Relationship of vacA genotypes of helicobacter pylori to cagA status, cytotoxin production, and clinical outcome

Helicobacter

Volumn 3, Issue 4, 1998, Pages 241-253

  Yamaoka, Yoshio ^a,b,d   Kodama, Tadashi ^b   Kita, Masakazu ^c   Imanishi, Jiro ^c   Kashima, Kei ^c   Graham, David Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b First Department of Internal Medicine   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^d MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI; VACA PROTEIN, HELICOBACTER PYLORI;

ADULT; AGE; AGED; ARTICLE; DNA SEQUENCE; FEMALE; GASTRITIS; GENETICS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; JAPAN; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PATHOLOGY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BASE SEQUENCE; FEMALE; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; JAPAN; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA;

EID: 0032253792     PISSN: 10834389     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-5378.1998.08056.x     Document Type: Article

References (13)

1. Graham DY. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: A model. Gastroenterology 1997;113:1983-91.
2. Cover TL, Dooley CP, Blaser MJ. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolating cytotoxin activity. Infect Immun 1990;58:603-10.
3. Crabtree JE, Taylor JD, Wyatt JI, Heatley RV, Shallcross TM, Thompkins DS, Rathbone BJ. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 1991;338:332-5.
4. Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N, Rappuoli R. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 1993; 90:5791-5.
5. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, Rappuoli R, Covacci A. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996;93: 14648-53.
6. Cover TL, Tummuru MKR, Cao P, Thompson SA, Blaser MJ. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 1994;269:10566-73.
7. Atherton JC, Cao P, Peek RM, Tummuru MKR, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. J Biol Chem 1995;270:17771-7.
8. Atherton JC, Peek RM, Tham KT, Cover TL, Blaser MJ. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997;112:92-9.
9. Yamaoka Y, Kita M, Kodama T, Sawai N, Kashima K, Imanishi J. Induction of various cytokines and development of severe mucosal inflammation by cagA gene-positive Helicobacter pylori strains. Gut 1997;41:442-51.
10. Shimoyma T, Fukuda S, Tanaka M, Mikami T, Saito Y, Munakata A. High prevalence of the CagA-positive Helicobacter pylori strains in Japanese asymptomatic patients and gastric cancer patients. Scand J Gastroenterol 1997;32:465-8.
11. Pan ZJ, van der Hulst RWM, Feller M, Xiao SD, Tytgat GNJ, Dankert J, van der Ende A. Equally high prevalences of infection with cag-A-positive Helicobacter pylori in Chinese patients with peptic ulcer disease and those with chronic gastritis-associated dyspepsia. J Clin Microbiol 1997;35:1344-7.
12. Miehlke S, Kibler K, Kim JG, Figura N, Small SM, Graham DY, Go MF. Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United States. Am J Gastroenterol 1996;91:1322-5.
13. Graham DY, Genta RM, Graham DP, Crabtree JE. Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: Lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis. J Clin Pathol 1996;49:829-32.