Treatment with daily consensus interferon (CIFN) plus ribavirin in non-responder patients with chronic hepatitis C: A randomized open-label pilot study

Journal of Hepatology

Volumn 44, Issue 2, 2006, Pages 291-301

  Cornberg, Markus ^a   Hadem, Johannes ^a   Herrmann, Eva ^b   Schuppert, Frank ^c   Schmidt, Hartmut H J ^d,e   Reiser, Markus ^f   Marschal, Oliver ^g   Steffen, Martin ^h   Manns, Michael P ^a   Wedemeyer, Heiner ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c Krankenhaus Bad Oeynhausen   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^f RUHR UNIVERSITY BOCHUM   (Germany)

^g Praxis Braunschweig   (Germany)

^h FRANZISKUS HOSPITAL   (Germany)

Author keywords

Chronic hepatitis C; Consensus interferon; Daily dosing; Hepatitis C virus; Induction dosing; Non responder; Ribavirin

Indexed keywords

ALANINE AMINOTRANSFERASE; CONSENSUS INTERFERON; RIBAVIRIN;

ADULT; ANEMIA; ANGER; ANXIETY; ARTHRALGIA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRY SKIN; DYSPNEA; FEMALE; FEVER; FLU LIKE SYNDROME; GASTROINTESTINAL DISEASE; GENOTYPE; HAIR LOSS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INJECTION SITE ABSCESS; LEUKOPENIA; LIVER HISTOLOGY; MALE; MENINGOCOCCEMIA; MENTAL DISEASE; MYALGIA; NAUSEA; PATIENT COMPLIANCE; PILOT STUDY; PRIORITY JOURNAL; PRURITUS; PSORIASIS; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SEPSIS; SIDE EFFECT; THROMBOCYTOPENIA; TREATMENT OUTCOME; VERTIGO; VIRUS REPLICATION; WEIGHT REDUCTION;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERONS; MALE; MIDDLE AGED; PILOT PROJECTS; RIBAVIRIN; RNA, VIRAL; TREATMENT OUTCOME;

EID: 30344483613     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.10.021     Document Type: Article

References (23)

1. M. Cornberg, H. Wedemeyer, and M.P. Manns Treatment of chronic hepatitis C with PEGylated interferon and ribavirin Curr Gastroenterol Rep 4 2002 23 30
2. M.L. Shiffman Management of patients with chronic hepatitis C virus infection and previous nonresponse Rev Gastroenterol Disord 4 Suppl. 1 2004 S22 S30
3. M.L. Shiffman, A.M. Di Bisceglie, K.L. Lindsay, C. Morishima, E.C. Wright, and G.T. Everson Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment Gastroenterology 126 2004 1015 1023
4. T. Poynard, E.R. Schiff, R. Terg, F. Goncales, M. Diago, and J. Reichen Sustained virological response (SVR) in the EPIC3 trial: week 12 virology predicts SVR in previous interferon/ribavirin treatment failures receiving PEG-intron/rebetol (PR) weight based dosing (WBD) J Hepatol 42 Suppl. 2 2005 40 41
5. M. Curry, A. Cardenas, and N.H. Afdhal Effect of maintenance PEG-Intron therapy on portal hypertension and its complications: results from the COPILOT study J Hepatol 42 Suppl. 2 2005 40
6. L.M. Blatt, J.M. Davis, S.B. Klein, and M.W. Taylor The biologic activity and molecular characterization of a novel synthetic interferon-alpha species, consensus interferon J Interferon Cytokine Res 16 1996 489 499
7. O.N. Ozes, Z. Reiter, S. Klein, L.M. Blatt, and M.W. Taylor A comparison of interferon-con1 with natural recombinant interferons-alpha: antiviral, antiproliferative, and natural killer-inducing activities J Interferon Res 12 1992 55 59
8. M.J. Tong, K.R. Reddy, W.M. Lee, P.J. Pockros, J.C. Hoefs, and E.B. Keeffe Treatment of chronic hepatitis C with consensus interferon: a multicenter, randomized, controlled trial. Consensus interferon study group Hepatology 26 1997 747 754
9. M.H. Sjogren, R. Sjogren, K. Holtzmuller, B. Winston, B. Butterfield, and S. Drake Interferon alfacon-1 and ribavirin versus interferon alpha-2b and ribavirin in the treatment of chronic hepatitis C Dig Dis Sci 50 2005 727 732
10. G. Fattovich, I. Zagni, E. Minola, M. Felder, P. Rovere, and A. Carlotto A randomized trial of consensus interferon in combination with ribavirin as initial treatment for chronic hepatitis C J Hepatol 39 2003 843 849
11. E.J. Heathcote, E.B. Keeffe, S.S. Lee, S.V. Feinman, M.J. Tong, and K.R. Reddy Re-treatment of chronic hepatitis C with consensus interferon Hepatology 27 1998 1136 1143
12. V.K. Rustgi, H.L. Bonkovsky, S. Arora, S. Zeuzem, M. Manns, and L.M. Blatt Daily versus three-times-weekly IFN alfacon-1 in previously untreated HCV patients results in a significant greater rate of SVR: final results of an international phase 4 study Gastroenterology 128 Supp. 2 2005 A-716
13. S. Kaiser, H.G. Hass, and M. Gregor Successful retreatment of interferon/ribavirin nonresponders with daily dosing of consensus interferon J Hepatol 42 Suppl. 2 2005 207 208
14. R.L. Carithers, S. Zeuzem, M.P. Manns, J.G. McHutchison, R.P. Perrillo, and R. Bailey Multicenter, randomized, controlled trail comparing high dose daily induction interferon plus ribavirin versus standard interferon alfa-2b plus ribavirin Hepatology 32 2000 317A
15. M.W. Fried, M. Shiffman, R.K. Sterling, J. Weinstein, J. Crippin, and G. Garcia A multicenter, randomized trial of daily high-dose interferon-alfa 2b for the treatment of chronic hepatitis c: pretreatment stratification by viral burden and genotype Am J Gastroenterol 95 2000 3225 3229
16. A.S. Hadziyannis, C. Papaioannou, F. Spanou, E.K. Manesis, and S.J. Hadziyannis Induction interferon therapy in naive patients with chronic hepatitis C: increased end-of-treatment virological responses but absence of long-term benefit Aliment Pharmacol Ther 15 2001 551 557
17. S.J. Cotler, J.E. Layden, A.U. Neumann, and D.M. Jensen First phase hepatitis c viral kinetics in previous nonresponders patients J Viral Hepat 10 2003 43 49
18. T.J. Layden, J.E. Layden, K.R. Reddy, R.S. Levy-Drummer, J. Poulakos, and A.U. Neumann Induction therapy with consensus interferon (CIFN) does not improve sustained virologic response in chronic hepatitis C J Viral Hepat 9 2002 334 339
19. K. Ishak, A. Baptista, L. Bianchi, F. Callea, J. De Groote, and F. Gudat Histological grading and staging of chronic hepatitis J Hepatol 22 1995 696 699
20. P.J. Pockros, R. Reindollar, J. McHutchinson, R. Reddy, T. Wright, and D.G. Boyd The safety and tolerability of daily infergen plus ribavirin in the treatment of naiive chronic hepatitis C patients J Viral Hepat 10 2003 55 60
21. J.G. McHutchison, M. Manns, K. Patel, T. Poynard, K.L. Lindsay, and C. Trepo Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C Gastroenterology 123 2002 1061 1069
22. E.L. Krawitt, T. Ashikaga, S.C. Gordon, N. Ferrentino, M.A. Ray, and S.D. Lidofsky Peginterferon alfa-2b and ribavirin for treatment-refractory chronic hepatitis C J Hepatol 43 2005 243 249
23. D.N. Moskovitz, P. Manoharan, and E.J. Heathcote High dose consensus interferon in nonresponders to interferon alpha-2b and ribavirin with chronic hepatitis C Can J Gastroenterol 17 2003 479 482