The role of fatty acids in gene expression: Health implications

Annals of Nutrition and Metabolism

Volumn 40, Issue 6, 1996, Pages 303-311

  Simopoulos, Artemis P ^a  

^a Center for Nutrition Genetics & Health   (United States)

Author keywords

Gene expression; Glycolysis; Growth related early response gene expression; Inflammation; Lipogenesis; Omega 3 fatty acids; Omega 6 fatty acids

Indexed keywords

CELL ADHESION MOLECULE; DOCOSAHEXAENOIC ACID; GLUCOSE TRANSPORTER; ICOSANOID; ICOSAPENTAENOIC ACID; REGULATOR PROTEIN; UNSATURATED FATTY ACID;

EARLY RESPONSE GENE; FATTY ACID METABOLISM; GENE EXPRESSION; GLYCOLYSIS; HUMAN; LIPOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 12644278297     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000177929     Document Type: Article

References (45)

1. Simopoulos AP: Genetic variation and nutrition. Part I. Population differences due to single gene defects and population differences in multi-factorial diseases due to polygenic effects. Nutr Today 1995:30:157-167.
2. Simopoulos AP: Genetic variation and nutrition. Pan 2. Genetic variation. nutrition and chronic diseases. Nutr Today 1995:30:194-206.
3. Leaf A. Weber PC: A new era for science in nutrition. Am J Clin Nutr 1987;45:1048-1053.
4. Simopoulos AP, Childs B (eds): Genetic variation and nutrition. World Rev Nutr Diet. Basel. Kargcr. 1990. vol 63.
5. Eaton SB. Konner M: Paleolithic nutrition: A consideration of its nature and current implications. N Engl J Med 1988:318:461-466.
6. Simopoulos AP: Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991:54:438-463.
7. Harris WS, Connor WE, Lindsey S: Will dietary' omega-3 fatly acids change the composition of human milk? Am J Clin Nutr 1984:40:780-785.
8. Olsen SE. Sorenson JD. Secher N.I. et al: Randomized controlled trial of effect of fish-oil supplementation of pregnancy duration. Lancet 1992; 339:1003-1007.
9. Connor WE, Lowensohn R, Hatcher L: Increased docosahexaenoie acid levels in human newborn infants by administration of sardines and fish oil during pregnancy. Lipids 1996: 3 LSI 83-SI87.
10. Uauv RD. Birch DG. Birth EE. Tyson JE. Hoffman DR: Effect of dietary omega-3 fatty acids on retinal function of very-low-birth-wcight neonates. Pediatr Res 1990:28:485-492.
11. Makridcs M. Simmer K. Goggin M. Gibson RA: Erythrocyte docosahex-acnoic acid correlates with the visual response of healthy, term infants. Pediatr Res 1993:33:425-427.
12. Carlson SE, Werkman SH, Rhodes PG. Tolley EA: Visual-acuity development in healthy preterm infants: Effect of marine-oil supplementation. Am J Clin Nutr 1993:58:35-42.
13. ISSFAL Board Statement: Recommendations for the essential fatty acid requirement for infant formulas: in Simopoulos AP (ed): Behavioral and Metabolic Aspects of Breastfeeding: InternationalTrends. World Rev Nutr Diet. Basel. Kargcr. 1995. vol 78. ppxv-xvii.
14. Agostoni C. Trojan S. Bellu R. Riva E. Giovanni M: Neurodcvelopmcn-tal quotient of healthy term infants at 4 months and feeding practice: The role of long-chain polyunsaturated fatty acids. Pediatr Res 1995: 38:262-266.
15. Makridcs M. Neumann M. Simmer K. Pater J. Gibson R: Arc long chain polyunsaturated fatly acids essential nutrients in infancy? Lancet 1995: 345:1463-1468.
16. Clandinin MT, Cheema S, Field CJ, Garg ML, Vckatraman J, Clandinin TR: Dietary fat: Exogenous determination of membrane structure and cell function. FASEB J 1991;5: 2761-2769.
17. Graber R, Sumida C, Nunez EA: Fatty acids and cell signal transduction. J Lipid Mediat Cell Signal 1994:9:91-116.
18. Clarke SD. Jump DB: Regulation of gene transcription by polyunsaturated fatty acids. Prog Lipid Res 1993: 32:139-149.
19. Clarke SD. Jump DB: Dietary polyunsaturated fatty acid regulation of gene transcription. Annu Rev Nutr 1994:14:83-98.
20. Gurney AL, Park EA, Liu J, ct al: Metabolic regulation of gene transcription. J Nutr 1994:124:1533S-1539S.
21. Clarke SD. Romsos DR. Lcvcille GA: Differential effects of dietary methylesters of long chain saturated and polyunsaturated fatty acids on rat liver and adipose tissue lipogene-sis. J Nutr 1977:107:1170-1180.
22. Clarke SD, Armstrong MK, Jump DB: Nutritional control of rat liver fatly acid synthase and SI4 mRNA abundance. J Nutr 1990:120:218-224.
23. Clarke SD. Jump DB: Fatty acid regulation of gene expression: A unique role for polyunsaturated fats: in Bcrdanicr C. Hargrove JL (eds): Nutrition and Gene Expression. Boca Raton. CRC Press. 1993. pp 227-246.
24. Clarke SD, Jump DB: Polyunsaturated fatty acid regulation of hepatic gene transcription. Lipids 1996:31 (suppl):7-l I.
25. Jump DB. Clarke SD. Thelen A. Lii-matta N: Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res 1994:35:1076-1084.
26. Tebbcy PW, McGowan KM, Stephens JM, Buttke TM, Pckata PH: Arachidonic acid down-regulates the insulin-dependent glucose transporter gene (Glut 4) in 3T3-L1 adipocytes by inhibiting transcription and enhancing mRNA turnover. J Biol Chem 1994;269:639-644.
27. Clarke SD. Armstrong MK. Jump DB: Dietary polyunsaturated fats uniquely suppress rat liver fatty acid synthase and SI 4 mRNA content. J Nutr 1990:120:225-232.
28. Liimatta M, Towle HC, Clarke SD, Jump DB: Dietary PUFA interfere with the insulin glucose activation of L-typc pyruvate kinase. Mol Endocrinol 1994:8:1147-1153.
29. Clarke SD. Romsos DR. Lcvcille GA: Differential effects of dietary methylesters of long chain saturated and polyunsaturated fatty acids on rat liver and adipose tissue lipogene-sis. J Nutr 1977:107:1170-1180.
30. Ntambi JM: Dietary regulation of stearovl-CoA desaturasc 1 gene expression in mouse liver. J Biol Chem 1991:267:10925-10930.
31. DeWillie JW. Farmer SJ: Linoleic acid controls neonatal tissue-specific stcaroyl-CoA desaturasc mRNA levels. Biochim Biophys Acta 1993:1170:291-295.
32. Cave WT: Dietary n-3 (w-3) polyunsaturated fatty acid effects on animal tumorigenesis. FASEB J 1991: 5:2160-2166.
33. Sellmayer A. Danesch U. Weber PC: Effects of different polyunsaturated fatty acids on growth-related early gene expression and cell growth. Lipids 1996:31:S37-S40.
34. Kaplan IV, Guo Y, Mowe D: Developmental expression of the immediate early gene EGR-I mirrors the critical period in cat visual cortex. Dev Brain Res 1995:90:174-179.
35. Etzioni A: Adhesion molecules -Their role in health and disease. Pc-diatr Res 1996:39:191-198.
36. De Caterina R, Libby P: Control of endothelial leukocyte adhesion molecules by fatty acids. Lipids 1996:31 (suppl):57-63.
37. Dinarcllo CA: The role of interleukin-1 in disease. N Engl J Med 1993: 328:106-113.
38. Endrcs S, Fülle HJ, Sinha B, et al: Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1-beta by human mononuclear cells. Immunology 1991:72:56-60.
39. Endres S, Ghorbani R, Kelley VE, et al: The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989:320:265-271.
40. Robinson DR. Urakaze M. Huang R. et al: Dietary marine lipids suppress the continuous expression of interleukin-IB gene transcription. Lipids 1996:31 (suppl):23-31.
41. Holian O. Nelson R: Action of long-chain fatty acids on protein kinase C activity: Comparison of omega-6 and omega-3 fatty acids. Anticanccr Res 1992:12:975-980.
42. Kaminski WE. Jendraschak E. Kicfl R. van Schacky C: Dietary omega-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells. Blood 1993: 81:1871-1879.
43. Lucas A. Morley R, Cole TJ. Lister G, Leeson-Payne C: Breast milk and subsequent intelligence quotient in children born premature. Lancet 1992:339:261-264.
44. Eurocat Working Group: Prevalence of neural tube defects in 20 regions of Europe and the impact of prenatal diagnosis 1980-86. J Epidemiol Community Health 1991; 45:52-58.
45. Zamboni M. Armellini F. Turcato E, Todcsco T. Bissoli L, Bergamo-Andreis IA, Bosello O: Effect of weight loss on regional body fat distribution in premenopausal women. Am J Clin Nutr 1993:58:29-34.