Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells

Nuclear Medicine and Biology

Volumn 31, Issue 5, 2004, Pages 623-630

  Morin, Kevin W ^a,b   Duan, Weili ^a   Xu, Lihua ^a   Zhou, Aihua ^a   Moharram, Sameh ^a   Knaus, Edward E ^a   McEwan, Alexander J B ^b   Wiebe, Leonard I ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 (2 IODOVINYL) 2' DEOXYURIDINE; 5 (2 IODOVINYL) 2' FLUORO 2' DEOXYARABINOURIDINE I 125; 5 (2 IODOVINYL) 2' FLUORO 2' DEOXYURIDINE I 125; 5 IODO 2' FLUORO 2' DEOXYARABINOURIDINE I 125; 5 IODO 2' FLUORO 2' DEOXYRIBOURIDINE I 125; GANCICLOVIR; IDOXURIDINE; NUCLEIC ACID; NUCLEOTIDE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BIOCHEMISTRY; CANCER CELL DESTRUCTION; CELL ACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG SELECTIVITY; GENE THERAPY; GENE TRANSFER; GENETIC ENGINEERING; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMAGING; ISOTOPE LABELING; LIPOPHILICITY; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOSIDE TRANSPORT; PHOSPHORYLATION; PROTEIN EXPRESSION; RADIATION DETECTION; RADIOACTIVITY; SUBSTITUTION REACTION; TUMOR CELL LINE; VIRUS GENE;

ANIMALS; BALB 3T3 CELLS; CELL LINE; CELL SURVIVAL; IODINE RADIOISOTOPES; MALE; MAMMALS; METABOLIC CLEARANCE RATE; MICE; NEOPLASMS; ORGAN SPECIFICITY; PYRIMIDINE NUCLEOSIDES; RADIOPHARMACEUTICALS; RECOMBINANT PROTEINS; THYMIDINE KINASE; TISSUE DISTRIBUTION; VIRAL PROTEINS;

EID: 3042664680     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2004.02.004     Document Type: Article

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