In vivo evaluation of the uptake of [123I]FIAU, [123I]IVFRU and [123I]IVFAU by normal mouse brain: Potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas

Nucleosides, Nucleotides and Nucleic Acids

Volumn 27, Issue 1, 2008, Pages 57-66

  Li, H F ^a,b   Winkeler, A ^a,b   Moharram, S ^c   Knaus, E E ^c   Dittmar, K ^a,b   Stockle M ^a,b   Heiss, W D ^b   Wiebe, L I ^c   Jacob, A J ^b  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Blood brain barrier (BBB); Gene expression, brain permeability; Herpes simplex virus type 1 thymidine kinase (HSV 1 TK)

Indexed keywords

(5 (2 IODOVINYL) 2' FLUORO 2' DEOXYARABINOURIDINE I 123; 5 (2 IODOVINYL) 2' FLUORO 2' DEOXYURIDINE I 123; 5 IODO 1 (2 FLUORO 2 DEOXY BETA DEXTRO ARABINOFURANOSYL)URACIL I 123; GLYCOSIDE; IODINE 123; RADIOPHARMACEUTICAL AGENT; THYMIDINE KINASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; URIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CHEMICAL BOND; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG HYDROLYSIS; DRUG PENETRATION; DRUG RETENTION; DRUG SCREENING; DRUG STABILITY; DRUG UPTAKE; GENE EXPRESSION; GLIOMA; HERPES SIMPLEX VIRUS 1; ISOTOPE LABELING; LIPOPHILICITY; MALE; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; ORGAN DISTRIBUTION; POSITRON EMISSION TOMOGRAPHY;

ANIMALS; ARABINOFURANOSYLURACIL; BLOOD-BRAIN BARRIER; BRAIN; BRAIN NEOPLASMS; FLOXURIDINE; GENE EXPRESSION; GLIOMA; HERPESVIRUS 1, HUMAN; IODINE RADIOISOTOPES; MALE; MICE; MICE, NUDE; THYMIDINE KINASE; TISSUE DISTRIBUTION; URIDINE;

HUMAN HERPESVIRUS 1; MUS;

EID: 38049100391     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701571933     Document Type: Article

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