Inhibition of MDM2 by hsp90 Contributes to Mutant p53 Stabilization

Journal of Biological Chemistry

Volumn 276, Issue 44, 2001, Pages 40583-40590

  Peng, Yanhua ^b   Chen, Lihong ^b   Li, Changgong ^b   Lu, Wenge ^b   Chen, Jiandong ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; DEGRADATION; DNA; MUTAGENESIS; PROTEINS;

ALTERNATIVE READING FRAME (ARF);

ONCOLOGY;

CHAPERONE; CORE PROTEIN; HEAT SHOCK PROTEIN 90; PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE; BENZOQUINONE DERIVATIVE; GELDANAMYCIN; MACROCYCLIC LACTAM; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; QUINONE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ENZYME INHIBITION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HYDROLYSIS; MUTATION; PHYSIOLOGY;

ANIMALIA;

BENZOQUINONES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYDROLYSIS; LACTAMS, MACROCYCLIC; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; QUINONES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035798547     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102817200     Document Type: Article

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