-
2
-
-
2342651518
-
Molecular chaperones and the stress of oncogenesis
-
Mosser DD Morimoto RI (2004) Molecular chaperones and the stress of oncogenesis. Oncogene 23, 2907 2918.
-
(2004)
Oncogene
, vol.23
, pp. 2907-2918
-
-
Mosser, D.D.1
Morimoto, R.I.2
-
3
-
-
25844466597
-
Heat shock response modulators as therapeutic tools for diseases of protein conformation
-
Westerheide SD Morimoto RI (2005) Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem 280, 33097 33100.
-
(2005)
J Biol Chem
, vol.280
, pp. 33097-33100
-
-
Westerheide, S.D.1
Morimoto, R.I.2
-
4
-
-
9144261127
-
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity
-
Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW et al. (2003) Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res 63, 8984 8995.
-
(2003)
Cancer Res
, vol.63
, pp. 8984-8995
-
-
Bisht, K.S.1
Bradbury, C.M.2
Mattson, D.3
Kaushal, A.4
Sowers, A.5
Markovina, S.6
Ortiz, K.L.7
Sieck, L.K.8
Isaacs, J.S.9
Brechbiel, M.W.10
-
5
-
-
2642521990
-
Therapeutic and diagnostic implications of Hsp90 activation
-
Kamal A, Boehm MF Burrows FJ (2004) Therapeutic and diagnostic implications of Hsp90 activation. Trends Mol Med 10, 283 290.
-
(2004)
Trends Mol Med
, vol.10
, pp. 283-290
-
-
Kamal, A.1
Boehm, M.F.2
Burrows, F.J.3
-
6
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC Burrows FJ (2003) A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425, 407 410.
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
Zhang, L.4
Boehm, M.F.5
Fritz, L.C.6
Burrows, F.J.7
-
7
-
-
21744445069
-
Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications
-
Ciocca DR Calderwood SK (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10, 86 103.
-
(2005)
Cell Stress Chaperones
, vol.10
, pp. 86-103
-
-
Ciocca, D.R.1
Calderwood, S.K.2
-
8
-
-
14344264703
-
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - An update
-
Neckers L Neckers K (2005) Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update. Expert Opin Emerg Drugs 10, 137 149.
-
(2005)
Expert Opin Emerg Drugs
, vol.10
, pp. 137-149
-
-
Neckers, L.1
Neckers, K.2
-
10
-
-
0022637380
-
Specific interaction between the p53 cellular tumour antigen and major heat shock proteins
-
Pinhasi-Kimhi O, Michalovitz D, Ben-Zeev A Oren M (1986) Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature 320, 182 184.
-
(1986)
Nature
, vol.320
, pp. 182-184
-
-
Pinhasi-Kimhi, O.1
Michalovitz, D.2
Ben-Zeev, A.3
Oren, M.4
-
11
-
-
15844363948
-
Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell
-
Sepehrnia B, Paz IB, Dasgupta G Momand J (1996) Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell. J Biol Chem 271, 15084 15090.
-
(1996)
J Biol Chem
, vol.271
, pp. 15084-15090
-
-
Sepehrnia, B.1
Paz, I.B.2
Dasgupta, G.3
Momand, J.4
-
12
-
-
0031909866
-
The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent
-
Whitesell L, Sutphin PD, Pulcini EJ, Martinez JD Cook PH (1998) The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Mol Cell Biol 18, 1517 1524.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1517-1524
-
-
Whitesell, L.1
Sutphin, P.D.2
Pulcini, E.J.3
Martinez, J.D.4
Cook, P.H.5
-
13
-
-
0030878952
-
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo
-
Whitesell L, Sutphin P, An WG, Schulte T, Blagosklonny MV Neckers L (1997) Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene 14, 2809 2816.
-
(1997)
Oncogene
, vol.14
, pp. 2809-2816
-
-
Whitesell, L.1
Sutphin, P.2
An, W.G.3
Schulte, T.4
Blagosklonny, M.V.5
Neckers, L.6
-
14
-
-
10344239940
-
Hsp90 chaperones wild-type p53 tumor suppressor protein
-
Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A Zylicz M (2004) Hsp90 chaperones wild-type p53 tumor suppressor protein. J Biol Chem 279, 48836 48845.
-
(2004)
J Biol Chem
, vol.279
, pp. 48836-48845
-
-
Walerych, D.1
Kudla, G.2
Gutkowska, M.3
Wawrzynow, B.4
Muller, L.5
King, F.W.6
Helwak, A.7
Boros, J.8
Zylicz, A.9
Zylicz, M.10
-
15
-
-
0035801391
-
Hsp70 interactions with the p53 tumour suppressor protein
-
Zylicz M, King FW Wawrzynow A (2001) Hsp70 interactions with the p53 tumour suppressor protein. EMBO J 20, 4634 4638.
-
(2001)
EMBO J
, vol.20
, pp. 4634-4638
-
-
Zylicz, M.1
King, F.W.2
Wawrzynow, A.3
-
16
-
-
0035890265
-
Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53
-
King FW, Wawrzynow A, Hohfeld J Zylicz M (2001) Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J 20, 6297 6305.
-
(2001)
EMBO J
, vol.20
, pp. 6297-6305
-
-
King, F.W.1
Wawrzynow, A.2
Hohfeld, J.3
Zylicz, M.4
-
17
-
-
0037051095
-
P53: An ubiquitous target of anticancer drugs
-
Blagosklonny MV (2002) p53: an ubiquitous target of anticancer drugs. Int J Cancer 98, 161 166.
-
(2002)
Int J Cancer
, vol.98
, pp. 161-166
-
-
Blagosklonny, M.V.1
-
18
-
-
0029145215
-
Geldanamycin selectively destabilizes and conformationally alters mutated p53
-
Blagosklonny MV, Toretsky J Neckers L (1995) Geldanamycin selectively destabilizes and conformationally alters mutated p53. Oncogene 11, 933 939.
-
(1995)
Oncogene
, vol.11
, pp. 933-939
-
-
Blagosklonny, M.V.1
Toretsky, J.2
Neckers, L.3
-
19
-
-
14844303887
-
Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: Implications for cancer therapy
-
Muller P, Ceskova P Vojtesek B (2005) Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy. J Biol Chem 280, 6682 6691.
-
(2005)
J Biol Chem
, vol.280
, pp. 6682-6691
-
-
Muller, P.1
Ceskova, P.2
Vojtesek, B.3
-
20
-
-
0035798547
-
Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization
-
Peng Y, Chen L, Li C, Lu W Chen J (2001) Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization. J Biol Chem 276, 40583 40590.
-
(2001)
J Biol Chem
, vol.276
, pp. 40583-40590
-
-
Peng, Y.1
Chen, L.2
Li, C.3
Lu, W.4
Chen, J.5
-
21
-
-
1442277689
-
Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein
-
Burch L, Shimizu H, Smith A, Patterson C Hupp TR (2004) Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. J Mol Biol 337, 129 145.
-
(2004)
J Mol Biol
, vol.337
, pp. 129-145
-
-
Burch, L.1
Shimizu, H.2
Smith, A.3
Patterson, C.4
Hupp, T.R.5
-
22
-
-
36349020165
-
MDM2 chaperones the p53 tumor suppressor
-
Wawrzynow B, Zylicz A, Wallace M, Hupp T Zylicz M (2007) MDM2 chaperones the p53 tumor suppressor. J Biol Chem 282, 32603 32612.
-
(2007)
J Biol Chem
, vol.282
, pp. 32603-32612
-
-
Wawrzynow, B.1
Zylicz, A.2
Wallace, M.3
Hupp, T.4
Zylicz, M.5
-
23
-
-
0242266896
-
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization
-
Poyurovsky MV, Jacq X, Ma C, Karin-Schmidt O, Parker PJ, Chalfie M, Manley JL Prives C (2003) Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell 12, 875 887.
-
(2003)
Mol Cell
, vol.12
, pp. 875-887
-
-
Poyurovsky, M.V.1
Jacq, X.2
Ma, C.3
Karin-Schmidt, O.4
Parker, P.J.5
Chalfie, M.6
Manley, J.L.7
Prives, C.8
-
24
-
-
33745949757
-
Dual-site regulation of MDM2 E3-ubiquitin ligase activity
-
Wallace M, Worrall E, Pettersson S, Hupp TR Ball KL (2006) Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Mol Cell 23, 251 263.
-
(2006)
Mol Cell
, vol.23
, pp. 251-263
-
-
Wallace, M.1
Worrall, E.2
Pettersson, S.3
Hupp, T.R.4
Ball, K.L.5
-
25
-
-
0030022559
-
Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins
-
Hansen S, Hupp TR Lane DP (1996) Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. J Biol Chem 271, 3917 3924.
-
(1996)
J Biol Chem
, vol.271
, pp. 3917-3924
-
-
Hansen, S.1
Hupp, T.R.2
Lane, D.P.3
-
26
-
-
0030896451
-
Correcting temperature-sensitive protein folding defects
-
Brown CR, Hong-Brown LQ Welch WJ (1997) Correcting temperature-sensitive protein folding defects. J Clin Invest 99, 1432 1444.
-
(1997)
J Clin Invest
, vol.99
, pp. 1432-1444
-
-
Brown, C.R.1
Hong-Brown, L.Q.2
Welch, W.J.3
-
27
-
-
0030154620
-
Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein
-
Brown CR, Hong-Brown LQ, Biwersi J, Verkman AS Welch WJ (1996) Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein. Cell Stress Chaperones 1, 117 125.
-
(1996)
Cell Stress Chaperones
, vol.1
, pp. 117-125
-
-
Brown, C.R.1
Hong-Brown, L.Q.2
Biwersi, J.3
Verkman, A.S.4
Welch, W.J.5
-
28
-
-
0027222956
-
Mapping of the p53 and mdm-2 interaction domains
-
Chen J, Marechal V Levine AJ (1993) Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol 13, 4107 4114.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 4107-4114
-
-
Chen, J.1
Marechal, V.2
Levine, A.J.3
-
29
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387, 296 299.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
30
-
-
33745951312
-
Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo
-
Shimizu H, Saliba D, Wallace M, Finlan L, Langridge-Smith PR Hupp TR (2006) Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo. Biochem J 397, 355 367.
-
(2006)
Biochem J
, vol.397
, pp. 355-367
-
-
Shimizu, H.1
Saliba, D.2
Wallace, M.3
Finlan, L.4
Langridge-Smith, P.R.5
Hupp, T.R.6
-
31
-
-
0037047345
-
The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo
-
Shimizu H, Burch LR, Smith AJ, Dornan D, Wallace M, Ball KL Hupp TR (2002) The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J Biol Chem 277, 28446 28458.
-
(2002)
J Biol Chem
, vol.277
, pp. 28446-28458
-
-
Shimizu, H.1
Burch, L.R.2
Smith, A.J.3
Dornan, D.4
Wallace, M.5
Ball, K.L.6
Hupp, T.R.7
-
32
-
-
0037445901
-
E2F and cell cycle control: A double-edged sword
-
Stevens C La Thangue NB (2003) E2F and cell cycle control: a double-edged sword. Arch Biochem Biophys 412, 157 169.
-
(2003)
Arch Biochem Biophys
, vol.412
, pp. 157-169
-
-
Stevens, C.1
La Thangue, N.B.2
-
33
-
-
0029028353
-
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
-
Martin K, Trouche D, Hagemeier C, Sorenson TS, La Thangue NB Kouzarides T (1995) Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375, 691 694.
-
(1995)
Nature
, vol.375
, pp. 691-694
-
-
Martin, K.1
Trouche, D.2
Hagemeier, C.3
Sorenson, T.S.4
La Thangue, N.B.5
Kouzarides, T.6
-
34
-
-
11144241617
-
The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth
-
Sdek P, Ying H, Zheng H, Margulis A, Tang X, Tian K Xiao Z-XJ (2004) The central acidic domain of MDM2 is critical in inhibition of retinoblastoma- mediated suppression of E2F and cell growth. J Biol Chem 279, 53317 53322.
-
(2004)
J Biol Chem
, vol.279
, pp. 53317-53322
-
-
Sdek, P.1
Ying, H.2
Zheng, H.3
Margulis, A.4
Tang, X.5
Tian, K.6
Z-Xj, X.7
-
35
-
-
27944478688
-
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway
-
Zang Z, Wang H, Li M, Rayburn ER, Agrawal S Zhang R (2005) Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene 24, 7238 7247.
-
(2005)
Oncogene
, vol.24
, pp. 7238-7247
-
-
Zang, Z.1
Wang, H.2
Li, M.3
Rayburn, E.R.4
Agrawal, S.5
Zhang, R.6
-
36
-
-
0031992159
-
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
-
Kowalik TF, DeGregori J, Leone G, Jakoi L Nevins JR (1998) E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ 9, 113 118.
-
(1998)
Cell Growth Differ
, vol.9
, pp. 113-118
-
-
Kowalik, T.F.1
Degregori, J.2
Leone, G.3
Jakoi, L.4
Nevins, J.R.5
-
37
-
-
0032939925
-
Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
-
Blattner C, Sparks A Lane D (1999) Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol Cell Biol 19, 3704 3713.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3704-3713
-
-
Blattner, C.1
Sparks, A.2
Lane, D.3
-
38
-
-
0033998439
-
Apoptotic and growth-promoting activity of E2F modulated by MDM2
-
Loughran O La Thangue NB (2000) Apoptotic and growth-promoting activity of E2F modulated by MDM2. Mol Cell Biol 20, 2186 2197.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2186-2197
-
-
Loughran, O.1
La Thangue, N.B.2
-
39
-
-
34249303144
-
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
-
Ambrosini G, Sambol EB, Carvajal D, Vassilev LT, Singer S Schwartz GK (2006) Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. Oncogene 26, 3473 3481.
-
(2006)
Oncogene
, vol.26
, pp. 3473-3481
-
-
Ambrosini, G.1
Sambol, E.B.2
Carvajal, D.3
Vassilev, L.T.4
Singer, S.5
Schwartz, G.K.6
-
40
-
-
0037182756
-
Mdm2 inhibition of p53 induces E2F1 transactivation via p21
-
Wunderlich M Berberich SJ (2002) Mdm2 inhibition of p53 induces E2F1 transactivation via p21. Oncogene 21, 4414 4421.
-
(2002)
Oncogene
, vol.21
, pp. 4414-4421
-
-
Wunderlich, M.1
Berberich, S.J.2
-
41
-
-
22844447871
-
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation
-
Esser C, Scheffner M Hohfeld J (2005) The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation. J Biol Chem 280, 27443 27448.
-
(2005)
J Biol Chem
, vol.280
, pp. 27443-27448
-
-
Esser, C.1
Scheffner, M.2
Hohfeld, J.3
-
42
-
-
0037441475
-
The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein
-
Strachan GD, Jordan-Sciutto KL, Rallapalli R, Tuan RS Hall DJ (2003) The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. J Cell Biochem 88, 557 568.
-
(2003)
J Cell Biochem
, vol.88
, pp. 557-568
-
-
Strachan, G.D.1
Jordan-Sciutto, K.L.2
Rallapalli, R.3
Tuan, R.S.4
Hall, D.J.5
|