Omega-3 fatty acids, exercise, physical activity and athletics

World Review of Nutrition and Dietetics

Volumn 98, Issue , 2008, Pages 23-50

  Simopoulos, Artemis P ^a  

^a Center for Nutrition Genetics & Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

CONFERENCE PAPER; DIET; ENDURANCE; EXERCISE; GENETICS; HEALTH STATUS; HUMAN; LIFESTYLE; MENTAL HEALTH; NUTRITIONAL STATUS; PHYSIOLOGY; SPORT;

DIET; EXERCISE; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; HEALTH STATUS; HUMANS; LIFE STYLE; MENTAL HEALTH; NUTRITIONAL STATUS; PHYSICAL ENDURANCE; SPORTS;

EID: 52949108793     PISSN: 00842230     EISSN: 16623975     Source Type: Book Series    
DOI: 10.1159/000152920     Document Type: Conference Paper

References (148)

1. Simopoulos AP, Childs B (eds): Genetic Variation and Nutrition. World Rev Nutr Diet. Basel, Karger, 1990, vol 63.
2. Simopoulos AP: Genetic variation and dietary response: nutrigenetics/nutrigenomics. Asian Pacific J Clin Nutr 2002;11(suppl 6):S117-S128.
3. Simopoulos AP: Genetics - implications for nutrition. Forum Nutr 2003;56:226-229.
4. Leaf A, Weber PC: A new era for science in nutrition. Am J Clin Nutr 1987;45:1048-1053.
5. Simopoulos AP: Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991;54:438-463.
6. Simopoulos AP: Genetic variation and evolutionary aspects of diet; in Papas A (ed): Antioxidants in Nutrition and Health. Boca Raton, CRC Press, 1999, pp 65-88.
7. Eaton SB, Konner M: Paleolithic nutrition: a consideration of its nature and current implications. N Engl J Med 1985;312:283-289.
8. Eaton SB, Konner M, Shostak M: Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective. Am J Med 1988;84:739-749.
9. Eaton SB, Eaton SB III, Sinclair AJ, Cordain L, Mann NJ: Dietary Intake of Long-Chain Polyunsaturated Fatty Acids during the Paleolithic. World Rev Nutr Diet. Basel, Karger, 1998, vol 83, pp 12-23.
10. Simopoulos AP: Overview of Evolutionary Aspects of ω-3 Fatty Acids in the Diet. World Rev Nutr Diet. Basel, Karger, 1998, vol 83, pp 1-11.
11. Simopoulos AP (ed): The Return of ω-3 Fatty Acids into the Food Supply. I. Land-Based Animal Food Products and Their Health Effects. World Rev Nutr Diet. Basel, Karger, 1998, vol 83.
12. Montgomery H: Genetic Variation and the Response to Exercise. World Rev Nutr Diet. Basel, Karger, 2001, vol 89, pp 118-133.
13. Vasquez A, Manso G, Cannell J: The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Altern Ther Health Med 2004;10:28-36.
14. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ: Human serum 25-hydroxychholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003;77:204-210.
15. Crawford MA: Fatty acid ratios in free-living and domestic animals. Lancet 1968;1:1329-1333.
16. Crawford MA, Gale MM, Woodford MH: Linoleic acid and linolenic acid elongation products in muscle tissue of Synderus coffer and other ruminant species. Biochem J 1969;115:25-27.
17. Sinclair AJ, Slattery WJ, O'Dea K: The analysis of polyunsaturated fatty acids in meat by capillary gas-liquid chromatography. J Food Sci Agric 1982;33:771-776.
18. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, Elwood PC, Deadman NM: Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and Reinfarction Trial (DART). Lancet 1989;2:757-761.
19. De Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, Delaye J: Mediterranean a-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994;343:1454-1459.
20. De Lorgeril M, Salen P: Modified Cretan Mediterranean Diet in the Prevention of Coronary Heart Disease and Cancer. World Rev Nutr Diet. Basel, Karger, 2000, vol 87, pp 1-23.
21. De Lorgeril M, Salen P: Modified Cretan Mediterranean Diet in the Prevention of Coronary Heart Disease and Cancer: An Update. World Rev Nutr Diet. Basel, Karger, 2007, vol 97, pp 1-32.
22. GISSI-Prevenzione Investigators: Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione Trial. Lancet 1999;354:447-455.
23. Marchioli R, Barzi F, Bomba E, Chieffo C, Di Gregorio D, Di Mascio R, Franzosi MG, Geraci E, Levantesi G, Maggioni AP, Mantini L, Marfisi RM, Mastrogiuseppe G, Mininni N, Nicolosi GL, Santini M, Schweiger C, Tavazzi L, Tognoni G, Tucci C, Valagussa F, GISSI-Prevenzione Investigators: Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction. Time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002;105:1897-1903.
24. Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubo Y, Tsugane S, JPHC Study Group: Intake of fish and n-3 fatty acids and risk of coronary heart disease among Japanese. The Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 2006;113:195-202.
25. Simopoulos AP: The role of fatty acids in gene expression: health implications. Ann Nutr Metab 1996;40:303-311.
26. Simopoulos AP: Essential fatty acids in health and chronic disease. Am J Clin Nutr 1999;70(suppl):560S-569S.
27. Simopoulos AP, Leaf A, Salem N Jr: Essentiality of and recommended dietary intakes for ω-6 and ω-3 fatty acids. Ann Nutr Metab 1999;43:127-130.
28. Simopoulos AP, Robinson J: The Omega Diet. The Lifesaving Nutritional Program Based on the Diet of the Island of Crete. New York, HarperCollins, 1999.
29. Simopoulos AP: Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 2002;21:495-505.
30. Hibbeln JR, Davis JM, Steer C, Emmett P, Rogers I, Williams C, Golding J: Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC Study): an observational cohort study. Lancet 2007;369:578-585.
31. Weber PC, Fischer S, von Schacky C, Lorenz R, Strasser T: Dietary ω-3 polyunsaturated fatty acids and eicosanoid formation in man; in Simopoulos AP, Kifer RR, Martin RE (eds): Health Effects of Polyunsaturated Fatty Acids in Seafoods. Orlando, Academic Press, 1986, pp 49-60.
32. Lewis RA, Lee TH, Austen KF: Effects of ω-3 fatty acids on the generation of products of the 5-lipoxygenase pathway; in Simopoulos AP, Kifer RR, Martin RE (eds): Health Effects of Polyunsaturated Fatty Acids in Seafoods. Orlando, Academic Press, 1986, pp 227-238.
33. Brox JH, Killie JE, Osterud B, Holme S, Nordoy A: Effects of cod liver oil on platelets and coagulation in familial hypercholesterolemia (type IIa). Acta Med Scand 1983;213:137-144.
34. Joist JH, Baker RK, Schonfeld G: Increased in vivo and in vitro platelet function in type II and type IV hyperlipoproteinemia. Thromb Res 1979;15:95-108.
35. Weber PC: Are we what we eat? Fatty acids in nutrition and in cell membranes: cell functions and disorders induced by dietary conditions. Report No 4. Svanoybukt/Norway, Svanoy Foundation, 1989, pp 9-18.
36. Raheja BS, Sadikot SM, Phatak RB, Rao MB: Significance of the n-6/n-3 ratio for insulin action in diabetes. Ann NY Acad Sci 1993;683:258-271.
37. Weber PC, Leaf A: Cardiovascular Effects of ω-3 Fatty Acids: Atherosclerotic Risk Factor Modification by ω-3 Fatty Acids. World Rev Nutr Diet. Basel, Karger, 1991, vol 66, pp 218-232.
38. Dwyer JH, Allayee H, Dwyer KM, Fan J, Wu H, Mar R, Lusis AJ, Mehrabian M: Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 2004;350:29-37.
39. Clarke SD, Romsos DR, Leveille GA: Differential effects of dietary methylesters of long chain saturated and polyunsaturated fatty acids on rat liver and adipose tissue lipogenesis. J Nutr 1977;107:1170-1180.
40. Clarke SD, Armstrong MK, Jump DB: Nutritional control of rat liver fatty acid synthase and S14 mRNA abundance. J Nutr 1990;120:218-224.
41. Clarke SD, Jump DB: Fatty acid regulation of gene expression: A unique role for polyunsaturated fats; in Berdanier C, Hargrove JL (eds): Nutrition and Gene Expression. Boca Raton, CRC Press, 1993, pp 227-246.
42. Clarke SD, Jump DB: Polyunsaturated fatty acid regulation of hepatic gene transcription. Lipids 1996;31(suppl):7-11.
43. Ntambi JM: Dietary regulation of stearoyl-CoA desaturase I gene expression in mouse liver. J Biol Chem 1991;267:10925-10930.
44. DeWillie JW, Farmer SJ: Linoleic acid controls neonatal tissue-specific stearoyl-CoA desaturase mRNA levels. Biochim Biophys Acta 1993;1170:291-295.
45. Jump DB, Clarke SD, Thelen A, Liimatta N: Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res 1994;35:1076-1084.
46. Liimatta M, Towle HC, Clarke SD, Jump DB: Dietary PUFA interfere with the insulin glucose activation of L-type pyruvate kinase. Mol Endocrinol 1994;8:1147-1153.
47. Tebbey PW, McGowan KM, Stephens JM, Buttke TM, Pekata PH: Arachidonic acid downregulates the insulin-dependent glucose transporter gene (Glut 4) in 3T3-L1 adipocytes by inhibiting transcription and enhancing mRNA turnover. J Biol Chem 1994;269:639-644.
48. Sellmayer A, Danesch U, Weber PC: Effects of different polyunsaturated fatty acids on growth-related early gene expression and cell growth. Lipids 1996;31:S37-S40.
49. De Caterina R, Libby P: Control of endothelial leukocyte adhesion molecules by fatty acids. Lipids 1996;31(suppl):57-63.
50. Robinson DR, Urakaze M, Huang R, Taki H, Sugiyama E, Knoell CT, Xu L, Yeh ET, Auron PE: Dietary marine lipids suppress the continuous expression of interleukin-1ß gene transcription. Lipids 1996;31(suppl):S23-S31.
51. Kaminski WE, Jendraschak E, Kiefl R, van Schacky C: Dietary ω-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells. Blood 1993;81:1871-1879.
52. Graber R, Sumida C, Nunez EA: Fatty acids and cell signal transduction. J Lipid Mediat Cell Signal 1994;9:91-116.
53. Clarke SD, Jump DB: Dietary polyunsaturated fatty acid regulation of gene transcription. Annu Rev Nutr 1994;14:83-98.
54. Salem N Jr, Simopoulos AP, Galli C, Lagarde M, Knapp HR (eds): Fatty acids and lipids from cell biology to human disease. Lipids 1996;31(suppl):S1- S326.
55. Indu M, Ghafoorunissa: n-3 fatty acids in Indian diets - comparison of the effects of precursor (α-linolenic acid) vs. product (long-chain n-3 polyunsaturated fatty acids). Nutr Res 1992;12:569-582.
56. Emken EA, Adlof RO, Gulley RM: Dietary linoleic and linolenic acids in young adult males. Biochim Biophys Acta 1994;1213:277-288.
57. Mantzioris E, James MJ, Gibson RA, Cleland LG: Dietary substitution with an α-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. Am J Clin Nutr 1994;59:1304-1309.
58. McLennan PL: Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am J Clin Nutr 1993;57:207-212.
59. Reaven P, Parthasarathy S, Grasse BJ, Miller E, Almazan F, Mattson FH, Khoo JC, Steinberg D, Witztum JL: Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. Am J Clin Nutr 1991;54:701-706.
60. Abbey M, Belling GB, Noakes M, Hirata F, Nestel PJ: Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. Am J Clin Nutr 1993;57:391-398.
61. Renaud S: Linoleic acid, platelet aggregation and myocardial infarction. Atherosclerosis 1990;80:255-256.
62. Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, van der Meer JW, Cannon JG, Rogers TS, Klempner MS, Weber PC: The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265-271.
63. Renaud S, Morazain R, Godsey F, Dumont E, Thevenon C, Martin JL, Mendy F: Nutrients, platelet function and composition in nine groups of French and British farmers. Atherosclerosis 1986;60:37-48.
64. Renaud S, Godsey F, Dumont E, Thevenon C, Ortchanian E, Martin JL: Influence of long-term diet modification on platelet function and composition in Moselle farmers. Am J Clin Nutr 1986;43:136-150.
65. Budowski P, Crawford MA: Alpha-linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio of n-6:n-3 fatty acids. Proc Nutr Soc 1985;44:221-229.
66. Berry EM, Hirsh J: Does dietary linoleic acid influence blood pressure? Am J Clin Nutr 1986;44:336-340.
67. Paschos GK, Magkos F, Panagiotakos DB, Votteas V, Zampelas A: Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-1206.
68. Ascherio A, RimmEB, Giovannucci EL, Spiegelman D, Stampfer M, Willett WC: Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 1996;313:84-90.
69. Simopoulos AP (ed): Proceedings of the First International Conference on Nutrition and Fitness. Am J Clin Nutr 1989;49(suppl):909-1124.
70. Simopoulos AP, Pavlou KN (eds): Volume I. Nutrition and Fitness for Athletes. Proceedings of the Second International Conference on Nutrition and Fitness. World Rev Nutr Diet. Basel, Karger, 1993, vol 71.
71. Simopoulos AP (ed): Volume II. Nutrition and Fitness in Health and Disease. Proceedings of the Second International Conference on Nutrition and Fitness. World Rev Nutr Diet. Basel, Karger, 1993, vol 72.
72. Simopoulos AP (ed): Volume I. Nutrition and Fitness: Evolutionary Aspects, Children's Health, Policies and Programs. Proceedings of the Third International Conference on Nutrition and Fitness. World Rev Nutr Diet. Basel, Karger, 1997, vol 81.
73. Simopoulos AP, Pavlou KN (eds): Volume II. Nutrition and Fitness: Metabolic and Behavioral Aspects in Health and Disease. Proceedings of the Third International Conference on Nutrition and Fitness. World Rev Nutr Diet. Basel, Karger, 1997, vol 82.
74. Simopoulos AP, Pavlou KN (eds): Volume 1. Nutrition and Fitness: Diet, Genes, Physical Activity and Health. Proceedings of the Fourth International Conference on Nutrition and Fitness. World Rev Nutr Diet. Basel, Karger, 2001, vol 89.
75. Simopoulos AP, Pavlou KN (eds): Volume 2. Nutrition and Fitness: Metabolic Studies in Health and Disease. Proceedings of the Fourth International Conference on Nutrition and Fitness. World Rev Nutr Diet. Basel, Karger, 2001, vol 89.
76. Simopoulos AP (ed): Nutrition and Fitness (vol. 1): Obesity, the Metabolic Syndrome, Cardiovascular Disease, and Cancer. Proceedings of the Fifth International Conference on Nutrition and Fitness. World Rev Nutr Diet. Basel, Karger, 2005, vol 94.
77. Simopoulos AP (ed): Nutrition and Fitness (vol. 2): Mental Health, Aging, and the Implementation of a Health Diet and Physical Activity Lifestyle. Proceedings of the Fifth International Conference on Nutrition and Fitness. World Rev Nutr Diet. Basel, Karger, 2005, vol 95.
78. Peoples GE, McLennan PL, Howe PRC, Groeller H: Fish oil reduces apparent myocardial oxygen consumption in trained cyclists but does not change time to fatigue; in Abstract Book of the Fourth International Conference on Nutrition and Fitness. Ancient Olympia, Greece, 2000.
79. Hwalla N, Sibai MA, Adra N: Adolescent Obesity and Physical Activity. World Rev Nutr Diet. Basel, Karger, 2005, 94, pp 42-50.
80. Rauramaa R, Salonen J, Kukkonen-Harjula K, Seppanen K, Seppala E, Vapaatalo H, Huttunen JK: Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid: a controlled randomised trial in middle aged men. BMJ 1984;288:603-606.
81. Demers LM, Harrison TS, Halbert DR, Santen RJ: Effect of prolonged exercise on plasma prostaglandin levels. Prostaglandins Med 1981;6:413-418.
82. Burghuber O, Sinzinger H, Silberbauer K, Wolf CH, Haber P: Decreased prostacyclin sensitivity of human platelets after jogging and squash. Prostaglandins Med 1981;6:127-130.
83. Ritter JM, Barrow SE, Blair IA, Dollery CT: Release of prostacyclin in vivo and its role in man. Lancet 1983;1:317-319.
84. Laustiola K, Seppala E, Nikkari T, Vapaatalo H: Exercise and arachidonic acid metabolites: effect of adrenergic β-blockade; in Schettler FG, Gotto AM, Middelhoff G, Habenicht AJR, Jurutka KR (eds): Atherosclerosis. VI. Proceedings of Sixth International Symposium. Berlin, Springer, 1983, vol 290.
85. Karlsson J: Exercise, Muscle Metabolism and the Antioxidant Defense. World Rev Nutr Diet. Basel, Karger, 1997, vol 82, pp 81-100.
86. Goransson U, Karlson J, Ronneberg R, Rasmusson M. Toomey WA: The 'Are' Sport Nutratherapy Program: The Rationale for Food Supplements in Sports Medicine. World Rev Nutr Diet. Basel, Karger, 1997, vol 82, pp 101-121.
87. Massiera F, Saint-Marc P, Seydoux J, Murata T, Kobayashi T, Narumiya S, Guesnet P, Amri E-Z, Negrel R, Ailhaud G: Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 2003;44:271-279.
88. Clearly MP, Philips FC, Morton AA: Genotype and diet effects in lean and obese Zucker rats fed either safflower or coconut oil diets. Proc Soc Exp Biol Med 1999;2220:153-161.
89. Parrish CC, Pathy DA, Angel A: Dietary fish oils limit adipose tissue hypertrophy in rats. Metabolism 1990;39:217-219.
90. Raclot T, Groscolas R, Langin D, Ferre P: Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. J Lipid Res 1997;38:1963-1972.
91. Steinberg H, Sykes E, Moss T, Lowery S, Le Boutillier N, Dewey A: Exercise enhances creativity independently of mood. Br J Sports Med 1997;31:240-245.
92. Solberg L, Horton T, Turek F: Circadian rhythms and depression: effects of exercise in an animal model. Am J Physiol 1999;276:152-161.
93. Steptoe A, Kimbell J, Pasford P: Exercise and the experience and appraisal of daily stressors: a naturalistic study. J Behav Med 1998;21:363-744.
94. Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Meltzer HY: Lowered ω-3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res 1999;85:275-291.
95. Peet M, Murphy B, Shay J, Horrobin D: Depletion of ω-3 fatty acid levels in red blood cell membranes of depressive patients. Biol Psychiatry 1998;43:315-319.
96. Puri BK, Counsell SJ, Hamilton G, Richardson AJ, Horrobin DF: Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover. Int J Clin Pract 2001;55:560-563.
97. Puri BK: High-resolution magnetic resonance imaging sinc-interpolation- based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in schizophrenia, depression, chronic fatigue syndrome and Huntington's disease. Int Rev Psychiatry 2006;18:149-154.
98. Marangell LB, Suppes T, Ketter TA, Dennehy EB, Zboyan H, Kertz B, Nierenberg A, Calabrese J, Wisniewski SR, Sachs G: Omega-3 fatty acids in bipolar disorder: clinical and research considerations. Prostaglandins Leukot Essent Fatty Acids 2006;75:315-321.
99. Freeman MP, Hibbeln JR, Wisner KL, Brumbach BH, Watchman M, Gelenberg AJ: Randomized dose-ranging pilot trial of ω-3 fatty acids for postpartum depression. Acta Psychiatr Scand 2006;113:31-35.
100. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, Aggarwal N, Schneider J: Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 2003;60:940-946.
101. Kyle DJ, Schaefer E, Patton G, Beiser A: Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. Lipids 1999;34:S245.
102. Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM: Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 2004;43:633-645.
103. Tully AM, Roche HM, Doyle R, Fallon C, Bruce I, Lawlor B, Coakley D, Gibney MJ: Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study. Br J Nutr 2003;89:483-489.
104. Stoll AL, Damico KE, Daly BP, Severus WE, Marangell LB: Methodological Considerations in Clinical Studies of Omega-3 Fatty Acids in Major Depression and Bipolar Disorder. World Rev Nutr Diet. Basel, Karger, 2001, vol 88, pp 58-67.
105. Schachter HM, Kourad K, Merali Z, Lumb A, Tran K, Miguelez M: Effects of ω-3 fatty acids on mental health. Evid Rep Technol Assess (Summ) 2005;116:1-11.
106. Lim WS, Gammack JK, Van Niekerk J, Dangour AD: Omega-3 fatty acid for the prevention of dementia. Cochrane Database Syst Rev 2006;1:CD005379.
107. Lee S, Gura KM, Kim S, Arsenault DA, Bistrian BR, Puder M: Current clinical applications of ω-6 and ω-3 fatty acids. Nutr Clin Pract 2006;21:323-341.
108. Peet M: Essential fatty acids: theoretical aspects and treatment implications for schizophrenia and depression. Adv Psych Treat 2002;8:223-229.
109. Hemingway H, Marmot M: Evidence based cardiology: psychosocial factors in the aetiology and prognosis of coronary heart disease. Systematic review of prospective cohort studies. BMJ 1999;318:1460-1467.
110. Frasure-Smith N, Lesperance F: Reflections on depression as a cardiac risk factor. Psychosom Med 2005;67(suppl 1):S19-S25.
111. Severus WE, Littman AB, Stoll AL: Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in major depressive disorder. Harv Rev Psychiatry 2001;9:280-293.
112. McMurchie EJ, Margetts BM, Beilin LJ, Croft KD, Vandongen R, Armstrong B: Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. Am J Clin Nutr 1996;39:975-980.
113. Storlien LH, Baur LA, Kriketos AD, Pan DA, Cooney GJ, Jenkins AB, Calvert GD, Campbell LV: Dietary fats and insulin action. Diabetologia 1996;39:621-631.
114. Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ, Campbell LV: The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med 1993;328:238-244.
115. Andersson A, Sjödin A, Olsson R, Vessby B: Effects of physical exercise on phospholipid fatty acid composition in skeletal muscle. Am J Physiol 1998;274:E432-E438.
116. Helge JW, Wu BJ, Willer M, Daugaard JR, Storlieln LH, Kiens B: Training affects muscle phospholipid fatty acid composition in humans. J Appl Physiol 2001;90:670-677.
117. Dela F, Mikines KJ, Sonne B, Galbo H: Effect of training on interaction between insulin and exercise in human muscle. J Appl Physiol 1994;76:2386-2393.
118. Koivisto VA, Yki-Järvinen H, DeFronzo RA: Physical training and insulin sensitivity. Diabetes Metab Rev 1986;1:445-481.
119. Mikines K, Sonne B, Farrell P, Tronier B, Galbo H: Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol 1988;254:E248-E259.
120. Morgan TE, Short FA, Cobb LA: Effect of long-term exercise on skeletal muscle lipid composition. Am J Physiol 1969;216:82-88.
121. Gorski J, Zendzian-Piotrowska M, de Jong YF, Niklinska W, Glatz JF: Effect of endurance training on the phospholipid content of skeletal muscle in the rat. Eur J Appl Physiol 1999;79:421-425.
122. Gudbjarnason S: Dynamics of n-3 and n-6 fatty acids in phospholipids of heart muscle. J Int Med 1989;225(suppl 1):117-128.
123. Kiens B, Essen-Gustavsson B, Christensen NJ, Saltin B: Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol (Lond) 1993;469:459-478.
124. Vessby B, Tengblad S, Lithell H: Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Diabetologia 1994;37:1044-1050.
125. Ginsberg BH, Brown TJ, Simon I, Spector AA: Effect of the membrane lipid environment on the properties of insulin receptors. Diabetes 1981;30:73-780.
126. Ginsberg BH, Jabour J, Spector AA: Effects of alterations in membrane lipid unsaturation on the properties of the insulin receptor of Ehrlich ascites cells. Biochem Biophys Acta 1982;690:157-164.
127. Grunfeld C, Baird KL, Kahn CR: Maintenance of 3t3-L1 cells in culture media containing saturated fatty acids decreases insulin binding and insulin action. Biochem Biophys Res Commun 1981;103:219-226.
128. Leaf A, Albert CM, Josephson M, Steinhaus D, Kluger J, Kang JX, Cox B, Zhang H, Schoenfeld D, Fatty Acid Antiarrhymnia Trial Investigators: Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation 2005;112:2762-2768.
129. Leaf A, Kang JX, Xiao YF: Omega-3 Fatty Acids and Ventricular Arrhythmias. World Rev Nutr Diet. Basel, Karger, 2005, vol 94, pp 129-138.
130. Walser B, Giordano RM, Stebbins CL: Supplementation with ω-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm contraction. Eur J Appl Physiol 2006;97:347-354.
131. Clavel S, Farout L, Briand M, Briand Y, Jouanel P: Effect of endurance training and/or fish oil supplemented diet on cytoplasmic fatty acid binding protein in rat skeletal muscles and heart. Eur J Appl Physiol 2002;87:193-201.
132. Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR: Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 1993;265:E380-E391.
133. Clarke SD: Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance. Br J Nutr 2000;83(suppl 1):S59-S66.
134. Larsson K, Ohlsen P, Larsson L, Malmberg P, Rydstrom PA, Ulriksen H: High prevalence of asthma in cross-country skiers. BMJ 1993;307:1326-1329.
135. Heir T, Oseid S: Self-reported asthma and exercise-induced asthma symptoms in high level competitive cross-country skiers. Scand J Med Sci Sports 1994;4:128-133.
136. Sue-Chu M, Larsson L, Bjermer L: Prevalence of asthma in young cross-country skiers in central Scandinavia: differences between Norway and Sweden. Respir Med 1996;90:99-105.
137. Helenius IJ, Tikkanen HO, Haahtela T: Occurrence of exercise-induced bronchospasm in elite runners: dependence on atopy and exposure to cold air and pollen. Br J Sports Med 1998;32:125-129.
138. Schoene RB, Giboney K, Schimmel C, Hagen J, Robinson J, Schoene RB, Sato W, Sullivan KN: Spirometry and airway reactivity in elite track and field athletes. Clin J Sport Med 1997;7:257-261.
139. Paul DW, Bogaard JM, Hop WC: The bronchoconstrictor effect of strenuous exercise at low temperatures in normal athletes. Int J Sports Med 1993;14:433-436.
140. Provost-Craig MA, Arbour KS, Sestili DC, Chabalko JJ, Ekinci E: The incidence of exerciseinduced bronchospasm in competitive figure skaters. J Asthma 1996;33:67-71.
141. Helenius IJ, Rytila P, Metso T, Haahtela T, Venge P, Tikkanen HO: Respiratory symptoms, bronchial responsiveness, and cellular characteristics of induced sputum in elite swimmers. Allergy 1998;53:346-352.
142. McFadden ER, Lenner KAM, Strahl KP: Postexertional airway rewarming and thermally induced asthma. J Clin Invest 1986;78:18-25.
143. Anderson SD, Schoeffel RE, Black JL, Daviskas E: Airway cooling in the stimulus to exercise-induced asthma: a re-evaluation. Eur J Respir Dis 1985;67:20-30.
144. Davis MS, Freed AN: Repetitive hyperpnoea causes peripheral airway obstruction and eosinophilia. Eur Respir J 1999;14:57-62.
145. Sue-Chu M, Larsson L, Moen T, Rennard SI, Bjermer L: Bronchoscopy and bronchoalveolar lavage findings in cross-country skiers with and without 'ski asthma'. Eur Respir J 1999;13:626-632.
146. Sue-Chu M, Karjalainen EM, Laitinen A, Larsson L, Laitinen LA, Bjermer L: Placebo-controlled study of inhaled budesonide on indices of airway inflammation in bronchoalveolar lavage fluid and bronchial biopsies in cross-country skiers. Respiration (Herrlisheim) 2000;67:417-425.
147. Karjalainen EM, Laitinen A, Sue-Chu M, Altraja A, Bjermer L, Laitinen LA: Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine. Am J Respir Crit Care Med 2000;161:2086-2091.
148. Mickleborough TD, Murray RL, Ionescu AA, Lindley MR: Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med 2003;168:1181-1189.