Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 780, Issue 2, 2002, Pages 371-379

  Zhang, Tianyi ^a   Zhu, Yongxin ^a   Gunaratna, Chandrani ^a  

^a BIOANALYTICAL SYSTEMS INC   (United States)

Author keywords

4 Hydroxymephenytoin; 4 Aminophenol; 4 Hydroxytolbutamide; 6 Hydroxytestosterone; Acetaminophen; Dextrorphan

Indexed keywords

BIOASSAY; BIOLOGICAL ORGANS; COST EFFECTIVENESS; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SUBSTRATES;

ELECTROSPRAY IONIZATION;

METABOLITES;

4 AMINOPHENOL; 4' HYDROXYMEPHENYTOIN; CYTOCHROME P450; DEXTRORPHAN; HYDROXYTOLBUTAMIDE; ISOENZYME; PARACETAMOL; TESTOSTERONE DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; INSTRUMENTATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLITE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; CALIBRATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; METHODOLOGY; QUALITY CONTROL; REPRODUCIBILITY;

CALIBRATION; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; MICROSOMES, LIVER; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY;

EID: 0037175449     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00548-2     Document Type: Article

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