High-throughput cytochrome P450 inhibition assays by ultrafast gradient liquid chromatography with tandem mass spectrometry using monolithic columns

Rapid Communications in Mass Spectrometry

Volumn 17, Issue 6, 2003, Pages 509-518

  Peng, Sean X ^a   Barbone, Arminda G ^a   Ritchie, David M ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

CYTOCHROMES P450; GENERIC METHOD; GRADIENT LIQUID CHROMATOGRAPHY; HIGH-THROUGHPUT; INHIBITION ASSAYS; LC-MS-MS; LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY (LCMS/MS); MONOLITHIC COLUMNS; ULTRA-FAST; ULTRA-FAST LIQUID CHROMATOGRAPHY;

SILICA;

CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; HYDROXYTOLBUTAMIDE; ISOENZYME; MIDAZOLAM; PARACETAMOL; PHENACETIN; PHENYTOIN DERIVATIVE; SILICON DIOXIDE; TESTOSTERONE; TESTOSTERONE DERIVATIVE; TOLBUTAMIDE;

ARTICLE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE; IC 50; LIQUID CHROMATOGRAPHY; REACTION ANALYSIS; REACTION TIME; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY;

EID: 0037232358     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.941     Document Type: Article

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