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Norga K.K., Gurganus M.C., Dilda C.L., Yamamoto A., Lyman R.F., Patel P.H., Rubin G.M., Hoskins R.A., Mackay T.F.C., Bellen H.J. Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Curr Biol. 13:2003;1388-1397 In this paper, we show that screening for quantitative effects of insertional mutations that have been induced in a co-isogenic background is a highly effective method for identifying known and novel loci affecting quantitative traits. The large numbers of inserts recovered affecting single traits implies that most loci have pleiotropic effects on many traits.
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In this paper, we quantify the large degree of transcriptional co-regulation induced by single mutations with subtle effects on olfactory behavior, all in the same co-isogenic background. Mutations in co-regulated genes also interact epistatically with the focal mutations, thus linking transcriptional networks with genetic networks.
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Anholt R.R.H., Dilda C.L., Chang S., Fanara J.J., Kulkarni N.H., Ganguly I., Rollmann S.M., Kamdar K.P., Mackay T.F.C. The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome. Nat Genet. 35:2003;180-184 In this paper, we quantify the large degree of transcriptional co-regulation induced by single mutations with subtle effects on olfactory behavior, all in the same co-isogenic background. Mutations in co-regulated genes also interact epistatically with the focal mutations, thus linking transcriptional networks with genetic networks.
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Here, differences in transcription between a line selected for increased, and one selected for decreased, geotactic behavior were quantified using microarrays. Mutations in three of five genes with significant changes in expression exhibited aberrant geotactic behavior, showing that analysis of expression differences between lines with different quantitative trait phenotypes can identify novel candidate genes affecting the trait.
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Gurganus M.C., Fry J.D., Nuzhdin S.V., Pasyukova E.G., Lyman R.F., Mackay T.F.C. Genotype-environment interaction for quantitative trait loci affecting sensory bristle number in Drosophila melanogaster. Genetics. 149:1998;1883-1898
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In this paper, we used recombination mapping to localize a single QTL affecting variation in olfactory behavior in both sexes to the distal end of chromosome 3L. Deficiency complementation mapping shows that this QTL fractionates into one male- and one female-specific QTL, and complementation to mutations show that a novel gene, Vanaso, is a candidate gene for the female-specific QTL.
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Fanara J.J., Robinson K.O., Rollmann S., Anholt R.R.H., Mackay T.F.C. Vanaso is a quantitative trait locus for Drosophila olfactory behavior. Genetics. 162:2002;1321-1328 In this paper, we used recombination mapping to localize a single QTL affecting variation in olfactory behavior in both sexes to the distal end of chromosome 3L. Deficiency complementation mapping shows that this QTL fractionates into one male- and one female-specific QTL, and complementation to mutations show that a novel gene, Vanaso, is a candidate gene for the female-specific QTL.
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In this paper, we used high-resolution recombination mapping to reveal that a large number of QTLs, with sex-, environment- and genotype-specific effects, affect natural variation in the archetypical 'additive' quantitative traits: numbers of abdominal and sternopleural bristles.
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