Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance

Cancer Research

Volumn 68, Issue 15, 2008, Pages 6313-6323

  Parreño, Matilde ^a   Casanova, Isolda ^a   Céspedes, María Virtudes ^a   Vaqué, Jose Pedro ^b   Pavón, Miguel Angel ^a   Leon, Javier ^b   Mangues, Ramon ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2,4,6 TRIIODOPHENOL; 2,6 DIISOPROPYL 4 IODOPHENOL; 3 CHLORO 2,4,6 TRIIODOPHENOL; 4 PHENYL 2,6 DIIODOPHENOL; APOPTOSIS INDUCING FACTOR; CASPASE; CATHEPSIN; CATHEPSIN B; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHENOL DERIVATIVE; PHOSPHOLIPASE A2; PROSTAGLANDIN SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; BOBEL 24;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DOWN REGULATION; ENZYME RELEASE; HUMAN; HUMAN CELL; LYSOSOME; MITOCHONDRION; PANCREAS CANCER; PANCREAS CARCINOMA; PRIORITY JOURNAL; CELL CYCLE; CELL MEMBRANE POTENTIAL; DRUG EFFECT; FLUORESCENCE MICROSCOPY; METABOLISM; PANCREAS TUMOR; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

APOPTOSIS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; HUMANS; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; PANCREATIC NEOPLASMS; PHENOLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 51049095460     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-1054     Document Type: Article

References (34)

1. Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin 2005;55:10-30.
2. Schneider G, Siveke JT, Eckel F, Schmid RM. Pancreatic cancer: basic and clinical aspects. Gastroenterology 2005;128:1606-25.
3. Westphal S, Kalthoff H. Apoptosis: targets in pancreatic cancer. Mol Cancer 2003;2:6.
4. Friess H, Lu Z, Andren-Sandberg A, et al. Moderate activation of the apoptosis inhibitor bcl-xL worsens the prognosis in pancreatic cancer. Ann Surg 1998;228:780-7.
5. Schniewind B, Christgen M, Kurdow R, et al. Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis. Int J Cancer 2004;109:182-8.
6. Parreño M, Vaque JP, Casanova I, et al. Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc. Mol Cancer Ther 2006;5:1166-75.
7. Broker LE, Kruyt FA, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res 2005;11:3155-62.
8. Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441-6.
9. Lorenzo HK, Susin SA. Mitochondrial effectors in caspase-independent cell death. FEBS Lett 2004;557:14-20.
10. Hong SJ, Dawson TM, Dawson VL. Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol Sci 2004;25:259-64.
11. Yu SW, Wang H, Poitras MF, et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002;297:259-63.
12. Guicciardi ME, Leist M, Gores GJ. Lysosomes in cell death. Oncogene 2004;23:2881-90.
13. Zhao M, Antunes F, Eaton JW, Brunk UT. Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis. Eur J Biochem 2003;270:3778-86.
14. Farre L, Casanova I, Guerrero S, Trias M, Capella G, Mangues R. Heterotopic implantation alters the regulation of apoptosis and the cell cycle and generates a new metastatic site in a human pancreatic tumor xenograft model. FASEB J 2002;16:975-82.
15. Pavón MA, Parreño M, León X, et al. Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer. Int J Cancer 2008;123:1068-79.
16. Tarafa G, Villanueva A, Farre L, et al. DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination. Oncogene 2000;19:546-55.
17. Farré L. Effect of tumor localization on the biological behaviour and response to antitumor agents in human pancreatic carcinoma. Doctoral Dissertation. Barcelona: University of Barcelona; 2002.
18. Mangues R, Henriquez R, Jimeno J. Use of aplidine for the treatment of pancreatic cancer. World Intellectual Property Digital Library. Pub. WO 03/033013 A1, 2003; p. 1-31.
19. Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001;2:589-98.
20. Shinzawa K, Tsujimoto Y. PLA2 activity is required for nuclear shrinkage in caspase-independent cell death. J Cell Biol 2003;163:1219-30.
21. Jaattela M, Tschopp J. Caspase-independent cell death in T lymphocytes. Nat Immunol 2003;4:416-23.
22. Foghsgaard L, Lademann U, Wissing D, Poulsen B, Jaattela M. Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells. J Biol Chem 2002;277:39499-506.
23. Zhao M, Brunk UT, Eaton JW. Delayed oxidant-induced cell death involves activation of phospholipase A2. FEBS Lett 2001;509:399-404.
24. Antunes F, Cadenas E, Brunk UT. Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture. Biochem J 2001;356:549-55.
25. Yu SW, Andrabi SA, Wang H, et al. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A 2006;103:18314-9.
26. Penzo D, Petronilli V, Angelin A, et al. Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway. J Biol Chem 2004;279:25219-25.
27. Jaattela M. Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene 2004;23:2746-56.
28. Kroemer G, Jaattela M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005;5:886-97.
29. Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007;26:1749-60.
30. Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 2001;8:569-81.
31. Mathiasen IS, Jaattela M. Triggering caspase-independent cell death to combat cancer. Trends Mol Med 2002;8:212-20.
32. Reyes G, Villanueva A, Garcia C, et al. Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. Cancer Res 1996;56:5713-9.
33. Troconiz IF, Zsolt I, Garrido MJ, Valle M, Antonijoan RM, Barbanoj MJ. Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor. Pharm Res 2006;23:1533-42.
34. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.