Transplant acceptance following anti-CD4 versus anti-CD40L therapy: Evidence for differential maintenance of graft-reactive T cells

American Journal of Transplantation

Volumn 8, Issue 10, 2008, Pages 2037-2048

  Wood, S C ^a   Lu, G ^a   Burrell, B E ^a   Bishop, D K ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Basic immunology; Cardiac allograft tolerance; CD4 + T cells; Costimulation blockade

Indexed keywords

CARBOXYFLUORESCEIN; CD4 ANTIGEN; CD40 LIGAND;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECIPIENT; SEVERE COMBINED IMMUNODEFICIENCY; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; FLUORESCEINS; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, SCID; SUCCINIMIDES; T-LYMPHOCYTES; TH2 CELLS; TRANSPLANTATION;

EID: 52049110333     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2008.02372.x     Document Type: Article

References (58)

1. Bishop DK, Shelby J, Eichwald EJ. Mobilization of T lymphocytes following cardiac transplantation: Evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejection. Transplantation 1992 53 : 849 857.
2. Bishop DK, Chan WS, Eichwald EJ, Orosz CG. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions. J Immunol 2001 166 : 3248 3255.
3. Nathan MJ, Yin D, Eichwald EJ, Bishop DK. The immunobiology of inductive anti-CD40L therapy in transplantation: Allograft acceptance is not dependent upon the deletion of graft-reactive T cells. Am J Transplant 2002 2 : 323 332.
4. Piccotti JR, Li K, Chan SY, Eichwald EJ, Bishop DK. Cytokine regulation of chronic cardiac allograft rejection: Evidence against a role for Th1 in the disease process. Transplantation 1999 67 : 1548 1555.
5. Csencsits K, Wood SC, Lu G et al. Transforming growth factor beta-induced connective tissue growth factor and chronic allograft rejection. Am J Transplant 2006 6 : 959 966.
6. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973 16 : 343 350.
7. Bishop DK, Li W, Chan SY, Ensley RD, Shelby J, Eichwald EJ. Helper T lymphocyte unresponsiveness to cardiac allografts following transient depletion of CD4-positive cells. Implications for cellular and humoral responses. Transplantation 1994 58 : 576 584.
8. Matesic D, Lehmann PV, Heeger PS. High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice. Transplantation 1998 65 : 906 914.
9. Piccotti JR, Chan SY, Goodman RE, Magram J, Eichwald EJ, Bishop DK. IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J Immunol 1996 157 : 1951 1957.
10. Chan SY, DeBruyne LA, Goodman RE, Eichwald EJ, Bishop DK. In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 1995 59 : 1155 1161.
11. Ghobrial RR, Boublik M, Winn HJ, Auchincloss H, Jr. In vivo use of monoclonal antibodies against murine T cell antigens. Clin Immunol Immunopathol 1989 52 : 486 506.
12. + T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. J Exp Med 2000 191 : 651 660.
13. Chen Y, Heeger PS, Valujskikh A. In vivo helper functions of alloreactive memory CD4+ T cells remain intact despite donor-specific transfusion and anti-CD40 ligand therapy. J Immunol 2004 172 : 5456 5466.
14. Piccotti JR, Chan SY, VanBuskirk AM, Eichwald EJ, Bishop DK. Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation 1997 63 : 619 624.
15. Le Moine A, Goldman M, Abramowicz D. Multiple pathways to allograft rejection. Transplantation 2002 73 : 1373 1381.
16. Le Moine A, Goldman M. Non-classical pathways of cell-mediated allograft rejection: New challenges for tolerance induction? Am J Transplant 2003 3 : 101 106.
17. Rocha PN, Plumb TJ, Crowley SD, Coffman TM. Effector mechanisms in transplant rejection. Immunol Rev 2003 196 : 51 64.
18. Piccotti JR, Li K, Chan SY et al. Alloantigen-reactive Th1 development in IL-12-deficient mice. J Immunol 1998 160 : 1132 1138.
19. Le Moine A, Surquin M, Demoor FX et al. IL-5 mediates eosinophilic rejection of MHC class II-disparate skin allografts in mice. J Immunol 1999 163 : 3778 3784.
20. Le Moine A, Flamand V, Demoor F-X et al. Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection. J Clin Invest 1999 103 : 1659 1667.
21. Martinez OM, Ascher NL, Ferrell L et al. Evidence for a nonclassical pathway of graft rejection involving interleukin 5 and eosinophils. Transplantation 1993 55 : 909 918.
22. Auchincloss H, Jr. In search of the elusive Holy Grail: The mechanisms and prospects for achieving clinical transplantation tolerance. Am J Transplant 2001 1 : 6 12.
23. Newell KA, Larsen CP, Kirk AD. Transplant tolerance: Converging on a moving target. Transplantation 2006 81 : 1 6.
24. Vincenti F. What's in the pipeline? New immunosuppressive drugs in transplantation. Am J Transplant 2002 2 : 898 903.
25. Waldmann H, Cobbold S. Exploiting tolerance processes in transplantation. Science 2004 305 : 209 212.
26. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation-how much of the promise has been realized? Nat Med 2005 11 : 605 613.
27. Kirk AD. Induction immunosuppression. Transplantation 2006 82 : 593 602.
28. Botto M, Dell'Agnola C, Bygrave AE et al. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 1998 19 : 56 59.
29. Bass H, Mosmann T, Strober S. Evidence for mouse Th1- and Th2-like helper T cells in vivo. Selective reduction of Th1-like cells after total lymphoid irradiation. J Exp Med 1989 170 : 1495 1511.
30. Jain S, Furness PN, Nicholson ML. The role of transforming growth factor beta in chronic renal allograft nephropathy. Transplantation 2000 69 : 1759 1766.
31. Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998 16 : 137 161.
32. Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 2006 24 : 99 146.
33. Ziegler SF. FOXP3: Of mice and men. Annu Rev Immunol 2006 24 : 209 226.
34. Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA 1992 89 : 6550 6554.
35. Grewal IS, Flavell RA. A central role of CD40 ligand in the regulation of CD4 +T-cell responses. Immunol Today 1996 17 : 410 414.
36. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol 2000 67 : 2 17.
37. Kirk AD, Blair PJ, Tadaki DK, Xu H, Harlan DM. The role of CD154 in organ transplant rejection and acceptance. Philos Trans R Soc Lond B Biol Sci 2001 356 : 691 702.
38. Quezada SA, Jarvinen LZ, Lind EF, Noelle RJ. CD40/CD154 interactions at the interface of tolerance and immunity. Annu Rev Immunol 2004 22 : 307 328.
39. Stout RD, Suttles J. The many roles of CD40 in cell-mediated inflammatory responses. Immunol Today 1996 17 : 487 492.
40. van Kooten C, Banchereau J. Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Immunol 1997 9 : 330 337.
41. Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998 16 : 111 135.
42. Nathan MJ, Mold JE, Wood SC et al. Requirement for donor and recipient CD40 expression in cardiac allograft rejection: Induction of Th1 responses and influence of donor-derived dendritic cells. J Immunol 2004 172 : 6626 6633.
43. Blotta MH, Marshall JD, DeKruyff RH, Umetsu DT. Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J Immunol 1996 156 : 3133 3140.
44. van Essen D, Kikutani H, Gray D. CD40 ligand-transduced co-stimulation of T cells in the development of helper function. Nature 1995 378 : 620 623.
45. Armitage RJ, Fanslow WC, Strockbine L et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992 357 : 80 82.
46. Castle BE, Kishimoto K, Stearns C, Brown ML, Kehry MR. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J Immunol 1993 151 : 1777 1788.
47. Roy M, Waldschmidt T, Aruffo A, Ledbetter JA, Noelle RJ. The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J Immunol 1993 151 : 2497 2510.
48. Ford GS, Barnhart B, Shone S, Covey LR. Regulation of CD154 (CD40 ligand) mRNA stability during T cell activation. J Immunol 1999 162 : 4037 4044.
49. Lee BO, Haynes L, Eaton SM, Swain SL, Randall TD. The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: Reciprocal regulation by interleukin (IL)-4 and IL-12. J Exp Med 2002 196 : 693 704.
50. Sanchez*-Fueyo A, Domenig C, Strom TB, Zheng XX. The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression. Transplantation 2002 74 : 898 900.
51. Monk NJ, Hargreaves RE, Marsh JE et al. Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med 2003 9 : 1275 1280.
52. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003 3 : 199 210.
53. Kang SM, Tang Q, Bluestone JA. CD4+CD25+ regulatory T cells in transplantation: Progress, challenges and prospects. Am J Transplant 2007 7 : 1457 1463.
54. Roncarolo MG, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol 2000 12 : 676 683.
55. Shevach EM. CD4+ CD25+ suppressor T cells: More questions than answers. Nat Rev Immunol 2002 2 : 389 400.
56. Jonuleit H, Schmitt E. The regulatory T cell family: Distinct subsets and their interrelations. J Immunol 2003 171 : 6323 6327.
57. Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006 6 : 295 307.
58. Chen D, Bromberg JS. T regulatory cells and migration. Am J Transplant 2006 6 : 1518 1523.