Vacuolating toxin production in clinical isolates of Helicobacter pylori with different vacA genotypes

Journal of Infectious Diseases

Volumn 178, Issue 1, 1998, Pages 207-212

  Wang, Hung Jung ^a   Kuo, Chun Hsien ^a   Yeh, Amy A M ^a   Chang, Paul C L ^a   Wang, Wen Ching ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN;

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; CELL VACUOLE; DISEASE ASSOCIATION; DYSPEPSIA; GENETIC ANALYSIS; GENOTYPE; HELICOBACTER PYLORI; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIC ULCER; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STOMACH CANCER; STRAIN DIFFERENCE;

EID: 0031845236     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515600     Document Type: Article

References (25)

1. Blaser MJ. Helicobacter pylori: its role in disease. Clin Infect Dis 1992;15:386-93.
2. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984;1:1311-5.
3. Goodwin CS, Armstrong JA, Marshall BJ. Campylobacter pyloridis gastritis and peptic ulceration. J Clin Pathol 1986;39:353-65.
4. Parsonnet J. Helicobacter pylori and gastric cancer. Gastroenterol Clin North Am 1993;22:89-104.
5. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Issacson PG. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175-6.
6. Figura N, Guglielmetti P, Rossolini A, et al. Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J Clin Microbiol 1989;27:225-6.
7. Crabtree JE, Taylor JD, Wyatt JI, Heatley RV, Shallcross TM, Tompkins DS. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration and gastric pathology. Lancet 1991;338:332-5.
8. Covacci A, Censini S, Bugnoli M, et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 1993;90:5791-5.
9. Tee W, Lambert JR, Dwyer B. Cytotoxin production by Helicobacter pylori from upper gastrointestinal tract disease. J Clin Microbiol 1995;33:1203-5.
10. Crabtree JE, Figura N, Taylor JD, Bugnoli M, Armellini D, Tompkins DS. Expression of 120 kilodalton protein and cytotoxicity in Helicobacter pylori. J Clin Pathol 1992;45:733-4.
11. Tummuru MKR, Cover TL, Blaser MJ. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun 1993;61:1799-809.
12. Censini S, Lange C, Xiang Z, et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996;93:14648-53.
13. Leunk RD, Johnson PT, David BC, Kraft WG, Morgan DR. Cytotoxic activity in broth culture filtrates of Campylobacter pylori. J Med Microbiol 1988;26:93-9.
14. Harris PR, Cover TL, Crowe DR, et al. Helicobacter pylori cytotoxin induces vacuolation of primary human mucosal epithelial cells. Infect Immun 1996;64:4867-71.
15. Marchetti M, Arico B, Burroni D, Figura N, Rappuoli R, Ghiara P. Helicobacter pylori infection in a mouse model that mimics human disease. Science 1995;267:1655-8.
16. Atherton JC, Cao P, Peek JRM, Tummuru MKR, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. J Biol Chem 1995;270:17771-7.
17. Xiang Z, Censini S, Bayeli PF, et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun 1995;63:94-8.
18. Cover TL, Tummuru MKR, Cao P, Thompson SA, Blaser MJ. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 1994;269:10566-73.
19. Schmitt W, Haas R. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol Microbiol 1994;12:307-19.
20. Telford JL, Ghiara P, Dell'Orco M, et al. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 1994;179:1653-8.
21. Phadnis SH, Ilver D, Janzon L, Normark S, Westblom TU. Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect Immun 1994;62:1557-65.
22. Atherton JC, Peek RM, Tham KT, Cover TL, Blaser MJ. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997;112:92-9.
23. + Helicobacter pylori strains. J Clin Microbiol 1995;33:1496-500.
24. Yang JC, Wang TH, Wang HJ, Kuo CH, Wang JT, Wang WC. Genetic analysis of the cytotoxin-associated gene and the vacuolating toxin gene in Helicobacter pylori strains isolated from Taiwanese patients. Am J Gastroenterol 1997;92:1316-21.
25. Mitchell HM, Hazell SL, Li YY, Hu PJ. Serological response to specific Helicobacter pylori antigens: antibody against CagA antigen is not predictive of gastric cancer in a developing country. Am J Gastroenterol 1996;91:1785-8.