Replacement of the proximal histidine iron ligand by a cysteine or tyrosine converts heme oxygenase to an oxidase

Biochemistry

Volumn 38, Issue 12, 1999, Pages 3733-3743

  Liu, Yi ^a   Moënne Loccoz, Pierre ^b   Hildebrand, Dean P ^c   Wilks, Angela ^a   Loehr, Thomas M ^b   Mauk, A Grant ^c   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; HEME OXYGENASE; HISTIDINE; OXYGENASE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; ELECTRON TRANSPORT; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME STRUCTURE; HUMAN; MUTATION; PRIORITY JOURNAL; RAMAN SPECTROMETRY; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; CATALYSIS; CYSTEINE; ELECTRON TRANSPORT; FERRIC COMPOUNDS; FERROUS COMPOUNDS; HEME; HEME OXYGENASE (DECYCLIZING); HISTIDINE; HUMANS; IRON; LIGANDS; MUTAGENESIS; OXIDATION-REDUCTION; OXIDOREDUCTASES; PEROXIDES; SPECTRUM ANALYSIS, RAMAN; TYROSINE;

EID: 0039021674     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982707s     Document Type: Article

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