-
1
-
-
0028858706
-
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N′-bis(2-chloroethyl)-N-nitrosourea
-
Pegg, A. E., Swenn, K., Chae, M. Y., Dolan, M. E. and Moschel, R. C. (1995) Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N′-bis(2-chloroethyl)-N-nitrosourea. Biochem. Pharmacol., 50, 1141-1148.
-
(1995)
Biochem. Pharmacol
, vol.50
, pp. 1141-1148
-
-
Pegg, A.E.1
Swenn, K.2
Chae, M.Y.3
Dolan, M.E.4
Moschel, R.C.5
-
2
-
-
0031589755
-
Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: Facts and models
-
Kaina, B., Ziouta, A., Ochs, K. and Coquerelle, T. (1997) Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models. Mutat. Res., 381, 227-241.
-
(1997)
Mutat. Res
, vol.381
, pp. 227-241
-
-
Kaina, B.1
Ziouta, A.2
Ochs, K.3
Coquerelle, T.4
-
3
-
-
0019965339
-
Induction and expression of mutations in mammalian cells in the absence of DNA synthesis and cell division
-
O'Neill, J. P. (1982) Induction and expression of mutations in mammalian cells in the absence of DNA synthesis and cell division. Mutat. Res., 106, 113-122.
-
(1982)
Mutat. Res
, vol.106
, pp. 113-122
-
-
O'Neill, J.P.1
-
4
-
-
0020546008
-
Correlation between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells
-
Beranek, D. T., Heflich, R. H., Kodell, R. L., Morris, S. M. and Casciano, D. A. (1983) Correlation between specific DNA-methylation products and mutation induction at the HGPRT locus in Chinese hamster ovary cells. Mutat. Res., 110, 171-180.
-
(1983)
Mutat. Res
, vol.110
, pp. 171-180
-
-
Beranek, D.T.1
Heflich, R.H.2
Kodell, R.L.3
Morris, S.M.4
Casciano, D.A.5
-
5
-
-
0019984275
-
Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents
-
Heflich, R. H., Beranek, D. T., Kodell, R. L. and Morris, S. M. (1982) Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents. Mutat. Res., 106, 147-161.
-
(1982)
Mutat. Res
, vol.106
, pp. 147-161
-
-
Heflich, R.H.1
Beranek, D.T.2
Kodell, R.L.3
Morris, S.M.4
-
6
-
-
0032552632
-
Transgenic systems in studies on genotoxicity of alkylating agents: Critical lesions, thresholds and defense mechanisms
-
Kaina, B., Fritz, G., Ochs, K. et al. (1998) Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms. Mutat. Res., 405, 179-191.
-
(1998)
Mutat. Res
, vol.405
, pp. 179-191
-
-
Kaina, B.1
Fritz, G.2
Ochs, K.3
-
7
-
-
0027337480
-
O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis
-
Nakatsuru, Y., Matsukuma, S., Nemoto, N., Sugano, H., Sekiguchi, M. and Ishikawa, T. (1993) O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. Proc. Natl Acad. Sci. USA, 90, 6468-6472.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 6468-6472
-
-
Nakatsuru, Y.1
Matsukuma, S.2
Nemoto, N.3
Sugano, H.4
Sekiguchi, M.5
Ishikawa, T.6
-
8
-
-
0027473747
-
The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase
-
Dumenco, L. L., Allay, E., Norton, K. and Gerson, S. L. (1993) The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase. Science, 259, 219-222.
-
(1993)
Science
, vol.259
, pp. 219-222
-
-
Dumenco, L.L.1
Allay, E.2
Norton, K.3
Gerson, S.L.4
-
9
-
-
0030749230
-
The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea
-
Becker, K., Gregel, C. M. and Kaina, B. (1997) The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea. Cancer Res., 57, 3335-3338.
-
(1997)
Cancer Res
, vol.57
, pp. 3335-3338
-
-
Becker, K.1
Gregel, C.M.2
Kaina, B.3
-
10
-
-
0032892044
-
DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents
-
Glassner, B. J., Weeda, G., Allan, J. M. et al. (1999) DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents. Mutagenesis, 14, 339-347.
-
(1999)
Mutagenesis
, vol.14
, pp. 339-347
-
-
Glassner, B.J.1
Weeda, G.2
Allan, J.M.3
-
11
-
-
8944258921
-
Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent
-
Tsuzuki, T., Sakumi, K., Shiraishi, A. et al. (1996) Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent. Carcinogenesis, 17, 1215-1220.
-
(1996)
Carcinogenesis
, vol.17
, pp. 1215-1220
-
-
Tsuzuki, T.1
Sakumi, K.2
Shiraishi, A.3
-
12
-
-
0031427721
-
High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase
-
Iwakuma, T., Sakumi, K., Nakatsuru, Y., Kawate, H., Igarashi, H., Shiraishi, A., Tsuzuki, T., Ishikawa, T. and Sekiguchi, M. (1997) High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase. Carcinogenesis, 18, 1631-1635.
-
(1997)
Carcinogenesis
, vol.18
, pp. 1631-1635
-
-
Iwakuma, T.1
Sakumi, K.2
Nakatsuru, Y.3
Kawate, H.4
Igarashi, H.5
Shiraishi, A.6
Tsuzuki, T.7
Ishikawa, T.8
Sekiguchi, M.9
-
13
-
-
0019759328
-
Pharmacology of cyclophosphamide and metabolites
-
Colvin, M. and Hilton, J. (1981) Pharmacology of cyclophosphamide and metabolites. Cancer Treat. Rep., 65 (suppl. 3), 89-95.
-
(1981)
Cancer Treat. Rep
, vol.65
, Issue.SUPPL. 3
, pp. 89-95
-
-
Colvin, M.1
Hilton, J.2
-
14
-
-
0033153762
-
Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity
-
Cai, Y., Wu, M. H., Ludeman, S. M., Grdina, D. J. and Dolan, M. E. (1999) Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity. Cancer Res., 59, 3059-3063.
-
(1999)
Cancer Res
, vol.59
, pp. 3059-3063
-
-
Cai, Y.1
Wu, M.H.2
Ludeman, S.M.3
Grdina, D.J.4
Dolan, M.E.5
-
15
-
-
0032962702
-
Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase
-
Friedman, H. S., Pegg, A. E., Johnson, S. P. et al. (1999) Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. Cancer Chemother. Pharmacol., 43, 80-85.
-
(1999)
Cancer Chemother. Pharmacol
, vol.43
, pp. 80-85
-
-
Friedman, H.S.1
Pegg, A.E.2
Johnson, S.P.3
-
16
-
-
0026611465
-
Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bonemarrowtransplantation
-
Lee, S. M., Crowther, D., Scarffe, J. H., Dougal, M., Elder, R. H., Rafferty, J. A. and Margison, G. P. (1992) Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bonemarrowtransplantation. Br. J. Cancer, 66, 331-336.
-
(1992)
Br. J. Cancer
, vol.66
, pp. 331-336
-
-
Lee, S.M.1
Crowther, D.2
Scarffe, J.H.3
Dougal, M.4
Elder, R.H.5
Rafferty, J.A.6
Margison, G.P.7
-
17
-
-
0028177572
-
O6-methylguanine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy
-
Chen, S. S., Citron, M., Spiegel, G. and Yarosh, D. (1994) O6-methylguanine-DNA methyltransferase in ovarian malignancy and its correlation with postoperative response to chemotherapy. Gynecol. Oncol., 52, 172-174.
-
(1994)
Gynecol. Oncol
, vol.52
, pp. 172-174
-
-
Chen, S.S.1
Citron, M.2
Spiegel, G.3
Yarosh, D.4
-
18
-
-
0031128016
-
Expression of genes of potential importance in the response to chemotherapy and DNA repair in patients with ovarian cancer
-
Codegoni, A. M., Broggini, M., Pitelli, M. R., Pantarotto, M., Torri, V., Mangioni, C. and D'Incalci, M. (1997) Expression of genes of potential importance in the response to chemotherapy and DNA repair in patients with ovarian cancer. Gynecol. Oncol., 65, 130-137.
-
(1997)
Gynecol. Oncol
, vol.65
, pp. 130-137
-
-
Codegoni, A.M.1
Broggini, M.2
Pitelli, M.R.3
Pantarotto, M.4
Torri, V.5
Mangioni, C.6
D'Incalci, M.7
-
19
-
-
0031594831
-
O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts
-
Mattern, J., Eichhorn, U., Kaina, B. and Volm, M. (1998) O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts. Int. J. Cancer, 77, 919-922.
-
(1998)
Int. J. Cancer
, vol.77
, pp. 919-922
-
-
Mattern, J.1
Eichhorn, U.2
Kaina, B.3
Volm, M.4
-
20
-
-
0033782928
-
Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase
-
Shiraishi, A., Sakumi, K. and Sekiguchi, M. (2000) Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase. Carcinogenesis, 21, 1879-1883.
-
(2000)
Carcinogenesis
, vol.21
, pp. 1879-1883
-
-
Shiraishi, A.1
Sakumi, K.2
Sekiguchi, M.3
-
21
-
-
0033153116
-
Myeloid malignancies induced by alkylating agents in Nf1 mice
-
Mahgoub, N., Taylor, B. R., Le Beau, M. M., Gratiot, M., Carlson, K. M., Atwater, S. K., Jacks, T. and Shannon, K. M. (1999) Myeloid malignancies induced by alkylating agents in Nf1 mice. Blood, 93, 3617-3623.
-
(1999)
Blood
, vol.93
, pp. 3617-3623
-
-
Mahgoub, N.1
Taylor, B.R.2
Le Beau, M.M.3
Gratiot, M.4
Carlson, K.M.5
Atwater, S.K.6
Jacks, T.7
Shannon, K.M.8
-
22
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
Boguski, M. S. and McCormick, F. (1993) Proteins regulating Ras and its relatives. Nature, 366, 643-654.
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
23
-
-
0028307836
-
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
-
Jacks, T., Shih, T. S., Schmitt, E. M., Bronson, R. T., Bernards, A. and Weinberg, R. A. (1994) Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat. Genet., 7, 353-361.
-
(1994)
Nat. Genet
, vol.7
, pp. 353-361
-
-
Jacks, T.1
Shih, T.S.2
Schmitt, E.M.3
Bronson, R.T.4
Bernards, A.5
Weinberg, R.A.6
-
24
-
-
27744592647
-
Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities
-
Hansen, R. J., Nagasubramanian, R., Delaney, S. M., Cherian, M. M., Lin, S., Kogan, S. C. and Dolan, M. E. (2005) Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities. J. Pharmacol. Exp. Ther., 315, 1247-1255.
-
(2005)
J. Pharmacol. Exp. Ther
, vol.315
, pp. 1247-1255
-
-
Hansen, R.J.1
Nagasubramanian, R.2
Delaney, S.M.3
Cherian, M.M.4
Lin, S.5
Kogan, S.C.6
Dolan, M.E.7
-
25
-
-
26644470352
-
Therapy-induced malignant neoplasms in Nf1 mutant mice
-
Chao, R. C., Pyzel, U., Fridlyand, J. et al. (2005) Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell, 8, 337-348.
-
(2005)
Cancer Cell
, vol.8
, pp. 337-348
-
-
Chao, R.C.1
Pyzel, U.2
Fridlyand, J.3
-
26
-
-
34447096146
-
Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice
-
Hansen, R. J., Nagasubramanian, R., Delaney, S. M., Samson, L. D. and Dolan, M. E. (2007) Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice. Carcinogenesis, 28, 1111-1116.
-
(2007)
Carcinogenesis
, vol.28
, pp. 1111-1116
-
-
Hansen, R.J.1
Nagasubramanian, R.2
Delaney, S.M.3
Samson, L.D.4
Dolan, M.E.5
-
27
-
-
24044439134
-
Epigenetic changes and their clinical relevance in Saudi diffuse large B-cell lymphoma. A molecular and tissue microarray analysis of 100 cases
-
Al-Kuraya, K. S., Siraj, A. K., Al-Dayel, F. A., Ezzat, A. A., Al-Jommah, N. A., Atizado, V. L. and Narayanappa, R. N. (2005) Epigenetic changes and their clinical relevance in Saudi diffuse large B-cell lymphoma. A molecular and tissue microarray analysis of 100 cases. Saudi Med. J., 26, 1099-1103.
-
(2005)
Saudi Med. J
, vol.26
, pp. 1099-1103
-
-
Al-Kuraya, K.S.1
Siraj, A.K.2
Al-Dayel, F.A.3
Ezzat, A.A.4
Al-Jommah, N.A.5
Atizado, V.L.6
Narayanappa, R.N.7
-
28
-
-
0037005988
-
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
-
Esteller, M., Gaidano, G., Goodman, S. N. et al. (2002) Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. J. Natl Cancer Inst., 94, 26-32.
-
(2002)
J. Natl Cancer Inst
, vol.94
, pp. 26-32
-
-
Esteller, M.1
Gaidano, G.2
Goodman, S.N.3
-
29
-
-
33744479180
-
Loss of O6-methylguanine-DNA methyltransferase protein expression is a favorable prognostic marker in diffuse large B-cell lymphoma
-
Ohno, T., Hiraga, J., Ohashi, H. et al. (2006) Loss of O6-methylguanine-DNA methyltransferase protein expression is a favorable prognostic marker in diffuse large B-cell lymphoma. Int. J. Hematol., 83, 341-347.
-
(2006)
Int. J. Hematol
, vol.83
, pp. 341-347
-
-
Ohno, T.1
Hiraga, J.2
Ohashi, H.3
-
30
-
-
0036834864
-
O(6)-methylguanine-DNA methyl transferase gene expression and prognosis in breast carcinoma
-
Cayre, A., Penault-Llorca, F., De Latour, M., Rolhion, C., Feillel, V., Ferriere, J. P., Kwiatkowski, F., Finat-Duclos, F. and Verrelle, P. (2002) O(6)-methylguanine-DNA methyl transferase gene expression and prognosis in breast carcinoma. Int. J. Oncol., 21, 1125-1131.
-
(2002)
Int. J. Oncol
, vol.21
, pp. 1125-1131
-
-
Cayre, A.1
Penault-Llorca, F.2
De Latour, M.3
Rolhion, C.4
Feillel, V.5
Ferriere, J.P.6
Kwiatkowski, F.7
Finat-Duclos, F.8
Verrelle, P.9
-
31
-
-
0028807377
-
Ras-related proteins in signal transduction and growth control
-
McCormick, F. (1995) Ras-related proteins in signal transduction and growth control. Mol. Reprod. Dev., 42, 500-506.
-
(1995)
Mol. Reprod. Dev
, vol.42
, pp. 500-506
-
-
McCormick, F.1
-
32
-
-
0025924488
-
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents
-
Dolan, M. E., Mitchell, R. B., Mummert, C., Moschel, R. C. and Pegg, A. E. (1991) Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res., 51, 3367-3372.
-
(1991)
Cancer Res
, vol.51
, pp. 3367-3372
-
-
Dolan, M.E.1
Mitchell, R.B.2
Mummert, C.3
Moschel, R.C.4
Pegg, A.E.5
-
33
-
-
0025571828
-
Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
-
Dolan, M. E., Stine, L., Mitchell, R. B., Moschel, R. C. and Pegg, A. E. (1990) Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. Cancer Commun., 2, 371-377.
-
(1990)
Cancer Commun
, vol.2
, pp. 371-377
-
-
Dolan, M.E.1
Stine, L.2
Mitchell, R.B.3
Moschel, R.C.4
Pegg, A.E.5
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