Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde

International Immunopharmacology

Volumn 8, Issue 8, 2008, Pages 1112-1118

  Duryee, Michael J ^a,b   Klassen, Lynell W ^a,b   Jones, Bonnie L ^a,b   Willis, Monte S ^d   Tuma, Dean J ^a,b   Thiele, Geoffrey M ^a,b,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b VA Alcohol Research Center   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Aldehyde adducts; DBA 2 mice; P815 mastocytoma; Tumor immunology

Indexed keywords

ACETALDEHYDE; EPITOPE; MALONALDEHYDE;

ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CANCER GRAFT; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOGENICITY; IMMUNOPATHOGENESIS; LYMPHOCYTE PROLIFERATION; MASTOCYTOMA; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR CELL CULTURE; TUMOR IMMUNOLOGY;

ACETALDEHYDE; ANIMALS; ANTIBODIES, NEOPLASM; CELL LINE, TUMOR; IMMUNIZATION; INTERLEUKIN-12; MACROPHAGES, PERITONEAL; MALONDIALDEHYDE; MASTOCYTOMA; MICE; MICE, INBRED DBA; NEOPLASM TRANSPLANTATION;

EID: 50949129855     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.03.022     Document Type: Article

References (41)

1. Cook R.T. Alcohol abuse, alcoholism, and damage to the immune system-a review. Alcohol Clin Exp Res 22 9 (1998) 1927-1942
2. Deviere J. Immune mechanisms in alcoholic liver disease. Acta Gastro-Enterol Belg 55 5-6 (1992) 450-456
3. Duryee M.J., Willis M.S., Freeman T.L., Kuszynski C.A., Tuma D.J., Klassen L.W., et al. Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity. Front Biosci 9 (2004) 3145-3155
4. Paronetto F. Immunologic reactions in alcoholic liver disease. Semin Liver Dis 13 2 (1993) 183-195
5. Thiele G.M., Freeman T.L., and Klassen L.W. Immunologic mechanisms of alcoholic liver injury. Semin Liver Dis 24 3 (2004) 273-287
6. Si L., Whiteside T.L., Schade R.R., and Van Thiel D. Lymphocyte subsets studied with monoclonal antibodies in liver tissues of patients with alcoholic liver disease. Alcohol Clin Exp Res 7 4 (1983) 431-435
7. Si L., Whiteside T.L., Van Thiel D.H., and Rabin B.S. Lymphocyte subpopulations at the site of "piecemeal" necrosis in end stage chronic liver diseases and rejecting liver allografts in cyclosporine-treated patients. Lab Invest 50 3 (1984) 341-347
8. Poralla T., Hutteroth T.H., and Meyer zum Buschenfelde K.H. Cellular cytotoxicity against autologous hepatocytes in alcoholic liver disease. Liver 4 2 (1984) 117-121
9. Izumi N., Hasumura Y., and Takeuchi J. Lymphocyte cytotoxicity for autologous human hepatocytes in alcoholic liver disease. Clin Exp Immunol 54 1 (1983) 219-224
10. Cochrane A.M., Moussouros A., Portmann B., McFarlane I.G., Thomson A.D., Eddleston, et al. Lymphocyte cytotoxicity for isolated hepatocytes in alcoholic liver disease. Gastroenterology 72 5 Pt 1 (1977) 918-923
11. Lytton S.D., Helander A., Zhang-Gouillon Z.Q., Stokkeland K., Bordone R., Arico S., et al. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Mol Pharmacol 55 2 (1999) 223-233
12. Ma Y., Meregalli M., Hodges S., Davies N., Bogdanos D.P., Fargion S., et al. Alcohol dehydrogenase: an autoantibody target in patients with alcoholic liver disease. Int J Immunopathol Pharmacol 18 1 (2005) 173-182
13. Niemela O. Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury. Free Radic Biol Med 31 12 (2001) 1533-1538
14. Niemela O., Parkkila S., Pasanen M., Iimuro Y., Bradford B., and Thurman R.G. Early alcoholic liver injury: formation of protein adducts with acetaldehyde and lipid peroxidation products, and expression of CYP2E1 and CYP3A. Alcohol Clin Exp Res 22 9 (1998) 2118-2124
15. Paradis V., Scoazec J.Y., Kollinger M., Holstege A., Moreau A., Feldmann G., et al. Cellular and subcellular localization of acetaldehyde-protein adducts in liver biopsies from alcoholic patients. J Histochem Cytochem 44 9 (1996) 1051-1057
16. Rolla R., Vay D., Mottaran E., Parodi M., Traverso N., Arico S., et al. Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease. Hepatology 31 4 (2000) 878-884
17. Viitala K., Makkonen K., Israel Y., Lehtimaki T., Jaakkola O., Koivula T., et al. Autoimmune responses against oxidant stress and acetaldehyde-derived epitopes in human alcohol consumers. Alcohol Clin Exp Res 24 7 (2000) 1103-1109
18. Tuma D.J., Thiele G.M., Xu D., Klassen L.W., and Sorrell M.F. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration. Hepatology 23 4 (1996) 872-880
19. McFarlane I.G., Wojcicka B.M., and Williams R. Antigens of the human liver. Clin Exp Immunol 40 1 (1980) 1-7
20. Behrens U.J., Vernace S., and Paronetto F. Studies on "liver-specific" antigens. II. Detection of serum antibodies to liver and kidney cell membrane antigens in patients with chronic liver disease. Gastroenterology 77 5 (1979) 1053-1061
21. Manns M., Meyer zum Buschenfelde K.H., and Hess G. Autoantibodies against liver-specific membrane lipoprotein in acute and chronic liver diseases: studies on organ-, species-, and disease-specificity. Gut 21 11 (1980) 955-961
22. Perperas A., Tsantoulas D., Portmann B., Eddleston A.L., and Williams R. Autoimmunity to a liver membrane lipoprotein and liver damage in alcoholic liver disease. Gut 22 2 (1981) 149-152
23. Clot P., Parola M., Bellomo G., Dianzani U., Carini R., Tabone M., et al. Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. Gastroenterology 113 1 (1997) 265-276
24. Loeper J., Descatoire V., Maurice M., Beaune P., Feldmann G., Larrey D., et al. Presence of functional cytochrome P-450 on isolated rat hepatocyte plasma membrane. Hepatology 11 5 (1990) 850-858
25. Loeper J., Descatoire V., Maurice M., Beaune P., Belghiti J., Houssin D., et al. Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. Gastroenterology 104 1 (1993) 203-216
26. Wu D., and Cederbaum A.I. Presence of functionally active cytochrome P-450 IIE1 in the plasma membrane of rat hepatocytes. Hepatology 15 3 (1992) 515-524
27. Clot P., Bellomo G., Tabone M., Arico S., and Albano E. Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis. Gastroenterology 108 1 (1995) 201-207
28. Terabayashi H., and Kolber M.A. The generation of cytotoxic T lymphocytes against acetaldehyde-modified syngeneic cells. Alcohol Clin Exp Res 14 6 (1990) 893-899
29. Willis M.S., Thiele G.M., Tuma D.J., and Klassen L.W. T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated. Int Immunopharmacol 3 10-11 (2003) 1381-1399
30. Thiele G.M., Tuma D.J., Willis M.S., Miller J.A., McDonald T.L., Sorrell M.F., et al. Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant. Alcohol Clin Exp Res 22 8 (1998) 1731-1739
31. Kikugawa K., Kosugi H., and Asakura T. Effect of malondialdehyde, a product of lipid peroxidation, on the function and stability of hemoglobin. Arch Biochem Biophys 229 1 (1984) 7-14
32. Xu D., Thiele G.M., Kearley M.L., Haugen M.D., Klassen L.W., Sorrell M.F., et al. Epitope characterization of malondialdehyde-acetaldehyde adducts using an enzyme-linked immunosorbent assay. Chem Res Toxicol 10 9 (1997) 978-986
33. Edelson P.J., Zwiebel R., and Cohn Z.A. The pinocytic rate of activated macrophages. J Exp Med 142 5 (1975) 1150-1164
34. Kamate C., Baloul S., Grootenboer S., Pessis E., Chevrot A., Tulliez M., et al. Inflammation and cancer, the mastocytoma P815 tumor model revisited: triggering of macrophage activation in vivo with pro-tumorigenic consequences. Int J Cancer 100 5 (2002) 571-579
35. Knisely T.L., Luckenbach M.W., Fischer B.J., and Niederkorn J.Y. Destructive and nondestructive patterns of immune rejection of syngeneic intraocular tumors. J Immunol 138 12 (1987) 4515-4523
36. Langrish C.L., McKenzie B.S., Wilson N.J., de Waal Malefyt R., Kastelein R.A., and Cua D.J. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 202 (2004) 96-105
37. Colombo M.P., and Trinchieri G. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev 13 2 (2002) 155-168
38. Duryee M.J., Freeman T.L., Willis M.S., Hunter C.D., Hamilton III B.C., Suzuki H., et al. Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins. Mol Pharmacol 68 5 (2005) 1423-1430
39. Duryee M.J., Klassen L.W., Freeman T.L., Willis M.S., Tuma D.J., and Thiele G.M. Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells. Alcohol Clin Exp Res 28 12 (2004) 1931-1938
40. Xu D., Thiele G.M., Beckenhauer J.L., Klassen L.W., Sorrell M.F., and Tuma D.J. Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats. Gastroenterology 115 3 (1998) 686-692
41. Thiele G.M., Klassen L.W., Tuma D.J., and Willis M.S. The increased binding of MAA (malondialdehyde-acetaldehyde) adducted protein to scavenger receptors and the up-regulation of B7 may play a role in immunogenicity. Hepatology 30 4 (1999) 328A-328A