Mapping quantitative trait loci affecting variation in drosophila triacylglycerol storage

Obesity Research

Volumn 13, Issue 9, 2005, Pages 1596-1605

  De Luca, Maria ^a   Yi, Nengjun ^a   Allison, David B ^a   Leips, Jeff ^b   Ruden, Douglas M ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

Fat body; Lipid metabolism; Quantitative complementation test; Quantitative trait loci mapping; Sex specific effect

Indexed keywords

DROSOPHILA MELANOGASTER; MAMMALIA;

TRIACYLGLYCEROL;

ADIPOGENESIS; ANIMAL; ARTICLE; BAYES THEOREM; CHROMOSOME MAP; DROSOPHILA MELANOGASTER; GENETIC EPISTASIS; GENETIC SCREENING; GENETICS; METABOLISM; QUANTITATIVE TRAIT LOCUS;

ADIPOGENESIS; ANIMALS; BAYES THEOREM; CHROMOSOME MAPPING; DROSOPHILA MELANOGASTER; EPISTASIS, GENETIC; GENETIC SCREENING; QUANTITATIVE TRAIT LOCI; TRIGLYCERIDES;

EID: 33644693344     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2005.196     Document Type: Article

References (54)

1. Allison DB, Pietrobelli A, Faith MS, et al. Genetic influences on obesity. In: Eckel RH, ed. Obesity: Mechanisms and Clinical Management. New York: Elsevier: 2002. pp. 31-74.
2. Miller MW, Duhl DM, Vrieling H, et al. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 1993;7:454-67.
3. Zhang YR, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-67.
4. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of leptin receptor, OB-R. Cell. 1995;83:1263-71.
5. Naggert JK, Fricker LD, Varlamov O, et al. Hyperproinsulinemia in obese fat/fat mice associated with carboxypeptidase E mutation which reduces enzyme activity. Nat Genet. 1995;10:135-42.
6. Kleyn PW, Fan W, Kovats SG, et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell. 1996;19:281-90.
7. Gunn TM, Miller KA, He L, et al. The mouse mahogany locus encodes a transmembrane form of human attractin. Nature. 1999;398:152-6.
8. Brockmann GA, Bevova MR. Using mouse models to dissect the genetics of obesity. Trends Genet. 2002;18:367-76.
9. Ruden DM, De Luca M, Garfinkel M, Bynum K, Lu X. Drosophila nutrigenomics can provide clues to human gene-nutrient interactions. Anna Rev Nutr. 2005;25:499-522.
10. Hirsh D, Stahl A, Lodish HF. A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci USA. 1998;95:8625-9.
11. Hayes SA, Miller JM, Hoshizaki DK. Serpent, a GATA-like transcription factor gene, induces fat-cell development in Drosophila melanogaster, Development. 2001;128:1193-200.
12. Maglich J, Sluder M, Guan X, et al. Comparison of complete nuclear receptor sets from the human. Caenorhabditis elevens and Drosophila genomes. Genome Biol. 2001;2:RESEARCH0029.
13. Dobrosotskaya IY, Seegmiller AC, Brown MS, Goldstein JL, Rawson RB. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila, Science. 2002;296:874-83.
14. Miura S, Gan J-W, Brzostowski J, et al. Functional conservation for lipid storage droplet association among Perilin. ADRP, and TIP47 (PAT)-related proteins in mammals. Drosophila, and Dictyostelium. J Biol Chem. 2002;277:32253-7.
15. Grönke S, Beller M, Fellert S, Ramakrishnan H, Jäckle H, Kühnlein RP. Control of fat storage by Drosophila PAT domain protein. Curr Biol. 2003;13:603-6.
16. Häder T, Müller S, Aguilera M, et al. Control of triglyceride storage by a WD40/TPR-domain protein. EMBO Rep. 2003;4:511-6.
17. Londos C, Brasaemie DL, Schultz CJ, Segrest JP, Kimmel AR. Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semin Cell Dev Biol. 1999;10:51-8.
18. Tong Q, Dalgin G, Xu H, et al. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science, 2000;290:134-8.
19. Montell DJ, Rorth P, Spradling AC. Slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila C/FBP, Cell. 1992;71:51-62.
20. Seegmiller AC, Dobrosotskaya I, Goldstein JL, et al. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell. 2002;2:229-38.
21. Clark AG, Keith LE. Variation among extracted lines of Drosophila malanogaster in triacylglycerol and carbohydrate storage, Genetic. 1988;119:595-607.
22. Clark AG. Causes and consequences of variation in energy storage in Drosophila melanogaster. Genetic, 1989;123:131-44.
23. Mackay TFC. The genetic architecture of quantitative traits. Annu Rev Genet. 2001;35:303-39.
24. Long AD, Mullaney SL, Mackay TFC, Langley CH. Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster.. Genetics, 1996;144:1497-510.
25. Gurganus MC. Nuzhdin SV, Leips JW, Mackay TFC. High-resolution mapping of quantitative trait loci for sterno-pleural bristle number in Drosophila melanogaster. Genetics, 1999;152:1585-604.
26. Pasyukova EG, Vieira C, Mackay TFC. Deficiency mapping ot quantitative trait loci affecting longevity in Drosophila melanogaster. Genetic, 2000;156:1129-46.
27. Wayne ML, Mcintyre LM. Combining mapping and arraying: An approach to candidate gene identification. Proc Natl Acad Sci USA. 2002;99:14903-6.
28. Fanara JJ, Robinson KO, Rollmann SM, Anholt RR, Mackay TFC. Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior. Genetic, 2002;162:1321-8.
29. De Luca M, Roshina NV. Geiger-Thornesberry GL, Lyman RF, Pasyukova EG, Mackay TFC. Dopa decarboxylase affects variation in Drosophila longevity. Nat Genet, 2003;34:429-33.
30. Harbison ST, Yamamoto AH, Fanara JJ, Norga KK, Mackay TFC. Quantitative trait loci affecting starvation resistance in Drosophila melanogaster. Genetics. 2004;166:1807-23.
31. Moehring AJ, Mackay TFC. The quantitative genetic basis of male mating behavior in Drosophila melanogaster. Genetics. 2004;167:1249-63.
32. Nuzhdin SV, Pasyukova EG, Dilda CL, Zeng ZB, Mackay TFC. Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster. Proc Natl Acad Sci USA. 1997;94:9734-9.
33. Leips J, Mackay TFC. Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density. Genetics. 2000;155:1773-88.
34. Lowry OH, Rosebrough NJ, Fair AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-75.
35. Robertson A. The sampling variance of the genetic correlation coefficient. Biometrics. 1959;15:469-85.
36. Zeng Z-B. Precision mapping of quantitative trait loci. Genetics. 1994;136:1457-68.
37. Yi N, Xu S. Mapping quantitative trait loci with epistatic effects. Genet Res. 2002;79:185-98.
38. Yi N, Xu S, Allison DB. Bayesian Model choice and search strategies for mapping interacting quantitative trait loci. Genetics. 2003; 165:867-83.
39. Wang S, Basten CJ, Zeng Z-B. Windows QTL Cartographer 2.0. Raleigh, NC: Department of Statistics, North Carolina State University; 2001-2004.
40. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics. 1994;138:963-71.
41. Xu S. Rheoretical basis of the Beavis effect. Genetics. 2003; 165;2259-68.
42. Montooth KL, Marden JH, Clark AG. Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics. 2003;165:623-35.
43. Curtsinger JW. Sex specificity, life-span QTLs, and statistical power. J Gerontol A Biol Sci Med Sci. 2002;57:B409-14.
44. Reiwitch SG, Nuzhdin SV. Quantitative trait loci for lifespan of mated Drosophila melanogaster affect both sexes. Genet Res. 2002;80:225-30.
45. Segal NL, Allison DB. Twins and virtual twins: bases of relative body weight revisited. Int J Obes Relat Metab Disord. 2002;26:437-41.
46. Ishimori N, Li R, Kelmenson PM, et al. Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 12981/SvImJ inbred mice. J Lipid Res. 2004;45:1624-32.
47. Yi N, Chiu S, Allison DB, Fisler JS, Warden CH. Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice. J Lipid Res. 2004;45:2063-70.
48. Dong C, Wang S, Li WD, Li D, Zhao H, Price RA. Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity. Am J Hum Genet. 2003;72:115-24.
49. Dong C, Li WD, Li D, Price RA. Interaction between obesity-susceptibility loci in chromosome regions 2p25-p24 and 13q13-q21. Eur J Hum Genet. 2005;13:102-8.
50. Ashrati K, Chang FY, Watts JL, et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003;421:268-72.
51. Petruschke T, Rohrig K, Hauner H. Transforming growth factor beta (TGF-beta) inhibits the differentiation of human adipocyte precursor cells in primary culture. Int J Obes Relat Metab Disord. 1994;18:532-6.
52. Alessi MC, Bastelica D, Morange P, et al. Plasminogen activator inhibitor 1, transforming growth factor-beta 1, and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes. 2000;49:1374-80.
53. Long JR, Liu PY, Liu YJ, et al. APOE and TGF-betal genes are associated with obesity phenotypes. J Med Genet. 2003;40:918-24.
54. Riddle DL, Albert PS. C. elegans II. In: Riddle DL, Blumenthal T, Meyer BJ, Priess JR, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1997, pp 739-68.