-
2
-
-
0024368522
-
Treatment of chronic hepatitis C with recombinant interferon α. A multicenter randomized, controlled trial. Hepatitis Interventional Therapy Group
-
Davis GL, Balart LA, Schiff ER et al. Treatment of chronic hepatitis C with recombinant interferon α. A multicenter randomized, controlled trial. Hepatitis Interventional Therapy Group. N. Engl. J. Med. 321(22), 1501-1506 (1989).
-
(1989)
N. Engl. J. Med
, vol.321
, Issue.22
, pp. 1501-1506
-
-
Davis, G.L.1
Balart, L.A.2
Schiff, E.R.3
-
3
-
-
0032547938
-
Interferon α-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group
-
McHutchison JG, Gordon SC, Schiff ER et al. Interferon α-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N. Engl. J. Med. 339(21), 1485-1492 (1998).
-
(1998)
N. Engl. J. Med
, vol.339
, Issue.21
, pp. 1485-1492
-
-
McHutchison, J.G.1
Gordon, S.C.2
Schiff, E.R.3
-
4
-
-
0031975124
-
Randomized, multicentre comparison of sodium alginate and cisapride in the symptomatic treatment of uncomplicated gastro-oesophageal reflux
-
Poynard T, Vernisse B, Agostini H. Randomized, multicentre comparison of sodium alginate and cisapride in the symptomatic treatment of uncomplicated gastro-oesophageal reflux. Aliment Pharmacol. Ther. 12(2), 159-165 (1998).
-
(1998)
Aliment Pharmacol. Ther
, vol.12
, Issue.2
, pp. 159-165
-
-
Poynard, T.1
Vernisse, B.2
Agostini, H.3
-
5
-
-
36749001029
-
The way forward in HCV treatment - finding the right path
-
Excellent review on other therapies currently in development for the treatment of HCV infection besides immunotherapies, •
-
Manns MP, Foster GR, Rockstroh JK, Zeuzem S, Zoulim F, Houghton M. The way forward in HCV treatment - finding the right path. Nat. Rev. Drug Discov. 6(12), 991-1000 (2007). • Excellent review on other therapies currently in development for the treatment of HCV infection besides immunotherapies.
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, Issue.12
, pp. 991-1000
-
-
Manns, M.P.1
Foster, G.R.2
Rockstroh, J.K.3
Zeuzem, S.4
Zoulim, F.5
Houghton, M.6
-
6
-
-
23944467250
-
Adaptive immune responses in acute and chronic hepatitis C virus infection
-
Excellent review on the correlates of immune protection for HCV infection, •
-
Bowen DG, Walker CM. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 436(7053), 946-952 (2005). • Excellent review on the correlates of immune protection for HCV infection.
-
(2005)
Nature
, vol.436
, Issue.7053
, pp. 946-952
-
-
Bowen, D.G.1
Walker, C.M.2
-
7
-
-
23944452579
-
Prospects for a vaccine against the hepatitis C virus
-
Houghton M, Abrignani S. Prospects for a vaccine against the hepatitis C virus. Nature 436(7053), 961-966 (2005).
-
(2005)
Nature
, vol.436
, Issue.7053
, pp. 961-966
-
-
Houghton, M.1
Abrignani, S.2
-
8
-
-
33747797031
-
Treating viral hepatitis C: Efficacy, side effects, and complications
-
Manns MP, Wedemeyer H, Cornberg M. Treating viral hepatitis C: efficacy, side effects, and complications. Gut 55(9), 1350-1359 (2006).
-
(2006)
Gut
, vol.55
, Issue.9
, pp. 1350-1359
-
-
Manns, M.P.1
Wedemeyer, H.2
Cornberg, M.3
-
9
-
-
0035934568
-
Peginterferon α-2b plus ribavirin compared with interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
Manns MP, McHutchison JG, Gordon SC et al. Peginterferon α-2b plus ribavirin compared with interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358(9286), 958-965 (2001).
-
(2001)
Lancet
, vol.358
, Issue.9286
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
-
10
-
-
0037179698
-
Peginterferon α-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried MW, Shiffman ML, Reddy KR et al. Peginterferon α-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 347(13), 975-982 (2002).
-
(2002)
N. Engl. J. Med
, vol.347
, Issue.13
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
11
-
-
33644551889
-
A Phase I/II study evaluating escalating doses of recombinant human albumin-interferon-α fusion protein in chronic hepatitis C patients who have failed previous interferon-α-based therapy
-
Balan V, Nelson DR, Sulkowski MS et al. A Phase I/II study evaluating escalating doses of recombinant human albumin-interferon-α fusion protein in chronic hepatitis C patients who have failed previous interferon-α-based therapy. Antivir. Ther. 11(1), 35-45 (2006).
-
(2006)
Antivir. Ther
, vol.11
, Issue.1
, pp. 35-45
-
-
Balan, V.1
Nelson, D.R.2
Sulkowski, M.S.3
-
12
-
-
33644918919
-
A Phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon α fusion protein in genotype 1 chronic hepatitis C patients
-
Bain VG, Kaita KD, Yoshida EM et al. A Phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon α fusion protein in genotype 1 chronic hepatitis C patients. J. Hepatol. 44(4), 671-678 (2006).
-
(2006)
J. Hepatol
, vol.44
, Issue.4
, pp. 671-678
-
-
Bain, V.G.1
Kaita, K.D.2
Yoshida, E.M.3
-
13
-
-
0029833999
-
The biologic activity and molecular characterization of a novel synthetic interferon-α species, consensus interferon
-
Blatt LM, Davis JM, Klein SB, Taylor MW. The biologic activity and molecular characterization of a novel synthetic interferon-α species, consensus interferon. J. Interferon Cytokine Res. 16(7), 489-499 (1996).
-
(1996)
J. Interferon Cytokine Res
, vol.16
, Issue.7
, pp. 489-499
-
-
Blatt, L.M.1
Davis, J.M.2
Klein, S.B.3
Taylor, M.W.4
-
14
-
-
0027058741
-
A comparison of interferon-Con1 with natural recombinant interferons-α: Antiviral, antiproliferative, and natural killer-inducing activities
-
Ozes ON, Reiter Z, Klein S, Blatt LM, Taylor MW. A comparison of interferon-Con1 with natural recombinant interferons-α: antiviral, antiproliferative, and natural killer-inducing activities. J. Interferon Res. 12(1), 55-59 (1992).
-
(1992)
J. Interferon Res
, vol.12
, Issue.1
, pp. 55-59
-
-
Ozes, O.N.1
Reiter, Z.2
Klein, S.3
Blatt, L.M.4
Taylor, M.W.5
-
15
-
-
17644415729
-
Interferon acon-1 and ribavirin versus interferon α-2b and ribavirin in the treatment of chronic hepatitis C
-
Sjogren MH, Sjogren R, Holtzmuller K et al. Interferon acon-1 and ribavirin versus interferon α-2b and ribavirin in the treatment of chronic hepatitis C. Dig. Dis. Sci. 50(4), 727-732 (2005).
-
(2005)
Dig. Dis. Sci
, vol.50
, Issue.4
, pp. 727-732
-
-
Sjogren, M.H.1
Sjogren, R.2
Holtzmuller, K.3
-
16
-
-
10744225023
-
A randomized trial of consensus interferon in combination with ribavirin as initial treatment for chronic hepatitis C
-
Fattovich G, Zagni I, Minola E et al. A randomized trial of consensus interferon in combination with ribavirin as initial treatment for chronic hepatitis C. J. Hepatol. 39(5), 843-849 (2003).
-
(2003)
J. Hepatol
, vol.39
, Issue.5
, pp. 843-849
-
-
Fattovich, G.1
Zagni, I.2
Minola, E.3
-
17
-
-
0345695221
-
Treatment of chronic hepatitis C with consensus interferon: A multicenter, randomized, controlled trial. Consensus Interferon Study Group
-
Tong MJ, Reddy KR, Lee WM et al. Treatment of chronic hepatitis C with consensus interferon: a multicenter, randomized, controlled trial. Consensus Interferon Study Group. Hepatology 26(3), 747-754 (1997).
-
(1997)
Hepatology
, vol.26
, Issue.3
, pp. 747-754
-
-
Tong, M.J.1
Reddy, K.R.2
Lee, W.M.3
-
18
-
-
0036097087
-
Consensus interferon for chronic hepatitis C patients with genotype 1 who failed to respond to, or relapsed after, interferon α-2b and ribavirin in combination: An Italian pilot study
-
Barbaro G, Barbarini G. Consensus interferon for chronic hepatitis C patients with genotype 1 who failed to respond to, or relapsed after, interferon α-2b and ribavirin in combination: an Italian pilot study. Eur. J. Gastroenterol. Hepatol. 14(5), 477-483 (2002).
-
(2002)
Eur. J. Gastroenterol. Hepatol
, vol.14
, Issue.5
, pp. 477-483
-
-
Barbaro, G.1
Barbarini, G.2
-
19
-
-
11144358311
-
Peginterferon α-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment
-
discussion
-
Shiffman ML, Di Bisceglie AM, Lindsay KL et al. Peginterferon α-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment. Gastroenterology 126(4), 1015-1023; discussion 1947 (2004).
-
(1947)
Gastroenterology
, vol.126
, Issue.4
, pp. 1015-1023
-
-
Shiffman, M.L.1
Di Bisceglie, A.M.2
Lindsay, K.L.3
-
20
-
-
33644646748
-
A randomized trial of pegylated interferon α-2b plus ribavirin in the retreatment of chronic hepatitis C
-
Jacobson IM, Gonzalez SA, Ahmed F et al. A randomized trial of pegylated interferon α-2b plus ribavirin in the retreatment of chronic hepatitis C. Am. J. Gastroenterol. 100(11), 2453-2462 (2005).
-
(2005)
Am. J. Gastroenterol
, vol.100
, Issue.11
, pp. 2453-2462
-
-
Jacobson, I.M.1
Gonzalez, S.A.2
Ahmed, F.3
-
21
-
-
30344483613
-
Treatment with daily consensus interferon (CIFN) plus ribavirin in non-responder patients with chronic hepatitis C: A randomized open-label pilot study
-
Cornberg M, Hadem J, Herrmann E et al. Treatment with daily consensus interferon (CIFN) plus ribavirin in non-responder patients with chronic hepatitis C: a randomized open-label pilot study. J. Hepatol. 44(2), 291-301 (2006).
-
(2006)
J. Hepatol
, vol.44
, Issue.2
, pp. 291-301
-
-
Cornberg, M.1
Hadem, J.2
Herrmann, E.3
-
22
-
-
36348931521
-
Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus
-
McHutchison JG, Bacon BR, Gordon SC et al. Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus. Hepatology 46(5), 1341-1349 (2007).
-
(2007)
Hepatology
, vol.46
, Issue.5
, pp. 1341-1349
-
-
McHutchison, J.G.1
Bacon, B.R.2
Gordon, S.C.3
-
23
-
-
24144448068
-
Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
-
Horsmans Y, Berg T, Desager JP et al. Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology 42(3), 724-731 (2005).
-
(2005)
Hepatology
, vol.42
, Issue.3
, pp. 724-731
-
-
Horsmans, Y.1
Berg, T.2
Desager, J.P.3
-
24
-
-
0034959575
-
Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity
-
Weiner AJ, Paliard X, Selby MJ et al. Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity. J. Virol. 75(15), 7142-7148 (2001).
-
(2001)
J. Virol
, vol.75
, Issue.15
, pp. 7142-7148
-
-
Weiner, A.J.1
Paliard, X.2
Selby, M.J.3
-
25
-
-
0034985916
-
Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection
-
Bassett SE, Guerra B, Brasky K et al. Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection. Hepatology 33(6), 1479-1487 (2001).
-
(2001)
Hepatology
, vol.33
, Issue.6
, pp. 1479-1487
-
-
Bassett, S.E.1
Guerra, B.2
Brasky, K.3
-
26
-
-
0347634389
-
Cross-genotype immunity to hepatitis C virus
-
Lanford RE, Guerra B, Chavez D et al. Cross-genotype immunity to hepatitis C virus. J. Virol. 78(3), 1575-1581 (2004).
-
(2004)
J. Virol
, vol.78
, Issue.3
, pp. 1575-1581
-
-
Lanford, R.E.1
Guerra, B.2
Chavez, D.3
-
27
-
-
0033458948
-
Diagnostic tests for hepatitis C
-
Pawlotsky JM. Diagnostic tests for hepatitis C. J. Hepatol. 31(Suppl. 1), 71-79 (1999).
-
(1999)
J. Hepatol
, vol.31
, Issue.SUPPL. 1
, pp. 71-79
-
-
Pawlotsky, J.M.1
-
28
-
-
0026767691
-
Lack of protective immunity against reinfection with hepatitis C virus
-
Farci P, Alter HJ, Govindarajan S et al. Lack of protective immunity against reinfection with hepatitis C virus. Science 258(5079), 135-140 (1992).
-
(1992)
Science
, vol.258
, Issue.5079
, pp. 135-140
-
-
Farci, P.1
Alter, H.J.2
Govindarajan, S.3
-
29
-
-
0028158455
-
Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children
-
Lai ME, Mazzoleni AP, Argiolu F et al. Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children. Lancet 343(8894), 388-390 (1994).
-
(1994)
Lancet
, vol.343
, Issue.8894
, pp. 388-390
-
-
Lai, M.E.1
Mazzoleni, A.P.2
Argiolu, F.3
-
30
-
-
0033119925
-
Analysis of a successful immune response against hepatitis C virus
-
Cooper S, Erickson AL, Adams EJ et al. Analysis of a successful immune response against hepatitis C virus. Immunity 10(4), 439-449 (1999).
-
(1999)
Immunity
, vol.10
, Issue.4
, pp. 439-449
-
-
Cooper, S.1
Erickson, A.L.2
Adams, E.J.3
-
31
-
-
2442663864
-
Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort
-
Post JJ, Pan Y, Freeman AJ et al. Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort. J. Infect. Dis. 189(10), 1846-1855 (2004).
-
(2004)
J. Infect. Dis
, vol.189
, Issue.10
, pp. 1846-1855
-
-
Post, J.J.1
Pan, Y.2
Freeman, A.J.3
-
32
-
-
34247552946
-
Hepatitis C virus - biology, host evasion strategies, and promising new therapies on the horizon
-
Qureshi SA. Hepatitis C virus - biology, host evasion strategies, and promising new therapies on the horizon. Med. Res. Rev. 27(3), 353-373 (2007).
-
(2007)
Med. Res. Rev
, vol.27
, Issue.3
, pp. 353-373
-
-
Qureshi, S.A.1
-
33
-
-
0033661891
-
Hepatitis C virus variability: Sequence ana lysis of an isolate after 10 years of chronic infection
-
Rispeter K, Lu M, Behrens SE, Fumiko C, Yoshida T, Roggendorf M. Hepatitis C virus variability: sequence ana lysis of an isolate after 10 years of chronic infection. Virus Genes 21(3), 179-188 (2000).
-
(2000)
Virus Genes
, vol.21
, Issue.3
, pp. 179-188
-
-
Rispeter, K.1
Lu, M.2
Behrens, S.E.3
Fumiko, C.4
Yoshida, T.5
Roggendorf, M.6
-
34
-
-
17644444485
-
Analysis of successful immune responses in persons infected with hepatitis C virus
-
Lechner F, Wong DK, Dunbar PR et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 191(9), 1499-1512 (2000).
-
(2000)
J. Exp. Med
, vol.191
, Issue.9
, pp. 1499-1512
-
-
Lechner, F.1
Wong, D.K.2
Dunbar, P.R.3
-
36
-
-
0035914925
-
Determinants of viral clearance and persistence during acute hepatitis C virus infection
-
Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J. Exp. Med. 194(10), 1395-1406 (2001).
-
(2001)
J. Exp. Med
, vol.194
, Issue.10
, pp. 1395-1406
-
-
Thimme, R.1
Oldach, D.2
Chang, K.M.3
Steiger, C.4
Ray, S.C.5
Chisari, F.V.6
-
37
-
-
0142178211
-
HCV persistence and immune evasion in the absence of memory T cell help
-
Grakoui A, Shoukry NH, Woollard DJ et al. HCV persistence and immune evasion in the absence of memory T cell help. Science 302(5645), 659-662 (2003).
-
(2003)
Science
, vol.302
, Issue.5645
, pp. 659-662
-
-
Grakoui, A.1
Shoukry, N.H.2
Woollard, D.J.3
-
38
-
-
0038543543
-
+ T cells are required for protection from persistent hepatitis C virus infection
-
+ T cells in clearance of HCV infection, •
-
+ T cells in clearance of HCV infection.
-
(2003)
J. Exp. Med
, vol.197
, Issue.12
, pp. 1645-1655
-
-
Shoukry, N.H.1
Grakoui, A.2
Houghton, M.3
-
39
-
-
0029778817
-
Quantitative ana lysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
-
Rehermann B, Chang KM, McHutchison JG, Kokka R, Houghton M, Chisari FV. Quantitative ana lysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J. Clin. Invest. 98(6), 1432-1440 (1996).
-
(1996)
J. Clin. Invest
, vol.98
, Issue.6
, pp. 1432-1440
-
-
Rehermann, B.1
Chang, K.M.2
McHutchison, J.G.3
Kokka, R.4
Houghton, M.5
Chisari, F.V.6
-
40
-
-
17644444485
-
Analysis of successful immune responses in persons infected with hepatitis C virus
-
Lechner F, Wong DK, Dunbar PR et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 1499-1512 (2000).
-
(2000)
J. Exp. Med
, vol.1499-1512
-
-
Lechner, F.1
Wong, D.K.2
Dunbar, P.R.3
-
41
-
-
4444354594
-
High resolution ana lysis of cellular immune responses in resolved and persistent hepatitis C virus infection
-
Lauer GM, Barnes E, Lucas M et al. High resolution ana lysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 127(3), 924-936 (2004).
-
(2004)
Gastroenterology
, vol.127
, Issue.3
, pp. 924-936
-
-
Lauer, G.M.1
Barnes, E.2
Lucas, M.3
-
42
-
-
0036191172
-
Interferon-g inhibits replication of subgenomic and genomic hepatitis C virus RNAs
-
Frese M, Schwarzle V, Barth K et al. Interferon-g inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology 35(3), 694-703 (2002).
-
(2002)
Hepatology
, vol.35
, Issue.3
, pp. 694-703
-
-
Frese, M.1
Schwarzle, V.2
Barth, K.3
-
43
-
-
10244225383
-
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
-
Missale G, Bertoni R, Lamonaca V et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin. Invest. 98(3), 706-714 (1996).
-
(1996)
J. Clin. Invest
, vol.98
, Issue.3
, pp. 706-714
-
-
Missale, G.1
Bertoni, R.2
Lamonaca, V.3
-
44
-
-
0029151623
-
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
-
Diepolder HM, Zachoval R, Hoffmann RM et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346(8981), 1006-1007 (1995).
-
(1995)
Lancet
, vol.346
, Issue.8981
, pp. 1006-1007
-
-
Diepolder, H.M.1
Zachoval, R.2
Hoffmann, R.M.3
-
45
-
-
0036891826
-
+ T-helper-cell responses in resolved hepatitis C virus infection
-
+ T-helper-cell responses in resolved hepatitis C virus infection. J. Virol. 76(24), 12584-12595 (2002).
-
(2002)
J. Virol
, vol.76
, Issue.24
, pp. 12584-12595
-
-
Day, C.L.1
Lauer, G.M.2
Robbins, G.K.3
-
46
-
-
0028147612
-
Vaccination of chimpanzees against infection by the hepatitis C virus
-
Choo QL, Kuo G, Ralston R et al. Vaccination of chimpanzees against infection by the hepatitis C virus. Proc. Natl Acad. Sci. USA 91(4), 1294-1298 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, Issue.4
, pp. 1294-1298
-
-
Choo, Q.L.1
Kuo, G.2
Ralston, R.3
-
47
-
-
32944465532
-
Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee
-
Youn JW, Park SH, Lavillette D et al. Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in the chimpanzee. Hepatology 42(6), 1429-1436 (2005).
-
(2005)
Hepatology
, vol.42
, Issue.6
, pp. 1429-1436
-
-
Youn, J.W.1
Park, S.H.2
Lavillette, D.3
-
48
-
-
34347213785
-
Immunization with hepatitis C virus-like particles results in control of hepatitis C virus infection in chimpanzees
-
Elmowalid GA, Qiao M, Jeong SH et al. Immunization with hepatitis C virus-like particles results in control of hepatitis C virus infection in chimpanzees. Proc. Natl Acad. Sci. USA 104(20), 8427-8432 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.20
, pp. 8427-8432
-
-
Elmowalid, G.A.1
Qiao, M.2
Jeong, S.H.3
-
49
-
-
32244435842
-
A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
-
Important paper showing that vaccine-induced cellular immune responses could be protective in heterologous HCV challenge in chimpanzees, •
-
Folgori A, Capone S, Ruggeri L et al. A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees. Nat. Med. 12(2), 190-197 (2006). • Important paper showing that vaccine-induced cellular immune responses could be protective in heterologous HCV challenge in chimpanzees.
-
(2006)
Nat. Med
, vol.12
, Issue.2
, pp. 190-197
-
-
Folgori, A.1
Capone, S.2
Ruggeri, L.3
-
50
-
-
10744230360
-
Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response
-
Rollier C, Depla E, Drexhage JA et al. Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response. J. Virol. 78(1), 187-196 (2004).
-
(2004)
J. Virol
, vol.78
, Issue.1
, pp. 187-196
-
-
Rollier, C.1
Depla, E.2
Drexhage, J.A.3
-
51
-
-
32444449395
-
A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that overcomes preexisting anti-Ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques
-
Capone S, Meola A, Ercole BB et al. A novel adenovirus type 6 (Ad6)-based hepatitis C virus vector that overcomes preexisting anti-Ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques. J. Virol. 80(4), 1688-1699 (2006).
-
(2006)
J. Virol
, vol.80
, Issue.4
, pp. 1688-1699
-
-
Capone, S.1
Meola, A.2
Ercole, B.B.3
-
52
-
-
33750796905
-
Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates
-
Capone S, Zampaglione I, Vitelli A et al. Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates. J. Immunol. 177(10), 7462-7471 (2006).
-
(2006)
J. Immunol
, vol.177
, Issue.10
, pp. 7462-7471
-
-
Capone, S.1
Zampaglione, I.2
Vitelli, A.3
-
53
-
-
0031068032
-
The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C
-
Nelson DR, Marousis CG, Davis GL et al. The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C. J. Immunol. 158(3), 1473-1481 (1997).
-
(1997)
J. Immunol
, vol.158
, Issue.3
, pp. 1473-1481
-
-
Nelson, D.R.1
Marousis, C.G.2
Davis, G.L.3
-
54
-
-
0037105567
-
+ T cells in chronic hepatitis C virus infection
-
+ T cells in chronic hepatitis C virus infection. J. Immunol. 169(6), 3447-3458 (2002).
-
(2002)
J. Immunol
, vol.169
, Issue.6
, pp. 3447-3458
-
-
Wedemeyer, H.1
He, X.S.2
Nascimbeni, M.3
-
55
-
-
0035000769
-
+ T lymphocytes after infection with hepatitis C virus
-
+ T lymphocytes after infection with hepatitis C virus. J. Virol. 75(12), 5550-5558 (2001).
-
(2001)
J. Virol
, vol.75
, Issue.12
, pp. 5550-5558
-
-
Gruener, N.H.1
Lechner, F.2
Jung, M.C.3
-
56
-
-
0036892605
-
+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C
-
+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C. J. Virol. 76(24), 12423-12434 (2002).
-
(2002)
J. Virol
, vol.76
, Issue.24
, pp. 12423-12434
-
-
Urbani, S.1
Boni, C.2
Missale, G.3
-
57
-
-
0036109159
-
+ T cells vary in differentiation phenotype in different persistent virus infections
-
+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8(4), 379-385 (2002).
-
(2002)
Nat. Med
, vol.8
, Issue.4
, pp. 379-385
-
-
Appay, V.1
Dunbar, P.R.2
Callan, M.3
-
58
-
-
0036139684
-
+ T cells by flow cytometry: Correlation with clinical disease stages
-
+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology 35(1), 190-198 (2002).
-
(2002)
Hepatology
, vol.35
, Issue.1
, pp. 190-198
-
-
Rosen, H.R.1
Miner, C.2
Sasaki, A.W.3
-
59
-
-
0142151747
-
A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C
-
Nevens F, Roskams T, Van Vlierberghe H et al. A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C. Hepatology 38(5), 1289-1296 (2003).
-
(2003)
Hepatology
, vol.38
, Issue.5
, pp. 1289-1296
-
-
Nevens, F.1
Roskams, T.2
Van Vlierberghe, H.3
-
60
-
-
3843137346
-
A candidate vaccine based on the hepatitis C E1 protein: Tolerability and immunogenicity in healthy volunteers
-
Leroux-Roels G, Depla E, Hulstaert F et al. A candidate vaccine based on the hepatitis C E1 protein: tolerability and immunogenicity in healthy volunteers. Vaccine 22(23-24), 3080-3086 (2004).
-
(2004)
Vaccine
, vol.22
, Issue.23-24
, pp. 3080-3086
-
-
Leroux-Roels, G.1
Depla, E.2
Hulstaert, F.3
-
61
-
-
34548210447
-
+ T cells in healthy individuals and chronic hepatitis C patients
-
+ T cells in healthy individuals and chronic hepatitis C patients. Vaccine 25(37-38), 6793-6806 (2007).
-
(2007)
Vaccine
, vol.25
, Issue.37-38
, pp. 6793-6806
-
-
Schlaphoff, V.1
Klade, C.S.2
Jilma, B.3
-
62
-
-
33646144429
-
Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: A randomized, placebo controlled trial for dose optimization in 128 healthy subjects
-
Firbas C, Jilma B, Tauber E et al. Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects. Vaccine 24(20), 4343-4353 (2006).
-
(2006)
Vaccine
, vol.24
, Issue.20
, pp. 4343-4353
-
-
Firbas, C.1
Jilma, B.2
Tauber, E.3
-
63
-
-
0032926935
-
Electropermeabilization of skeletal muscle enhances gene transfer in vivo
-
Mathiesen I. Electropermeabilization of skeletal muscle enhances gene transfer in vivo. Gene Ther. 6(4), 508-514 (1999).
-
(1999)
Gene Ther
, vol.6
, Issue.4
, pp. 508-514
-
-
Mathiesen, I.1
-
64
-
-
14844291308
-
Gene expression and immune response kinetics using electroporation-mediated DNA delivery to muscle
-
Gronevik E, von Steyern FV, Kalhovde JM, Tjelle TE, Mathiesen I. Gene expression and immune response kinetics using electroporation-mediated DNA delivery to muscle. J. Gene Med. 7(2), 218-227 (2005).
-
(2005)
J. Gene Med
, vol.7
, Issue.2
, pp. 218-227
-
-
Gronevik, E.1
von Steyern, F.V.2
Kalhovde, J.M.3
Tjelle, T.E.4
Mathiesen, I.5
-
65
-
-
33846859783
-
Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity
-
Peng B, Zhao Y, Xu L, Xu Y. Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity. Vaccine 25(11), 2064-2073 (2007).
-
(2007)
Vaccine
, vol.25
, Issue.11
, pp. 2064-2073
-
-
Peng, B.1
Zhao, Y.2
Xu, L.3
Xu, Y.4
-
67
-
-
43949114521
-
Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation
-
Liu J, Kjeken R, Mathiesen I, Barouch DH. Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation. J. Virol. 82(11), 5643-5649 (2008).
-
(2008)
J. Virol
, vol.82
, Issue.11
, pp. 5643-5649
-
-
Liu, J.1
Kjeken, R.2
Mathiesen, I.3
Barouch, D.H.4
-
68
-
-
1242293129
-
Immunization of chimpanzees with an envelope protein-based vaccine enhances specific humoral and cellular immune responses that delay hepatitis C virus infection
-
Puig M, Major ME, Mihalik K, Feinstone SM. Immunization of chimpanzees with an envelope protein-based vaccine enhances specific humoral and cellular immune responses that delay hepatitis C virus infection. Vaccine 22(8), 991-1000 (2004).
-
(2004)
Vaccine
, vol.22
, Issue.8
, pp. 991-1000
-
-
Puig, M.1
Major, M.E.2
Mihalik, K.3
Feinstone, S.M.4
-
69
-
-
33947409611
-
Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity
-
Rollier CS, Paranhos-Baccala G, Verschoor EJ et al. Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity. Hepatology 45(3), 602-613 (2007).
-
(2007)
Hepatology
, vol.45
, Issue.3
, pp. 602-613
-
-
Rollier, C.S.1
Paranhos-Baccala, G.2
Verschoor, E.J.3
-
70
-
-
0004016899
-
-
Hepatitis C www.who.int/csr/disease/hepatitis/HepC.pdf
-
Hepatitis C
-
-
-
72
-
-
51549117339
-
-
DIRECT trial www.directtrial.com/sec/design.html
-
DIRECT trial
-
-
-
74
-
-
40549101273
-
-
Online
-
Drug Information Online www.drugs.com/clinical_trials/intercell-8217-s- therapeutic-hepatitis-c-vaccinemeets-primary-endpoints-phase-ii-3345.html
-
Drug Information
-
-
-
75
-
-
51549089418
-
-
CHRONVAC-C® study http://clinicaltrials.gov/ct2/show/NCT00563173
-
CHRONVAC-C® study
-
-
|