Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans

BMC Genetics

Volumn 9, Issue , 2008, Pages

  De Luca, Maria ^a,b   Chambers, Michelle Moses ^a   Casazza, Krista ^a,b   Lok, Kerry H ^b   Hunter, Gary R ^a,b   Gower, Barbara A ^a,b   Fernández, José R ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; GENE PRODUCT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LAMININ; LAMININ A; LIPID; MUTANT PROTEIN; PROTEIN LAMA5; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; LAMININ ALPHA5;

ADULT; AFRICAN AMERICAN; ARTICLE; BODY COMPOSITION; BODY HEIGHT; CHROMOSOME 20Q; COHORT ANALYSIS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ETHNIC GROUP; EUROPEAN AMERICAN; FEMALE; GENE LOCUS; GENE MAPPING; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC COMPLEMENTATION; GENETIC CONSERVATION; GENETIC IDENTIFICATION; GENETIC LINKAGE; GENETIC STRAIN; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MULTIGENE FAMILY; MUTATIONAL ANALYSIS; NONHUMAN; OBESITY; POPULATION RESEARCH; PROTEIN CONTENT; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; ANIMAL; CAUCASIAN; COMPARATIVE STUDY; GENE FREQUENCY; GENETICS; GENOTYPE; METABOLISM; QUANTITATIVE TRAIT; QUANTITATIVE TRAIT LOCUS; SPECIES DIFFERENCE;

DROSOPHILA MELANOGASTER; LANA;

AFRICAN AMERICANS; ALLELES; ANIMALS; BODY COMPOSITION; DROSOPHILA MELANOGASTER; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LAMININ; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; SPECIES SPECIFICITY; TRIGLYCERIDES; VARIATION (GENETICS);

EID: 51649111701     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-9-52     Document Type: Article

References (43)

1. Klein S Burke LE Bray GA Blair S Allison DB Pi-Sunyer X Hong YL Eckel RH: Clinical implications of obesity with specific focus on cardiovascular disease - A statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism - Endorsed by the American College of Cardiology Foundation. Circulation 2004, 110:2952-2967. 15509809
2. Ruden DM De Luca M Garfinkel MD Bynum KL Lu X: Drosophila nutrigenomics can provide clues to human gene-nutrient interactions. Annu Rev Nutr 2005, 25:499-522. 16011476
3. De Luca M Yi N Allison DB Leips J Ruden DM: Mapping quantitative trait loci affecting variation in Drosophila triacylglycerol storage. Obes Res 2005, 13:1596-1605. 16222063
4. Mackay TF Anholt RR: Of Flies and Man: Drosophila as a Model for Human Complex Traits. Annu Rev Genomics Hum Genet 2006, 7:339-367. 16756480
5. Mott R: Finding the molecular basis of complex genetic variation in humans and mice. Philos Trans R Soc Lond B Biol Sci 2006, 361:393-401. 1609339 16524828
6. Mackay TF: The genetic architecture of quanLitative traits: lessons from Drosophila. Curr Opin Genet Dev 2004, 14:253-257. 15172667
7. De Luca M Leips J: Mapping genetic polymorphisms affecting natural variation in Drosophila longevity. Methods Mol Biol 2007, 371:307-320. 17634590
8. Yalcin B Willis-Owen SAG Fullerton J Meesaq A Deacon RM Rawlins JNP Copley RR Morris AP Flint J Mott R: Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 2004, 36:1197-1202. 15489855
9. Ryder E Ashburner M Bautista-Llacer R Drummond J Webster J Johnson G Morley T Chan YS Blows F Coulson D Reuter G Baisch H Apelt C Kauk A Rudolph T Kube M Klimm M Nickel C Szidonya J Maróy P Pal M Rasmuson-Lestander A Ekström K Stocker H Hugentobler C Hafen E Gubb D Pflugfelder G Dorner C Marhold J Serras F Corominas M Punset A Roote J Russell S: The DrosDel Deletion Collection: A Drosophila Genomewide Chromosomal Deficiency Resource. Genetics 2007:177:615. 2013729 17720900
10. Parks AL Cook KR Belvin M Dompe NA Fawcett R Huppert K Tan LR Winter CG Bogart KP Deal JE Deal-Herr ME Grant D Marcinko M Miyazaki WY Robertson S Shaw KJ Tabios M Vysotskaia V Zhao L Andrade RS Edgar KA Howie E Killpack K Milash B Norton A Thao D Whittaker K Winner MA Friedman L Margolis J Singer MA Kopczynski C Curtis D Kaufman TC Plowman GD Duyk G Francis-Lang HL: Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nat Genet 2004, 36:288-292. 14981519
11. Thibault ST Singer MA Miyazaki WY Milash B Dompe NA Singh CM Buchholz R Demsky M Fawcett R Francis-Lang HL: A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet 2004, 36:283-287. 14981521
12. Drysdale RA Crosby MA FlyBase: Genes and gene models. Nucleic Acids Res 2005, 33:D390-D395. 540000 15608223
13. Dulloo AG Seydoux J Jacquet J: Adaptive thermogenesis and uncoupling proteins: A reappraisal of their roles in fat metabolism and energy balance. Physiol Behav 2004, 83(4):587-602. 15621064
14. Schonfeld-Warden NA Warden CH: Physiological effects of variants in human uncoupling proteins: UCP2 influences body-mass index. Biochem Soc Trans 2001, 29:777-784. 11709074
15. Colognato H Yurchenco PD: Form and function: The laminin family of heterotrimers. Dev Dyn 2000, 218:213-234. 10842354
16. Miner JH Lewis RM Sanes JR: Molecular-Cloning of A Novel Laminin Chain, Alpha-5, and Widespread Expression in Adult-Mouse Tissues. J Biol Chem 1995, 270:28523-28526. 7499364
17. Durkin ME Loechel F Mattei MG Gilpin BJ Albrechtsen R Wewer UM: Tissue-specific expression of the human laminin a5-chain, and mapping of the gene to human chromosome 20q13. 2-13.3 and to distal mouse chromosome2 near the locus for the ragged (Ra) mutation. FEBS Letters 1997, 411:296-300. 9271224
18. Rankinen T Zuberi A Chagnon YC Weisnagel SJ Argyropoulos G Walts B Perusse L Bouchard C. The human obesity gene map: The 2005 update. Obesity (Silver Spring) 2006, 14:529-644. 16741264
19. Doerge RW Churchill GA: Permutation tests for multiple loci affecting a quantitative character. Genetics 1996, 142:285-294. 1206957 8770605
20. Legare ME Bartlett FS Frankel WN: A major effect QTL determined by multiple genes in epileptic EL mice. Genome Res 2000, 10:42-48. 310503 10645948
21. Wandstrat A Wakeland E: The genetics of complex autoimmune diseases: non-MHC susceptibility genes. Nat Immunol 2001, 2:802-809. 11526390
22. Christensen K Murray JC: What Genome-wide Association Studies Can Do for Medicine. N Engl J Med 2007, 356:1094. 17360987
23. Ardlie. KG Kruglyak L Seielstad M: Patterns of linkage disequilibrium in the human genome. Nat Rev Genet 2002, 3:299-309. 11967554
24. Shannon MB Patton BL Harvey SJ Miner JH: A Hypomorphic Mutation in the Mouse Laminin {alpha} 5 Gene Causes Polycystic Kidney Disease. J Am Soc Nephrol 2006, 17(7):1913-22. 16790509 1482806
25. Lin PI Vance JM Pericak-Vance MA Martin ER: No gene is an island: The flip-flop phenomenon. Am J Hum Genet 2007, 80:531-538. 1821115 17273975
26. Ungerer MC Linder CR Rieseberg LH: Effects of genetic background on response to selection in experimental populations of Arabidopsis thaliana. Genetics 2003, 163:277-286. 1462413 12586715
27. Leips J Mackay TFC: Quantitative Trait Loci for Life Span in Drosophila melanogaster Interactions With Genetic Background and Larval Density. Genetics 2000, 155:1773-1788. 1461186 10924473
28. Yi N Diament A Chiu S Kim K Allison DB Fisler JS Warden CH: Characterization of Epistasis Influencing Complex Spontaneous Obesity in the BSB Model. Genetics 2004, 167:399-409. 1470871 15166164
29. Engel J: EGF-like domains in extracellular maLrix proteins: localized signals for growth and differentiation?. FEBS Lett 1989, 251:1-7. 2666164
30. Timpl R Tisi D Talts JF Andac Z Sasaki T Hohenester E: Structure and function of laminin LG modules. Matrix Biol 2000, 19:309-317. 10963991
31. Kolset SO Salmivirta M: Cell surface heparan sulfate proteoglycans and lipoprotein metabolism. Cell Mol Life Sci 1999, 56(9-10):857-870. 11212344
32. Wilsie LC Chanchani S Navaratna D Orlando RA: Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes. Lipids Health Dis 2005:4. 545935 15636641
33. Divers J Vaughan LK Padilla MA Fernandez JR Allison DB Redden DT: Correcting for measurement error in individual ancestry estimates in structured association tests. Genetics 2007, 176:1823-1833. 1931538 17507670
34. Chanock SJ Manolio T Boehnke M Boerwinkle E Hunter DJ Thomas G Hirschhorn JN Abecasis G Altshuler D Bailey-Wilson JE Brooks LD Cardon LR Daly M Donnelly P Fraumeni JF Jr. Freimer NB Gerhard DS Gunter C Guttmacher AE Guyer MS Harris EL Hoh J Hoover R Kong CA Merikangas KR Morton CC Palmer LJ Phimister EG Rice JP Roberts J Rotimi C Tucker MA Vogan KJ Wacholder S Wijsman EM Winn DM Collins FS: Replicating genotype-phenotype associations. Nature 2007, 447:655-660. 17554299
35. Pasyukova EG Vieira C Mackay TF: Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster. Genetics 2000, 156:1129-1146. 1461330 11063689
36. Friedewald WT Levy RI Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502. 4337382
37. Huffman DM Landy NM Potter TR Nagy TR Gower BA: Comparison of the LUNA DPX-L and Prodigy dual-energy X-ray absorptiometers for assesing total and regional body composition. Int J Body Composition Res 2005, 3:25-30.
38. Ronaghi M Uhlen M Nyren P: A sequencing method based on real-time pyrophosphate. Science 1998,281:363, 365 9705713
39. Akey JM Sosnoski D Parra E Dios S Hiester K Su B Bonilla C Jin L Shriver MD: Melting curve analysis of SNPs (McSNP (R)): A gel-free and inexpensive approach for SNP genotyping. Biotechniques 2001, 30:358-367. 11233605
40. Parra EJ Kittles RA Argyropoulos G Pfaff CL Hiester K Bonilla C Sylvester N Parrish-Gause D Garvey WT Jin L McKeigue PM Kamboh MI Ferrell RE Pollitzer WS Shriver MD: Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina. Am J Phys Anthropol 2001, 114:18-29. 11150049
41. Shriver MD Parra EJ Dios S Bonilla C Norton H Jovel C Pfaff C Jones C Massac A Cameron N Baron A Jackson T Argyropoulos G Jin L Hoggart CJ McKeigue PM Kittles RA: Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet 2003, 112:387-399. 12579416
42. Excoffier L Laval G Schneider S: Arlequin ver. 3.0: An integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online 2005, 1:47-50.
43. Choi JW Choe HW Pai SH: Serum lipid concentrations correlate more strongly with total body fat than with body mass index in obese humans. Clin Chim Acta 2003, 329:83-87. 12589969