Downregulation of CD94/NKG2A inhibitory receptors on CD8+ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts

Retrovirology

Volumn 4, Issue , 2007, Pages

  Zeddou, Mustapha ^a   Rahmouni, Souad ^a   Vandamme, Arnaud ^a   Jacobs, Nathalie ^a   Frippiat, Frédéric ^b   Leonard, Philippe ^b   Schaaf Lafontaine, Nicole ^b   Vaira, Dolores ^b   Boniver, Jacques ^a   Moutschen, Michel ^a,b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2A; CD94 ANTIGEN; IMMUNOGLOBULIN RECEPTOR; NATURAL KILLER CELL ACTIVATING RECEPTORS; UNCLASSIFIED DRUG;

ARTICLE; CD8+ T LYMPHOCYTE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSTIMULATION; NATURAL KILLER CELL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; VIREMIA; VIRUS LOAD; CHRONIC DISEASE; COMPARATIVE STUDY; DOWN REGULATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIGENS, CD94; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; DOWN-REGULATION; HIV INFECTIONS; HIV-1; HUMANS; KILLER CELLS, NATURAL; RECEPTORS, IMMUNOLOGIC; VIRAL LOAD;

EID: 36649015552     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-4-72     Document Type: Article

References (16)

1. Chang CA Rodriguez M Carretero M Lopez-Botet JH Phillips Lanier LL: Molecular characterization of human CD94: A type II membrane glycoprotein related to the C-type lectin superfamily. Eur J Immunol 1995, 25:2433-2437. 10.1002/eji.1830250904 7589107
2. Brooks AG Posch PE Scorzelli CJ Borrego F Coligan JE: NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. J Exp Med 1997, 185:795-800. 10.1084/jem.185.4.795 9034158
3. Carretero M Cantoni C Bellon T Bottino C Biassoni R Rodriguez A Perez-Villar JJ Moretta L Moretta A Lopez-Botet M: The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules. Eur J Immunol 1997, 27:563-567. 10.1002/eji.1830270230 9045931
4. Brooks AG Borrego F Posch PE Patamawenu A Scorzelli CJ Ulbrecht M Weiss EH Coligan JE: Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells. J Immunol 1999, 162(1):305-313. 9886400
5. Lee N Llano M Carretero M Ishitani A Navarro F Lopez-Botet M Geraghty DE: HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci USA 1998, 95:5199-5204. 20238 9560253 10.1073/pnas.95.9.5199
6. Kabat J Borrego F Brooks A Coligan JE: Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal. J Immunol 2002, 169:1948-1958. 12165520
7. Lanier LL Corliss B Wu J Phillips JH: Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity 1998, 8:693-701. 10.1016/S1074-7613(00)80574-9 9655483
8. Mavilio D Benjamin J Daucher M Lombardo G Kottilil S Planta MA Marcenaro E Bottino C Moretta L Moretta A Fauci AS: Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci USA 2003, 100:15011-15016. 299884 14645713 10.1073/pnas.2336091100
9. Galiani MD Aguado E Tarazona R Romero P Molina I Santamaria M Solana R Pena J: Expression of killer inhibitory receptors on cytotoxic cells from HIV-1-infected individuals. Clin Exp Immunol 1999, 115:472-476. 1905253 10193420 10.1046/j.1365-2249.1999.00833.x
10. Tarazona R DelaRosa O Casado JG Torre-Cisneros J Villanueva JL Galiani MD Pena J Solana R: NK-associated receptors on CD8 T cells from treatment-naive HIV-infected individuals: Defective expression of CD56. AIDS 2002, 16:197-200. 10.1097/00002030-200201250-00008 11807303
11. Wesch D Kabelitz D: Differential expression of natural killer receptors on Vdelta1 gammadelta T cells in HIV-1-infected individuals. J Acquir Immune Defic Syndr 2003, 33:420-425. 12869830
12. Moser JM Byers AM Lukacher AE NK: Cell receptors in antiviral immunity. Curr Opin Immunol 2002, 14:509-516. 10.1016/S0952-7915(02)00357-6 12088687
13. Costa P Rusconi S Fogli M Mavilio D Murdaca G Puppo F Mingari MC Galli M Moretta L De MA: Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients. AIDS 2003, 17:257-260. 10.1097/ 00002030-200301240-00017 12545087
14. McMahon CW Zajac AJ Jamieson AM Corral L Hammer GE Ahmed R Raulet DH: Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. J Immunol 2002, 169:1444-1452. 12133970
15. Thimme R Appay V Koschella M Panther E Roth E Hislop AD Rickinson AB Rowland-Jones SL Blum HE Pircher H: Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J Virol 2005, 79:12112-12116. 1212638 16140789 10.1128/ JVI.79.18.12112-12116.2005
16. Byers AM Andrews NP Lukacher AE: CD94/NKG2A expression is associated with proliferative potential of CD8 T cells during persistent polyoma virus infection. J Immunol 2006, 176:6121-6129. 16670321