Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia

Developmental Biology

Volumn 322, Issue 1, 2008, Pages 33-45

  Kirjavainen, Anna ^a   Sulg, Marilin ^a   Heyd, Florian ^b   Alitalo, Kari ^c   Ylä Herttuala, Seppo ^d   Möröy, Tarik ^b   Petrova, Tatiana V ^c   Pirvola, Ulla ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Atoh1; Differentiation; Gfi1; Hair cell; Inner ear; p57Kip2; Prox1; Supporting cell; Survival

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ATOH1; TRANSCRIPTION FACTOR GFI1; TRANSCRIPTION FACTOR PROX1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CELL DIFFERENTIATION; CELL SURVIVAL; EXPLANT; FEMALE; GENE INTERACTION; GENE REPRESSION; GENETIC TRANSDUCTION; HAIR CELL; INNER EAR; MOUSE; NEUROEPITHELIUM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

MAMMALIA; MUS;

EID: 52049087103     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2008.07.004     Document Type: Article

References (65)

1. Acar M., et al. Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development 133 (2006) 1979-1989
2. Bermingham-McDonogh B., et al. FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia. Dev. Biol. 238 (2001) 247-259
3. Bermingham-McDonogh B., et al. Expression of Prox1 during mouse cochlear development. J. Comp. Neurol. 496 (2006) 172-186
4. Kip1 links cell proliferation to morphogenesis in the developing organ of Corti. Development 126 (1999) 1581-1590
5. Chen P., et al. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nature Cell Biol. 5 (2003) 422-426
6. Choksi S.P., et al. Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev. Cell 11 (2006) 775-789
7. Colvin J.S., et al. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat. Genet. 12 (1996) 390-397
8. Cunningham J.J., and Rousssel M.F. Cyclin-dependent kinase inhibitors in the development of the central nervous system. Cell Growth Differ. 12 (2001) 387-396
9. Doe C.Q., et al. The prospero gene specifies cell fates in the Drosophila central nervous system. Cell 65 (1991) 451-464
10. Duan Z., and Horwitz M. Targets of the transcriptional repressor oncoprotein Gfi-1. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 5932-5937
11. Duan Z., et al. Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1. Mol. Cell. Biol. 25 (2005) 10338-10351
12. Kip2 regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina. Development 127 (2000) 3593-3605
13. Dyer M.A., et al. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat. Genet. 34 (2003) 53-58
14. Fekete D.M., et al. Hair cells and supporting cells share a common progenitor in the avian inner ear. J. Neurosci. 18 (1998) 7811-7821
15. Fiolka K., et al. Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development. EMBO Rep. 3 (2006) 326-333
16. Grimes H.L., et al. The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. Mol. Cell. Biol. 16 (1996) 6263-6272
17. Hasson T., et al. Unconventional myosins in inner-ear sensory epithelia. J. Cell Biol. 137 (1997) 1287-1307
18. Helms A.W., and Johnson J.E. Progenitors of dorsal commissural interneurons are defined by MATH1 expression. Development 125 (1998) 919-928
19. ddl/ddl identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum. Mol. Genet. 13 (2004) 2143-2153
20. Hock H., et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 431 (2004) 1002-1007
21. Hong Y.K., et al. Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev. Dyn. 225 (2002) 351-357
22. Izumikawa M., et al. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat. Med. 11 (2005) 271-276
23. Jafar-Nejad H., and Bellen H.J. Gfi/Pag-3/senseless zinc finger proteins: a unifying theme? Mol. Cell. Biol. 24 (2004) 8803-8812
24. Kip2 cooperates with Nurr1 in developing dopamine cells. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 15619-15624
25. Jögi A., et al. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J. Biol. Chem. 277 (2002) 9118-9126
26. Jones J.M., et al. Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. J. Neurosci. 26 (2006) 550-558
27. Karsunky, et al. High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells. Oncogene 21 (2002) 1571-1579
28. Kazanjian A., et al. The growth factor independence-1 transcription factor: New functions and new insights. Crit. Rev. Oncol. Hematol. 59 (2006) 85-97
29. Kelley M.W. Regulation of cell fate in the sensory epithelia of the inner ear. Nat. Rev. Neurosci. 7 (2006) 837-849
30. Cip1 collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J. Neurosci. 27 (2007) 1434-1444
31. Laitinen M., et al. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia. Hum. Gene Ther. 9 (1998) 1481-1486
32. Kip1 transcription directs cell cycle exit during organ of Corti. Development 133 (2006) 2817-2826
33. Lewis A. Notch signalling and the control of cell fate choices in vertebrates. Semin. Cell Dev. Biol. 9 (1998) 583-589
34. Li L., and Vaessin H. Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev. 14 (2000) 147-151
35. Lyden D., et al. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 401 (1999) 670-677
36. Manning L., and Doe C.Q. Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage. Development 126 (1999) 2063-2071
37. Mantela J., et al. The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development 132 (2005) 2377-2388
38. Möröy T. The zinc finger transcription factor Growth factor independence 1 (Gfi1). Int. J. Biochem. Cell Biol. 37 (2005) 541-546
39. Mueller K.L., et al. Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. J. Neurosci. 22 (2002) 9368-9377
40. Kip2 during mouse development. Anat. Embryol. 203 (2001) 77-87
41. Nishijima I., and Ohtoshi A. Characterization of a novel prospero-related homeobox gene, Prox2. Mol. Genet. Genomics 275 (2006) 471-478
42. Nolo R., et al. Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102 (2000) 349-362
43. Osawa M., et al. Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood 100 (2002) 2769-2777
44. Peters K., et al. Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev. Biol. 155 (1993) 423-430
45. Petrova T.V., et al. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J. 21 (2002) 4593-4599
46. Pirvola U., et al. The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 9269-9273
47. Ruben R.J. Development of the inner ear of the mouse: A radioautographic study of terminal mitoses. Acta Otolaryngol. Suppl. 220 (1967) 221-244
48. Sharina I.G., et al. CCAAT-binding factor regulates expression of the β1 subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma cell line. Proc. Natl. Acad. Sci. U. S. A. 100 (2000) 11523-11528
49. Shin J.W., et al. Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol. Biol. Cell 17 (2006) 576-584
50. Shroyer N.F., et al. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 19 (2005) 2412-2417
51. Sosa-Pineda B., et al. Hepatocyte migration during liver development requires Prox1. Nat. Genet. 25 (2000) 254-255
52. Wallis D., et al. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development 130 (2003) 221-232
53. Kip2 during embryo morphogenesis. Mech. Dev. 109 (2001) 83-89
54. Wigle J.T., and Oliver G. Prox1 function is required for the development of the murine lymphatic system. Cell 98 (1999) 769-778
55. Wigle J.T., et al. An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 21 (2002) 1505-1513
56. Wigle J.T., et al. Prox1 function is crucial for mouse lens-fibre elongation. Nat. Genet. 21 (1999) 318-322
57. Wilkinson D.G., and Green J. In situ hybridization and the three-dimensional construction of serial sections. In: Copp A.J., and Cockroft D.L. (Eds). Postimplantation Mammalian Embryos (1991), Oxford University Press, IRL. 447-473
58. Xie B., et al. Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development 134 (2007) 4243-4253
59. Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev. 11 (1997) 973-983
60. Yücel R., et al. Gfi1:Green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development. J. Biol. Chem. 279 (2004) 40906-40917
61. Zeng Z., et al. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 23 (2004) 4116-4125
62. KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature 387 (1997) 151-158
63. Zheng J.L., and Gao W.Q. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat. Neurosci. 3 (2000) 580-586
64. Zheng J.L., et al. Hes1 is a negative regulator of inner ear differentiation. Development 127 (2000) 4551-4560
65. Zweidler-Mckay P.A., et al. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Mol. Cell. Biol. 16 (1996) 4024-4034