CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8349-8358

  Castellano, Sabrina ^a   Stefancich, Giorgio ^b   Ragno, Rino ^c   Schewe, Katarzyna ^d   Santoriello, Marisabella ^a   Caroli, Antonia ^c   Hartmann, Rolf W ^d   Sbardella, Gianluca ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

3D QSAR; Antifungal agents; Aromatase inhibitors; CYP19; Ligand based drug design

Indexed keywords

4 [N (4 BROMOBENZYL) N (1,2,4 TRIAZOL 4 YL)AMINO]BENZONITRILE; AMINOGLUTETHIMIDE; ANASTROZOLE; AROMATASE; AROMATASE INHIBITOR; FADROZOLE; FINROZOLE; LETROZOLE; VOROZOLE;

ARTICLE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; IC 50; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION ANALYSIS;

ANTIFUNGAL AGENTS; AROMATASE INHIBITORS; DRUG DESIGN; LIGANDS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEROID 17-ALPHA-HYDROXYLASE;

EID: 51449099183     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.046     Document Type: Article

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