Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk

Cancer Causes and Control

Volumn 19, Issue 9, 2008, Pages 975-980

  Hazra, Aditi ^a,b   Fuchs, Charles S ^b,c   Chan, Andrew T ^b   Giovannucci, Edward L ^a,b   Hunter, David J ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Colorectal adenoma; Colorectal cancer; Polymorphism; TCF7L2; WNT pathway

Indexed keywords

T CELL FATOR 7 LIKE 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER RISK; COLORECTAL ADENOMA; COLORECTAL CANCER; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TCF7L2 GENE; TUMOR GENE;

ADENOMA; ADULT; AGED; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEALTH SURVEYS; HUMANS; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; TCF TRANSCRIPTION FACTORS;

EID: 52549105588     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-008-9164-3     Document Type: Article

References (31)

1. WJ Nelson R Nusse 2004 Convergence of Wnt, beta-catenin, and cadherin pathways Science 303 1483 1487
2. A Duval J Gayet XP Zhou B Iacopetta G Thomas R Hamelin 1999 Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability Cancer Res 59 4213 4215
3. A Duval S Rolland E Tubacher H Bui G Thomas R Hamelin 2000 The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines Cancer Res 60 3872 3879
4. P Cuilliere-Dartigues J El-Bchiri A Krimi O Buhard P Fontanges JF Flejou R Hamelin A Duval 2006 TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription Oncogene 25 4441 4448
5. T Sjöblom 2006 The consensus coding sequences of human breast and colorectal cancers Science 314 268 274
6. SF Grant G Thorleifsson I Reynisdottir R Benediktsson A Manolescu J Sainz A Helgason H Stefansson V Emilsson A Helgadottir U Styrkarsdottir KP Magnusson GB Walters E Palsdottir T Jonsdottir T Gudmundsdottir A Gylfason J Saemundsdottir RL Wilensky MP Reilly DJ Rader Y Bagger C Christiansen V Gudnason G Sigurdsson U Thorsteinsdottir JR Gulcher A Kong K Stefansson 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 320 323
7. R Sladek G Rocheleau J Rung C Dina L Shen D Serre P Boutin D Vincent A Belisle S Hadjadj B Balkau B Heude G Charpentier TJ Hudson A Montpetit AV Pshezhetsky M Prentki BI Posner DJ Balding D Meyre C Polychronakos P Froguel 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 881 885
8. Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PIW, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D, the Diabetes Prevention Program (2006) TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241-250
9. C Zhang L Qi DJ Hunter JB Meigs JE Manson RM van Dam FB Hu 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men Diabetes 55 2645 2648
10. R Saxena L Gianniny NP Burtt V Lyssenko C Giuducci M Sjogren JC Florez P Almgren B Isomaa M Orho-Melander U Lindblad MJ Daly T Tuomi JN Hirschhorn KG Ardlie LC Groop D Altshuler 2006 Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals Diabetes 55 2890 2895
11. LJ Scott LL Bonnycastle CJ Willer AG Sprau AU Jackson N Narisu WL Duren PS Chines HM Stringham MR Erdos TT Valle J Tuomilehto RN Bergman KL Mohlke FS Collins M Boehnke 2006 Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample Diabetes 55 2649 2653
12. CJ Groves E Zeggini J Minton TM Frayling MN Weedon NW Rayner GA Hitman M Walker S Wiltshire AT Hattersley MI McCarthy 2006 Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk Diabetes 55 2640 2644
13. CM Damcott TI Pollin LJ Reinhart SH Ott H Shen KD Silver BD Mitchell AR Shuldiner 2006 Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance Diabetes 55 2654 2659
14. EA Platz SE Hankinson N Rifai GA Colditz FE Speizer E Giovannucci 1999 Glycosylated hemoglobin and risk of colorectal cancer and adenoma (United States) Cancer Causes Control 10 379 386
15. EK Wei J Ma MN Pollak 2006 C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women Cancer Epidemiol Biomarkers Prev 15 750 755
16. EK Wei J Ma MN Pollak 2005 A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women Cancer Epidemiol Biomarkers Prev 14 850 855
17. TT Tran D Naigamwalla AI Oprescu 2006 Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo Endocrinology 147 1830 1837
18. A Koushik P Kraft C Fuchs SE Hankinson WC Willett EL Giovannucci DJ Hunter 2006 Polymorphisms in one-carbon metabolism genes and associations with colorectal cancer Cancer Epidemiol Biomarkers Prev 15 2408 2417
19. GJ Tranah E Giovannucci J Ma C DJ Fuchs Hunter 2005 APC Asp1822Val and Gly2502Ser polymorphisms and risk of colorectal cancer and adenoma Cancer Epidemiol Biomarkers Prev 14 863 870
20. KJ Livak 1999 Allelic discrimination using fluorogenic probes and 5′ nuclease assay Genet Anal 14 143 149
21. Hart MJ, de los Santos R, Albert IN, Rubinfeld B, Polakis P (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol 8:573-581
22. P Polakis 2000 Wnt signaling and cancer Genes Dev 14 1837 1851
23. O Tetsu F McCormick 1999 Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 422 426
24. TC He AB Sparks C Rago H Hermeking L Zawel LT da Costa PJ Morin B Vogelstein KW Kinzler 1998 Identification of c-MYC as a target of the APC pathway Science 281 1509 1512
25. R Sladek G Rocheleau J Rung 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 881 885
26. LJ Scott KL Mohlke LL Bonnycastle et al 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 1341 1345
27. Diabetes Genetics Initiative 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336
28. V Steinthorsdottir G Thorleifsson I Reynisdottir et al 2007 A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Nat Gen 39 770 775
29. B Burwinkel KS Shanugam K Hemminki A Meindl RK Schmutzler C Sutter B Wappenschmidt M Kiechle CR Bartram B Frank 2006 Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study BMC Cancer 6 268
30. S Cauchi Y El Achhab H Choquet C Dina F Krempler F Krempler R Weitgasser C Nejjari W Patsch M Chikri D Meyre P Froguel 2007 TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis J Mol Med 85 777 782
31. F Yi PL Brubaker T Jin 2005 TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta J Biol Chem 280 1457 1464