Locus control region mediated regulation of adult β-globin gene expression

Journal of Cellular Biochemistry

Volumn 105, Issue 1, 2008, Pages 9-16

  Liang, Shermi ^a,b   Moghimi, Babak ^a,b   Yang, Thomas P ^a,b   Strouboulis, John ^c   Bungert, Jörg ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c Biomedical Sciences Research Center Alexander Fleming Institute of Molecular Oncology   (Greece)

Author keywords

Gene regulation; Globin; Locus control region; Transcription; Transcription factor

Indexed keywords

BETA GLOBIN; CIS ACTING ELEMENT; DEOXYRIBONUCLEASE I; ERYTHROID KRUPPEL LIKE FACTOR; HELIX LOOP HELIX PROTEIN; LEUCINE ZIPPER PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR NF E2; ZINC FINGER PROTEIN;

ADULT; CELL DIFFERENTIATION; CHROMOSOME 11; DNA BINDING; ERYTHROID PRECURSOR CELL; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; REGULATOR GENE; REVIEW; TISSUE SPECIFICITY;

AGING; ANIMALS; GENE EXPRESSION REGULATION; GLOBINS; HUMANS; LOCUS CONTROL REGION; MODELS, GENETIC; TRANS-ACTIVATORS;

EID: 51849098920     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21820     Document Type: Review

References (51)

1. Armstrong JA, Bieker JJ, Emerson BM. 1998. A SWI/SNF related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF. Cell 95:93-104.
2. Bieker JJ. 2001. Kruppel-like factors: Three fingers in many pies. J Biol Chem 276:34355-34358.
3. Bottardi S, Aumont A, Grosveld F, Milot E. 2003. Developmental stage-specific epigenetic control of human β-globin expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activation. Blood 102:3989-3997.
4. Bottardi S, Ross J, Pierre-Charles N, Blank V, Milot E. 2006. Lineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors. EMBO J 25:3586-3595.
5. Bungert J, Dave U, Lim KC, Lieuw KH, Shavit JA, Liu Q, Engel JD. 1995. Synergistic regulation of human β-globin gene switching by locus control region elements HS3 and HS4. Genes Dev 9:3083-3096.
6. Chakalova L, Debrand E, Mitchell JA, Osborne CS, Fraser P. 2005. Replication and transcription: Shaping the landscape of the genome. Nat Rev Genet 6:669-677.
7. Choi OR, Engel JD. 1988. Developmental regulation of beta-globin gene switching. Cell 55:17-26.
8. Corre S, Galibert MD. 2005. Upstream stimulating factors: Highly versatile stress-responsive transcription factors. Pigment Cell Res 18:337-348.
9. Crusselle-Davis VJ, Vieira KF, Zhuo Z, Anantharaman A, Bungert J. 2006. Antagonistic regulation of β-globin gene expression by helix-loop-helix proteins USF and TFII-I. Mol Cell Biol 26:6832-6843.
10. Crusselle-Davis VJ, Zhuo Z, Anantharaman A, Moghimi B, Dodev T, Huang S, Bungert J. 2007. Recruitment of coregulator complexes to the β-globin gene locus by TFlI-I and upstream stimulatory factor. FEBS J 274:6065-6073.
11. Demers C, Chaturvedi CP, Ranish JA, Juban G, Lai P, Morle F, Aebersold R, Dilworth FJ, Groudine M, Brand M. 2007. Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell 27:573-584.
12. Drissen R, Palstra RJ, Gillemans N, Splinter E, Grosveld F, Philipsen S, de Laat W. 2004. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev 18:2485-2490.
13. Elnitski L, Miller W, Hardison R. 1997. Conserved E-boxes function as part of the enhancer in hypersensitive site 2 of the β-globin locus control region: Role of helix-loop-helix proteins. J Biol Chem 272:369-378.
14. Engel JD, Tanimoto K. 2000. Looping, linking and chromatin activity: New insights into β-globin locus regulation. Cell 100:499-502.
15. Epner E, Reik A, Cimbora D, Telling A, Bender MA, Fiering S, Enver T, Martin DI, Kennedy M, Keller G, Groudine M. 1998. The β-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse β-globin locus. Mol Cell 2:447-455.
16. Fang X, Sun J, Xiang P, Yu M, Navas PA, Peterson KR, Stamatoyannopoulos G, Li Q. 2005. Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5′ HS3 deletion mutations: Implication for LCR chromatin architecture. Mol Cell Biol 25:7033-7041.
17. Feng D, Kan YW. 2005. The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes. Proc Natl Acad Sci USA 102:9896-9900.
18. Grosveld F. 1999. Activation by locus control regions? Curr Opin Genet Dev 9:152-157.
19. Haussecker D, Proudfoot NJ. 2005. Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster. Mol Cell Biol 25:9724-9733.
20. Huang S, Li X, Yusufzai TM, Qiu Y, Felsenfeld G. 2007. USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier. Mol Cell Biol 27:7991-8002.
21. Iborra FJ, Pombo A, McManus J, Jackson DA, Cook PR. 1996. The topology of transcription by immobilized polymerase. Exp Cell Res 229:167-173.
22. Johnson KD, Grass JA, Boyer ME, Kiekhaefer CM, Blobel GA, Weiss MJ, Bresnick EH. 2002. Cooperative activities of hematopoietic regulators recruit RNA Polymerase II to a tissue-specific chromatin domain. Proc Natl Acad Sci USA 99:11760-11765.
23. Johnson KD, Grass JA, Park C, Im H, Choi K, Bresnick EH. 2003. Highly restricted localization of RNA polymerase II within a locus control region of a tissue-specific chromatin domain. Mol Cell Biol 23:6484-6493.
24. Kim SI, Bresnick EH. 2007. Transcriptional control of erythropoiesis: Emerging mechanisms and principles. Oncogene 15:6777-6794.
25. Kooren J, Palstra RJ, Klous P, Splinter E, von Lindern M, Grosveld F, de Laat W. 2007. Beta-globin active chromatin hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice. J Biol Chem 282:16544-16552.
26. Leach KM, Nightingale K, Igarashi K, Levings PP, Engel JD, Becker PB, Bungert J. 2001. Reconstitution of human β-globin locus control region hypersensitive sites in the absence of chromatin assembly. Mol Cell Biol 21:2629-2640.
27. Leach KM, Vieira KF, Kang SH, Aslanian A, Teichmann M, Roeder RG, Bungert J. 2003. Characterization of the human β-globin downstream promoter region. Nucl Acids Res 31:1292-1301.
28. Levings PP, Bungert J. 2002. The human β-globin locus control region: A center of attraction. Eur J Biochem 269:1589-1599.
29. Levings PP, Zhou Z, Vieira KF, Crusselle-Davis VJ, Bungert J. 2006. Recruitment of transcription complexes to the β-globin locus control region and transcription of hypersensitive site 3 prior to erythroid differentiation of murine embryonic stem cells. FEBS J 273:746-755.
30. Mpollo MS, Beaudoin D, Berg PE, Beauchemin H, D'Agati V, Trudel M. 2006. BP1 is a negative modulator of definitive erythropoiesis. Nucleic Acids Res 34:5232-5237.
31. Ogawa K, Sun J, Taketani S, Nakajima O, Nishitani C, Sassa S, Hayashi N, Yamamoto M, Shibahara S, Fujita H, Igarashi K. 2001. Heme mediates derepression of a Maf recognition element through direct binding to transcription repressor Bach1. EMBO J 20:2835-2843.
32. Orphanides G, Reinberg D. 2000. RNA polymerase II elongation through chromatin. Nature 407:471-476.
33. Palstra RJ, Tolhuis B, Splinter E, Nijmeijer R, Grosveld F, de Laat W. 2003. The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet 35:190-194.
34. Palstra RJ, Simonis M, Klous P, Brasset E, Eijkelkamp B, de Laat W. 2008. Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription. PLoS ONE 3:e1661.
35. Rada-Iglesias A, Ameur A, Kapranov P, Enroth S, Komorowski J, Gingeras TR, Wadelius C. 2008. Whole genome maps of USF1 and USF2 binding and H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders. Genome Res 18:380-392.
36. Ragoczy T, Bender MA, Telling A, Byron R, Groudine M. 2006. The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation. Genes Dev 20:1447-1457.
37. Rodriguez P, Bonte E, Krijgsveld J, Kolodziej KE, Guyot B, Heck AJ, Vyas P, de Boer E, Grosveld F, Strouboulis J. 2005. GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J 24:2354-2366.
38. Sawado T, Halow J, Bender MA, Groudine M. 2003. The beta-globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. Genes Dev 17:1009-1018.
39. Song SH, Hou C, Dean A. 2007. A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell 28:810-822.
40. Stamatoyannopoulos G. 2005. Control of globin gene expression during development and erythroid differentiation. Exp Hematol 33:259-271.
41. Szutorisz H, Georgiou A, Tora L, Dillon N. 2006. The proteasome restricts permissive transcription at tissue-specific gene loci in embryonic stem cells. Cell 127:1375-1388.
42. Tanimoto K, Liu Q, Bungert J, Engel JD. 1999. Effect of altered gene order or orientation of the locus control region on human β-globin gene expression in transgenic mice. Nature 398:344-348.
43. Tanimoto K, Sugiura A, Omori A, Felsenfeld G, Engel JD, Fukamizu A. 2003. Human β-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer blocking activity in erythroid cells. Mol Cell Biol 23:8946-8952.
44. Tuan D, Kong S, Hu K. 1992. Transcription of the hypersensitive site HS2 enhancer in erythroid cells. Proc Natl Acad Sci USA 89:11219-11223.
45. Vakoc CR, Letting DL, Gheldof N, Sawado T, Bender MA, Groudine M, Weiss MJ, Dekker J, Blobel GA. 2005. Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell 17:453-462.
46. Vernimmen D, De Gobbi M, Sloane-Stanley JA, Wood WG, Higgs DR. 2007. Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression. EMBO J 26:2041-2051.
47. Vieira KF, Levings PP, Hill MA, Crusselle VJ, Kang SH, Engel JD, Bungert J. 2004. Recruitment of transcription complexes to the β-globin gene locus in vivo and in vitro. J Biol Chem 279:50350-50357.
48. Wijgerde M, Grosveld F, Fraser P. 1995. Transcription complex stability and chromatin dynamics in vivo. Nature 377:209-213.
49. Yoshida C, Tokumasu F, Hohmura KI, Bungert J, Hayashi N, Nagasawa T, Engel JD, Yamamoto M, Takeyasu K, Igarashi K. 1999. Long range interaction of cis-DNA elements mediated by architectural protein Bachl. Genes Cells 4:643-655.
50. Zhou D, Pawlik KM, Ren J, Sun CW, Townes TM. 2006. Differential binding of erythroid krupple-like factor to embryonic/fetal globin gene promoters during development. J Biol Chem 281:16052-16057.
51. Zhu X, Ling J, Zhang L, Pi W, Wu M, Tuan D. 2007. A facilitated tracking and transcription mechanism of long-range enhancer function. Nucl Acids Res 35:5532-5544.