메뉴 건너뛰기




Volumn 19, Issue 1, 1998, Pages 80-100

Bisphosphonates: Mechanisms of action

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; EB 1053; ETIDRONIC ACID; IBANDRONIC ACID; INCADRONIC ACID; NERIDRONIC ACID; OLPADRONIC ACID; PAMIDRONIC ACID; RISEDRONIC ACID; TILUDRONIC ACID; UNCLASSIFIED DRUG; ZOLEDRONIC ACID; [1 HYDROXY 2 (IMIDAZO[1,2 A]PYRIDIN 3 YL)ETHYLIDENE]BISPHOSPHONIC ACID;

EID: 0032468984     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/edrv.19.1.0325     Document Type: Review
Times cited : (986)

References (274)
  • 1
    • 84977244524 scopus 로고
    • Ueber die einwirkung des chloracetyls auf phosphorige säure
    • Menschutkin N 1865 Ueber die Einwirkung des Chloracetyls auf phosphorige Säure. Ann Chem Pharm 133:317-320
    • (1865) Ann Chem Pharm , vol.133 , pp. 317-320
    • Menschutkin, N.1
  • 4
    • 0002446620 scopus 로고
    • History of the bisphosphonates: Discovery and history of the non-medical uses of bisphosphonates
    • Bijvoet OLM, Fleisch HA, Canfield RE, Russell RGG (eds) Elsevier, Amsterdam
    • Blomen LJMJ 1995 History of the bisphosphonates: discovery and history of the non-medical uses of bisphosphonates. In: Bijvoet OLM, Fleisch HA, Canfield RE, Russell RGG (eds) Bisphosponate on Bones. Elsevier, Amsterdam, pp 111-124
    • (1995) Bisphosponate on Bones , pp. 111-124
    • Blomen, L.J.M.J.1
  • 5
    • 34250517118 scopus 로고
    • The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution of calcium phosphate in vitro and in vivo
    • Fleisch H, Russell RGG, Bisaz S, Casey PA, Mühlbauer RC 1968 The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution of calcium phosphate in vitro and in vivo. Calcif Tissue Res 2:10-10A
    • (1968) Calcif Tissue Res , vol.2
    • Fleisch, H.1    Russell, R.G.G.2    Bisaz, S.3    Casey, P.A.4    Mühlbauer, R.C.5
  • 6
    • 0001372897 scopus 로고
    • Isolation from urine of pyrophosphate, a calcification inhibitor
    • Fleisch H, Bisaz S 1962 Isolation from urine of pyrophosphate, a calcification inhibitor. Am J Physiol 203:671-675
    • (1962) Am J Physiol , vol.203 , pp. 671-675
    • Fleisch, H.1    Bisaz, S.2
  • 7
    • 0014029045 scopus 로고
    • Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis
    • Fleisch H, Russell RGG, Straumann F 1966 Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis. Nature 212:901-903
    • (1966) Nature , vol.212 , pp. 901-903
    • Fleisch, H.1    Russell, R.G.G.2    Straumann, F.3
  • 8
    • 0000192287 scopus 로고
    • Bisphosphonates: Structure-activity relationships and therapeutic implications
    • Heersche JNM, Kanis JA (eds) Elsevier, Amsterdam
    • Geddes AD, D'Souza SM, Ebetino FH, Ibbotson KJ 1994 Bisphosphonates: structure-activity relationships and therapeutic implications. In: Heersche JNM, Kanis JA (eds) Bone and Mineral Research. Elsevier, Amsterdam, vol 8: 265-306
    • (1994) Bone and Mineral Research , vol.8 , pp. 265-306
    • Geddes, A.D.1    D'Souza, S.M.2    Ebetino, F.H.3    Ibbotson, K.J.4
  • 9
    • 0028036624 scopus 로고
    • Bisphosphonates in development for metabolic bone disease
    • Sietsema WK, Ebetino FH 1994 Bisphosphonates in development for metabolic bone disease. Exp Opin Invest Drugs 3:1255-1276
    • (1994) Exp Opin Invest Drugs , vol.3 , pp. 1255-1276
    • Sietsema, W.K.1    Ebetino, F.H.2
  • 10
    • 0345662599 scopus 로고
    • Studies with isolated cells and cell systems
    • Bijvoet OLM, Fleisch HA, Canfield RE, Russell RGG (eds) Elsevier, Amsterdam
    • Felix R 1995 Studies with isolated cells and cell systems. In: Bijvoet OLM, Fleisch HA, Canfield RE, Russell RGG (eds) Bisphosphonate on Bones. Elsevier, Amsterdam, pp 189-204
    • (1995) Bisphosphonate on Bones , pp. 189-204
    • Felix, R.1
  • 11
    • 0342685680 scopus 로고
    • Mechanisms of action of bisphosphonates: Information from animal models
    • Bijvoet OLM, Fleisch HA, Canfield RE, Russell RGG (eds) Elsevier, Amsterdam
    • Mühlbauer RC 1995 Mechanisms of action of bisphosphonates: information from animal models. In: Bijvoet OLM, Fleisch HA, Canfield RE, Russell RGG (eds) Bisphosphonate on Bones. Elsevier, Amsterdam, pp 171-187
    • (1995) Bisphosphonate on Bones , pp. 171-187
    • Mühlbauer, R.C.1
  • 12
    • 0002665298 scopus 로고    scopus 로고
    • Bisphosphonates: Mechanisms of action and clinical use
    • Bilezikian JP, Raisz LG, Rodan GA (eds) Academic Press, San Diego
    • Fleisch H 1996 Bisphosphonates: mechanisms of action and clinical use. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, San Diego, pp 1037-1052
    • (1996) Principles of Bone Biology , pp. 1037-1052
    • Fleisch, H.1
  • 13
    • 0029884643 scopus 로고    scopus 로고
    • Bisphosphonates: Mechanisms of action
    • Rodan GA, Fleisch H 1996 Bisphosphonates: mechanisms of action. J Clin Invest 97:2692-2696
    • (1996) J Clin Invest , vol.97 , pp. 2692-2696
    • Rodan, G.A.1    Fleisch, H.2
  • 14
    • 0003348061 scopus 로고    scopus 로고
    • Bisphosphonates in bone disease
    • The Parthenon Publishing Group, New York
    • Fleisch H 1997 Bisphosphonates in bone disease. From the Laboratory to the Patient, ed 3. The Parthenon Publishing Group, New York
    • (1997) From the Laboratory to the Patient, Ed 3.
    • Fleisch, H.1
  • 15
    • 0014759515 scopus 로고
    • The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo
    • Fleisch H, Russell RGG, Bisaz S, Mühlbauer RC, Williams DA 1970 The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo. Eur J Clin Invest 1:12-18
    • (1970) Eur J Clin Invest , vol.1 , pp. 12-18
    • Fleisch, H.1    Russell, R.G.G.2    Bisaz, S.3    Mühlbauer, R.C.4    Williams, D.A.5
  • 16
    • 0017682977 scopus 로고
    • The effects of various diphosphonates on a rat model of cardiac calciphylaxis
    • Rosenblum IY, Black HE, Ferrell JF 1977 The effects of various diphosphonates on a rat model of cardiac calciphylaxis. Calcif Tissue Res 23:151-159
    • (1977) Calcif Tissue Res , vol.23 , pp. 151-159
    • Rosenblum, I.Y.1    Black, H.E.2    Ferrell, J.F.3
  • 18
    • 0018134775 scopus 로고
    • The effect of agents interfering with soft tissue calcification and cell proliferation on calcific fibrous-fatty plaques in rabbits
    • Kramsch DM, Chan CT 1978 The effect of agents interfering with soft tissue calcification and cell proliferation on calcific fibrous-fatty plaques in rabbits. Circ Res 42:562-571
    • (1978) Circ Res , vol.42 , pp. 562-571
    • Kramsch, D.M.1    Chan, C.T.2
  • 19
    • 0023270006 scopus 로고
    • Prevention of leaflet calcification of bioprosthetic heart valves with diphosphonate injection therapy
    • Levy RJ, Schoen FJ, Lund SA, Smith MS 1987 Prevention of leaflet calcification of bioprosthetic heart valves with diphosphonate injection therapy. J Thorac Cardiovasc Surg 94:551-557
    • (1987) J Thorac Cardiovasc Surg , vol.94 , pp. 551-557
    • Levy, R.J.1    Schoen, F.J.2    Lund, S.A.3    Smith, M.S.4
  • 20
    • 0021994181 scopus 로고
    • Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate
    • Levy RJ, Wolfrum J, Schoen FJ, Hawley MA, Lund SA, Langer R 1985 Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate. Science 228:190-192
    • (1985) Science , vol.228 , pp. 190-192
    • Levy, R.J.1    Wolfrum, J.2    Schoen, F.J.3    Hawley, M.A.4    Lund, S.A.5    Langer, R.6
  • 21
    • 0023035506 scopus 로고
    • Controlled release of diphosphonate to inhibit bioprosthetic heart valve calcification: Dose-response and mechanistic studies
    • Golomb G, Langer R, Schoen FJ, Smith MS, Choi YM, Levy RJ 1986 Controlled release of diphosphonate to inhibit bioprosthetic heart valve calcification: dose-response and mechanistic studies. J Contr Rel 4:181-194
    • (1986) J Contr Rel , vol.4 , pp. 181-194
    • Golomb, G.1    Langer, R.2    Schoen, F.J.3    Smith, M.S.4    Choi, Y.M.5    Levy, R.J.6
  • 22
    • 0023378514 scopus 로고
    • Inhibition of bioprosthetic heart valve calcification with covalently bound aminopropanehydroxydiphosphonate
    • Webb CL, Benedict JJ, Schoen FJ, Linden JA, Levy RJ 1987 Inhibition of bioprosthetic heart valve calcification with covalently bound aminopropanehydroxydiphosphonate. ASAIO Trans 33:592-595
    • (1987) ASAIO Trans , vol.33 , pp. 592-595
    • Webb, C.L.1    Benedict, J.J.2    Schoen, F.J.3    Linden, J.A.4    Levy, R.J.5
  • 23
    • 0015292564 scopus 로고
    • The influence of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on the development of experimentally induced urinary stones in rats
    • Fraser D, Russell RGG, Pohler O, Robertson WG, Fleisch H 1972 The influence of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on the development of experimentally induced urinary stones in rats. Clin Sci 42:197-207
    • (1972) Clin Sci , vol.42 , pp. 197-207
    • Fraser, D.1    Russell, R.G.G.2    Pohler, O.3    Robertson, W.G.4    Fleisch, H.5
  • 24
    • 0015025092 scopus 로고
    • The control of dental calculus in experimental animals
    • Briner WW, Francis MD, Widder JS 1971 The control of dental calculus in experimental animals. Int Dent J 21:61-73
    • (1971) Int Dent J , vol.21 , pp. 61-73
    • Briner, W.W.1    Francis, M.D.2    Widder, J.S.3
  • 25
    • 0018092567 scopus 로고
    • The effect of ethane-1-hydroxy-1,1-diphosphonic acid (EHDP) on matrix induced ectopic bone formation
    • Plasmans CMT, Kuypers W, Slooff TJJH 1978 The effect of ethane-1-hydroxy-1,1-diphosphonic acid (EHDP) on matrix induced ectopic bone formation. Clin Orthop 132:233-243
    • (1978) Clin Orthop , vol.132 , pp. 233-243
    • Plasmans, C.M.T.1    Kuypers, W.2    Slooff, T.J.J.H.3
  • 26
    • 0022596551 scopus 로고
    • Prevention of ectopic bone formation by local application of ethane-1-hydroxy-1,1-diphosphonate (EHDP): An experimental study in rabbits
    • Ahrengart L, Lindgren U 1986 Prevention of ectopic bone formation by local application of ethane-1-hydroxy-1,1-diphosphonate (EHDP): an experimental study in rabbits. J Orthop Res 4:18-26
    • (1986) J Orthop Res , vol.4 , pp. 18-26
    • Ahrengart, L.1    Lindgren, U.2
  • 27
    • 0001219905 scopus 로고
    • Bisphosphonates: A new class of drugs in diseases of bone and calcium metabolism
    • Baker PF (ed) Springer-Verlag, New York
    • Fleisch H 1988 Bisphosphonates: a new class of drugs in diseases of bone and calcium metabolism. In: Baker PF (ed) Handbook of Experimental Pharmacology. Springer-Verlag, New York, vol 83: 440-466
    • (1988) Handbook of Experimental Pharmacology , vol.83 , pp. 440-466
    • Fleisch, H.1
  • 28
    • 0018179647 scopus 로고
    • Biochemical and clinical effects of ethane-1-hydroxy-1,1-diphosphonate in calcium nephrolithiasis
    • Baumann JM, Bisaz S, Fleisch H, Wacker M 1978 Biochemical and clinical effects of ethane-1-hydroxy-1,1-diphosphonate in calcium nephrolithiasis. Clin Sci Mol Med 54:509-516
    • (1978) Clin Sci Mol Med , vol.54 , pp. 509-516
    • Baumann, J.M.1    Bisaz, S.2    Fleisch, H.3    Wacker, M.4
  • 30
    • 0015097048 scopus 로고
    • Reduction of dental calculus in humans through the use of a dentifrice containing a crystal-growth inhibitor
    • Sturzenberger OP, Swancar JR, Reiter G 1971 Reduction of dental calculus in humans through the use of a dentifrice containing a crystal-growth inhibitor. J Periodontol 42:416-419
    • (1971) J Periodontol , vol.42 , pp. 416-419
    • Sturzenberger, O.P.1    Swancar, J.R.2    Reiter, G.3
  • 31
    • 0344799638 scopus 로고
    • Diphosphonate treatment in myositis ossificans progressiva
    • Caniggia A (ed) Istituto Gentili, Pisa
    • Reiner M, Sautter V, Olah A, Bossi E, Largiadèr U, Fleisch H 1980 Diphosphonate treatment in myositis ossificans progressiva. In: Caniggia A (ed) Etidronate. Istituto Gentili, Pisa, pp 237-241
    • (1980) Etidronate , pp. 237-241
    • Reiner, M.1    Sautter, V.2    Olah, A.3    Bossi, E.4    Largiadèr, U.5    Fleisch, H.6
  • 32
    • 0016306973 scopus 로고
    • The use of a diphosphonate in para-articular ossifications after total hip replacement. A clinical study
    • Slooff TJJH, Feith R, Bijvoet OLM, Nollen AJG 1974 The use of a diphosphonate in para-articular ossifications after total hip replacement. A clinical study. Acta Orthop Belg 40:820-828
    • (1974) Acta Orthop Belg , vol.40 , pp. 820-828
    • Slooff, T.J.J.H.1    Feith, R.2    Bijvoet, O.L.M.3    Nollen, A.J.G.4
  • 33
    • 0019745608 scopus 로고
    • Heterotopic ossification following hip replacement or spinal cord injury. Two clinical studies with EHDP
    • Finerman GAM, Stover SL 1981 Heterotopic ossification following hip replacement or spinal cord injury. Two clinical studies with EHDP. Metab Bone Dis Relat Res 4:337-342
    • (1981) Metab Bone Dis Relat Res , vol.4 , pp. 337-342
    • Finerman, G.A.M.1    Stover, S.L.2
  • 34
    • 0021915520 scopus 로고
    • Results of the administration of diphosphonate for the prevention of heterotopic ossification after total hip arthoplasty
    • Thomas BJ, Amstutz HC 1985 Results of the administration of diphosphonate for the prevention of heterotopic ossification after total hip arthoplasty. J Bone Joint Surg [Am] 67:400-403
    • (1985) J Bone Joint Surg [am] , vol.67 , pp. 400-403
    • Thomas, B.J.1    Amstutz, H.C.2
  • 35
    • 0015000291 scopus 로고
    • Effect of disodium ethane-1-hydroxy-1,1-diphosphonate on bone formation
    • King WR, Francis MD, Michael WR 1971 Effect of disodium ethane-1-hydroxy-1,1-diphosphonate on bone formation. Clin Orthop 78:251-270
    • (1971) Clin Orthop , vol.78 , pp. 251-270
    • King, W.R.1    Francis, M.D.2    Michael, W.R.3
  • 36
    • 0015921397 scopus 로고
    • 2 [scap]mDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats
    • 2 [scap]mDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats. Calcif Tissue Res 11:196-214
    • (1973) Calcif Tissue Res , vol.11 , pp. 196-214
    • Schenk, R.1    Merz, W.A.2    Mühlbauer, R.3    Russell, R.G.G.4    Fleisch, H.5
  • 38
    • 0016144963 scopus 로고
    • The short-term effects of high doses of ethylene-1-hydroxy-1,1-diphosphonates upon early dentin formation
    • Larsson A 1974 The short-term effects of high doses of ethylene-1-hydroxy-1,1-diphosphonates upon early dentin formation. Calcif Tissue Res 16:109-127
    • (1974) Calcif Tissue Res , vol.16 , pp. 109-127
    • Larsson, A.1
  • 39
    • 0343002194 scopus 로고
    • Disturbances in enamel and dentin formation of rat incisor following injection with sodium fluoride, strontium (II) chloride and EHDP
    • Ogawa Y 1980 Disturbances in enamel and dentin formation of rat incisor following injection with sodium fluoride, strontium (II) chloride and EHDP. Jpn J Oral Biol 22:199-226
    • (1980) Jpn J Oral Biol , vol.22 , pp. 199-226
    • Ogawa, Y.1
  • 40
    • 0025580827 scopus 로고
    • Effects of single doses of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) on the mineralizing front of rat incisor enamel: A microradiographic and scanning electron microscopic study
    • Weile V, Josephsen K, Fejerskov O 1990 Effects of single doses of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) on the mineralizing front of rat incisor enamel: a microradiographic and scanning electron microscopic study. Arch Oral Biol 35:857-867
    • (1990) Arch Oral Biol , vol.35 , pp. 857-867
    • Weile, V.1    Josephsen, K.2    Fejerskov, O.3
  • 41
    • 0029929636 scopus 로고    scopus 로고
    • Root surface defects in rat molar induced by 1-hydroxyethylidene-1,1-bisphosphonate
    • Alatli I, Hammarström L 1996 Root surface defects in rat molar induced by 1-hydroxyethylidene-1,1-bisphosphonate. Acta Odontol Scand 54:59-65
    • (1996) Acta Odontol Scand , vol.54 , pp. 59-65
    • Alatli, I.1    Hammarström, L.2
  • 44
    • 0015609538 scopus 로고
    • Indirect inhibition of the biosynthesis of 1,25-dihydroxycholecalciferol in rats treated with a diphosphonate
    • Hill LF, Lumb GA, Mawer EB, Stanbury SW 1973 Indirect inhibition of the biosynthesis of 1,25-dihydroxycholecalciferol in rats treated with a diphosphonate. Clin Sci 44:335-347
    • (1973) Clin Sci , vol.44 , pp. 335-347
    • Hill, L.F.1    Lumb, G.A.2    Mawer, E.B.3    Stanbury, S.W.4
  • 45
  • 46
    • 0345507965 scopus 로고
    • Intestinal calcium absorption, Ca-binding protein, and CA-ATPase in diphosphonate-treated rats
    • Bonjour JP, Russell RGG, Morgan DB, Fleisch H 1973 Intestinal calcium absorption, Ca-binding protein, and CA-ATPase in diphosphonate-treated rats. Am J Physiol 224:1011-1017
    • (1973) Am J Physiol , vol.224 , pp. 1011-1017
    • Bonjour, J.P.1    Russell, R.G.G.2    Morgan, D.B.3    Fleisch, H.4
  • 47
    • 0017390312 scopus 로고
    • Relation between bone mineralization, Ca absorption, and plasma Ca in phosphonate-treated rats
    • Trechsel U, Schenk R, Bonjour JP, Russell RGG, Fleisch H 1977 Relation between bone mineralization, Ca absorption, and plasma Ca in phosphonate-treated rats. Am J Physiol 232:E298-E305
    • (1977) Am J Physiol , vol.232
    • Trechsel, U.1    Schenk, R.2    Bonjour, J.P.3    Russell, R.G.G.4    Fleisch, H.5
  • 48
    • 0016581871 scopus 로고
    • Stimulation of calcium absorption and apparent increased intestinal, 1,25-dihydroxycholecalciferol in rats treated with low doses of ethane-1-hydroxy-1,1-diphosphonate
    • Guilland D, Trechsel U, Bonjour JP, Fleisch H 1975 Stimulation of calcium absorption and apparent increased intestinal, 1,25-dihydroxycholecalciferol in rats treated with low doses of ethane-1-hydroxy-1,1-diphosphonate. Clin Sci Mol Med 48:157-160
    • (1975) Clin Sci Mol Med , vol.48 , pp. 157-160
    • Guilland, D.1    Trechsel, U.2    Bonjour, J.P.3    Fleisch, H.4
  • 49
    • 0015130762 scopus 로고
    • The treatment of osteoporosis with disodium ethane-1-hydroxy-1,1-diphosphonate
    • Jowsey J, Riggs BL, Kelly PJ, Hoffman DL, Bordier P 1971 The treatment of osteoporosis with disodium ethane-1-hydroxy-1,1-diphosphonate. J Lab Clin Med 78:574-584
    • (1971) J Lab Clin Med , vol.78 , pp. 574-584
    • Jowsey, J.1    Riggs, B.L.2    Kelly, P.J.3    Hoffman, D.L.4    Bordier, P.5
  • 52
    • 0028230280 scopus 로고
    • Long-term effects of intravenous pamidronate in fibrous dysplasia of bone
    • Liens D, Delmas PD, Meunier PJ 1994 Long-term effects of intravenous pamidronate in fibrous dysplasia of bone. Lancet 343: 953-954
    • (1994) Lancet , vol.343 , pp. 953-954
    • Liens, D.1    Delmas, P.D.2    Meunier, P.J.3
  • 53
    • 0015537942 scopus 로고
    • Inhibition by diphosphonates of bone resorption in mice and comparison with grey lethal osteopetrosis
    • Reynolds JJ, Murphy H, Mühlbauer RC, Morgan DB, Fleisch H 1973 Inhibition by diphosphonates of bone resorption in mice and comparison with grey lethal osteopetrosis. Calcif Tissue Res 12: 59-71
    • (1973) Calcif Tissue Res , vol.12 , pp. 59-71
    • Reynolds, J.J.1    Murphy, H.2    Mühlbauer, R.C.3    Morgan, D.B.4    Fleisch, H.5
  • 54
    • 0022548092 scopus 로고
    • Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat
    • Schenk R, Eggli P, Fleisch H, Rosini S 1986 Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat. Calcif Tissue Int 38:342-349
    • (1986) Calcif Tissue Int , vol.38 , pp. 342-349
    • Schenk, R.1    Eggli, P.2    Fleisch, H.3    Rosini, S.4
  • 55
    • 0015375096 scopus 로고
    • The influence of two diphosphonates on calcium metabolism in the rat
    • Gasser AB, Morgan DB, Fleisch HA, Richelle LJ 1972 The influence of two diphosphonates on calcium metabolism in the rat. Clin Sci 43:31-45
    • (1972) Clin Sci , vol.43 , pp. 31-45
    • Gasser, A.B.1    Morgan, D.B.2    Fleisch, H.A.3    Richelle, L.J.4
  • 56
    • 0029970562 scopus 로고    scopus 로고
    • 45ca kinetics in the intact rat
    • 45Ca kinetics in the intact rat. Osteoporos Int 6:166-170
    • (1996) Osteoporos Int , vol.6 , pp. 166-170
    • Fleisch, H.1
  • 57
    • 0025087070 scopus 로고
    • A method for continual monitoring of bone resorption in rats: Evidence for a diurnal rhythm
    • Mühlbauer RC, Fleisch H 1990 A method for continual monitoring of bone resorption in rats: evidence for a diurnal rhythm. Am J Physiol 259:R679-R689
    • (1990) Am J Physiol , vol.259
    • Mühlbauer, R.C.1    Fleisch, H.2
  • 58
    • 0019136797 scopus 로고
    • Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxy-propylidene)-1,1-bisphosphonate (APD) in rats
    • Reitsma PH, Bijvoet OLM, Verlinden-Ooms H, van der Wee-Pals LJA 1980 Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxy-propylidene)-1,1-bisphosphonate (APD) in rats. Calcif Tissue Int 32:145-157
    • (1980) Calcif Tissue Int , vol.32 , pp. 145-157
    • Reitsma, P.H.1    Bijvoet, O.L.M.2    Verlinden-Ooms, H.3    Van Der Wee-Pals, L.J.A.4
  • 59
    • 0028586042 scopus 로고
    • Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment
    • Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD 1994 Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 79:1693-1700
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1693-1700
    • Garnero, P.1    Shih, W.J.2    Gineyts, E.3    Karpf, D.B.4    Delmas, P.D.5
  • 60
    • 0014684354 scopus 로고
    • Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
    • Fleisch H, Russell RGG, Francis MD 1969 Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo. Science 165:1262-1264
    • (1969) Science , vol.165 , pp. 1262-1264
    • Fleisch, H.1    Russell, R.G.G.2    Francis, M.D.3
  • 61
    • 0014902988 scopus 로고
    • The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised rats
    • Russell RGG, Mühlbauer RC, Bisaz S, Williams DA, Fleisch H 1970 The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised rats. Calcif Tissue Res 6:183-196
    • (1970) Calcif Tissue Res , vol.6 , pp. 183-196
    • Russell, R.G.G.1    Mühlbauer, R.C.2    Bisaz, S.3    Williams, D.A.4    Fleisch, H.5
  • 62
    • 0023481282 scopus 로고
    • Hypercalcemia induced with an arotinoid in thyroparathyroidectomized rats. A new model to study bone resorption in vivo
    • Trechsel U, Stutzer A, Fleisch H 1987 Hypercalcemia induced with an arotinoid in thyroparathyroidectomized rats. A new model to study bone resorption in vivo. J Clin Invest 80:1679-1686
    • (1987) J Clin Invest , vol.80 , pp. 1679-1686
    • Trechsel, U.1    Stutzer, A.2    Fleisch, H.3
  • 63
    • 0015062775 scopus 로고
    • The effects of diphosphonates, polyphosphates and calcitonin on "immobilisation osteoporosis" in rats
    • Mühlbauer RC, Russell RGG, Williams DA, Fleisch H 1971 The effects of diphosphonates, polyphosphates and calcitonin on "immobilisation osteoporosis" in rats. Eur J Clin Invest 1:336-344
    • (1971) Eur J Clin Invest , vol.1 , pp. 336-344
    • Mühlbauer, R.C.1    Russell, R.G.G.2    Williams, D.A.3    Fleisch, H.4
  • 64
    • 0024307588 scopus 로고
    • Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats
    • Wronski TJ, Dann LM, Scott KS, Crooke LR 1989 Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats. Endocrinology 125:810-816
    • (1989) Endocrinology , vol.125 , pp. 810-816
    • Wronski, T.J.1    Dann, L.M.2    Scott, K.S.3    Crooke, L.R.4
  • 66
    • 0022378674 scopus 로고
    • The effects of dichloromethylene bisphosphonate on osteoporotic femora of adult castrate male rats
    • Wink CS, Onge MS, Parker B 1985 The effects of dichloromethylene bisphosphonate on osteoporotic femora of adult castrate male rats. Acta Anat (Basel) 124:117-121
    • (1985) Acta Anat (Basel) , vol.124 , pp. 117-121
    • Wink, C.S.1    Onge, M.S.2    Parker, B.3
  • 68
    • 0019432426 scopus 로고
    • Effect of dichloromethane diphosphonate on cortisol-induced bone loss in young adult rabbits
    • Jee WSS, Black HE, Gotcher JE 1981 Effect of dichloromethane diphosphonate on cortisol-induced bone loss in young adult rabbits. Clin Orthop 156:39-51
    • (1981) Clin Orthop , vol.156 , pp. 39-51
    • Jee, W.S.S.1    Black, H.E.2    Gotcher, J.E.3
  • 70
    • 0027738472 scopus 로고
    • Four-year study of intermittent cyclic etidronate treatment of postmenopausal osteoporosis: Three years of blinded therapy followed by one year of open therapy
    • Harris ST, Watts NB, Jackson RD, Genant HK, Wasnich RD, Ross P, Miller PD, Licata AA, Chesnut III CH 1993 Four-year study of intermittent cyclic etidronate treatment of postmenopausal osteoporosis: three years of blinded therapy followed by one year of open therapy. Am J Med 95:557-567
    • (1993) Am J Med , vol.95 , pp. 557-567
    • Harris, S.T.1    Watts, N.B.2    Jackson, R.D.3    Genant, H.K.4    Wasnich, R.D.5    Ross, P.6    Miller, P.D.7    Licata, A.A.8    Chesnut C.H. III9
  • 74
    • 0029855832 scopus 로고    scopus 로고
    • The effect on bone mass and bone markers of different doses of ibandronate: A new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: A 1-year, randomized, double-blind, placebo-controlled dose-finding study
    • Ravn P, Clemmesen B, Riis BJ, Christiansen C 1996 The effect on bone mass and bone markers of different doses of ibandronate: a new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: a 1-year, randomized, double-blind, placebo-controlled dose-finding study. Bone 19:527-533
    • (1996) Bone , vol.19 , pp. 527-533
    • Ravn, P.1    Clemmesen, B.2    Riis, B.J.3    Christiansen, C.4
  • 75
    • 0023839421 scopus 로고
    • Prevention of steroid-induced osteoporosis with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD)
    • Reid IR, King AR, Alexander CJ, Ibbertson HK 1988 Prevention of steroid-induced osteoporosis with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD). Lancet 1:143-146
    • (1988) Lancet , vol.1 , pp. 143-146
    • Reid, I.R.1    King, A.R.2    Alexander, C.J.3    Ibbertson, H.K.4
  • 80
    • 0027487286 scopus 로고
    • Effects of the bisphosphonate tiludronate on bone resorption, calcium balance, and bone mineral density
    • Ammann P, Rizzoli R, Caverzasio J, Shigematsu T, Slosman D, Bonjour JP 1993 Effects of the bisphosphonate tiludronate on bone resorption, calcium balance, and bone mineral density. J Bone Miner Res 8:1491-1498
    • (1993) J Bone Miner Res , vol.8 , pp. 1491-1498
    • Ammann, P.1    Rizzoli, R.2    Caverzasio, J.3    Shigematsu, T.4    Slosman, D.5    Bonjour, J.P.6
  • 81
    • 0027498016 scopus 로고
    • Protective effects of disodium etidronate and pamidronate against the biochemical repercussion of betamethasone-induced osteopenia in growing rat femurs
    • Ferretti JL, Delgado CJ, Capozza RF, Cointry G, Montuori E, Roldán E, Pérez Lloret A, Zanchetta JR 1993 Protective effects of disodium etidronate and pamidronate against the biochemical repercussion of betamethasone-induced osteopenia in growing rat femurs. Bone Miner 20:265-276
    • (1993) Bone Miner , vol.20 , pp. 265-276
    • Ferretti, J.L.1    Delgado, C.J.2    Capozza, R.F.3    Cointry, G.4    Montuori, E.5    Roldán, E.6    Pérez Lloret, A.7    Zanchetta, J.R.8
  • 82
    • 0029047908 scopus 로고
    • Effects of the bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovari-ectomized beagles on concomitant dietary calcium restriction
    • Motoie H, Nakamura T, O'Uchi N, Nishikawa H, Kanoh H, Abe T, Kawashima H 1995 Effects of the bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovari-ectomized beagles on concomitant dietary calcium restriction. J Bone Miner Res 10:910-920
    • (1995) J Bone Miner Res , vol.10 , pp. 910-920
    • Motoie, H.1    Nakamura, T.2    O'Uchi, N.3    Nishikawa, H.4    Kanoh, H.5    Abe, T.6    Kawashima, H.7
  • 84
    • 0018854165 scopus 로고
    • The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis
    • Galasko CSB, Samuel AW, Rushton S, Lacey E 1980 The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis. Br J Surg 67:493-496
    • (1980) Br J Surg , vol.67 , pp. 493-496
    • Galasko, C.S.B.1    Samuel, A.W.2    Rushton, S.3    Lacey, E.4
  • 85
    • 0019483875 scopus 로고
    • Inhibition by two diphosphonates of bone lysis in tumor conditioned media
    • Jung A, Mermillod B, Barras C, Baud M, Courvoisier B 1981 Inhibition by two diphosphonates of bone lysis in tumor conditioned media. Cancer Res 41:3233-3237
    • (1981) Cancer Res , vol.41 , pp. 3233-3237
    • Jung, A.1    Mermillod, B.2    Barras, C.3    Baud, M.4    Courvoisier, B.5
  • 86
    • 0142169194 scopus 로고
    • The effects of diphosphonates on tumor-induced hypercalcemia and osteolysis in walker carcinosarcoma 256 (W-256) of rats
    • Donath A, Courvoisier B (eds) Editions Médecine et Hygiène, Geneva
    • Johnson KY, Wesseler MA, Olson HM, Martodam RR, Poser JW 1982 The effects of diphosphonates on tumor-induced hypercalcemia and osteolysis in Walker carcinosarcoma 256 (W-256) of rats. In: Donath A, Courvoisier B (eds) Diphosphonates and Bone. Editions Médecine et Hygiène, Geneva, pp 386-389
    • (1982) Diphosphonates and Bone , pp. 386-389
    • Johnson, K.Y.1    Wesseler, M.A.2    Olson, H.M.3    Martodam, R.R.4    Poser, J.W.5
  • 87
    • 0021277629 scopus 로고
    • Inhibition by diphosphonates of bone resorption induced by the walker tumor of the rat
    • Jung A, Bornand J, Mermillod B, Edouard C, Meunier PJ 1984 Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat. Cancer Res 44:3007-3011
    • (1984) Cancer Res , vol.44 , pp. 3007-3011
    • Jung, A.1    Bornand, J.2    Mermillod, B.3    Edouard, C.4    Meunier, P.J.5
  • 88
    • 0020505982 scopus 로고
    • The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat leydig cell tumor
    • Martodam RR, Thornton KS, Sica DA, D'Souza SM, Flora L, Mundy GR 1983 The effects of dichloromethylene diphosphonate on hypercalcemia and other parameters of the humoral hypercalcemia of malignancy in the rat Leydig cell tumor. Calcif Tissue Int 35:512-519
    • (1983) Calcif Tissue Int , vol.35 , pp. 512-519
    • Martodam, R.R.1    Thornton, K.S.2    Sica, D.A.3    D'Souza, S.M.4    Flora, L.5    Mundy, G.R.6
  • 89
    • 0022467341 scopus 로고
    • Parathyroid hormone-like changes in renal calcium and phosphate reabsorption induced by leydig cell tumor in thyroparathyroidectomized rats
    • Rizzoli R, Caverzasio J, Fleisch H, Bonjour JP 1986 Parathyroid hormone-like changes in renal calcium and phosphate reabsorption induced by Leydig cell tumor in thyroparathyroidectomized rats. Endocrinology 119:1004-1009
    • (1986) Endocrinology , vol.119 , pp. 1004-1009
    • Rizzoli, R.1    Caverzasio, J.2    Fleisch, H.3    Bonjour, J.P.4
  • 90
    • 0026318521 scopus 로고
    • Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease
    • Fleisch H 1991 Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease. Drugs 42:919-944
    • (1991) Drugs , vol.42 , pp. 919-944
    • Fleisch, H.1
  • 92
    • 0027520387 scopus 로고
    • Increased growth rate and tumor burden of spontaneously metastatic Walker 256 cancer cells in the skeleton of bisphosphonate-treated rats
    • Kostenuik PJ, Orr FW, Suyama K, Singh G 1993 Increased growth rate and tumor burden of spontaneously metastatic Walker 256 cancer cells in the skeleton of bisphosphonate-treated rats. Cancer Res 53:5452-5457
    • (1993) Cancer Res , vol.53 , pp. 5452-5457
    • Kostenuik, P.J.1    Orr, F.W.2    Suyama, K.3    Singh, G.4
  • 93
    • 0028945736 scopus 로고
    • Facilitation and suppression of bone metastasis
    • Mundy GR, Yoneda T 1995 Facilitation and suppression of bone metastasis. Clin Orthop 312:34-44
    • (1995) Clin Orthop , vol.312 , pp. 34-44
    • Mundy, G.R.1    Yoneda, T.2
  • 94
    • 0020039162 scopus 로고
    • Comparison of two parenteral diphosphonates in hypercalcemia of malignancy
    • Jung A 1982 Comparison of two parenteral diphosphonates in hypercalcemia of malignancy. Am J Med 72:221-226
    • (1982) Am J Med , vol.72 , pp. 221-226
    • Jung, A.1
  • 95
    • 0028724953 scopus 로고
    • Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease
    • Dunn CJ, Fitton A, Sorkin EM 1994 Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs Aging 5:446-474
    • (1994) Drugs Aging , vol.5 , pp. 446-474
    • Dunn, C.J.1    Fitton, A.2    Sorkin, E.M.3
  • 96
    • 0028285203 scopus 로고
    • Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease
    • Plosker GL, Goa KL 1994 Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs 47:945-982
    • (1994) Drugs , vol.47 , pp. 945-982
    • Plosker, G.L.1    Goa, K.L.2
  • 100
    • 0019441793 scopus 로고
    • The progress of the periodontal syndrome in the rice rat II. The effects of a diphosphonate on the periodontium
    • Gotcher JE, Jee WSS 1981 The progress of the periodontal syndrome in the rice rat II. The effects of a diphosphonate on the periodontium. J Periodont Res 16:441-455
    • (1981) J Periodont Res , vol.16 , pp. 441-455
    • Gotcher, J.E.1    Jee, W.S.S.2
  • 102
    • 0029340796 scopus 로고
    • Inhibitory effects of a bisphosphonate (risedronate) on experimental periodontitis in rats
    • Shoji K, Horiuchi H, Shinoda H 1995 Inhibitory effects of a bisphosphonate (risedronate) on experimental periodontitis in rats. J Periodont Res 30:277-284
    • (1995) J Periodont Res , vol.30 , pp. 277-284
    • Shoji, K.1    Horiuchi, H.2    Shinoda, H.3
  • 105
    • 0028202499 scopus 로고
    • Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound
    • Green JR, Müller K, Jaeggi KA 1994 Preclinical pharmacology of CGP 42'446, a new, potent, heterocyclic bisphosphonate compound. J Bone Miner Res 9:745-751
    • (1994) J Bone Miner Res , vol.9 , pp. 745-751
    • Green, J.R.1    Müller, K.2    Jaeggi, K.A.3
  • 107
    • 0025371890 scopus 로고
    • Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy
    • Sato M, Grasser W 1990 Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy. J Bone Miner Res 5:31-40
    • (1990) J Bone Miner Res , vol.5 , pp. 31-40
    • Sato, M.1    Grasser, W.2
  • 108
    • 0028045711 scopus 로고
    • The effect of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) on the resorptive function of osteoclasts of known nuclear number
    • Piper K, Boyde A, Jones SJ 1994 The effect of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) on the resorptive function of osteoclasts of known nuclear number. Calcif Tissue Int 54:56-61
    • (1994) Calcif Tissue Int , vol.54 , pp. 56-61
    • Piper, K.1    Boyde, A.2    Jones, S.J.3
  • 109
    • 0027193759 scopus 로고
    • Bisphosphonates act on rat bone resorption through the mediation of osteoblasts
    • Sahni M, Guenther HL, Fleisch H, Collin P, Martin TJ 1993 Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest 91:2004-2011
    • (1993) J Clin Invest , vol.91 , pp. 2004-2011
    • Sahni, M.1    Guenther, H.L.2    Fleisch, H.3    Collin, P.4    Martin, T.J.5
  • 112
    • 0023149994 scopus 로고
    • Enhancement of the inhibitory action of APD on the transformation of osteoclast precursors into resorbing cells after dimethylation of the amino group
    • Boonekamp PM, Löwik CWGM, van der Wee-Pals LJA, van Wijk-van Lennep MLL, Bijvoet OLM 1987 Enhancement of the inhibitory action of APD on the transformation of osteoclast precursors into resorbing cells after dimethylation of the amino group. Bone Miner 2:29-42
    • (1987) Bone Miner , vol.2 , pp. 29-42
    • Boonekamp, P.M.1    Löwik, C.W.G.M.2    Van Der Wee-Pals, L.J.A.3    Van Wijk-Van Lennep, M.L.L.4    Bijvoet, O.L.M.5
  • 114
    • 0027322564 scopus 로고
    • Studies on novel bone resorption inhibitors. I. Synthesis and pharmacological activities of aminomethylenebisphosphonate derivatives
    • Takeuchi M, Sakamoto S, Yoshida M, Abe T, Isomura Y 1993 Studies on novel bone resorption inhibitors. I. Synthesis and pharmacological activities of aminomethylenebisphosphonate derivatives. Chem Pharm Bull (Tokyo) 41:688-693
    • (1993) Chem Pharm Bull (Tokyo) , vol.41 , pp. 688-693
    • Takeuchi, M.1    Sakamoto, S.2    Yoshida, M.3    Abe, T.4    Isomura, Y.5
  • 116
    • 0027405193 scopus 로고
    • Changes in bone histomorphometry after long-term treatment with intermittent, cyclic etidronate for postmenopausal osteoporosis
    • Storm T, Steiniche T, Thamsborg G, Melsen F 1993 Changes in bone histomorphometry after long-term treatment with intermittent, cyclic etidronate for postmenopausal osteoporosis. J Bone Miner Res 8:199-208
    • (1993) J Bone Miner Res , vol.8 , pp. 199-208
    • Storm, T.1    Steiniche, T.2    Thamsborg, G.3    Melsen, F.4
  • 117
    • 0028909290 scopus 로고
    • The effects of risedronate on canine cancellous bone remodeling: Three-dimensional kinetic reconstruction of the remodeling site
    • Boyce RW, Paddock CL, Gleason JR, Sletsema WK, Eriksen EF 1995 The effects of risedronate on canine cancellous bone remodeling: three-dimensional kinetic reconstruction of the remodeling site. J Bone Miner Res 10:211-221
    • (1995) J Bone Miner Res , vol.10 , pp. 211-221
    • Boyce, R.W.1    Paddock, C.L.2    Gleason, J.R.3    Sletsema, W.K.4    Eriksen, E.F.5
  • 118
    • 0028576958 scopus 로고
    • Intramembranous and endochondral bone changes induced by a new bisphosphonate (YM175) in the beagle dog
    • Nii A, Fujimoto R, Okazaki A, Narita K, Miki H 1994 Intramembranous and endochondral bone changes induced by a new bisphosphonate (YM175) in the beagle dog. Toxicol Pathol 22:536-544
    • (1994) Toxicol Pathol , vol.22 , pp. 536-544
    • Nii, A.1    Fujimoto, R.2    Okazaki, A.3    Narita, K.4    Miki, H.5
  • 120
    • 0029873660 scopus 로고    scopus 로고
    • Human protein tyrosine phosphatase-σ alternative splicing and inhibition by bisphosphonates
    • Endo N, Rutledge SJ, Opas EE, Vogel R, Rodan GA, Schmidt A 1996 Human protein tyrosine phosphatase-σ alternative splicing and inhibition by bisphosphonates. J Bone Miner Res 11:535-543
    • (1996) J Bone Miner Res , vol.11 , pp. 535-543
    • Endo, N.1    Rutledge, S.J.2    Opas, E.E.3    Vogel, R.4    Rodan, G.A.5    Schmidt, A.6
  • 121
    • 0018091543 scopus 로고
    • The effects of diphosphonates on the growth and glycolysis of connec-tive-tissue cells in culture
    • Fast DK, Felix R, Dowse C, Neuman WF, Fleisch H 1978 The effects of diphosphonates on the growth and glycolysis of connec-tive-tissue cells in culture. Biochem J 172:97-107
    • (1978) Biochem J , vol.172 , pp. 97-107
    • Fast, D.K.1    Felix, R.2    Dowse, C.3    Neuman, W.F.4    Fleisch, H.5
  • 122
    • 0019854630 scopus 로고
    • The effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on collagen synthesis by rabbit articular chondrocytes and rat bone cells
    • Guenther HL, Guenther HE, Fleisch H 1981 The effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on collagen synthesis by rabbit articular chondrocytes and rat bone cells. Biochem J 196:293-301
    • (1981) Biochem J , vol.196 , pp. 293-301
    • Guenther, H.L.1    Guenther, H.E.2    Fleisch, H.3
  • 123
    • 0019465480 scopus 로고
    • The influence of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on lysine hydroxylation and cross-link formation in rat bone, cartilage and skin collagen
    • Guenther HL, Guenther HE, Fleisch H 1981 The influence of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on lysine hydroxylation and cross-link formation in rat bone, cartilage and skin collagen. Biochem J 196:303-310
    • (1981) Biochem J , vol.196 , pp. 303-310
    • Guenther, H.L.1    Guenther, H.E.2    Fleisch, H.3
  • 124
    • 0018604750 scopus 로고
    • Effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on rabbit articular chondrocytes in culture
    • Guenther HL, Guenther HE, Fleisch H 1979 Effects of 1-hydroxyethane-1,1-diphosphonate and dichloromethanediphosphonate on rabbit articular chondrocytes in culture. Biochem J 184: 203-214
    • (1979) Biochem J , vol.184 , pp. 203-214
    • Guenther, H.L.1    Guenther, H.E.2    Fleisch, H.3
  • 125
    • 0020398399 scopus 로고
    • Rapid intracellular degradation of newly synthesized collagen by bone cells. Effect of dichloromethylenebisphosphonate
    • Gallagher JA, Guenther HL, Fleisch H 1982 Rapid intracellular degradation of newly synthesized collagen by bone cells. Effect of dichloromethylenebisphosphonate. Biochim Biophys Acta 719:349-355
    • (1982) Biochim Biophys Acta , vol.719 , pp. 349-355
    • Gallagher, J.A.1    Guenther, H.L.2    Fleisch, H.3
  • 126
    • 0001591139 scopus 로고
    • Alendronate stimulates b-FGF production and mineralized nodule formation in human osteoblastic cells and osteoblastogenesis in human bone marrow cultures
    • (Abstract 129)
    • Giuliani N, Girasole G, Pedrazzoni M, Passeri G, Gatti C, Passeri M 1995 Alendronate stimulates b-FGF production and mineralized nodule formation in human osteoblastic cells and osteoblastogenesis in human bone marrow cultures. J Bone Miner Res 10:S171 (Abstract 129)
    • (1995) J Bone Miner Res , vol.10
    • Giuliani, N.1    Girasole, G.2    Pedrazzoni, M.3    Passeri, G.4    Gatti, C.5    Passeri, M.6
  • 128
    • 0023520871 scopus 로고
    • Paget's disease of bone: Early and late responses to three different modes of treatment with aminohydroxypropylidene bisphosphonate (APD)
    • Harinck HIJ, Papapoulos SE, Blanksma HJ, Moolenaar AJ, Vermeij P, Bijvoet OLM 1987 Paget's disease of bone: early and late responses to three different modes of treatment with aminohydroxypropylidene bisphosphonate (APD). Br Med J 295:1301-1305
    • (1987) Br Med J , vol.295 , pp. 1301-1305
    • Harinck, H.I.J.1    Papapoulos, S.E.2    Blanksma, H.J.3    Moolenaar, A.J.4    Vermeij, P.5    Bijvoet, O.L.M.6
  • 133
    • 0014463723 scopus 로고
    • The inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphates
    • Francis MD 1969 The inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphates. Calcif Tissue Res 3:151-162
    • (1969) Calcif Tissue Res , vol.3 , pp. 151-162
    • Francis, M.D.1
  • 134
    • 0014684364 scopus 로고
    • Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo
    • Francis MD, Russell RGG, Fleisch H 1969 Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo. Science 165:1264-1266
    • (1969) Science , vol.165 , pp. 1264-1266
    • Francis, M.D.1    Russell, R.G.G.2    Fleisch, H.3
  • 136
    • 0018894419 scopus 로고
    • Effects of pyrophosphate and diphosphates on the dissolution of hydroxyapatites using a flow system
    • Evans JR, Robertson WG, Morgan DB, Fleisch H 1980 Effects of pyrophosphate and diphosphates on the dissolution of hydroxyapatites using a flow system. Calcif Tissue Int 31:153-159
    • (1980) Calcif Tissue Int , vol.31 , pp. 153-159
    • Evans, J.R.1    Robertson, W.G.2    Morgan, D.B.3    Fleisch, H.4
  • 137
    • 0015939609 scopus 로고
    • The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals
    • Jung A, Bisaz S, Fleisch H 1973 The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals. Calcif Tissue Res 11:269-280
    • (1973) Calcif Tissue Res , vol.11 , pp. 269-280
    • Jung, A.1    Bisaz, S.2    Fleisch, H.3
  • 138
    • 0000412862 scopus 로고
    • 2O; implications for polynuclear complex formation
    • 2O; implications for polynuclear complex formation. J Phys Chem 76:1304-1310
    • (1972) J Phys Chem , vol.76 , pp. 1304-1310
    • Uchtman, V.A.1
  • 139
    • 0001502142 scopus 로고
    • Structure of disodium dihydrogen 1-hydroxyethylidene-diphosphonate tetrahydrate: A bone growth regulator
    • Barnett BL, Strickland LC 1979 Structure of disodium dihydrogen 1-hydroxyethylidene-diphosphonate tetrahydrate: a bone growth regulator. Acta Crystallogr B 35:1212-1214
    • (1979) Acta Crystallogr B , vol.35 , pp. 1212-1214
    • Barnett, B.L.1    Strickland, L.C.2
  • 140
    • 0017409002 scopus 로고
    • The inhibition of calcium oxalate crystal growth by multidentate organic phosphonates
    • Meyer JL, Lee KE, Bergert JH 1977 The inhibition of calcium oxalate crystal growth by multidentate organic phosphonates. Calcif Tissue Res 28:83-86
    • (1977) Calcif Tissue Res , vol.28 , pp. 83-86
    • Meyer, J.L.1    Lee, K.E.2    Bergert, J.H.3
  • 141
    • 0015918874 scopus 로고
    • Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro
    • Robertson WG, Peacock M, Nordin BEC 1973 Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro. Clin Chim Acta 43:31-37
    • (1973) Clin Chim Acta , vol.43 , pp. 31-37
    • Robertson, W.G.1    Peacock, M.2    Nordin, B.E.C.3
  • 142
    • 0017170313 scopus 로고
    • The metabolic heterogeneity of glycosaminoglycans of the different zones of the epiphyseal growth plate and the effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) upon glycosaminoglycan synthesis in vivo
    • Larsson SE 1976 The metabolic heterogeneity of glycosaminoglycans of the different zones of the epiphyseal growth plate and the effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) upon glycosaminoglycan synthesis in vivo. Calcif Tissue Res 21:67-82
    • (1976) Calcif Tissue Res , vol.21 , pp. 67-82
    • Larsson, S.E.1
  • 143
    • 0018832483 scopus 로고
    • A micropuncture study of growth cartilage in phosphonate (EHDP) induced rickets
    • Howell DS, Muniz OE, Blanco LN, Pita JC 1980 A micropuncture study of growth cartilage in phosphonate (EHDP) induced rickets. Calcif Tissue Int 30:35-42
    • (1980) Calcif Tissue Int , vol.30 , pp. 35-42
    • Howell, D.S.1    Muniz, O.E.2    Blanco, L.N.3    Pita, J.C.4
  • 144
    • 0023259563 scopus 로고
    • Effects of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) on the synthesis of dentine matrix proteins in the mouse
    • Van den Bos T, Beertsen W 1987 Effects of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) on the synthesis of dentine matrix proteins in the mouse. Collagen Rel Res 7:135-147
    • (1987) Collagen Rel Res , vol.7 , pp. 135-147
    • Van Den Bos, T.1    Beertsen, W.2
  • 145
    • 0024499443 scopus 로고
    • 1-hydroxyethylidene-1,1-bisphosphonate (HEPB) simultaneously induces two distinct types of hypomineralization in the rat incisor dentine
    • Ogawa Y, Adachi Y, Hong S, Yagi T 1989 1-hydroxyethylidene-1,1-bisphosphonate (HEPB) simultaneously induces two distinct types of hypomineralization in the rat incisor dentine. Calcif Tissue Int 44:46-60
    • (1989) Calcif Tissue Int , vol.44 , pp. 46-60
    • Ogawa, Y.1    Adachi, Y.2    Hong, S.3    Yagi, T.4
  • 147
    • 0018214760 scopus 로고
    • Effects of diphosphonates on glycosaminoglycan synthesis and proteoglycan aggregation in normal adult articular cartilage
    • Palmoski M, Brandt K 1978 Effects of diphosphonates on glycosaminoglycan synthesis and proteoglycan aggregation in normal adult articular cartilage. Arthritis Rheum 21:942-949
    • (1978) Arthritis Rheum , vol.21 , pp. 942-949
    • Palmoski, M.1    Brandt, K.2
  • 148
    • 0002581690 scopus 로고
    • The physiologic and pathogenetic significance of bone histomorphometric data
    • Coe FL, Favus MJ (eds) Raven Press, New York
    • Parfitt AM 1992 The physiologic and pathogenetic significance of bone histomorphometric data. In: Coe FL, Favus MJ (eds) Disorders of Bone and Mineral Metabolism. Raven Press, New York, pp 475-489
    • (1992) Disorders of Bone and Mineral Metabolism , pp. 475-489
    • Parfitt, A.M.1
  • 150
    • 0030039250 scopus 로고    scopus 로고
    • A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates
    • Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF 1996 A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res 11:150-159
    • (1996) J Bone Miner Res , vol.11 , pp. 150-159
    • Parfitt, A.M.1    Mundy, G.R.2    Roodman, G.D.3    Hughes, D.E.4    Boyce, B.F.5
  • 151
    • 0029156967 scopus 로고
    • Direct stereological estimation of three-dimensional connectivity in rat vertebrae: Effect of estrogen, etidronate and risedronate following ovariectomy
    • Boyce RW, Wronski TJ, Ebert DC, Stevens ML, Paddock CL, Youngs TA, Gundersen HJG 1995 Direct stereological estimation of three-dimensional connectivity in rat vertebrae: effect of estrogen, etidronate and risedronate following ovariectomy. Bone 16: 209-213
    • (1995) Bone , vol.16 , pp. 209-213
    • Boyce, R.W.1    Wronski, T.J.2    Ebert, D.C.3    Stevens, M.L.4    Paddock, C.L.5    Youngs, T.A.6    Gundersen, H.J.G.7
  • 153
    • 0029091836 scopus 로고
    • The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate-Is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system?
    • Delmas PD, Vergnaud P, Arlot ME, Pastoureau P, Meunier PJ, Nilssen MHL 1995 The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate-Is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system? Bone 16:603-610
    • (1995) Bone , vol.16 , pp. 603-610
    • Delmas, P.D.1    Vergnaud, P.2    Arlot, M.E.3    Pastoureau, P.4    Meunier, P.J.5    Nilssen, M.H.L.6
  • 154
    • 0029144772 scopus 로고
    • Parathyroid hormone monotherapy and cotherapy with antiresorptive agents restore vertebral bone mass and strength in aged ovariectomized rats
    • Li M, Mosekilde Li Sogaard CH, Thomsen JS, Wronski TJ 1995 Parathyroid hormone monotherapy and cotherapy with antiresorptive agents restore vertebral bone mass and strength in aged ovariectomized rats. Bone 16:629-635
    • (1995) Bone , vol.16 , pp. 629-635
    • Li, M.1    Mosekilde Li Sogaard, C.H.2    Thomsen, J.S.3    Wronski, T.J.4
  • 155
    • 0029078109 scopus 로고
    • Extra cancellous bone induced by combined prostaglandin E2 and risedronate administration is maintained after their withdrawal in older female rats
    • Jee WSS, Lin BY, Ma YF, Ke HZ 1995 Extra cancellous bone induced by combined prostaglandin E2 and risedronate administration is maintained after their withdrawal in older female rats. J Bone Miner Res 10:963-970
    • (1995) J Bone Miner Res , vol.10 , pp. 963-970
    • Jee, W.S.S.1    Lin, B.Y.2    Ma, Y.F.3    Ke, H.Z.4
  • 156
    • 0028923855 scopus 로고
    • Cyclical treatment of osteopenic ovariectomized adult rats with PTH(1-34) and pamidronate
    • Cheng PT, Chan C, Müller K 1995 Cyclical treatment of osteopenic ovariectomized adult rats with PTH(1-34) and pamidronate. J Bone Miner Res 10:119-126
    • (1995) J Bone Miner Res , vol.10 , pp. 119-126
    • Cheng, P.T.1    Chan, C.2    Müller, K.3
  • 157
    • 0028818157 scopus 로고
    • Partial maintenance of extra cancellous bone mass by antiresorptive agents after discontinuation of human parathyroid hormone (1-38) in right hindlimb immobilized rats
    • Ma Y, Jee WSS, Chen Y, Gasser J, Ke HZ, Li XJ, Kimmel DB 1995 Partial maintenance of extra cancellous bone mass by antiresorptive agents after discontinuation of human parathyroid hormone (1-38) in right hindlimb immobilized rats. J Bone Miner Res 10: 1726-1734
    • (1995) J Bone Miner Res , vol.10 , pp. 1726-1734
    • Ma, Y.1    Jee, W.S.S.2    Chen, Y.3    Gasser, J.4    Ke, H.Z.5    Li, X.J.6    Kimmel, D.B.7
  • 158
    • 0030045173 scopus 로고    scopus 로고
    • Maintaining bone mass by bisphosphonate incadronate disodium (YM175) sequential treatment after discontinuation of intermittent human parathyroid hormone (1-34) administration in ovariectomized rats
    • Takano Y, Tanizawa T, Mashiba T, Endo N, Nishida S, Takahashi HE 1996 Maintaining bone mass by bisphosphonate incadronate disodium (YM175) sequential treatment after discontinuation of intermittent human parathyroid hormone (1-34) administration in ovariectomized rats. J Bone Miner Res 11:169-177
    • (1996) J Bone Miner Res , vol.11 , pp. 169-177
    • Takano, Y.1    Tanizawa, T.2    Mashiba, T.3    Endo, N.4    Nishida, S.5    Takahashi, H.E.6
  • 159
    • 0029055554 scopus 로고
    • Combined therapy with estrogen and etidronate has an additive effect on bone mineral density in the hip and vertebrae: Four-year randomized study
    • Wimalawansa SJ 1995 Combined Therapy with estrogen and etidronate has an additive effect on bone mineral density in the hip and vertebrae: four-year randomized study. Am J Med 99:36-42
    • (1995) Am J Med , vol.99 , pp. 36-42
    • Wimalawansa, S.J.1
  • 160
    • 0024406012 scopus 로고
    • Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow
    • Hughes DE, MacDonald BR, Russell RGG, Gowen M 1989 Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest 83:1930-1935
    • (1989) J Clin Invest , vol.83 , pp. 1930-1935
    • Hughes, D.E.1    MacDonald, B.R.2    Russell, R.G.G.3    Gowen, M.4
  • 161
    • 0023318392 scopus 로고
    • Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages
    • Cecchini MG, Felix R, Fleisch H, Cooper PH 1987 Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages. J Bone Miner Res 2:135-142
    • (1987) J Bone Miner Res , vol.2 , pp. 135-142
    • Cecchini, M.G.1    Felix, R.2    Fleisch, H.3    Cooper, P.H.4
  • 162
    • 0025175649 scopus 로고
    • Bisphosphonates in vitro specifically inhibit, among the hematopoietic series, the development of the mouse mononuclear phagocyte lineage
    • Cecchini MG, Fleisch H 1990 Bisphosphonates in vitro specifically inhibit, among the hematopoietic series, the development of the mouse mononuclear phagocyte lineage. J Bone Miner Res 5:1019-1027
    • (1990) J Bone Miner Res , vol.5 , pp. 1019-1027
    • Cecchini, M.G.1    Fleisch, H.2
  • 164
    • 0029934545 scopus 로고    scopus 로고
    • Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption
    • Vitté C, Fleisch H, Guenther HL 1996 Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption. Endocrinology 137:2324-2333
    • (1996) Endocrinology , vol.137 , pp. 2324-2333
    • Vitté, C.1    Fleisch, H.2    Guenther, H.L.3
  • 165
    • 0029550878 scopus 로고
    • Etidronate inhibits osteoclast adhesion to bone surfaces but does not interfere with their specific recognition of single bone proteins
    • Colucci S, Minielli V, Zambonin G, Grano M 1995 Etidronate inhibits osteoclast adhesion to bone surfaces but does not interfere with their specific recognition of single bone proteins. Ital J Miner Electrolyte Metab 9:159-164
    • (1995) Ital J Miner Electrolyte Metab , vol.9 , pp. 159-164
    • Colucci, S.1    Minielli, V.2    Zambonin, G.3    Grano, M.4
  • 168
    • 0029766224 scopus 로고    scopus 로고
    • Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
    • Rogers MJ, Chilton KM, Coxon FP, Lawry J, Smith MO, Suri S, Russell RGG 1996 Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism. J Bone Miner Res 11:1482-1491
    • (1996) J Bone Miner Res , vol.11 , pp. 1482-1491
    • Rogers, M.J.1    Chilton, K.M.2    Coxon, F.P.3    Lawry, J.4    Smith, M.O.5    Suri, S.6    Russell, R.G.G.7
  • 169
    • 0018758295 scopus 로고
    • The effect of dichloromethylenediphosphonate, a pyrophosphate analog, on bone and bone cell structure in the growing rat
    • Miller SC, Jee WSS 1979 The effect of dichloromethylenediphosphonate, a pyrophosphate analog, on bone and bone cell structure in the growing rat. Anat Rec 193:439-462
    • (1979) Anat Rec , vol.193 , pp. 439-462
    • Miller, S.C.1    Jee, W.S.S.2
  • 170
    • 0027536485 scopus 로고
    • Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increase macrophages, granulocytes, and osteoclasts in vivo
    • Endo Y, Nakamura M, Kikuchi T, Shinoda H, Takeda Y, Nitta Y, Kumagai K 1993 Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increase macrophages, granulocytes, and osteoclasts in vivo. Calcif Tissue Int 52:248-254
    • (1993) Calcif Tissue Int , vol.52 , pp. 248-254
    • Endo, Y.1    Nakamura, M.2    Kikuchi, T.3    Shinoda, H.4    Takeda, Y.5    Nitta, Y.6    Kumagai, K.7
  • 171
    • 0029097506 scopus 로고
    • A possible mechanism of the specific action of bisphosphonates on osteoclasts: Tiludronate preferentially affects polarized osteoclasts having ruffled borders
    • Murakami H, Takahashi N, Sasaki T, Udagawa N, Tanaka S, Nakamura I, Zhang D, Barbier A, Suda T 1995 A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders. Bone 17:137-144
    • (1995) Bone , vol.17 , pp. 137-144
    • Murakami, H.1    Takahashi, N.2    Sasaki, T.3    Udagawa, N.4    Tanaka, S.5    Nakamura, I.6    Zhang, D.7    Barbier, A.8    Suda, T.9
  • 172
    • 0028077307 scopus 로고
    • The effects of bisphosphonates on the resorption cycle of isolated osteoclasts
    • Selander K, Lehenkari P, Väänänen HK 1994 The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif Tissue Int 55:368-375
    • (1994) Calcif Tissue Int , vol.55 , pp. 368-375
    • Selander, K.1    Lehenkari, P.2    Väänänen, H.K.3
  • 174
    • 0021287134 scopus 로고
    • 14C] dichloromethylenebisphosphonate and [14C] 1-hydroxyethylidene-1,1-bisphosphonate in cultured calvaria cells
    • 14C] dichloromethylenebisphosphonate and [14C] 1-hydroxyethylidene-1,1-bisphosphonate in cultured calvaria cells. Calcif Tissue Int 36:108-113
    • (1984) Calcif Tissue Int , vol.36 , pp. 108-113
    • Felix, R.1    Guenther, H.L.2    Fleisch, H.3
  • 175
    • 0029164610 scopus 로고
    • Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models
    • Azuma Y, Sato H, Oue Y, Okabe K, Ohta T, Tsuchimoto M, Kiyoki M 1995 Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models. Bone 16:235-245
    • (1995) Bone , vol.16 , pp. 235-245
    • Azuma, Y.1    Sato, H.2    Oue, Y.3    Okabe, K.4    Ohta, T.5    Tsuchimoto, M.6    Kiyoki, M.7
  • 176
    • 0015739550 scopus 로고
    • 2 [scap]mDP) and calcitonin on bone resorption, lactate production and phosphatase and pyrophosphatase content of mouse calvaria treated with parathyroid hormone in vitro
    • 2 [scap]mDP) and calcitonin on bone resorption, lactate production and phosphatase and pyrophosphatase content of mouse calvaria treated with parathyroid hormone in vitro. Calcif Tissue Res 13:287-294
    • (1973) Calcif Tissue Res , vol.13 , pp. 287-294
    • Morgan, D.B.1    Monod, A.2    Russell, R.G.G.3    Fleisch, H.4
  • 177
    • 0025091788 scopus 로고
    • Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro
    • Carano A, Teitelbaum SL, Konsek JD, Schlesinger PH, Blair HC 1990 Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro. J Clin Invest 85:456-461
    • (1990) J Clin Invest , vol.85 , pp. 456-461
    • Carano, A.1    Teitelbaum, S.L.2    Konsek, J.D.3    Schlesinger, P.H.4    Blair, H.C.5
  • 178
    • 0028859369 scopus 로고
    • Acid extrusion is induced by osteoclast attachment to bone: Inhibition by alendronate and calcitonin
    • Zimolo Z, Wesolowski G, Rodan GA 1995 Acid extrusion is induced by osteoclast attachment to bone: inhibition by alendronate and calcitonin. J Clin Invest 96:2277-2283
    • (1995) J Clin Invest , vol.96 , pp. 2277-2283
    • Zimolo, Z.1    Wesolowski, G.2    Rodan, G.A.3
  • 181
    • 0017287702 scopus 로고
    • The effect of several diphosphonates on acid phosphohydrolases and other lysosomal enzymes
    • Felix R, Russell RGG, Fleisch H 1976 The effect of several diphosphonates on acid phosphohydrolases and other lysosomal enzymes. Biochim Biophys Acta 429:429-438
    • (1976) Biochim Biophys Acta , vol.429 , pp. 429-438
    • Felix, R.1    Russell, R.G.G.2    Fleisch, H.3
  • 182
    • 0022341487 scopus 로고
    • Bisphosphonates and bone resorption: Effects on collagenase and lysosomal enzyme excretion
    • Delaissé JM, Eeckhout Y, Vaes G 1985 Bisphosphonates and bone resorption: effects on collagenase and lysosomal enzyme excretion. Life Sci 37:2291-2296
    • (1985) Life Sci , vol.37 , pp. 2291-2296
    • Delaissé, J.M.1    Eeckhout, Y.2    Vaes, G.3
  • 183
    • 0019848239 scopus 로고
    • Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells
    • Felix R, Bettex JD, Fleisch H 1981 Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells. Calcif Tissue Int 33:549-552
    • (1981) Calcif Tissue Int , vol.33 , pp. 549-552
    • Felix, R.1    Bettex, J.D.2    Fleisch, H.3
  • 184
    • 0021797302 scopus 로고
    • Effect of bisphosphonates on prostaglandin synthesis by rat bone cells and mouse calvaria in culture
    • Ohya K, Yamada S, Felix R, Fleisch H 1985 Effect of bisphosphonates on prostaglandin synthesis by rat bone cells and mouse calvaria in culture. Clin Sci 69:403-411
    • (1985) Clin Sci , vol.69 , pp. 403-411
    • Ohya, K.1    Yamada, S.2    Felix, R.3    Fleisch, H.4
  • 185
    • 0028960818 scopus 로고
    • Different effects of bisphosphonate and estrogen therapy on free and peptide-bound bone cross-links excretion
    • Garnero P, Gineyts E, Arbault P, Christiansen C, Delmas PD 1995 Different effects of bisphosphonate and estrogen therapy on free and peptide-bound bone cross-links excretion. J Bone Miner Res 10:641-649
    • (1995) J Bone Miner Res , vol.10 , pp. 641-649
    • Garnero, P.1    Gineyts, E.2    Arbault, P.3    Christiansen, C.4    Delmas, P.D.5
  • 186
    • 0016781930 scopus 로고
    • Properties of inorganic pyrophosphatase of pig scapula cartilage
    • Felix R, Fleisch H 1975 Properties of inorganic pyrophosphatase of pig scapula cartilage. Biochem J 147:111-118
    • (1975) Biochem J , vol.147 , pp. 111-118
    • Felix, R.1    Fleisch, H.2
  • 188
    • 0345662530 scopus 로고    scopus 로고
    • Deleted in proof
    • Deleted in proof
  • 189
    • 1842405434 scopus 로고
    • Clodronate and liposome-encapsulated clodronate are metabolised to a toxic ATP analogue, adenosine 5′(β,γ-dichloromethylene)triphosphate, by mammalian cells in vitro
    • Frith JC, Mönkkönen J, Blackburn GM, Russell RGG, Rogers MJ 1977 Clodronate and liposome-encapsulated clodronate are metabolised to a toxic ATP analogue, adenosine 5′(β,γ-dichloromethylene)triphosphate, by mammalian cells in vitro. J Bone Miner Res 12:1358-1367
    • (1977) J Bone Miner Res , vol.12 , pp. 1358-1367
    • Frith, J.C.1    Mönkkönen, J.2    Blackburn, G.M.3    Russell, R.G.G.4    Rogers, M.J.5
  • 190
    • 0019847761 scopus 로고
    • Role of osteoblasts in hormonal control of bone resorption: A hypothesis
    • Rodan GA, Martin TJ 1981 Role of osteoblasts in hormonal control of bone resorption: a hypothesis. Calcif Tissue Int 33:349-351
    • (1981) Calcif Tissue Int , vol.33 , pp. 349-351
    • Rodan, G.A.1    Martin, T.J.2
  • 191
    • 0023037395 scopus 로고
    • Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption
    • McSheehy PMJ, Chambers TJ 1986 Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption. Endocrinology 119:1654-1659
    • (1986) Endocrinology , vol.119 , pp. 1654-1659
    • McSheehy, P.M.J.1    Chambers, T.J.2
  • 192
    • 0024450163 scopus 로고
    • Partial characterization of a parathyroid hormone-stimulated resorption factor(s) from osteoblast-like cells
    • Perry HM, Skogen W, Chappel J, Kahn AJ, Wilner G, Teitelbaum SL 1989 Partial characterization of a parathyroid hormone-stimulated resorption factor(s) from osteoblast-like cells. Endocrinology 125:2075-2082
    • (1989) Endocrinology , vol.125 , pp. 2075-2082
    • Perry, H.M.1    Skogen, W.2    Chappel, J.3    Kahn, A.J.4    Wilner, G.5    Teitelbaum, S.L.6
  • 193
    • 0025234682 scopus 로고
    • The parathyroid hormone-related protein stimulates human osteoblast-like cells to secrete a 9,000 dalton bone resorbing protein
    • Morris CA, Mitnick ME, Weir EC, Horowitz H, Kreider BL, Isogna KL 1990 The parathyroid hormone-related protein stimulates human osteoblast-like cells to secrete a 9,000 Dalton bone resorbing protein. Endocrinology 126:1783-1785
    • (1990) Endocrinology , vol.126 , pp. 1783-1785
    • Morris, C.A.1    Mitnick, M.E.2    Weir, E.C.3    Horowitz, H.4    Kreider, B.L.5    Isogna, K.L.6
  • 195
    • 0030039250 scopus 로고    scopus 로고
    • A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates
    • Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF 1996 A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res 11:150-159
    • (1996) J Bone Miner Res , vol.11 , pp. 150-159
    • Parfitt, A.M.1    Mundy, G.R.2    Roodman, G.D.3    Hughes, D.E.4    Boyce, B.F.5
  • 196
    • 0027317860 scopus 로고
    • Estrogen stimulates the elaboration of cell/matrix surface-associated inhibitory factor of osteoclastic bone resorption from osteoblastic cells
    • Ishii T, Saito T, Morimoto K, Takeuchi Y, Asano S, Kumegawa M, Ogata E, Matsumoto T 1993 Estrogen stimulates the elaboration of cell/matrix surface-associated inhibitory factor of osteoclastic bone resorption from osteoblastic cells. Biochem Biophys Res Commun 191:495-502
    • (1993) Biochem Biophys Res Commun , vol.191 , pp. 495-502
    • Ishii, T.1    Saito, T.2    Morimoto, K.3    Takeuchi, Y.4    Asano, S.5    Kumegawa, M.6    Ogata, E.7    Matsumoto, T.8
  • 197
    • 0030271596 scopus 로고    scopus 로고
    • Interaction between effects of parathyroid hormone and bisphosphonate on regulation of osteoclast activity by the osteoblast-like cell line UMR-106
    • Yu X, Schøller J, Foged NT 1996 Interaction between effects of parathyroid hormone and bisphosphonate on regulation of osteoclast activity by the osteoblast-like cell line UMR-106. Bone 19: 339-345
    • (1996) Bone , vol.19 , pp. 339-345
    • Yu, X.1    Schøller, J.2    Foged, N.T.3
  • 199
    • 0019170675 scopus 로고
    • Diphosphonates inhibit bone resorption by macrophages in vitro
    • Chambers TJ 1980 Diphosphonates inhibit bone resorption by macrophages in vitro. J Pathol 132:255-262
    • (1980) J Pathol , vol.132 , pp. 255-262
    • Chambers, T.J.1
  • 200
    • 0022654308 scopus 로고
    • Cytotoxic and migration inhibitory effects of bisphosphonates on macrophages
    • Stevenson PH, Stevenson JR 1986 Cytotoxic and migration inhibitory effects of bisphosphonates on macrophages. Calcif Tissue Int 38:227-233
    • (1986) Calcif Tissue Int , vol.38 , pp. 227-233
    • Stevenson, P.H.1    Stevenson, J.R.2
  • 202
    • 0018286952 scopus 로고
    • Assessment of the protective action of diphosphonate compounds against damage to T-lymphocytes by antilymphocytic serum
    • Zernov IN, Stefani DV, Vel'tishchev YE 1979 Assessment of the protective action of diphosphonate compounds against damage to T-lymphocytes by antilymphocytic serum. Bull Exp Biol Med 87: 253-254
    • (1979) Bull Exp Biol Med , vol.87 , pp. 253-254
    • Zernov, I.N.1    Stefani, D.V.2    Vel'tishchev, Y.E.3
  • 204
    • 0028322891 scopus 로고
    • Clodronate (dichloromethylene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells
    • Mönkkönen J, Pennanen N, Lapinjoki S, Urtti A 1994 Clodronate (dichloromethylene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells. Life Sci 54:229-234
    • (1994) Life Sci , vol.54 , pp. 229-234
    • Mönkkönen, J.1    Pennanen, N.2    Lapinjoki, S.3    Urtti, A.4
  • 205
    • 0029056655 scopus 로고
    • Effect of liposomal and free bisphosphonates on the IL-1β, IL-6 and TNFα secretion from RAW 264 cells in vitro
    • Pennanen N, Lapinjoki S, Urtti A, Mönkkönen J 1995 Effect of liposomal and free bisphosphonates on the IL-1β, IL-6 and TNFα secretion from RAW 264 cells in vitro. Pharmacol Res 12:916-922
    • (1995) Pharmacol Res , vol.12 , pp. 916-922
    • Pennanen, N.1    Lapinjoki, S.2    Urtti, A.3    Mönkkönen, J.4
  • 206
    • 0030424359 scopus 로고    scopus 로고
    • Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro
    • Makkonen N, Hirvonen MR, Teräväinen T, Savolainen K, Mönkkönen J 1996 Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro. J Pharmacol Exp Ther 277:1097-1102
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1097-1102
    • Makkonen, N.1    Hirvonen, M.R.2    Teräväinen, T.3    Savolainen, K.4    Mönkkönen, J.5
  • 207
    • 0018150549 scopus 로고
    • Inhibition of hypersensitivity of delayed and immediate types in guinea pigs by methylenediphosphonic acid
    • Komissarenko SV, Zhuravskii NI, Karlova NP, Gulyi MF 1977 Inhibition of hypersensitivity of delayed and immediate types in guinea pigs by methylenediphosphonic acid. Bull Exp Biol Med 84:1322-1323
    • (1977) Bull Exp Biol Med , vol.84 , pp. 1322-1323
    • Komissarenko, S.V.1    Zhuravskii, N.I.2    Karlova, N.P.3    Gulyi, M.F.4
  • 209
    • 0020967572 scopus 로고
    • Dichloromethylene diphosphonate-induced impairment of T-lymphocyte function
    • Milhaud G, Labat ML, Moricard Y 1983 (Dichloromethylene) diphosphonate-induced impairment of T-lymphocyte function. Proc Natl Acad Sci USA 80:4469-4473
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4469-4473
    • Milhaud, G.1    Labat, M.L.2    Moricard, Y.3
  • 210
    • 0021017342 scopus 로고
    • Lack of a T-cell dependent subpopulation of macrophages in (dichloromethylene) diphosphonate-treated mice
    • Labat ML, Tzehoval E, Moricard Y, Feldman M, Milhaud G 1983 Lack of a T-cell dependent subpopulation of macrophages in (dichloromethylene) diphosphonate-treated mice. Biomed Pharmacother 37:270-276
    • (1983) Biomed Pharmacother , vol.37 , pp. 270-276
    • Labat, M.L.1    Tzehoval, E.2    Moricard, Y.3    Feldman, M.4    Milhaud, G.5
  • 212
    • 0021164231 scopus 로고
    • Elimination of phagocytic cells in the spleen after intravenous injection of liposomeencapsulated dichloromethylene diphosphonate: An enzyme-histochemical study
    • Van Rooijen N, van Nieuwmegen R 1984 Elimination of phagocytic cells in the spleen after intravenous injection of liposomeencapsulated dichloromethylene diphosphonate: an enzyme-histochemical study. Cell Tissue Res 238:355-358
    • (1984) Cell Tissue Res , vol.238 , pp. 355-358
    • Van Rooijen, N.1    Van Nieuwmegen, R.2
  • 215
    • 0029010690 scopus 로고
    • Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate
    • Schweitzer DH, Oostendorp-van de Ruit M, van der Pluijm G, Löwik CWGM, Papapoulos SE 1995 Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. J Bone Miner Res 10:956-962
    • (1995) J Bone Miner Res , vol.10 , pp. 956-962
    • Schweitzer, D.H.1    Oostendorp-Van De Ruit, M.2    Van Der Pluijm, G.3    Löwik, C.W.G.M.4    Papapoulos, S.E.5
  • 217
    • 0015274723 scopus 로고
    • The effects of disodium ethane-1-hydroxy-1,1-diphosphonate on adjuvant induced arthritis in rats
    • Francis MD, Flora L, King WR 1972 The effects of disodium ethane-1-hydroxy-1,1-diphosphonate on adjuvant induced arthritis in rats. Calcif Tissue Res 9:109-121
    • (1972) Calcif Tissue Res , vol.9 , pp. 109-121
    • Francis, M.D.1    Flora, L.2    King, W.R.3
  • 218
    • 0018595947 scopus 로고
    • Comparative antiinflammatory and bone protective effects of two diphosphonates in adjuvant arthritis
    • Flora L 1979 Comparative antiinflammatory and bone protective effects of two diphosphonates in adjuvant arthritis. Arthritis Rheum 22:340-346
    • (1979) Arthritis Rheum , vol.22 , pp. 340-346
    • Flora, L.1
  • 219
    • 0024953794 scopus 로고
    • NE-58095: A diphosphonate which prevents bone erosion and preserves joint architecture in experimental arthritis
    • Francis MD, Hovancik K, Boyce RW 1989 NE-58095: a diphosphonate which prevents bone erosion and preserves joint architecture in experimental arthritis. Int J Tissue React 11:239-252
    • (1989) Int J Tissue React , vol.11 , pp. 239-252
    • Francis, M.D.1    Hovancik, K.2    Boyce, R.W.3
  • 221
  • 222
    • 0029565958 scopus 로고
    • Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes
    • Kinne RW, Schmidt-Weber CB, Hoppe R, Buchner E, Palombo-Kinne E, Nürnberg E, Emmrich F 1995 Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes. Arthritis Rheum 38: 1777-1790
    • (1995) Arthritis Rheum , vol.38 , pp. 1777-1790
    • Kinne, R.W.1    Schmidt-Weber, C.B.2    Hoppe, R.3    Buchner, E.4    Palombo-Kinne, E.5    Nürnberg, E.6    Emmrich, F.7
  • 227
    • 0027531814 scopus 로고
    • Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer
    • Paterson AHG, Powles TJ, Kanis JA, McCloskey E, Hanson J, Ashley S 1993 Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer. J Clin Oncol 11:59-65
    • (1993) J Clin Oncol , vol.11 , pp. 59-65
    • Paterson, A.H.G.1    Powles, T.J.2    Kanis, J.A.3    McCloskey, E.4    Hanson, J.5    Ashley, S.6
  • 228
    • 0019826634 scopus 로고
    • Increase in fatty acid oxidation in calvaria cells cultured with diphosphonates
    • Felix R, Fleisch H 1981 Increase in fatty acid oxidation in calvaria cells cultured with diphosphonates. Biochem J 196:237-245
    • (1981) Biochem J , vol.196 , pp. 237-245
    • Felix, R.1    Fleisch, H.2
  • 229
    • 0018907471 scopus 로고
    • Effect of diphosphonates on glycogen content of rabbit ear cartilage cells in culture
    • Felix R, Fast DK, Sallis JD, Fleisch H 1980 Effect of diphosphonates on glycogen content of rabbit ear cartilage cells in culture. Calcif Tissue Int 30:163-166
    • (1980) Calcif Tissue Int , vol.30 , pp. 163-166
    • Felix, R.1    Fast, D.K.2    Sallis, J.D.3    Fleisch, H.4
  • 230
    • 0018697577 scopus 로고
    • Increase in alkaline phosphatase activity in calvaria cells cultured with diphosphonates
    • Felix R, Fleisch H 1979 Increase in alkaline phosphatase activity in calvaria cells cultured with diphosphonates. Biochem J 183:73-81
    • (1979) Biochem J , vol.183 , pp. 73-81
    • Felix, R.1    Fleisch, H.2
  • 232
    • 0344367780 scopus 로고
    • Effects of pyrophosphate and diphosphonates on parathyroid hormone- and fluoride-stimulated adenylate cyclase activity
    • Pilczyk R, Sutcliffe H, Martin TJ 1972 Effects of pyrophosphate and diphosphonates on parathyroid hormone- and fluoride-stimulated adenylate cyclase activity. FEBS Lett 24:225-228
    • (1972) FEBS Lett , vol.24 , pp. 225-228
    • Pilczyk, R.1    Sutcliffe, H.2    Martin, T.J.3
  • 233
    • 0017083397 scopus 로고
    • Effect of diphosphonates on adenosine 3′:5′ cyclic monophosphate in mouse calvaria after stimulation by parathyroid hormone in vitro
    • Gebauer U, Russell RGG, Touabi M, Fleisch H 1976 Effect of diphosphonates on adenosine 3′:5′ cyclic monophosphate in mouse calvaria after stimulation by parathyroid hormone in vitro. Clin Sci Mol Med 50:473-478
    • (1976) Clin Sci Mol Med , vol.50 , pp. 473-478
    • Gebauer, U.1    Russell, R.G.G.2    Touabi, M.3    Fleisch, H.4
  • 234
    • 0022358511 scopus 로고
    • Effect of bisphosphonates on production of interleukin 1-like activity by macrophages and its effect on rabbit chondrocytes
    • Evéquoz V, Trechsel U, Fleisch H 1985 Effect of bisphosphonates on production of interleukin 1-like activity by macrophages and its effect on rabbit chondrocytes. Bone 6:439-444
    • (1985) Bone , vol.6 , pp. 439-444
    • Evéquoz, V.1    Trechsel, U.2    Fleisch, H.3
  • 236
    • 0020429825 scopus 로고
    • Analog inhibitors for the pyrophosphate-dependent phosphofructokinase of entamoeba histolytica and their effect on culture growth
    • Eubank WB, Reeves RE 1982 Analog inhibitors for the pyrophosphate-dependent phosphofructokinase of entamoeba histolytica and their effect on culture growth. J Parasitol 68:599-602
    • (1982) J Parasitol , vol.68 , pp. 599-602
    • Eubank, W.B.1    Reeves, R.E.2
  • 237
    • 0016270523 scopus 로고
    • The effect of two diphosphonates on the handling of calcium by rat kidney mitochondria in vitro
    • Guilland DF, Sallis JD, Fleisch H 1974 The effect of two diphosphonates on the handling of calcium by rat kidney mitochondria in vitro. Calcif Tissue Res 15:303-314
    • (1974) Calcif Tissue Res , vol.15 , pp. 303-314
    • Guilland, D.F.1    Sallis, J.D.2    Fleisch, H.3
  • 238
    • 0016318674 scopus 로고
    • The effect of in vivo treatment with EHDP and/or 1,25-DHCC on calcium uptake and release in isolated kidney mitochondria
    • Guilland DF, Fleisch H 1974 The effect of in vivo treatment with EHDP and/or 1,25-DHCC on calcium uptake and release in isolated kidney mitochondria. Biochem Biophys Res Commun 61: 906-911
    • (1974) Biochem Biophys Res Commun , vol.61 , pp. 906-911
    • Guilland, D.F.1    Fleisch, H.2
  • 239
    • 0025024765 scopus 로고
    • The bisphosphonate, clodronate, inhibits calcium-induced contraction in vascular smooth muscle
    • Paspaliaris V, Leaver DD 1990 The bisphosphonate, clodronate, inhibits calcium-induced contraction in vascular smooth muscle. Eur J Pharmacol 183:1257
    • (1990) Eur J Pharmacol , vol.183 , pp. 1257
    • Paspaliaris, V.1    Leaver, D.D.2
  • 240
    • 0025282138 scopus 로고
    • Blocking the calcium cascade in experimental acute renal failure
    • Greif F, Anais D, Frei L, Arbeit L, Sorroff HS 1990 Blocking the calcium cascade in experimental acute renal failure. Isr J Med Sci 26:301-305
    • (1990) Isr J Med Sci , vol.26 , pp. 301-305
    • Greif, F.1    Anais, D.2    Frei, L.3    Arbeit, L.4    Sorroff, H.S.5
  • 241
    • 0024437867 scopus 로고
    • A new class of calcium entry blockers defined by 1,3-diphosphonates
    • Rossier JR, Cox JA, Niesor EJ, Bentzen CL 1989 A new class of calcium entry blockers defined by 1,3-diphosphonates. J Biol Chem 264:16598-16607
    • (1989) J Biol Chem , vol.264 , pp. 16598-16607
    • Rossier, J.R.1    Cox, J.A.2    Niesor, E.J.3    Bentzen, C.L.4
  • 245
    • 0028965149 scopus 로고
    • Structure-activity relationships of new heterocycle-containing bisphosphonates as inhibitors of bone resorption and as inhibitors of growth of dictyostelium discoideum amoebae
    • Rogers MJ, Xiong X, Brown RJ, Watts DJ, Russell RGG, Bayless AV, Ebetino FH 1995 Structure-activity relationships of new heterocycle-containing bisphosphonates as inhibitors of bone resorption and as inhibitors of growth of Dictyostelium discoideum amoebae. Mol Pharmacol 47:398-402
    • (1995) Mol Pharmacol , vol.47 , pp. 398-402
    • Rogers, M.J.1    Xiong, X.2    Brown, R.J.3    Watts, D.J.4    Russell, R.G.G.5    Bayless, A.V.6    Ebetino, F.H.7
  • 246
    • 0027364293 scopus 로고
    • Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model
    • Boulenc X, Marti E, Joyeux H, Roques C, Berger Y, Fabre G 1993 Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model. Biochem Pharmacol 46:1591-1600
    • (1993) Biochem Pharmacol , vol.46 , pp. 1591-1600
    • Boulenc, X.1    Marti, E.2    Joyeux, H.3    Roques, C.4    Berger, Y.5    Fabre, G.6
  • 247
    • 0026345116 scopus 로고
    • Sodium EDTA enhances intestinal absorption of two bisphosphonates
    • Janner M, Mühlbauer RC, Fleisch H 1991 Sodium EDTA enhances intestinal absorption of two bisphosphonates. Calcif Tissue Int 49:280-283
    • (1991) Calcif Tissue Int , vol.49 , pp. 280-283
    • Janner, M.1    Mühlbauer, R.C.2    Fleisch, H.3
  • 248
    • 0029075935 scopus 로고
    • Bisphosphonates increase tight junction permeability in the human intestinal epithelial (Caco-2) model
    • Boulenc X, Roques C, Joyeux H, Berger Y, Fabre G 1995 Bisphosphonates increase tight junction permeability in the human intestinal epithelial (Caco-2) model. Int J Pharmacol 123:13-24
    • (1995) Int J Pharmacol , vol.123 , pp. 13-24
    • Boulenc, X.1    Roques, C.2    Joyeux, H.3    Berger, Y.4    Fabre, G.5
  • 250
    • 0020516186 scopus 로고
    • Ultrafiltrability and chromatographic properties of pyrophosphate, 1-hydroxyethylidene-1,1-bisphosphonate, and dichloromethylenebisphosphonate in aqueous buffers and in human plasma
    • Wiedmer WH, Zbinden AM, Trechsel U, Fleisch H 1983 Ultrafiltrability and Chromatographic properties of pyrophosphate, 1-hydroxyethylidene-1,1-bisphosphonate, and dichloromethylenebisphosphonate in aqueous buffers and in human plasma. Calcif Tissue Int 35:397-400
    • (1983) Calcif Tissue Int , vol.35 , pp. 397-400
    • Wiedmer, W.H.1    Zbinden, A.M.2    Trechsel, U.3    Fleisch, H.4
  • 251
    • 33947293707 scopus 로고
    • Polynuclear complex formation in solutions of calcium ion and ethane-1-hydroxy-1,1-diphosphonic acid. I. Complexometric and pH titrations
    • Grabenstetter RJ, Cilley WA 1971 Polynuclear complex formation in solutions of calcium ion and ethane-1-hydroxy-1,1-diphosphonic acid. I. Complexometric and pH titrations. J Phys Chem 75:676-682
    • (1971) J Phys Chem , vol.75 , pp. 676-682
    • Grabenstetter, R.J.1    Cilley, W.A.2
  • 252
    • 0021129391 scopus 로고
    • Calcium and 1-hydroxyethylidene-1,1-bisphosphonic acid: Polynuclear complex formation in the physiological range of pH
    • Lamson ML, Fox JL, Huguchi WI 1984 Calcium and 1-hydroxyethylidene-1,1-bisphosphonic acid: polynuclear complex formation in the physiological range of pH. Int J Pharm 21:143-154
    • (1984) Int J Pharm , vol.21 , pp. 143-154
    • Lamson, M.L.1    Fox, J.L.2    Huguchi, W.I.3
  • 253
    • 0009572303 scopus 로고
    • Model selection for complex systems involving polynuclear species
    • Lamson ML, Fox JL, Higuchi WI 1985 Model selection for complex systems involving polynuclear species. Polyhedron 4:133-141
    • (1985) Polyhedron , vol.4 , pp. 133-141
    • Lamson, M.L.1    Fox, J.L.2    Higuchi, W.I.3
  • 254
    • 0028283603 scopus 로고
    • Nonlinear kinetics of alendronate. Plasma protein binding and bone uptake
    • Lin JH, Chen I-W, DeLuna FA 1994 Nonlinear kinetics of alendronate. Plasma protein binding and bone uptake. Drug Metab Dispos 22:400-405
    • (1994) Drug Metab Dispos , vol.22 , pp. 400-405
    • Lin, J.H.1    Chen, I.-W.2    DeLuna, F.A.3
  • 255
    • 0027434079 scopus 로고
    • Role of calcium in plasma protein binding and renal handling of alendronate in hypo- and hypercalcemic rats
    • Lin JH, Chen IW, DeLuna FA, Hichens M 1993 Role of calcium in plasma protein binding and renal handling of alendronate in hypo- and hypercalcemic rats. J Pharmacol Exp Ther 267:670-675
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 670-675
    • Lin, J.H.1    Chen, I.W.2    DeLuna, F.A.3    Hichens, M.4
  • 257
    • 0029886359 scopus 로고    scopus 로고
    • Bisphosphonates: A review of their pharmacokinetic properties
    • Lin JH 1996 Bisphosphonates: a review of their pharmacokinetic properties. Bone 18:75-85
    • (1996) Bone , vol.18 , pp. 75-85
    • Lin, J.H.1
  • 258
    • 0017891632 scopus 로고
    • Uptake by bone of pyrophosphate, diphosphonates and their technetium derivatives
    • Bisaz S, Jung A, Fleisch H 1978 Uptake by bone of pyrophosphate, diphosphonates and their technetium derivatives. Clin Sci Mol Med 54:265-272
    • (1978) Clin Sci Mol Med , vol.54 , pp. 265-272
    • Bisaz, S.1    Jung, A.2    Fleisch, H.3
  • 259
    • 0026064309 scopus 로고
    • Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease
    • Fitton A, McTavish D 1991 Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs 41:289-318
    • (1991) Drugs , vol.41 , pp. 289-318
    • Fitton, A.1    McTavish, D.2
  • 261
  • 264
    • 0027489470 scopus 로고
    • Synthesis of gem-bisphosphonic methotrexate conjugates and their biological response towards Walker's osteosarcoma
    • Sturtz G, Couthon H, Fabulet O, Mian M, Rosini S 1993 Synthesis of gem-bisphosphonic methotrexate conjugates and their biological response towards Walker's osteosarcoma. Eur J Med Chem 28: 899-903
    • (1993) Eur J Med Chem , vol.28 , pp. 899-903
    • Sturtz, G.1    Couthon, H.2    Fabulet, O.3    Mian, M.4    Rosini, S.5
  • 265
    • 0018909103 scopus 로고
    • 14C-labeled ethylene-1-hydroxy-1,1-diphosphonate in normal and treated young rats. An autoradiographic and ultrastructural study
    • 14C-labeled ethylene-1-hydroxy-1,1-diphosphonate in normal and treated young rats. An autoradiographic and ultrastructural study. Toxicol Appl Pharmacol 52:391-399
    • (1980) Toxicol Appl Pharmacol , vol.52 , pp. 391-399
    • Larsson, A.1    Rohlin, M.2
  • 266
    • 0022403020 scopus 로고
    • Distribution of 3-amino-1-hydroxypropane-1,1-diphosphonic acid in rats and effects on rat osteosarcoma
    • Wingen F, Schmähl D 1985 Distribution of 3-amino-1-hydroxypropane-1,1-diphosphonic acid in rats and effects on rat osteosarcoma. Arzneimittelforschung 35:1565-1571
    • (1985) Arzneimittelforschung , vol.35 , pp. 1565-1571
    • Wingen, F.1    Schmähl, D.2
  • 267
    • 0023871089 scopus 로고
    • A one year follow-up study of the distribution of 14C-clodronate in mice and rats
    • Mönkkönen J 1988 A one year follow-up study of the distribution of 14C-clodronate in mice and rats. Pharmacol Toxicol 62:51-53
    • (1988) Pharmacol Toxicol , vol.62 , pp. 51-53
    • Mönkkönen, J.1
  • 268
    • 0025164063 scopus 로고
    • Comparison of the distribution of three bisphosphonates in mice
    • Mönkkönen J, Koponen HM, Ylitalo P 1990 Comparison of the distribution of three bisphosphonates in mice. Pharmacol Toxicol 66:294-298
    • (1990) Pharmacol Toxicol , vol.66 , pp. 294-298
    • Mönkkönen, J.1    Koponen, H.M.2    Ylitalo, P.3
  • 270
    • 0026694920 scopus 로고
    • Retention of etidronate in human, dog, and rat
    • Kasting GB, Francis MD 1992 Retention of etidronate in human, dog, and rat. J Bone Miner Res 7:513-522
    • (1992) J Bone Miner Res , vol.7 , pp. 513-522
    • Kasting, G.B.1    Francis, M.D.2
  • 271
    • 0024552952 scopus 로고
    • Development of an acute model for the study of chloromethanediphosphonate nephrotoxicity
    • Alden CL, Parker RD, Eastman DF 1989 Development of an acute model for the study of chloromethanediphosphonate nephrotoxicity. Toxicol Pathol 17:27-32
    • (1989) Toxicol Pathol , vol.17 , pp. 27-32
    • Alden, C.L.1    Parker, R.D.2    Eastman, D.F.3
  • 272
    • 0025681661 scopus 로고
    • Disposition and nephrotoxicity of 3-animo-1-hydroxypropylidene-1,1-bisphosphonate (APD) in rats and mice
    • Cal JC, Daley-Yates PT 1990 Disposition and nephrotoxicity of 3-animo-1-hydroxypropylidene-1,1-bisphosphonate (APD) in rats and mice. Toxicology 65:179-197
    • (1990) Toxicology , vol.65 , pp. 179-197
    • Cal, J.C.1    Daley-Yates, P.T.2
  • 273
    • 0020325399 scopus 로고
    • Fault of ossification and calcification and angular deformities of long bone in th mouse fetuses caused by high doses of ethane-1-hydroxy-1,1-diphosphonate (EHDP) during pregnancy
    • Eguchi M, Yamaguchi T, Shiota E, Handa S 1982 Fault of ossification and calcification and angular deformities of long bone in th mouse fetuses caused by high doses of ethane-1-hydroxy-1,1-diphosphonate (EHDP) during pregnancy. Cong Anom 22:47-52
    • (1982) Cong Anom , vol.22 , pp. 47-52
    • Eguchi, M.1    Yamaguchi, T.2    Shiota, E.3    Handa, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.