Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses

Virology

Volumn 380, Issue 1, 2008, Pages 124-135

  Wu, Jing Qin ^a   Dwyer, Dominic E ^b   Dyer, Wayne B ^c   Yang, Yee Hwa ^d   Wang, Bin ^a   Saksena, Nitin K ^a  

^a WESTMEAD HOSPITAL   (Australia)

^b Centre for Infectious Diseases and Microbiology   (Australia)

^c AUSTRALIAN RED CROSS BLOOD SERVICE   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

AZT; CD8+; CTL; cytotoxic T lymphocyte; Cytotoxicity; enrichment score; ES; false discovery rate; FDR; Gene expression; gene ontology; gene set enrichment analysis; GO; GSEA; HAART; highly active antiretroviral therapy; HIV; HIV sero negative individuals; Interferon; interferon stimulated genes; ISG; long term non progressor; LTNP; Microarray; Mitochondria; NEG; NES; normalized enrichment score; NRTI; nucleoside reverse transcriptase inhibitors; oxidative phosphorylation; OXPHOS; VIR; viremic patients; zidovudine

Indexed keywords

INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; DNA FINGERPRINTING; DRUG RESPONSE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; UPREGULATION; VIRUS PATHOGENESIS;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD8-POSITIVE T-LYMPHOCYTES; GENE EXPRESSION PROFILING; HIV INFECTIONS; HIV-1; HUMANS; INTERFERONS; OXIDATIVE PHOSPHORYLATION; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 52249115840     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.06.039     Document Type: Article

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