Chapter 6 Renal Conservation of Folates. Role of Folate Transport Proteins

Vitamins and Hormones

Volumn 79, Issue , 2008, Pages 185-202

  Damaraju, Vijaya L ^a,b   Cass, Carol E ^a,b   Sawyer, Michael B ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; DRUG DERIVATIVE; FOLIC ACID; FOLIC ACID ANTAGONIST; METHOTREXATE;

CHEMISTRY; HUMAN; KIDNEY; METABOLISM; REVIEW;

CARRIER PROTEINS; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; KIDNEY; METHOTREXATE;

EID: 51849157726     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(08)00406-8     Document Type: Review

References (85)

1. Anderson R.G., Kamen B.A., Rothberg K.G., and Lacey S.W. Potocytosis: Sequestration and transport of small molecules by caveolae. Science 255 (1992) 410-411
2. Balinska M., Nimec Z., and Galivan J. Characteristics of methotrexate polyglutamate formation in cultured hepatic cells. Arch. Biochem. Biophys. 216 (1982) 466-476
3. Bhandari S.D., Joshi S.K., and McMartin K.E. Folate binding and transport by rat kidney brush-border membrane vesicles. Biochim. Biophys. Acta 937 (1988) 211-218
4. Bhandari S.D., Fortney T., and McMartin K.E. Analysis of the pH dependence of folate binding and transport by rat kidney brush border membrane vesicles. Proc. Soc. Exp. Biol. Med. 196 (1991) 451-456
5. Birn H. The kidney in vitamin B12 and folate homeostasis: Characterization of receptors for tubular uptake of vitamins and carrier proteins. Am. J. Physiol. Ren. Physiol. 291 (2006) F22-F36
6. Birn H., Nielsen S., and Christensen E.I. Internalization and apical-to-basolateral transport of folate in rat kidney proximal tubule. Am. J. Physiol. 272 (1997) F70-F78
7. Birn H., Spiegelstein O., Christensen E.I., and Finnell R.H. Renal tubular reabsorption of folate mediated by folate binding protein 1. J. Am. Soc. Nephrol. 16 (2005) 608-615
8. Blount B.C., and Ames B.N. Analysis of uracil in DNA by gas chromatography-mass spectrometry. Anal. Biochem. 219 (1994) 195-200
9. Bourke R.S., Chheda G., Bremer A., Watanabe O., and Tower D.B. Inhibition of renal tubular transport of methotrexate by probenecid. Cancer Res. 35 (1975) 110-116
10. Brigle K.E., Spinella M.J., Westin E.H., and Goldman I.D. Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells. Biochem. Pharmacol. 47 (1994) 337-345
11. Calvert A.H., Bondy P.K., and Harrap K.R. Some observations on the human pharmacology of methotrexate. Cancer Treat. Rep. 61 (1977) 1647-1656
12. Cha S.H., Sekine T., Fukushima J.I., Kanai Y., Kobayashi Y., Goya T., and Endou H. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol. 59 (2001) 1277-1286
13. Chen Z.S., Lee K., Walther S., Raftogianis R.B., Kuwano M., Zeng H., and Kruh G.D. Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 62 (2002) 3144-3150
14. Damaraju V.L., Hamilton K.F., Seth-Smith M.L., Cass C.E., and Sawyer M.B. Characterization of binding of folates and antifolates to brush-border membrane vesicles isolated from human kidney. Mol. Pharmacol. 67 (2005) 453-459
15. Eichner E.R., and Hillman R.S. The evolution of anemia in alcoholic patients. Am. J. Med. 50 (1971) 218-232
16. Eichner E.R., and Hillman R.S. Effect of alcohol on serum folate level. J. Clin. Invest. 52 (1973) 584-591
17. Evers R., Zaman G.J., van Deemter L., Jansen H., Calafat J., Oomen L.C., Oude Elferink R.P., Borst P., and Schinkel A.H. Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. J. Clin. Invest. 97 (1996) 1211-1218
18. Goh B.C., Ratain M.J., Bertucci D., Smith R., Mani S., Vogelzang N.J., Schilsky R.L., Hutchison M., Smith M., Averbuch S., and Douglass E. Phase I study of ZD9331 on short daily intravenous bolus infusion for 5 days every 3 weeks with fixed dosing recommendations. J. Clin. Oncol. 19 (2001) 1476-1484
19. Goresky C.A., Watanabe H., and Johns D.G. The renal excretion of folic acid. J. Clin. Invest. 42 (1963) 1841-1849
20. Halsted C.H. Folate deficiency in alcoholism. Am. J. Clin. Nutr. 33 (1980) 2736-2740
21. Hamid A., and Kaur J. Kinetic characteristics of folate binding to rat renal brush border membrane in chronic alcoholism. Mol. Cell. Biochem. 280 (2005) 219-225
22. Hendel J., and Nyfors A. Nonlinear renal elimination kinetics of methotrexate due to saturation of renal tubular reabsorption. Eur. J. Clin. Pharmacol. 26 (1984) 121-124
23. Hirohashi T., Suzuki H., and Sugiyama Y. Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J. Biol. Chem. 274 (1999) 15181-15185
24. Holm J., Hansen S.I., and Lyngbye J. High-affinity binding of folate to a protein in serum of male subjects. Clin. Chim. Acta 100 (1980) 113-119
25. Hooijberg J.H., Broxterman H.J., Kool M., Assaraf Y.G., Peters G.J., Noordhuis P., Scheper R.J., Borst P., Pinedo H.M., and Jansen G. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. 59 (1999) 2532-2535
26. Huang K.C., Wenczak B.A., and Liu Y.K. Renal tubular transport of methotrexate in the rhesus monkey and dog. Cancer Res. 39 (1979) 4843-4848
27. Jansen G., Barr H., Kathmann I., Bunni M.A., Priest D.G., Noordhuis P., Peters G.J., and Assaraf Y.G. Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: Role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration. Mol. Pharmacol. 55 (1999) 761-769
28. Johns D.G., Sperti S., and Burgen A.S. The disposal of tritiated folic acid injected intravenously in man. Can. Med. Assoc. J. 84 (1961) 77-79
29. Kamen B.A., and Caston J.D. Identification of a folate binder in hog kidney. J. Biol. Chem. 250 (1975) 2203-2205
30. Kamen B.A., Wang M.T., Streckfuss A.J., Peryea X., and Anderson R.G. Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J. Biol. Chem. 263 (1988) 13602-13609
31. Kusuhara H., Han Y.H., Shimoda M., Kokue E., Suzuki H., and Sugiyama Y. Reduced folate derivatives are endogenous substrates for cMOAT in rats. Am. J. Physiol. 275 (1998) G789-G796
32. Lacey S.W., Sanders J.M., Rothberg K.G., Anderson R.G., and Kamen B.A. Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol. J. Clin. Invest. 84 (1989) 715-720
33. Liegler D.G., Henderson E.S., Hahn M.A., and Oliverio V.T. The effect of organic acids on renal clearance of methotrexate in man. Clin. Pharmacol. Ther. 10 (1969) 849-857
34. Lu R., Chan B.S., and Schuster V.L. Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C. Am. J. Physiol. 276 (1999) F295-F303
35. Masuda S., Saito H., Nonoguchi H., Tomita K., and Inui K. mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules. FEBS Lett. 407 (1997) 127-131
36. Matherly L.H. Molecular and cellular biology of the human reduced folate carrier. Prog. Nucleic Acid Res. Mol. Biol. 67 (2001) 131-162
37. Matherly L.H., and Goldman D.I. Membrane transport of folates. Vitam. Horm. 66 (2003) 403-456
38. Maziarz K.M., Monaco H.L., Shen F., and Ratnam M. Complete mapping of divergent amino acids responsible for differential ligand binding of folate receptors alpha and beta. J. Biol. Chem. 274 (1999) 11086-11091
39. McMartin K.E., Collins T.D., and Bairnsfather L. Cumulative excess urinary excretion of folate in rats after repeated ethanol treatment. J. Nutr. 116 (1986) 1316-1325
40. McMartin K.E., Morshed K.M., Hazen-Martin D.J., and Sens D.A. Folate transport and binding by cultured human proximal tubule cells. Am. J. Physiol. 263 (1992) F841-F848
41. Monjanel S., Rigault J.P., Cano J.P., Carcassonne Y., and Favre R. High-dose methotrexate: Preliminary evaluation of a pharmacokinetic approach. Cancer Chemother. Pharmacol. 3 (1979) 189-196
42. Morshed K.M., Ross D.M., and McMartin K.E. Folate transport proteins mediate the bidirectional transport of 5-methyltetrahydrofolate in cultured human proximal tubule cells. J. Nutr. 127 (1997) 1137-1147
43. Moscow J.A., Gong M., He R., Sgagias M.K., Dixon K.H., Anzick S.L., Meltzer P.S., and Cowan K.H. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res. 55 (1995) 3790-3794
44. Muldoon R.T., and McMartin K.E. Ethanol acutely impairs the renal conservation of 5-methyltetrahydrofolate in the isolated perfused rat kidney. Alcohol. Clin. Exp. Res. 18 (1994) 333-339
45. Murphy R.F., Powers S., and Cantor C.R. Endosome pH measured in single cells by dual fluorescence flow cytometry: Rapid acidification of insulin to pH 6. J. Cell Biol. 98 (1984) 1757-1762
46. Nguyen T.T., Dyer D.L., Dunning D.D., Rubin S.A., Grant K.E., and Said H.M. Human intestinal folate transport: Cloning, expression, and distribution of complementary RNA. Gastroenterology 112 (1997) 783-791
47. Prasad P.D., Mahesh V.B., Leibach F.H., and Ganapathy V. Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells. Biochim. Biophys. Acta 1222 (1994) 309-314
48. Prasad P.D., Ramamoorthy S., Leibach F.H., and Ganapathy V. Molecular cloning of the human placental folate transporter. Biochem. Biophys. Res. Commun. 206 (1995) 681-687
49. Qiu A., Jansen M., Sakaris A., Min S.H., Chattopadhyay S., Tsai E., Sandoval C., Zhao R., Akabas M.H., and Goldman I.D. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127 (2006) 917-928
50. Ragoussis J., Senger G., Trowsdale J., and Campbell I.G. Genomic organization of the human folate receptor genes on chromosome 11q13. Genomics 14 (1992) 423-430
51. Reidy J.A. Folate- and deoxyuridine-sensitive chromatid breakage may result from DNA repair during G2. Mutat. Res. 192 (1987) 217-219
52. Romanoff R.L., Ross D.M., and McMartin K.E. Acute ethanol exposure inhibits renal folate transport, but repeated exposure upregulates folate transport proteins in rats and human cells. J. Nutr. 137 (2007) 1260-1265
53. Ross D.M., and McMartin K.E. Effect of ethanol on folate binding by isolated rat renal brush border membranes. Alcohol 13 (1996) 449-454
54. Rothberg K.G., Ying Y.S., Kamen B.A., and Anderson R.G. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. J. Cell Biol. 111 (1990) 2931-2938
55. Russell R.M., Rosenberg I.H., Wilson P.D., Iber F.L., Oaks E.B., Giovetti A.C., Otradovec C.L., Karwoski P.A., and Press A.W. Increased urinary excretion and prolonged turnover time of folic acid during ethanol ingestion. Am. J. Clin. Nutr. 38 (1983) 64-70
56. Sadasivan E., and Rothenberg S.P. The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA. J. Biol. Chem. 264 (1989) 5806-5811
57. Said H.M. Recent advances in carrier-mediated intestinal absorption of water-soluble vitamins. Annu. Rev. Physiol. 66 (2004) 419-446
58. Sawyer M.B., Ratain M.J., Bertucci D., Smith R.P., Schilsky R.L., Vogelzang N.J., Shulman K., Douglass E.C., and Fleming G.F. Phase I study of an oral formulation of ZD9331 administered daily for 28 days. J. Clin. Oncol. 21 (2003) 1859-1865
59. Schaub T.P., Kartenbeck J., Konig J., Vogel O., Witzgall R., Kriz W., and Keppler D. Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J. Am. Soc. Nephrol. 8 (1997) 1213-1221
60. Scheffer G.L., Kool M., de Haas M., de Vree J.M., Pijnenborg A.C., Bosman D.K., Elferink R.P., van der Valk P., Borst P., and Scheper R.J. Tissue distribution and induction of human multidrug resistant protein 3. Lab. Invest. 82 (2002) 193-201
61. Selhub J., and Rosenberg I.H. Demonstration of high-affinity folate binding activity associated with the brush border membranes of rat kidney. Proc. Natl. Acad. Sci. USA 75 (1978) 3090-3093
62. Selhub J., and Franklin W.A. The folate-binding protein of rat kidney. Purification, properties, and cellular distribution. J. Biol. Chem. 259 (1984) 6601-6606
63. Selhub J., Emmanouel D., Stavropoulos T., and Arnold R. Renal folate absorption and the kidney folate binding protein. I. Urinary clearance studies. Am. J. Physiol. 252 (1987) F750-F756
64. Sikka P.K., and McMartin K.E. Determination of folate transport pathways in cultured rat proximal tubule cells. Chem. Biol. Interact. 114 (1998) 15-31
65. Soliman H.A., and Olesen H. Folic acid binding by human plasma albumin. Scand. J. Clin. Lab. Invest. 36 (1976) 299-304
66. Spinella M.J., Brigle K.E., Sierra E.E., and Goldman I.D. Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. J. Biol. Chem. 270 (1995) 7842-7849
67. Stover P.J. Physiology of folate and vitamin B12 in health and disease. Nutr. Rev. 62 (2004) S3-S12 discussion S13
68. Sun W., Wu R.R., van Poelje P.D., and Erion M.D. Isolation of a family of organic anion transporters from human liver and kidney. Biochem. Biophys. Res. Commun. 283 (2001) 417-422
69. Takeda M., Babu E., Narikawa S., and Endou H. Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur. J. Pharmacol. 438 (2002) 137-142
70. Takeuchi A., Masuda S., Saito H., Doi T., and Inui K. Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate. Kidney Int. 60 (2001) 1058-1068
71. Tamura T., and Halsted C.H. Folate turnover in chronically alcoholic monkeys. J. Lab. Clin. Med. 101 (1983) 623-628
72. Tojo A., Sekine T., Nakajima N., Hosoyamada M., Kanai Y., Kimura K., and Endou H. Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J. Am. Soc. Nephrol. 10 (1999) 464-471
73. Tolner B., Roy K., and Sirotnak F.M. Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5′ end heterogeneity. Gene 211 (1998) 331-341
74. van Aubel R.A., Smeets P.H., Peters J.G., Bindels R.J., and Russel F.G. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: Putative efflux pump for urinary cAMP and cGMP. J. Am. Soc. Nephrol. 13 (2002) 595-603
75. Wang Y., Zhao R., Russell R.G., and Goldman I.D. Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochim. Biophys. Acta 1513 (2001) 49-54
76. Weitman S.D., Weinberg A.G., Coney L.R., Zurawski V.R., Jennings D.S., and Kamen B.A. Cellular localization of the folate receptor: Potential role in drug toxicity and folate homeostasis. Cancer Res. 52 (1992) 6708-6711
77. Whetstine J.R., Flatley R.M., and Matherly L.H. The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: Identification of seven non-coding exons and characterization of a novel promoter. Biochem. J. 367 (2002) 629-640
78. Williams F.M., and Flintoff W.F. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J. Biol. Chem. 270 (1995) 2987-2992
79. Wong S.C., Proefke S.A., Bhushan A., and Matherly L.H. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J. Biol. Chem. 270 (1995) 17468-17475
80. Zeng H., Liu G., Rea P.A., and Kruh G.D. Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res. 60 (2000) 4779-4784
81. Zeng H., Chen Z.S., Belinsky M.G., Rea P.A., and Kruh G.D. Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: Effect of polyglutamylation on MTX transport. Cancer Res. 61 (2001) 7225-7232
82. Zettner A., and Duly P.E. The weak binding reaction between folate and human serum proteins. Ann. Clin. Lab. Sci. 8 (1978) 57-63
83. Zhao R., and Goldman I.D. The molecular identity and characterization of a proton-coupled folate transporter-PCFT; biological ramifications and impact on the activity of pemetrexed. Cancer Metastasis. Rev. 26 (2007) 129-139
84. Zhao R., Gao F., Hanscom M., and Goldman I.D. A prominent low-pH methotrexate transport activity in human solid tumors: Contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier. Clin. Cancer Res. 10 (2004) 718-727
85. Zhao R., Hanscom M., and Goldman I.D. The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells. Biochim. Biophys. Acta 1715 (2005) 57-64