Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice

Cancer Research

Volumn 56, Issue 24, 1996, Pages 5713-5719

  Reyes, Germán ^a   Villanueva, Alberto ^a   García, Carmen ^a   Sancho, Francisco J ^b   Piulats, Jaume ^c   Lluís, Fèlix ^b   Capellà, Gabriel ^a,b  

^a Institut de Recerca   (Spain)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^c Laboratori de Biomvestigació   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA; ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CANCER IMMUNOLOGY; GENE DELETION; GENE LOSS; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; METASTASIS; MOUSE; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; XENOGRAFT;

ADENOCARCINOMA; ANIMALS; CODON; GENES, P53; GENES, RAS; HUMANS; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; POINT MUTATION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0029774144     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Boring, C. C., Squires, T S., Tong, T , and Montgomery, S. Cancer statistics, 1994. CA Cancer J Clin., 44: 7-26, 1994.
2. Lillemoe, K D Current management of pancreatic carcinoma. Ann. Surg., 221: 133-148, 1995.
3. Hahn, S. A., Seymour, A. B , Shamsul Hoque A. T. M., Schutte, M., da Costa, L. T., Redston, M. S., Caldas, C , Weinstein, G. L., Fisher, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. Allelotype of pancreatic adenocarcinoma using xenograft enrichment Cancer Res , 55: 4670-4675, 1995.
4. Fidler, I J. Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis Cancer Metastasis Rev., 5: 29-49, 1986
5. Vezeridis, M. P , Doremus, C M , Tibbetts, L. M., Tzanakakis, G., and Jackson, B. T Invasion and metastasis following orthotopic transplantation of human pancreatic cancer in the nude mouse J. Surg. Oncol., 40: 261-265, 1989
6. Manncola, F. M., Drucker, B. J , Siao, B. Y , Hough, K L , and Holder, W. D. The nude mouse as a model for the study of human pancreatic cancer. J Surg. Res., 47: 520-529, 1989.
7. Tan, M. H , and Chu, T. M. Characterization of the tumorigenic and metastatic properties of a human pancreatic tumor cell line (AsPc-1) implanted orthotopically into nude mice Tumor Biol, 6 89-98, 1985.
8. Fu, X., Guadagni, F., and Hoffman, R M A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens. Proc. Natl Acad. Sci. USA. 89: 5645-5649, 1992
9. Scarpa, A., Capelli, P., Villanueva, A., Zamboni, G., Lluís, F., Accolla, R , Mariuzzi, G., and Capellá, G. Pancreatic cancer in Europe Ki-ras gene mutation pattern shows geographical differences Int. J Cancer, 57: 167-171, 1994.
10. Capellá, G., Villanueva, A., Erill, N., and Lluís, F. Molecular epidemiology of protooncogene and tumour-suppressor gene mutations. In: J P. Neoptolemos and N. R. Lemoine (eds.), Pancreatic Cancer: Molecular and Clinical Advances, pp. 169-180. Oxford, United Kingdom: Blackwell Science, 1996.
11. Berrozpe, G., Schaeffer, J , Peinado, M. A , Real, F. X , and Perucho, M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int. J. Cancer, 58: 185-191, 1994.
12. Scarpa, A., Capelli, P., Mukai, K., Zamboni, G , Oda, T , Iacono, C , and Hirohashi, S Pancreatic carcinomas frequently show p53 gene mutations Am J Pathol, 142: 1534-1543, 1993.
13. Redston, M. S., Caldas, C , Seymour, A. B , Hruban, R H , da Costa, L. T., Yeo, C. J., and Kern, S E. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions Cancer Res., 54: 3025-3033, 1994.
14. Caldas, C., Hahn, S. A , da Costa, L. T., Redson, M. S . Schutte, M., Seymour, A. B., Weinstein, C L , Hruban, R. H , Yeo, C. J , and Kern, S. E. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat. Genet., 8, 27-32, 1994.
15. Hahn, S. A., Schutte, M., Shamsul Hoque A. T. M., Moskaluk, C. A., da Costa, L. T., Rozemblum, E., Weinstein, C. L., Fisher, A , Yeo, C. J., Hruban, R. H., and Kern, S. A. DPC4, a candidate tumor suppressor gene at human chromosome 18q21 1. Science (Washington DC), 271: 350-353, 1996.
16. Villanueva, A., Reyes, G., Cuatrecasas, M , Martínez, A., Erill, N., Lerma, E., Farré, A., Lluís F., and Capellá, G Diagnostic utility of K-ras mutations in fine needle aspirates of pancreatic masses Gastroenterology, 110: 1587-1594, 1996.
17. Morl, M., and Schmelzer, C. A simple method for isolation of intact RNA from dried polyacrylamjde gels. Nucleic Acids Res., 21: 2016, 1993.
18. Kirchweger, R., Zeillinger, R., Schneeberger, C., Speiser, P., Louason, G., and Theillet, G. Patterns of allele losses suggest the existence of five distinct regions of LOH on chromosome 17 in breast cancer Int. J. Cancer, 56: 193-199, 1994.
19. Matias-Guiu, X., Cuatrecasas, M., Musulen, E. and Prat, J. p53 expression in anaplastic carcinomas arising from thyroid papillary carcinomas. J. Clin. Pathol., 47: 337-339, 1994
20. Jen, J., Harper, J W , Bigner, S. H , Bigner, D. D., Papadopoulus, N., Markowitz, S., Willson, J. K., Kinzler, K. W., and Vogelstein, B. Deletion of p16 and p15 genes in brain tumors. Cancer Res., 54 6353-6358, 1994.
21. Brenner, A., and Aldaz, C. Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells. Cancer Res., 55: 2892-2895, 1995.
22. Groden, J , Thliveris, A., Samowitz, W , Carlson, M , Gelbert, L., Albertsen, H., Joslyn, G., Stevens, J., Spirio, L., Robertson, M., Sargeant, L , Krapcho, K., Wolff, E , Burt, R., Hughes, J. P , Warrington, J., McPherson, J., Wasmuth, J., Lepaslier, D., Abderrahim, H., Cohen, D., Leppert, M., and White, R. Identification and characterization of the familial adenomatous polyposis coli gene Cell, 66: 589-600, 1991.
23. Parry, P. J., Markie, D., Fearon, E. R., Nigro, J. M , Vogelstein, B , and Bodmer, W F PCR-based detection of two MspI polymorphic sites at D18S8. Nucleic Acids Res., 19: 6983, 1991.
24. Greenwald, B. D., Harpaz, N., Ying, J., Huang, Y., Tong, Y., Brown, V. L., McDaniel, T., Newkirk, C , Resau, J. H., and Meltzer, S J Loss of heterozygosity affecting the p53. Rb. and MCC/APC tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis. Cancer Res., 52: 741-745, 1992
25. Huang, L., Goodrow, T. L , Zhang, S. Y., Klein-Szanto, A J P., Chang, H., and Ruggeri, B. A. Deletion and mutation analysis of the p16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-detived cell lines than in primary ductal adenocarcinomas. Cancer Res., 56: 1137-1141, 1996
26. Villanueva, A., Reyes, G , Erill, N., García, C., Farré, A., Lluís, F., and Capellá, G. Multiple genetic alterations in human carcinoma of the exocrine pancreas. Digestion, 56: A328, 1995.
27. Graeber, T. G., Osmanian, C., Jacks, T , Housman, D. E . Koch, C J., Lowe, S. W., and Giaccia, A. J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (Lond.), 379: 88-91, 1996.
28. Horii, A , Nakatsuru, S , Miyoshi, Y , Ichii, S., Nagase, H., Ando, H., Yanagisawa, A , Tsuchiya, E , Kato, Y., and Nakamura, Y. Frequent somatic mutations of the APC gene in human pancreatic cancer Cancer Res , 52: 6696-6698, 1992.
29. Seymour, A. B , Hruban, R. H., Redston, M., Caldas, C. Powell, S M , Kinzler, K. W , Yeo, C. J., and Kern, S. E. Allelotype of pancreatic adenocarcinoma. Cancer Res, 54: 2761-2764. 1994
30. McKie, A. B , Filipe, M. I., and Lemoine, N R. Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer. Int. J Cancer, 55, 598-603, 1993
31. Kayahara, M , Nagakawa, T , Konishi, I , Ueno, K , Ohta, T , and Miyazaki, I. Clinicopathological study of pancreatic carcinoma with particular reference to the invasion of the extrapancreatic neural plexus. Int J. Pancreatol., 10: 105-111, 1991.
32. Nagakawa, T., Kobayashi, H , Ueno, K., Ohta, T., Kayahara, M., Mori, K., Nakano, T , Takeda, T , Konishi, I., and Miyazaki, I., The pattern of lymph node involvement in carcinoma of the head of the pancreas A histological study of the surgical findings in patients undergoing extensive nodal dissections. Int. J Pancreatol, 13: 15-22, 1993.
33. Cho, K R., Oliner, J D , Simons, I. W., Hednck, L., Fearon, E. R , Preisinger, A. C., Hedge, P., Silverman, G. A , and Vogelstein, B The DCC gene: structural analysis and mutations in colorectal carcinomas. Genomics, 19: 525-531, 1994.
34. Shibata, D., Capellá, G., and Perucho, M Mutational activation of the c-K-ras gene in human pancreatic carcinoma. Ballière's Clin Gastroenterol., 4: 151-169, 1990.
35. Hofmann, M., Rudy, W , Gùnthert, U., Zimmer, S G., Zawadzki, V , Zoller, M , Lichtner R. B , Herrlich, P., and Ponta, H. A link between ras and metastatic behaviour of tumor cells, ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells. Cancer Res . 53: 1516-1521, 1993
36. Cannistra, S A., Kansas, G. S , Niloff, J., DeFranzo, B., Kim, Y., and Ottensmeier, C Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H. Cancer Res , 53: 3830-3838, 1993.
37. Potmesil, M., Vardeman, D., Kozielski, A. J. Mendoza, J., Stehlin, J S., and Giovanella, B C. Growth inhibition of human cancer metastases by camptothecins in newly developed xenograft models. Cancer Res., 55: 5637-5641, 1995.