Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1413-1419

  Su, Bin ^a   Diaz Cruz, Edgar S ^a   Landini, Serena ^a   Brueggemeier, Robert W ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANILIDE; AROMATASE INHIBITOR; CYCLOOXYGENASE 2; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N (2 CYCLOPENTYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N (2 METHYLCYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N [2 (1 ETHYLPROPYLOXY 4 NITROPHENYL)]METHANESULFONAMIDE; N METHYL N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N METHYL N (2 CYCLOPENTYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N METHYL N (2 METHYLCYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N METHYL N [2 (1 ETHYLPROPYLOXY 4 NITROPHENYL)]METHANESULFONAMIDE; PROSTAGLANDIN E2; SULFONANILIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; EVALUATION; HUMAN; HUMAN CELL; MICROSOME; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

ANILINE COMPOUNDS; AROMATASE; AROMATASE INHIBITORS; BREAST NEOPLASMS; CELL LINE, TUMOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MICROSOMES; NEOPLASMS, HORMONE-DEPENDENT; NITROBENZENES; PLACENTA; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFONAMIDES; TRANSCRIPTION, GENETIC;

EID: 33144457107     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051126f     Document Type: Article

References (25)

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