Synthesis and in vitro evaluation of 5-[18F]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression

Journal of Medicinal Chemistry

Volumn 51, Issue 18, 2008, Pages 5690-5701

  Chacko, Ann Marie ^a   Qu, Wenchao ^a   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUOROBUTYLPYRIMIDINE F 18; 5 FLUOROPENTYLPYRIMIDINE F 18; 5 FLUOROPROPYLPYRIMIDINE F 18; FLUORINE 18; PYRIMIDINE NUCLEOSIDE DERIVATIVE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE PROBE; HERPES SIMPLEX VIRUS 1; IC 50; ISOTOPE LABELING; MOLECULAR IMAGING; MOUSE; NONHUMAN; RADIOCHEMISTRY; REPORTER GENE;

DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; GENES, REPORTER; HERPESVIRUS 1, HUMAN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINE NUCLEOSIDES; THYMIDINE KINASE;

EID: 52449126958     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800501d     Document Type: Article

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