Heme impairs allosterically drug binding to human serum albumin Sudlow's site I

Biochemical and Biophysical Research Communications

Volumn 334, Issue 2, 2005, Pages 481-486

  Ascenzi, Paolo ^a,d   Bocedi, Alessio ^a   Notari, Stefania ^a   Menegatti, Enea ^b   Fasano, Mauro ^c  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF INSUBRIA   (Italy)

^d ROMA TRE UNIVERSITY   (Italy)

Author keywords

Allostery; Drugs; Ferric heme; Ferric heme human serum albumin; Human serum albumin; Ligand binding

Indexed keywords

CHLORPROPAMIDE; DIGITOXIN; FERRIC ION; FUROSEMIDE; HEME; HUMAN SERUM ALBUMIN; INDOMETACIN; PHENYLBUTAZONE; SULFAFURAZOLE; TOLBUTAMIDE;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG PROTEIN BINDING; EQUILIBRIUM CONSTANT; HUMAN; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL;

ALLOSTERIC SITE; BINDING SITES; HEME; HUMANS; KINETICS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; SERUM ALBUMIN; STEREOISOMERISM;

EID: 22144459777     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.06.127     Document Type: Article

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