Neuropathic pain - Neurochemical aspects;Dor neuropática - Aspectos neuroquímicos

Revista Brasileira de Anestesiologia

Volumn 58, Issue 5, 2008, Pages 492-505

  Kraychete, Durval Campos ^a,c   Gozzani, Judymara Lauzi ^b   Kraychete, Angiolina Campos ^a  

^a UFBA ^*

^b FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO   (Brazil)

^c SP ^*  (Brazil)

Author keywords

Pain: Neuropathic; Physiology: Neurotransmitters

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ADENOSINE; ADENOSINE RECEPTOR; ADENOSINE TRIPHOSPHATE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; AMPA RECEPTOR; ANTIINFLAMMATORY AGENT; BRADYKININ; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCITONIN GENE RELATED PEPTIDE; CYTOKINE; GLUTAMIC ACID; ICOSANOID; KAINIC ACID; LEUKOTRIENE B4; LYSOPHOSPHATIDIC ACID; MU OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; NEUROTROPHIN; NITRIC OXIDE; PACLITAXEL; PROSTAGLANDIN; PURINERGIC P2X3 RECEPTOR; SEROTONIN; SODIUM CHANNEL; SUBSTANCE P; TUMOR NECROSIS FACTOR ALPHA; VANILLOID RECEPTOR 1; VINCRISTINE;

CANCER CHEMOTHERAPY; CHRONIC CONSTRICTIVE INJURY; DIABETIC NEUROPATHY; EXPERIMENTAL MODEL; GLIA CELL; HYPERALGESIA; IMMUNE SYSTEM; NERVE DEGENERATION; NERVE INJURY; NERVE LIGATION; NEUROCHEMISTRY; NEUROPATHIC PAIN; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PAIN; PATHOPHYSIOLOGY; REVIEW; SCIATIC NERVE; SENSITIZATION; SENSORY NERVE; SPINAL NERVE; STREPTOZOCIN DIABETES;

EID: 52249117245     PISSN: 00347094     EISSN: 1806907X     Source Type: Journal    
DOI: 10.1590/s0034-70942008000500008     Document Type: Review

References (69)

1. Dworkin B and the Members of the Classification Subcommittee of the Special Interest Group of the International Association for the Study of Pain. Disponível em http://www.neupsig.org/.
2. Garcia-Larrea L, Magnin M - Physiopathologie de la douleur neuropathique: revue des modèles expérimentaux et des mécanismes proposés. Presse Med, 2008;37:315-340.
3. Campbell JN, Meyer RA - Mechanisms of neuropathic pain. Neuron, 2006;52:77-92.
4. Meyer RA, Ringkamp M, Campbell JN et al. - Peripheral Mechanisms of Cutaneous Nociception, em: McMahon SB, Koltzenburg M - Wall and Melzack's - Textbook of Pain. London, Elsevier, 2006;3-34.
5. Ibrahim MM, Deng H, Zvonok A et al. - Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci USA, 2003;100:10529-10533.
6. Gardell LR, Wang R, Ehrenfels C et al. - Multiple actions of systemic artemin in experimental neuropathy. Nat Med, 2003;9: 1383-1389.
7. Devor M - Response of Nerves to Injury in Relation to Neuropathic Pain, em: McMahon SB, Koltzenburg M - Wall and Melzack's - Textbook of Pain. London, Elsevier, 2006;905-927.
8. Sukhotinsky I, Ben Dor E, Raber P et al. - Key role of the dorsal root ganglion in neuropathic tactile hypersensibility. Eur J Pain, 2004;8:135-143.
9. Schäfers M, Lee DH, Brors D et al. - Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci, 2003;23:3028-3038.
10. Katsura H, Obata K, Mizushima T et al. - Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol, 2006;200:112-123.
11. Rogers M, Tang L, Madge DJ et al. - The role of sodium channels in neuropathic pain. Semin Cell Dev Biol, 2006;17:571-81.
12. KohnoT, Ji RR, Ito N et al. - Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. Pain, 2005;117:77-87.
13. Li CY, Song YH, Higuera ES et al. - Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia. J Neurosci, 2004; 24:8494-8499.
14. Zimmermann M - Pathobiology of neuropathic pain. Eur J Pharmacol, 2001;429:23-37.
15. McLean PG, Ahluwalia A, Perretti M - Association between kinin B (1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules. J Exp Med, 2000;192: 367- 380.
16. Baron R, Schwarz K, Kleinert A et al. - Histamine-induced itch converts into pain in neuropathic hiperalgesia. Neuroreport, 2001;12:3475-78.
17. Mekori YA, Metcalfe DD - Mast cells in innate immunity. Immunol Rev, 2000;173:131-140.
18. Woolf CJ - Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy. J Life Sci. 2004;74:2605- 2610.
19. Zuo Y, Perkins NM, Tracey DJ et al. - Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells. Pain, 2003;105:467-479.
20. Brück W - The role of macrophages in Wallerian degeneration. Brain Pathol, 1997;7:741-752.
21. Liu T, Van Rooijen N, Tracey DJ - Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury. Pain, 2000;86:25-32.
22. Moalem G, Xu K, Yu L - T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats. Neuroscience, 2004;134:1399 -1411.
23. Mosmann TR, Sad S - The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today, 1996;17:138-146.
24. Raghavendra V, Tanga F, DeLeo JA - Inhibition of microglial activation attenuates the development but not existing hipersensitivity in a rat model neuropathy. J Pharmacol Exp Ther, 2003;306:624-630.
25. Tanga FY, Nutile-McMenemy N, DeLeo JA - The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci USA, 2005;102:5856-5861.
26. Watkins LR, Milligan ED, Maier SF - Glial activation: a driving force for pathological pain. Trends Neurosci, 2001;24:450-455.
27. Spataro LE, Sloane EM, Milligan ED et al. - Spinal gap junctions potential involvement in pain facilitation. Clin J Pain, 2004;5:392-405.
28. Bergsteinsdottir K, Kingston A, Jessen KR - Rat Schwann cells can be induced to express major histocompatibility complex class II molecules in vivo. J Neurocytol, 1992;21:382-390.
29. Liu GJ, Werry EL, Bennett MR - Secretion of ATP from Schwann cells in response to uridine triphosphate. Eur J Neurosci, 2005; 21:151-160.
30. Skundric DS, Bealmear B, Lisak RP - Induced upregulation of IL-1, IL-1RA and IL-1R type I gene expression by Schwann cells. J Neuroimmunol, 1997;74:9-18.
31. Wang H, Kohno T, Amaya F et al. - Bradykinin produces pain hupersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci, 2005;25:7986-7992.
32. Burnstock G, Knight GE - Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol, 2004; 240:281-304.
33. Javis MF, Bugard EC, McGaraughty S et al. - A-317491, a novel potent and selective non-nucleotide P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in rats. Proc Natl Acad Sci USA, 2002;99:17179-17184.
34. Tsuda M, Shigemoto-Mogami Y, Koizumi S et al. - P2X4 receptors induced in spinal microglia gate tactile alodynia after nerve injury. Nature, 2003;424:778-783.
35. Chessell IP, Hatcher JP, Bountra C et al. - Disruption of the P2X7 purinoreceptor gene4 abolishes chronic inflammatoty and neuropathic pain. Pain, 2005;114:386-96.
36. Xiao HS, Huang QH, Zhang FX et al. - Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci USA, 2002;99:8360-8365.
37. Hong Y, Abbott FV - Behavioural effects of intraplantar injection of inflammatory mediators in the rat. Neuroscience, 1994;63: 827-836.
38. Moalem G, Grafe P, Tracey DJ - Chemical mediators enhance the excitability of unmyelinated sensory axons in normal and injured peripheral nerve of the rat. Neuroscience, 2005;134:1399-1411.
39. Taiwo YO, Levine JD - Prostaglandin effects after elimination of indirect hyperalgic mechanisms in the skin of the rat. Brain Res, 1989;492:397-399.
40. Malberg AB, Yaksh TL - Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science, 1992;257:1276-1279.
41. Ma W, Einsenach JC - Morphological and pharmacological evidence of the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. Eur J Neurosci, 2002;15:1037-1047.
42. Zhao Z, Chen SR, Eisenach JC et al. - Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. Neuroscience, 2000;97:743-748.
43. Ma W, Quirion R - Does COX2-dependent PGE2 play a role in neuropathic pain? Neurosci Lett, 2008;437:165-169.
44. Levine JD, Lau W, Kwiat G et al. - Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes. Science, 1984;225:743-745.
45. Bennett G, al-Rashed S, Hoult JR et al. - Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils. Pain, 1998;77:315-322.
46. Watikins LR, Hansen MK, Nguyen KT et al. - Dynamic regulation of the pro-inflammatory cytokines, interleukin-1beta: molecular biology for non molecular biologists. Life Sci, 1999;65:449-481.
47. Sommer C, Kress M - Recent findings on how proinflammatory cytokines cause pain: Peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett, 2004;361:184-187.
48. Sung CS, Wen ZH, Chang WK et al. - Intrathecal Interleukin-1beta administration induces thermal hiperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord. Brain Res, 2004;1015:145-153.
49. Gillen C, Jander S, Stroll G - Sequential expression of mRNA for proinflammatory cytokines and interleukin-10 in the rat peripheral nervous system: comparison between immune-mediated demylination and Wallerian degeneration. J Neurosci, 1998;51: 489-496.
50. DeLeo JA, Yezierski RP - The role of neuroinflammation and neuroimmune activation in persistent pain. Pain, 2001;90:1-6.
51. Oka T, Oka K, Hosoi M et al. - Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats. Brain Res, 1995;692:123-128.
52. Murphy PG, Ramer MS, Borthwick L et al. - Endogenous interleukin-6 contributes to hipersensitivity to cutaneous stimuli and changes in europeptides associated with chronic nerve constriction in mice. Eur J Neurosci, 1999;11:2243-2253.
53. Cunha FQ, Poole S , Lorenzetti BB et al. - The pivotal role of tumor necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol, 1992;107:660-664.
54. Zelenka M, Shäfers M, Sommer C - Intraneural injection of interleukin-1beta and tumor necrois factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain. Pain, 2005;116:257-263.
55. Ignatowski TA, Covey WC, Knight PR et al. - Brain-derived TNFalpha mediates neuropathic pain. Brain Res, 1999;841:70-77.
56. Moalem G, Gdalyahu A, Shani Y et al. - Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J Autoimmun, 2000;15:331-345.
57. Nykjaer A, Willnow TE, Petersen CM - P75(NTR).... Live or let die. Curr Opin Neurobiol, 2005;15:49-57.
58. Funakoshi H, Frisen J, Barbany G et al. - Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J Cell Biol, 1993;123:455-465.
59. Woolf CJ, Safieh-Garabedian B, Ma QP et al. - Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience, 1994;62:327-331.
60. Pezet S, Malcangio M, McMahon SB - BDNF: a neuromodulator in nociceptive pathways? Brain Res Rev, 2002;40:240-249.
61. Miletic G, Miletic V. - Increases in the concentration of brain derived neurotrophic factor in the lumbar spinal dorsal horn are associated with pain behavior following chronic constriction injury in rats. Neurosci Lett, 2002;319:137-140.
62. Aley KO, McCarter G, Levine JD - Nitric oxide signaling in pain and nociceptor sensitization in the rat. J Neurosci, 1998;18: 7008-7014.
63. Levy D, Zochodne DW - No pain: potential roles of nitric oxide in neuropathic pain. Pain Pract, 2004;4:11-18.
64. Ueda H - Molecular mechanisms of neuropathic pain - phenotypic switch and initiation mechanisms. Clin Pharmacol Ther, 2006;109:57-77.
65. Üçeler N, Sommer C - Wallerian degeneration and neuropathic pain. Drug Discov Today Dis Mech, 2006:3:351-356.
66. McMahon SB - Neuropathic Pain Mechanisms, em: Giamberardino MA - Pain 2002 - an updated review: Refresher course syllabuss. IASP Press: Seattle, 2002;155-161.
67. Mannion RJ, Woolf CJ - Pain mechanisms and management: a central perspective. Clin J Pain, 2000;16:S144-156.
68. Rowbotham MC, Fields HL - The relationship of pain, allodynia and thermal sensation in post-herpetic neuralgia. Brain, 1996; 119:347-354.
69. Choi B, Rowbotham MC - Effect of adrenergic receptor activation on post-herpetic neuralgia pain and sensory disturbances. Pain, 1997;69:55-63.