cagA, vacA, and iceA genotypes of Helicobacter pylori in Korean children

Pediatrics International

Volumn 50, Issue 5, 2008, Pages 628-631

  Ko, Jae Sung ^a   Kim, Kyung Mo ^b   Oh, Young Lyun ^c   Seo, Jeong Kee ^a,d  

^a Seoul National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

Author keywords

cagA; Children; Helicobacter pylori; iceA; vacA

Indexed keywords

BACTERIAL PROTEIN; CAGA PROTEIN; PROTEIN ICEA; UNCLASSIFIED DRUG; VACUOLATING TOXIN;

ADOLESCENT; ARTICLE; CHILD; CHRONIC INFLAMMATION; CLINICAL ARTICLE; DISEASE SEVERITY; DNA EXTRACTION; FEMALE; GASTRITIS; GENOTYPE; HELICOBACTER PYLORI; HUMAN; KOREA; MALE; NEUTROPHIL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCORING SYSTEM; STOMACH ANTRUM; STOMACH BIOPSY;

ADOLESCENT; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; CHILD; CHILD, PRESCHOOL; ENDOSCOPY, DIGESTIVE SYSTEM; FEMALE; GASTRITIS; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; KOREA; MALE; SEVERITY OF ILLNESS INDEX; VIRULENCE FACTORS;

EID: 52449111003     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2008.02641.x     Document Type: Article

References (31)

1. Graham DY. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: A model. Gastroenterology 1997 113 : 1983 91.
2. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. JAMA 1994 272 : 65 9.
3. Dunn BE, Cohen H, Blaser MJ. Helicobacter pylori. Clin. Microbiol. Rev. 1997 10 : 720 41.
4. Holtmann G, Talley NJ, Mitchell H, Hazell S. Antibody response to specific H. pylori antigens in functional dyspepsia, duodenal ulcer disease, and health. Am. J. Gastroenterol. 1998 93 : 1222 7.
5. Blaser MJ, Perez-Perez GI, Cover TL et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of stomach. Cancer Res. 1995 55 : 2111 15.
6. Atherton JC, Cao P, Peek RMJ, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Clin. Biol. Chem. 1995 270 : 17771 7.
7. van Doorn LJ, Gigueriedo C, Sanna R et al. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology 1998 115 : 58 66.
8. Atherton JC, Peek RM, Tham KY, Cover TL, Blaser MJ. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997 112 : 92 9.
9. Maeda S, Ogura K, Yoshida H et al. Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut 1998 42 : 338 43.
10. Yamaoka Y, Kodama T, Gutierrez O, Kim JG, Kashima K, Graham DY. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome; studies in four different countries. J. Clin. Microbiol. 1999 37 : 2274 9.
11. Azuma T, Kato S, Zhou W et al. Diversity of vacA and cagA genes of Helicobacter pylori in Japanese children. Aliment. Pharmacol. Ther. Suppl. 2004 20 : 7 12.
12. Podzorski RP, Podzorski DS, Wuerth A, Tolia V. Analysis of the vacA, cagA, cagE, iceA, and babA2 genes in Helicobacter pylori from sixty-one pediatric patients from the Midwestern United States. Diagn. Microbiol. Infect. Dis. 2003 46 : 83 8.
13. Benenson S, Halle D, Rudensky B et al. Helicobacter pylori genotypes in Israeli children: The significance of geography. J. Pediatr. Gastroenterol. Nutr. 2002 35 : 680 84.
14. Karhukorpi J, Yan Y, Kolho KL et al. cagA, vacA and iceA virulence genes of Helicobacter pylori isolates of children in Finland. Eur. J. Clin. Microbiol. Infect. Dis. 2000 19 : 790 93.
15. Lu JJ, Perng CL, Shyu RY et al. Comparison of five PCR methods for detection of Helicobacter pylori DNA in gastric tissue. J. Clin. Microbiol. 1999 37 : 772 4.
16. Dixon MF, Genta Rm, Yardley JH, Correa P. Classification and grading of gastritis the updated Sydney system. Am. J. Surg. Pathol. 1996 20 : 1161 81.
17. Park HS, Park HJ, Yoon SA et al. Diagnosis of Helicobacter pylori using polymerase chain reaction and relation between cagA and severity of gastritis. Korean J. Gastroenterol. 1998 31 : 281 9.
18. Park SM, Park J, Kim JG et al. Infection with Helicobacter pylori expressing the cagA gene is not associated with an increased risk of developing peptic ulcer diseases in Korean patients. Scand. J. Gastroenterol. 1998 33 : 923 7.
19. Tummuru MKR, Cover TL, Blaser MJ. Cloning and expression of a high-molecular mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production. Infect. Immun. 1993 61 : 1799 1809.
20. Censini S, Lange C, Xiang Z et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated factors. Proc. Natl Acad. Sci. USA 1996 93 : 14648 53.
21. Fisher W, Puls J, Buhrdorf R, Gebert B, Odenbreit S, Haas R. Systemic mutagenesis of the Helicobacter pylori cag pathogenicity island: Essential genes for CagA translocation in host cells and induction of interleukin-8. Mol. Microbiol. 2001 42 : 1337 48.
22. Atherton JC, Tham KT, Peek RM, Cover TL, Blaser MJ. Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J. Infect. Dis. 1996 174 : 552 6.
23. Yamaoka Y, Kodama T, Kita M, Imanishi J, Kashima K, Graham DY. Relation between clinical presentation, Helicobacter pylori density, interleukin 1β and 8 production and cagA status. Gut 1999 45 : 804 11.
24. Yamaoka Y, Kodama T, Kita M, Imanishi J, Kashima K, Graham DY. Relationship of vacA genotypes of Helicobacter pylori to cagA status, cytotoxin production, and clinical outcome. Helicobacter 1998 4 : 241 53.
25. Gold BD, van Doorn LJ, Guarner J et al. Genotypic, clinical and demographic characteristics of children infected with Helicobacter pylori. J. Clin. Microbiol. 2001 39 : 1348 52.
26. Wang HJ, Kuo CH, Yeh AA, Chang PC, Wang WC. Vacuolating toxin production in clinical isolates of Helicobacter pylori with different vacA genotypes. J. Infect. Dis. 1998 178 : 207 12.
27. Zheng PY, Hua J, Yeoh JG, Ho B. Association of peptic ulcer with increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori with different vacA genotypes. J. Infect. Dis. 1998 178 : 207 12.
28. Peek RM, Thompson SA, Donahue JP et al. Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome. Proc. Assoc. Am. Physicians 1998 110 : 531 44.
29. Nishiya D, Shimoyama T, Fukuda S, Yoshimura T, Tanaka M, Munakata A. Evaluation of the clinical relevance of the iceA1 gene in patients with Helicobacter pylori infection in Japan. Scand. J. Gastroenterol. 2000 35 : 36 9.
30. Oleastro M, Gerhard M, Lopes AI et al. Helicobacter pylori virulence genotypes in Portuguese children and adults with gastroduodenal pathology. Eur. J. Clin. Microbiol. Infect. Dis. 2003 22 : 85 91.
31. Yamaoka Y, Malaty HM, Osato MS, Graham DY. Conservation of Helicobacter pylori genotypes in different ethnic groups in Houston, Texas. J. Infect. Dis. 2000 181 : 2083 6.