Rapid drug metabolite profiling using fast liquid chromatography, automated multiple-stage mass spectrometry and receptor-binding

Journal of Chromatography A

Volumn 831, Issue 2, 1999, Pages 227-241

  Lim, H K ^a   Stellingweif, S ^a   Sisenwine, S ^a   Chan, K W ^a  

^a PFIZER INC   (United States)

Author keywords

Adatanserin; Multiple stage mass spectrometry; Raloxifene; Rapid metabolite profiling; Tamoxifen

Indexed keywords

ADATANSERIN; DRUG METABOLITE; HYDROXYTAMOXIFEN; NORTAMOXIFEN; RALOXIFENE; REAGENT; TAMOXIFEN;

ARTICLE; AUTOANALYSIS; CONTROLLED STUDY; DEVICE; DRUG METABOLISM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MASS SPECTROMETRY; MICROSOME; MOLECULAR RECOGNITION; PRIORITY JOURNAL; RECEPTOR AFFINITY; ULTRAFILTRATION;

ANIMALS; AUTOANALYSIS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; MASS SPECTROMETRY; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; PIPERIDINES; RALOXIFENE; RATS; RECEPTORS, DRUG; STRUCTURE-ACTIVITY RELATIONSHIP; TAMOXIFEN;

EID: 0033046884     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(98)00956-X     Document Type: Article

References (30)

1. Balkenhohl F., Bussche-Huennefeld C., Lansky A., Zechel C. Angew. Chem. Int. Ed. Engl. 35:1996;2288.
2. Bevan P., Ryder H., Shaw I. Trends Biotechnol. 13:1995;115.
3. Desai M.C., Zuckermann R.N., Moos W.H. Drug Dev. Res. 33:1994;147.
4. Gallop M.A., Barrett R.W., Dower W.J., Fodor S.P.A., Gordon E.M. J. Med. Chem. 37:1994;1233.
5. Smith D.A. Eur. J. Drug Metab. Pharmacokinet. 3:1994;193.
6. Potts W., Lundberg D., Peters J., Bi H., Stelman G., Sandhu G. ISSX Proceedings. 8:1995;404.
7. Bergman J., Halm K., Adkison K., Shaffer J. J. Med. Chem. 40:1997;827.
8. McLoughlin D.A., Olah T.V., Gilbert J.D. J. Pharm. Biomed. Anal. 15:1997;1893.
9. Hop C.E.C.A., Wang Z., Chen Q., Kwei G. J. Pharm. Sci. 87(7):1998;901.
10. J.P. Bulgarelli, S.M. Michael, Presented at the 46th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, 31 May-4 June, 1998.
11. G. Rusing, C. Sauber, M. Kinzig-Schippers, P. Nickel, F. Sorgel, Presented at the Annual Meeting of the American Association of Pharmaceutical Scientisits, Boston, Massachusettes, 2-6 November, 1997.
12. Rodrigues A.D., Kukulka M.J., Surber B.W., Thomas S.B., Uchic J.T., Rotert G.A., Michel G., Thome-Kromer B. Anal. Biochem. 219:1994;309.
13. Tweedie D.J. ISSX Proceedings. 10:1996;31.
14. S.C. Taylor, A.M. Starrett, G.C. DiDonato, M.S. Lee, Presented at the 43rd ASMS Conference on Mass Spectrometry and Allied Topics, Atlanta, Georgia, 21-26 May, 1995, p. 442.
15. Kirkland J.J., Yau W.W., Stoklosa H.J., Dilks C.H. Jr. J. Chromatogr. Sci. 15:1977;303.
16. F.J. Yang, W. Lai, D.C. Park, C.T. Tang, LC·GC, Supplement, May (1997) S34.
17. L.R. Snyder, J.J. Kirkland, J.L. Glajch, Practical HPLC Method Development, 2nd ed., Wiley, New York, 1997.
18. Lonning P.E., Lien E.A., Lundgren S., Kvinnsland S. Clin. Pharmacokinet. 22:1992;327.
19. Potter G.A., McCague R., Jarman M. Carcinogenesis. 15:1994;439.
20. Beussman D.J., Vlasak P.R., McLane R.D., Seeterlin M., Enke C.G. Anal. Chem. 67:1995;3952.
21. Kuar S., McGuire L., Tang D., Dollinger G., Huebner V. J. Protein Chem. 16:1997;505.
22. Van Breemen R.B., Huang C.R., Nikolic D., Woodbury C.P., Zhoa Y.Z., Venton D. Anal. Chem. 69:1997;2159.
23. Wieboldt R., Zweigenbaum J., Henion J. Anal. Chem. 69:1997;1683.
24. E.Y. Yang, J. Zweigenbaum, J. Henion, Presented at the 45th ASMS Conference on Mass Spectrometry and Allied Topics, Palm Springs, California, 1-5 June, 1997, p. 1081.
25. Garattini S. Clin. Pharmacokinet. 10:1985;216.
26. Balant L.P., Gundert-Remy U., Boobis A.R., von Bahr C. Eur. Clin. Pharmacol. 36:1989;551.
27. Fabian C., Tilzer L., Sternson L. Biopharm. Drug Dispos. 2:1981;381.
28. Jordan V.C., Collins M.M., Rowsby L., Prestwich G. J. Endocrinol. 75:1977;305.
29. Fromson J.M., Pearson S., Bramah S. Xenobiotica. 3:1973;711.
30. Keasling H.H., Schueler F.W. J. Am. Pharm. Assoc. 39:1950;87.