메뉴 건너뛰기




Volumn 198, Issue 2, 2008, Pages 375-384

Phosphatidylinositol 3-kinase-dependent insulin regulation of long-chain fatty acid (LCFA) metabolism in L6 muscle cells: Involvement of atypical protein kinase C-ζ in LCFA uptake but not oxidation

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LONG CHAIN FATTY ACID; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C ZETA; WORTMANNIN;

EID: 51349111244     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0122     Document Type: Article
Times cited : (12)

References (49)
  • 1
    • 0030812546 scopus 로고    scopus 로고
    • Evidence for involvement of protein kinase C (PKC)-ς and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes
    • Bandyopadhyay G, Standaert M, Galloway L, Moscat J & Farese R 1997 Evidence for involvement of protein kinase C (PKC)-ς and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Endocrinology 138 4721-4731.
    • (1997) Endocrinology , vol.138 , pp. 4721-4731
    • Bandyopadhyay, G.1    Standaert, M.2    Galloway, L.3    Moscat, J.4    Farese, R.5
  • 3
    • 0022653568 scopus 로고
    • The development of insulin receptors and responsiveness is an early marker of differentiation in the muscle cell line L6
    • Beguinot F, Kahn R, Moses A & Smith R 1986 The development of insulin receptors and responsiveness is an early marker of differentiation in the muscle cell line L6. Endocrinology 18 446-455.
    • (1986) Endocrinology , vol.18 , pp. 446-455
    • Beguinot, F.1    Kahn, R.2    Moses, A.3    Smith, R.4
  • 5
    • 33745668478 scopus 로고    scopus 로고
    • siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS 2/Akt1 in glucose and lipid metabolism in human skeletal muscle
    • Bouzakri K, Zachrisson A, Al-Khalili L, Zhang B, Koistinen H, Krook A & Zierath J 2006 siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS 2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cellular Metabolism 4 89-96.
    • (2006) Cellular Metabolism , vol.4 , pp. 89-96
    • Bouzakri, K.1    Zachrisson, A.2    Al-Khalili, L.3    Zhang, B.4    Koistinen, H.5    Krook, A.6    Zierath, J.7
  • 7
    • 0027978816 scopus 로고
    • The inhibition of glycogen synthase kinase 3 by insulin or insulin like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: Evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf
    • Cross D, Alessi D, Vandenheede Jj, McDowell H, Honda H & Cohen P 1994 The inhibition of glycogen synthase kinase 3 by insulin or insulin like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Journal of Biological Chemistry 303 21-26.
    • (1994) Journal of Biological Chemistry , vol.303 , pp. 21-26
    • Cross, D.1    Alessi, D.2    Vandenheede, J.3    McDowell, H.4    Honda, H.5    Cohen, P.6
  • 9
    • 33750572410 scopus 로고    scopus 로고
    • Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
    • Dimopoulos N, Watson M, Sakamoto K & Hundal HS 2006 Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochemical Journal 399 473-481.
    • (2006) Biochemical Journal , vol.399 , pp. 473-481
    • Dimopoulos, N.1    Watson, M.2    Sakamoto, K.3    Hundal, H.S.4
  • 11
    • 0034984029 scopus 로고    scopus 로고
    • Insulin-sensitive phospholipid signaling systems and glucose transport. Update II
    • Farese R 2001 Insulin-sensitive phospholipid signaling systems and glucose transport. Update II. Experimental and Biological Medicine 226 283-295.
    • (2001) Experimental and Biological Medicine , vol.226 , pp. 283-295
    • Farese, R.1
  • 12
    • 27144450970 scopus 로고    scopus 로고
    • Insulin-sensitive protein kinase (atypical protein kinase C and protein kinase B/Akt): Actions and defects in obesity and type 2 diabetes
    • Farese R, Sajan M & Standaert M 2005 Insulin-sensitive protein kinase (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type 2 diabetes. Experimental and Biological Medicine 230 593-605.
    • (2005) Experimental and Biological Medicine , vol.230 , pp. 593-605
    • Farese, R.1    Sajan, M.2    Standaert, M.3
  • 13
    • 0030869792 scopus 로고    scopus 로고
    • Insulin inhibition of 5′ adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation
    • Gamble J & Lopaschuk G 1997 Insulin inhibition of 5′ adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation. Metabolism 45 1270-1274.
    • (1997) Metabolism , vol.45 , pp. 1270-1274
    • Gamble, J.1    Lopaschuk, G.2
  • 14
    • 29044440372 scopus 로고    scopus 로고
    • Signaling mechanisms regulating lipolysis
    • Gonzalez C & Sanchez V 2006 Signaling mechanisms regulating lipolysis. Cellular Signaling 18 401-408.
    • (2006) Cellular Signaling , vol.18 , pp. 401-408
    • Gonzalez, C.1    Sanchez, V.2
  • 15
    • 0031782480 scopus 로고    scopus 로고
    • Constitutive activation of protein kinase Bα by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
    • Hajduch E, Alessi D, Hemmings B & Hundal H 1998 Constitutive activation of protein kinase Bα by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 47 1006-1013.
    • (1998) Diabetes , vol.47 , pp. 1006-1013
    • Hajduch, E.1    Alessi, D.2    Hemmings, B.3    Hundal, H.4
  • 16
    • 33744931101 scopus 로고    scopus 로고
    • Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: Evidence of a mitochondrial lactate oxidation complex
    • Hashimoto T, Hussein R & Brooks G 2006 Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex. American Journal of Physiology. Endocrinology and Metabolism 290 1237-1244.
    • (2006) American Journal of Physiology. Endocrinology and Metabolism , vol.290 , pp. 1237-1244
    • Hashimoto, T.1    Hussein, R.2    Brooks, G.3
  • 17
    • 0034076660 scopus 로고    scopus 로고
    • Fuel selection in human skeletal muscle in insulin resistance; a reexamination
    • Kelley D & Mandarino L 2000 Fuel selection in human skeletal muscle in insulin resistance; a reexamination. Diabetes 49 677-683.
    • (2000) Diabetes , vol.49 , pp. 677-683
    • Kelley, D.1    Mandarino, L.2
  • 20
    • 0025815205 scopus 로고
    • Diderential regulation ofthe GLUT-1 and GLUT-4 glucose transport systems by glucose and insulin and insulin in L6 muscle cells in culture
    • Koivisto U, Martinez-Valdez H, Bilan P, Burdett E, Ramlal T & Klip A 1991 Diderential regulation ofthe GLUT-1 and GLUT-4 glucose transport systems by glucose and insulin and insulin in L6 muscle cells in culture. Journal of Biological Chemistry 266 2615-2621.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 2615-2621
    • Koivisto, U.1    Martinez-Valdez, H.2    Bilan, P.3    Burdett, E.4    Ramlal, T.5    Klip, A.6
  • 23
    • 0026609929 scopus 로고
    • Developmental regulation of the subcellular distribution and glycosylation of GLUT 1 and GLUT 4 glucose transporters during myogensis of L6 muscle cells
    • Mitsumoto Y & Klip A 1992 Developmental regulation of the subcellular distribution and glycosylation of GLUT 1 and GLUT 4 glucose transporters during myogensis of L6 muscle cells. Journal of Biological Chemistry 267 4957-4962.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 4957-4962
    • Mitsumoto, Y.1    Klip, A.2
  • 24
    • 0033005654 scopus 로고    scopus 로고
    • Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice
    • Muoio D, Dohm G, Tapscott E & Coleman R 1999 Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. American Journal of Physioligy 276 E913-E921.
    • (1999) American Journal of Physioligy , vol.276
    • Muoio, D.1    Dohm, G.2    Tapscott, E.3    Coleman, R.4
  • 25
    • 24144459843 scopus 로고    scopus 로고
    • Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin
    • Palanivel R & Sweeney G 2005 Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Letters 579 5049-5054.
    • (2005) FEBS Letters , vol.579 , pp. 5049-5054
    • Palanivel, R.1    Sweeney, G.2
  • 26
    • 34547823071 scopus 로고    scopus 로고
    • Evidence for the regulation of contraction-induced FA oxidation via ERK1/2 activation independent of changes in FA uptake
    • Raney MA & Turcotte LP 2007 Evidence for the regulation of contraction-induced FA oxidation via ERK1/2 activation independent of changes in FA uptake. Metabolism 56 1192-1200.
    • (2007) Metabolism , vol.56 , pp. 1192-1200
    • Raney, M.A.1    Turcotte, L.P.2
  • 29
    • 33745198007 scopus 로고    scopus 로고
    • Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport
    • Sajan M, Rivas J, Li F, Standaert M & Farese R 2006 Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport. Journal of Biological Chemistry 281 17466-17473.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 17466-17473
    • Sajan, M.1    Rivas, J.2    Li, F.3    Standaert, M.4    Farese, R.5
  • 30
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose and lipid metabolism
    • Salteil A & Kahn R 2001 Insulin signaling and the regulation of glucose and lipid metabolism. Nature 4 799-806.
    • (2001) Nature , vol.4 , pp. 799-806
    • Salteil, A.1    Kahn, R.2
  • 31
    • 0037862006 scopus 로고    scopus 로고
    • Unravelling the activation mechanisms of protein kinase B/Akt
    • Scheid M & Woodgert J 2003 Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Letters 546 108-112.
    • (2003) FEBS Letters , vol.546 , pp. 108-112
    • Scheid, M.1    Woodgert, J.2
  • 32
    • 0015067373 scopus 로고
    • Alterations of enzymatic activities during muscle differentiation in vitro
    • Shainberg A, Yagil G & Yaffe D 1971 Alterations of enzymatic activities during muscle differentiation in vitro. Developmental Biology 25 1-29.
    • (1971) Developmental Biology , vol.25 , pp. 1-29
    • Shainberg, A.1    Yagil, G.2    Yaffe, D.3
  • 35
    • 4744344777 scopus 로고    scopus 로고
    • Fatty acid-induced insulin resistance in L6 myombes is prevented by inhibition of activation and nuclear localization of nuclear factor B
    • Sinha S, Perdomo G, Brown N & O'Doherty R 2004 Fatty acid-induced insulin resistance in L6 myombes is prevented by inhibition of activation and nuclear localization of nuclear factor B. Journal of Biological Chemistry 279 41294-41301.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 41294-41301
    • Sinha, S.1    Perdomo, G.2    Brown, N.3    O'Doherty, R.4
  • 36
    • 0031906001 scopus 로고    scopus 로고
    • Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells
    • Somwar R, Sweeney G, Ramlal T & Klip A 1998 Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells. Clinical Therapeutics 20 125-141.
    • (1998) Clinical Therapeutics , vol.20 , pp. 125-141
    • Somwar, R.1    Sweeney, G.2    Ramlal, T.3    Klip, A.4
  • 37
  • 38
    • 0029122720 scopus 로고
    • Multiple toles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transport in L6 skeletal muscle cells
    • Tsakiridis T, McDowell H, Walker T, Downes P, Hundal H, Vranic M & Klip A 1995 Multiple toles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transport in L6 skeletal muscle cells. Endocrinology 136 4315-4322.
    • (1995) Endocrinology , vol.136 , pp. 4315-4322
    • Tsakiridis, T.1    McDowell, H.2    Walker, T.3    Downes, P.4    Hundal, H.5    Vranic, M.6    Klip, A.7
  • 40
    • 0032778746 scopus 로고    scopus 로고
    • Training-induced elevation in FABPpm is associated with increased palmitate use in contracting muscle
    • Turcotte LP, Swenberger J, Tucker M & Yee A 1999 Training-induced elevation in FABPpm is associated with increased palmitate use in contracting muscle. Journal of Applied Physiology 87 285-293.
    • (1999) Journal of Applied Physiology , vol.87 , pp. 285-293
    • Turcotte, L.P.1    Swenberger, J.2    Tucker, M.3    Yee, A.4
  • 44
    • 0034696951 scopus 로고    scopus 로고
    • Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C ς -dependent manner
    • Valverde A, Lorenzo M, Navarro P, Mur C & Benito M 2000 Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C ς -dependent manner. FEBS Letters 472 153-158.
    • (2000) FEBS Letters , vol.472 , pp. 153-158
    • Valverde, A.1    Lorenzo, M.2    Navarro, P.3    Mur, C.4    Benito, M.5
  • 45
    • 0036227755 scopus 로고    scopus 로고
    • Insulin-resistance, defective insulin receptor substrate 2-associated phophatidylinositol-3′ kinase activation, and impaired atypical protein kinase C (ς/λ) activation in myotubes from obese patients with impaired glucose tolerance
    • Vollenweilder P, Menard B & Nicod P 2002 Insulin-resistance, defective insulin receptor substrate 2-associated phophatidylinositol-3′ kinase activation, and impaired atypical protein kinase C (ς/λ) activation in myotubes from obese patients with impaired glucose tolerance. Diabetes 51 1052-1059.
    • (2002) Diabetes , vol.51 , pp. 1052-1059
    • Vollenweilder, P.1    Menard, B.2    Nicod, P.3
  • 46
    • 33745214270 scopus 로고    scopus 로고
    • Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes
    • Watt M, Steinberg G, Chen Z, Kemp B & Febbraio M 2006 Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. Journal of Physiology 1 139-147.
    • (2006) Journal of Physiology , vol.1 , pp. 139-147
    • Watt, M.1    Steinberg, G.2    Chen, Z.3    Kemp, B.4    Febbraio, M.5
  • 47
    • 0033666193 scopus 로고    scopus 로고
    • Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated
    • Winder W & Holmes B 2000 Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated. Journal of Applied Physiology 89 2430-2437.
    • (2000) Journal of Applied Physiology , vol.89 , pp. 2430-2437
    • Winder, W.1    Holmes, B.2
  • 48
    • 0026782061 scopus 로고
    • Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5′ AMPK-activated protein kinase
    • Witters L & Kemp B 1992 Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5′ AMPK-activated protein kinase. Journal of Biological Chemistry 267 2864-2867.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 2864-2867
    • Witters, L.1    Kemp, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.