34.
23. J. Lewtas, Human exposure to complex mixtures of air pollutants, Toxicol. Lett. 72 (1994) 163-169.
24. 32P-postlabelling of aromatic DNA adducts in white blood cells from iron foundry workers, Mutation Res. 204 (1988) 531-541.
25. A. Haugen, S. Ovrebo, P.A. Drablos, Biomonitoring of genotoxic exposure of aluminum plant workers, Med. Lab. 83 (5) (1992) 506-510.
26. P.S. Nielsen, N. de Pater, H. Okkels, H. Autrup, Environmental air pollution and DNA adducts in Copenhagen bus drivers - Effect of GSTM1 and NAT2 genotypes on adduct level, Carcinogenesis 17 (1996) 1021-1027.
27. 32P-postlabeling, Scand. J. Work Environ. Health 16 (1990) 135-143.
28. F.J. van Schooten, F.J. Jongeneelen, M.J.X. Hillebrand, F.E. van Leewen, A.J.A. de Looff, A.P.G. Dijkmans, M.J.G. van Rooij, L. den Engelse, E. Kriek, Polycyclic aromatic hydrocarbon-DNA adducts in white blood cell DNA and 1-hyroxyprene in the urine from aluminum workers: relation with job category and synergistic effect of smoking, Cancer Epidemiol. Biomark. Prevent. 4 (1995) 69-77.