메뉴 건너뛰기




Volumn 14, Issue 3, 2004, Pages 253-257

The genetic architecture of quantitative traits: Lessons from Drosophila

Author keywords

Ddc; Dopa decarboxylase; LD; linkage disequilibrium; QTL; QTN; quantitative trait locus; quantitative trait nucleotide; recombinant inbred; RI; smell impaired; smi

Indexed keywords

ALLELE; DROSOPHILA; ENVIRONMENTAL FACTOR; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; GENE INSERTION; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MODEL; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC TRAIT; GENOME ANALYSIS; GENOTYPE; MOLECULAR GENETICS; MUTAGENESIS; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT; REGULATORY MECHANISM; REVIEW; SEQUENCE ANALYSIS; SEX; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; TRANSGENE;

EID: 2542454771     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2004.04.003     Document Type: Review
Times cited : (179)

References (50)
  • 1
    • 0030087712 scopus 로고    scopus 로고
    • The nature of quantitative genetic variation revisited: Lessons from Drosophila bristles
    • Mackay T.F.C. The nature of quantitative genetic variation revisited: lessons from Drosophila bristles. Bioessays. 18:1996;113-121
    • (1996) Bioessays , vol.18 , pp. 113-121
    • MacKay, T.F.C.1
  • 2
    • 0003455528 scopus 로고
    • Cold Spring Harbor, NY: Cold Spring Harbor Laboratory press
    • Ashburner M: Drosophila - A Laboratory Handbook. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory press; 1989.
    • (1989) Drosophila - A Laboratory Handbook
    • Ashburner, M.1
  • 3
    • 0037122913 scopus 로고    scopus 로고
    • Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila
    • This paper describes a technique for constructing stable RNA interference constructs that can be expressed in subsets of cells or tissues using the binary GAL4/UAS system. Using this system, reverse genetic analyses are now possible in Drosophila.
    • Kalidas S., Smith D.P. Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila. Neuron. 33:2002;177-184 This paper describes a technique for constructing stable RNA interference constructs that can be expressed in subsets of cells or tissues using the binary GAL4/UAS system. Using this system, reverse genetic analyses are now possible in Drosophila.
    • (2002) Neuron , vol.33 , pp. 177-184
    • Kalidas, S.1    Smith, D.P.2
  • 5
    • 0031747186 scopus 로고    scopus 로고
    • Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster
    • Long A.D., Lyman R.F., Langley C.H., Mackay T.F.C. Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster. Genetics. 149:1998;999-1017
    • (1998) Genetics , vol.149 , pp. 999-1017
    • Long, A.D.1    Lyman, R.F.2    Langley, C.H.3    MacKay, T.F.C.4
  • 7
    • 0029960341 scopus 로고    scopus 로고
    • Effects of single P element insertions on olfactory behavior in Drosophila melanogaster
    • Anholt R.R.H., Lyman R.F., Mackay T.F.C. Effects of single P element insertions on olfactory behavior in Drosophila melanogaster. Genetics. 143:1996;293-301
    • (1996) Genetics , vol.143 , pp. 293-301
    • Anholt, R.R.H.1    Lyman, R.F.2    MacKay, T.F.C.3
  • 8
    • 0029963798 scopus 로고    scopus 로고
    • Effects of single P element insertions on bristle number and viability in Drosophila melanogaster
    • Lyman R.F., Lawrence F., Nuzhdin S.V., Mackay T.F.C. Effects of single P element insertions on bristle number and viability in Drosophila melanogaster. Genetics. 143:1996;277-292
    • (1996) Genetics , vol.143 , pp. 277-292
    • Lyman, R.F.1    Lawrence, F.2    Nuzhdin, S.V.3    MacKay, T.F.C.4
  • 9
    • 0042426031 scopus 로고    scopus 로고
    • Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development
    • In this paper, we show that screening for quantitative effects of insertional mutations that have been induced in a co-isogenic background is a highly effective method for identifying known and novel loci affecting quantitative traits. The large numbers of inserts recovered affecting single traits implies that most loci have pleiotropic effects on many traits.
    • Norga K.K., Gurganus M.C., Dilda C.L., Yamamoto A., Lyman R.F., Patel P.H., Rubin G.M., Hoskins R.A., Mackay T.F.C., Bellen H.J. Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Curr Biol. 13:2003;1388-1397 In this paper, we show that screening for quantitative effects of insertional mutations that have been induced in a co-isogenic background is a highly effective method for identifying known and novel loci affecting quantitative traits. The large numbers of inserts recovered affecting single traits implies that most loci have pleiotropic effects on many traits.
    • (2003) Curr Biol , vol.13 , pp. 1388-1397
    • Norga, K.K.1    Gurganus, M.C.2    Dilda, C.L.3    Yamamoto, A.4    Lyman, R.F.5    Patel, P.H.6    Rubin, G.M.7    Hoskins, R.A.8    MacKay, T.F.C.9    Bellen, H.J.10
  • 10
    • 0034425606 scopus 로고    scopus 로고
    • The roads from phenotypic variation to gene discovery: Mutagenesis versus QTL
    • Nadeau J.H., Frankel D. The roads from phenotypic variation to gene discovery: mutagenesis versus QTL. Nat Genet. 25:2000;381-384
    • (2000) Nat Genet , vol.25 , pp. 381-384
    • Nadeau, J.H.1    Frankel, D.2
  • 13
    • 0031917465 scopus 로고    scopus 로고
    • Epistatic interactions between smell-impaired loci in Drosophila melanogaster
    • Fedorowicz G.M., Fry J.D., Anholt R.R.H., Mackay T.F.C. Epistatic interactions between smell-impaired loci in Drosophila melanogaster. Genetics. 148:1998;1885-1891
    • (1998) Genetics , vol.148 , pp. 1885-1891
    • Fedorowicz, G.M.1    Fry, J.D.2    Anholt, R.R.H.3    MacKay, T.F.C.4
  • 14
    • 0036672661 scopus 로고    scopus 로고
    • The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster
    • Kulkarni N.H., Yamamoto A., Robinson K.O., Mackay T.F.C., Anholt R.R.H. The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster. Genetics. 161:2002;1507-1516
    • (2002) Genetics , vol.161 , pp. 1507-1516
    • Kulkarni, N.H.1    Yamamoto, A.2    Robinson, K.O.3    MacKay, T.F.C.4    Anholt, R.R.H.5
  • 15
    • 0041317006 scopus 로고    scopus 로고
    • Scribble is essential for olfactory behavior in Drosophila
    • Ganguly I., Mackay T.F.C., Anholt R.R.H. Scribble is essential for olfactory behavior in Drosophila. Genetics. 164:2003;1447-1457
    • (2003) Genetics , vol.164 , pp. 1447-1457
    • Ganguly, I.1    MacKay, T.F.C.2    Anholt, R.R.H.3
  • 16
    • 0034628471 scopus 로고    scopus 로고
    • Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    • Bilder D., Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. 403:2000;676-680
    • (2000) Nature , vol.403 , pp. 676-680
    • Bilder, D.1    Perrimon, N.2
  • 17
    • 0141730402 scopus 로고    scopus 로고
    • The genetic architecture of odor-guided behavior in Drosophila: Epistasis and the transcriptome
    • In this paper, we quantify the large degree of transcriptional co-regulation induced by single mutations with subtle effects on olfactory behavior, all in the same co-isogenic background. Mutations in co-regulated genes also interact epistatically with the focal mutations, thus linking transcriptional networks with genetic networks.
    • Anholt R.R.H., Dilda C.L., Chang S., Fanara J.J., Kulkarni N.H., Ganguly I., Rollmann S.M., Kamdar K.P., Mackay T.F.C. The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome. Nat Genet. 35:2003;180-184 In this paper, we quantify the large degree of transcriptional co-regulation induced by single mutations with subtle effects on olfactory behavior, all in the same co-isogenic background. Mutations in co-regulated genes also interact epistatically with the focal mutations, thus linking transcriptional networks with genetic networks.
    • (2003) Nat Genet , vol.35 , pp. 180-184
    • Anholt, R.R.H.1    Dilda, C.L.2    Chang, S.3    Fanara, J.J.4    Kulkarni, N.H.5    Ganguly, I.6    Rollmann, S.M.7    Kamdar, K.P.8    MacKay, T.F.C.9
  • 18
    • 0036699933 scopus 로고    scopus 로고
    • Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait
    • Here, differences in transcription between a line selected for increased, and one selected for decreased, geotactic behavior were quantified using microarrays. Mutations in three of five genes with significant changes in expression exhibited aberrant geotactic behavior, showing that analysis of expression differences between lines with different quantitative trait phenotypes can identify novel candidate genes affecting the trait.
    • Toma D.P., White K.P., Hirsch J., Greenspan R.J. Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait. Nat Genet. 31:2002;349-353 Here, differences in transcription between a line selected for increased, and one selected for decreased, geotactic behavior were quantified using microarrays. Mutations in three of five genes with significant changes in expression exhibited aberrant geotactic behavior, showing that analysis of expression differences between lines with different quantitative trait phenotypes can identify novel candidate genes affecting the trait.
    • (2002) Nat Genet , vol.31 , pp. 349-353
    • Toma, D.P.1    White, K.P.2    Hirsch, J.3    Greenspan, R.J.4
  • 19
    • 0028224156 scopus 로고
    • Precision mapping of quantitative trait loci
    • Zeng Z.B. Precision mapping of quantitative trait loci. Genetics. 136:1994;1457-1468
    • (1994) Genetics , vol.136 , pp. 1457-1468
    • Zeng, Z.B.1
  • 20
    • 0030052609 scopus 로고    scopus 로고
    • Permutation tests for multiple loci affecting a quantitative character
    • Doerge R.W., Churchill G.A. Permutation tests for multiple loci affecting a quantitative character. Genetics. 142:1996;285-294
    • (1996) Genetics , vol.142 , pp. 285-294
    • Doerge, R.W.1    Churchill, G.A.2
  • 21
    • 0030967939 scopus 로고    scopus 로고
    • Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster
    • Nuzhdin S.V., Pasyukova E.G., Dilda C., Mackay T.F.C. Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster. Proc Natl Acad Sci USA. 94:1997;9734-9739
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9734-9739
    • Nuzhdin, S.V.1    Pasyukova, E.G.2    Dilda, C.3    MacKay, T.F.C.4
  • 22
    • 0033979887 scopus 로고    scopus 로고
    • Genotype-environment interaction for quantitative trait loci affecting lifespan in Drosophila melanogaster
    • Vieira C., Pasyukova E.G., Zeng Z.B., Hackett J.B., Lyman R.F., Mackay T.F.C. Genotype-environment interaction for quantitative trait loci affecting lifespan in Drosophila melanogaster. Genetics. 154:2000;213-227
    • (2000) Genetics , vol.154 , pp. 213-227
    • Vieira, C.1    Pasyukova, E.G.2    Zeng, Z.B.3    Hackett, J.B.4    Lyman, R.F.5    MacKay, T.F.C.6
  • 23
    • 0033870603 scopus 로고    scopus 로고
    • Quantitative trait loci for lifespan in Drosophila melanogaster: Interactions with genetic background and larval density
    • Leips J., Mackay T.F.C. Quantitative trait loci for lifespan in Drosophila melanogaster: interactions with genetic background and larval density. Genetics. 155:2000;1773-1788
    • (2000) Genetics , vol.155 , pp. 1773-1788
    • Leips, J.1    MacKay, T.F.C.2
  • 24
    • 0036791332 scopus 로고    scopus 로고
    • The complex genetic architecture of Drosophila life span
    • Leips J., Mackay T.F.C. The complex genetic architecture of Drosophila life span. Exp Aging Res. 28:2002;361-390
    • (2002) Exp Aging Res , vol.28 , pp. 361-390
    • Leips, J.1    MacKay, T.F.C.2
  • 25
    • 0031902270 scopus 로고    scopus 로고
    • Genotype-environment interaction for quantitative trait loci affecting sensory bristle number in Drosophila melanogaster
    • Gurganus M.C., Fry J.D., Nuzhdin S.V., Pasyukova E.G., Lyman R.F., Mackay T.F.C. Genotype-environment interaction for quantitative trait loci affecting sensory bristle number in Drosophila melanogaster. Genetics. 149:1998;1883-1898
    • (1998) Genetics , vol.149 , pp. 1883-1898
    • Gurganus, M.C.1    Fry, J.D.2    Nuzhdin, S.V.3    Pasyukova, E.G.4    Lyman, R.F.5    MacKay, T.F.C.6
  • 27
    • 0036861671 scopus 로고    scopus 로고
    • Vanaso is a quantitative trait locus for Drosophila olfactory behavior
    • In this paper, we used recombination mapping to localize a single QTL affecting variation in olfactory behavior in both sexes to the distal end of chromosome 3L. Deficiency complementation mapping shows that this QTL fractionates into one male- and one female-specific QTL, and complementation to mutations show that a novel gene, Vanaso, is a candidate gene for the female-specific QTL.
    • Fanara J.J., Robinson K.O., Rollmann S., Anholt R.R.H., Mackay T.F.C. Vanaso is a quantitative trait locus for Drosophila olfactory behavior. Genetics. 162:2002;1321-1328 In this paper, we used recombination mapping to localize a single QTL affecting variation in olfactory behavior in both sexes to the distal end of chromosome 3L. Deficiency complementation mapping shows that this QTL fractionates into one male- and one female-specific QTL, and complementation to mutations show that a novel gene, Vanaso, is a candidate gene for the female-specific QTL.
    • (2002) Genetics , vol.162 , pp. 1321-1328
    • Fanara, J.J.1    Robinson, K.O.2    Rollmann, S.3    Anholt, R.R.H.4    MacKay, T.F.C.5
  • 28
    • 0035997585 scopus 로고    scopus 로고
    • Quantitative trait loci affecting a courtship signal in Drosophila melanogaster
    • Gleason J.M., Nuzhdin S.V., Ritchie M.G. Quantitative trait loci affecting a courtship signal in Drosophila melanogaster. Heredity. 89:2002;1-6
    • (2002) Heredity , vol.89 , pp. 1-6
    • Gleason, J.M.1    Nuzhdin, S.V.2    Ritchie, M.G.3
  • 29
    • 0242286604 scopus 로고    scopus 로고
    • Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila
    • Montooth K.L., Marden J.H., Clark A.G. Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics. 165:2003;623-635
    • (2003) Genetics , vol.165 , pp. 623-635
    • Montooth, K.L.1    Marden, J.H.2    Clark, A.G.3
  • 30
    • 0028961745 scopus 로고
    • High resolution mapping of genetic factors affecting abdominal bristle number in Drosophila melanogaster
    • Long A.D., Mullaney S.L., Reid L.A., Fry J.D., Langley C.H., Mackay T.F.C. High resolution mapping of genetic factors affecting abdominal bristle number in Drosophila melanogaster. Genetics. 139:1995;1273-1291
    • (1995) Genetics , vol.139 , pp. 1273-1291
    • Long, A.D.1    Mullaney, S.L.2    Reid, L.A.3    Fry, J.D.4    Langley, C.H.5    MacKay, T.F.C.6
  • 31
    • 0345466642 scopus 로고    scopus 로고
    • High resolution mapping of quantitative trait loci affecting sternopleural bristle number in Drosophila melanogaster
    • Gurganus M.C., Nuzhdin S.V., Leips J.W., Mackay T.F.C. High resolution mapping of quantitative trait loci affecting sternopleural bristle number in Drosophila melanogaster. Genetics. 152:1999;1585-1604
    • (1999) Genetics , vol.152 , pp. 1585-1604
    • Gurganus, M.C.1    Nuzhdin, S.V.2    Leips, J.W.3    MacKay, T.F.C.4
  • 32
    • 0032713423 scopus 로고    scopus 로고
    • The genetic architecture of selection response: Inferences from fine-scale mapping of bristle number quantitative trait loci in Drosophila melanogaster
    • Nuzhdin S.V., Dilda C.L., Mackay T.F.C. The genetic architecture of selection response: Inferences from fine-scale mapping of bristle number quantitative trait loci in Drosophila melanogaster. Genetics. 153:1999;1317-1331
    • (1999) Genetics , vol.153 , pp. 1317-1331
    • Nuzhdin, S.V.1    Dilda, C.L.2    MacKay, T.F.C.3
  • 33
    • 0036959393 scopus 로고    scopus 로고
    • The genetic architecture of Drosophila sensory bristle number
    • In this paper, we used high-resolution recombination mapping to reveal that a large number of QTLs, with sex-, environment- and genotype-specific effects, affect natural variation in the archetypical 'additive' quantitative traits: numbers of abdominal and sternopleural bristles.
    • Dilda C.L., Mackay T.F.C. The genetic architecture of Drosophila sensory bristle number. Genetics. 162:2002;1655-1674 In this paper, we used high-resolution recombination mapping to reveal that a large number of QTLs, with sex-, environment- and genotype-specific effects, affect natural variation in the archetypical 'additive' quantitative traits: numbers of abdominal and sternopleural bristles.
    • (2002) Genetics , vol.162 , pp. 1655-1674
    • Dilda, C.L.1    MacKay, T.F.C.2
  • 34
    • 0032819610 scopus 로고    scopus 로고
    • An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster
    • Weber K., Eisman R., Morey L., Patty A., Sparks J., Tausek M., Zeng Z.B. An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster. Genetics. 153:1999;773-786
    • (1999) Genetics , vol.153 , pp. 773-786
    • Weber, K.1    Eisman, R.2    Morey, L.3    Patty, A.4    Sparks, J.5    Tausek, M.6    Zeng, Z.B.7
  • 35
    • 0035675989 scopus 로고    scopus 로고
    • An analysis of polygenes affecting wing shape on chromosome 2 in Drosophila melanogaster
    • Weber K., Eisman R., Higgins S., Morey L., Patty A., Tausek M., Zeng Z.B. An analysis of polygenes affecting wing shape on chromosome 2 in Drosophila melanogaster. Genetics. 159:2001;1045-1057
    • (2001) Genetics , vol.159 , pp. 1045-1057
    • Weber, K.1    Eisman, R.2    Higgins, S.3    Morey, L.4    Patty, A.5    Tausek, M.6    Zeng, Z.B.7
  • 36
    • 0024495795 scopus 로고
    • Genotype-environment interactions and the maintenance of polygenic variation
    • Gillespie J.H., Turelli M. Genotype-environment interactions and the maintenance of polygenic variation. Genetics. 121:1989;129-138
    • (1989) Genetics , vol.121 , pp. 129-138
    • Gillespie, J.H.1    Turelli, M.2
  • 37
    • 0033760527 scopus 로고    scopus 로고
    • Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster
    • Pasyukova E.G., Vieira C., Mackay T.F.C. Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster. Genetics. 156:2000;1129-1146
    • (2000) Genetics , vol.156 , pp. 1129-1146
    • Pasyukova, E.G.1    Vieira, C.2    MacKay, T.F.C.3
  • 38
    • 0043095549 scopus 로고    scopus 로고
    • Dopa-decarboxylase affects variation in Drosophila longevity
    • Here we use deficiency and mutant complementation tests to implicate Ddc as a candidate gene affecting longevity. LD mapping reveals that an amino acid polymorphism and two polymorphisms in non-coding regions of Ddc interact epistatically to affect longevity. This study implicates Ddc as a candidate gene affecting longevity in other species, and illustrates the complexity of intragenic interactions affecting variation in quantitative trait phenotypes.
    • De Luca M., Roshina N.V., Geiger-Thornsberry G.L., Lyman R.F., Pasyukova E.G., Mackay T.F.C. Dopa-decarboxylase affects variation in Drosophila longevity. Nat Genet. 34:2003;429-433 Here we use deficiency and mutant complementation tests to implicate Ddc as a candidate gene affecting longevity. LD mapping reveals that an amino acid polymorphism and two polymorphisms in non-coding regions of Ddc interact epistatically to affect longevity. This study implicates Ddc as a candidate gene affecting longevity in other species, and illustrates the complexity of intragenic interactions affecting variation in quantitative trait phenotypes.
    • (2003) Nat Genet , vol.34 , pp. 429-433
    • De Luca, M.1    Roshina, N.V.2    Geiger-Thornsberry, G.L.3    Lyman, R.F.4    Pasyukova, E.G.5    MacKay, T.F.C.6
  • 39
    • 0032883802 scopus 로고    scopus 로고
    • The Berkeley Drosophila Genome Project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes
    • Spradling A.C., Stern D., Beaton A., Rhem E.J., Laverty T., Mozden N., Misra S., Rubin G.M. The Berkeley Drosophila Genome Project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. Genetics. 153:1999;135-177
    • (1999) Genetics , vol.153 , pp. 135-177
    • Spradling, A.C.1    Stern, D.2    Beaton, A.3    Rhem, E.J.4    Laverty, T.5    Mozden, N.6    Misra, S.7    Rubin, G.M.8
  • 40
    • 0037069380 scopus 로고    scopus 로고
    • Combining mapping and arraying: An approach to candidate gene identification
    • QTLs for ovariole number were mapped with high resolution using complementation tests to deficiencies, followed by quantification of differences in gene expression between the two parental lines using expression microarrays. A strong candidate gene for ovariole number was identified on the basis of large differences in expression between the two lines mapped and localization within the QTL region.
    • Wayne M.L., McIntyre L.M. Combining mapping and arraying: an approach to candidate gene identification. Proc Natl Acad Sci USA. 99:2002;14903-14906 QTLs for ovariole number were mapped with high resolution using complementation tests to deficiencies, followed by quantification of differences in gene expression between the two parental lines using expression microarrays. A strong candidate gene for ovariole number was identified on the basis of large differences in expression between the two lines mapped and localization within the QTL region.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14903-14906
    • Wayne, M.L.1    McIntyre, L.M.2
  • 41
    • 0025949335 scopus 로고
    • Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression associated with the allozyme polymorphism in Drosophila melanogaster
    • Choudhary M., Laurie C.C. Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression associated with the allozyme polymorphism in Drosophila melanogaster. Genetics. 129:1991;481-488
    • (1991) Genetics , vol.129 , pp. 481-488
    • Choudhary, M.1    Laurie, C.C.2
  • 42
    • 0037097866 scopus 로고    scopus 로고
    • Targeted mutagenesis by homologous recombination in D. melanogaster
    • This paper describes a method for allelic substitution using homologous recombination. The method is a critical addition to the Drosophila toolkit for evaluation of subtle functional differences in phenotype between candidate gene alleles.
    • Rong Y.S., Titen S.W., Xie H.B., Golic M.M., Bastiani M., Bandyopadhyay P., Olivera B.M., Brodsky M., Rubin G.M., Golic K.G. Targeted mutagenesis by homologous recombination in D. melanogaster. Genes Dev. 16:2002;1568-1581 This paper describes a method for allelic substitution using homologous recombination. The method is a critical addition to the Drosophila toolkit for evaluation of subtle functional differences in phenotype between candidate gene alleles.
    • (2002) Genes Dev , vol.16 , pp. 1568-1581
    • Rong, Y.S.1    Titen, S.W.2    Xie, H.B.3    Golic, M.M.4    Bastiani, M.5    Bandyopadhyay, P.6    Olivera, B.M.7    Brodsky, M.8    Rubin, G.M.9    Golic, K.G.10
  • 43
    • 0345168212 scopus 로고    scopus 로고
    • Ecological adaptation during incipient speciation revealed by precise gene replacement
    • ••] is utilized to show that natural variation in desaturase 2 alleles affects variation in stress resistance.
    • ••] is utilized to show that natural variation in desaturase 2 alleles affects variation in stress resistance.
    • (2003) Science , vol.302 , pp. 1754-1757
    • Greenberg, A.J.1    Moran, J.R.2    Coyne, J.A.3    Wu, C.I.4
  • 44
    • 0022828323 scopus 로고
    • Molecular population genetics of the alcohol dehydrogenase gene region of Drosophila melanogaster
    • Aquadro C.F., Desse S.F., Bland M.M., Langley C.H., Laurie-Ahlberg C.C. Molecular population genetics of the alcohol dehydrogenase gene region of Drosophila melanogaster. Genetics. 114:1986;1165-1190
    • (1986) Genetics , vol.114 , pp. 1165-1190
    • Aquadro, C.F.1    Desse, S.F.2    Bland, M.M.3    Langley, C.H.4    Laurie-Ahlberg, C.C.5
  • 45
    • 0025123985 scopus 로고
    • Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster
    • Mackay T.F.C., Langley C.H. Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster. Nature. 348:1990;64-66
    • (1990) Nature , vol.348 , pp. 64-66
    • MacKay, T.F.C.1    Langley, C.H.2
  • 46
    • 0028578184 scopus 로고
    • Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus in Drosophila melanogaster
    • Lai C., Lyman R.F., Long A.D., Langley C.H., Mackay T.F.C. Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus in Drosophila melanogaster. Science. 266:1994;1697-1702
    • (1994) Science , vol.266 , pp. 1697-1702
    • Lai, C.1    Lyman, R.F.2    Long, A.D.3    Langley, C.H.4    MacKay, T.F.C.5
  • 47
    • 0034056305 scopus 로고    scopus 로고
    • Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute Complex are associated with variation in bristle number in Drosophila melanogaster
    • Long A.D., Lyman R.F., Morgan A.H., Langley C.H., Mackay T.F.C. Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute Complex are associated with variation in bristle number in Drosophila melanogaster. Genetics. 154:2000;1255-1269
    • (2000) Genetics , vol.154 , pp. 1255-1269
    • Long, A.D.1    Lyman, R.F.2    Morgan, A.H.3    Langley, C.H.4    MacKay, T.F.C.5
  • 48
    • 0033369916 scopus 로고    scopus 로고
    • Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster
    • Lyman R.F., Lai C., Mackay T.F.C. Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster. Genet Res. 74:1999;303-311
    • (1999) Genet Res , vol.74 , pp. 303-311
    • Lyman, R.F.1    Lai, C.2    MacKay, T.F.C.3
  • 49
    • 0036743491 scopus 로고    scopus 로고
    • Hairy: A quantitative trait locus for Drosophila bristle number
    • Robin C., Lyman R.F., Long A.D., Langley C.H., Mackay T.F.C. hairy: a quantitative trait locus for Drosophila bristle number. Genetics. 162:2002;155-164
    • (2002) Genetics , vol.162 , pp. 155-164
    • Robin, C.1    Lyman, R.F.2    Long, A.D.3    Langley, C.H.4    MacKay, T.F.C.5
  • 50
    • 0030453209 scopus 로고    scopus 로고
    • Molecular dissection of a major gene effect on a quantitative trait: The level of alcohol dehydrogenase expression in Drosophila melanogaster
    • Stam L.F., Laurie C.C. Molecular dissection of a major gene effect on a quantitative trait: the level of alcohol dehydrogenase expression in Drosophila melanogaster. Genetics. 144:1996;1559-1564
    • (1996) Genetics , vol.144 , pp. 1559-1564
    • Stam, L.F.1    Laurie, C.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.