B cells limit epitope spreading and reduce severity of EAE induced with PLP peptide in BALB/c mice

Journal of Autoimmunity

Volumn 31, Issue 2, 2008, Pages 149-155

  Lyons, Jeri Anne ^a   Ramsbottom, Michael J ^a   Mikesell, Robert J ^a   Cross, Anne H ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Antibody; B cells; Epitope spreading; Experimental autoimmune encephalomyelitis; Proteolipid protein

Indexed keywords

EPITOPE; GAMMA INTERFERON; PROTEOLIPID PROTEIN;

ACUTE DISEASE; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; CENTRAL NERVOUS SYSTEM; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; LYMPHOID CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPLEEN CELL; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MYELIN PROTEOLIPID PROTEIN; PEPTIDES; SEVERITY OF ILLNESS INDEX;

EID: 50849117484     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2008.04.025     Document Type: Article

References (52)

1. Prineas J.W., and Raine C.S. Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions. Neurology 26 (1976) 29-32
2. Prineas J.W., and Wright R.G. Macrophages lymphocytes and plasma cells in the perivascular compartment in chronic multiple sclerosis. J Exp Med 38 (1978) 409-421
3. Avasarala J.R., Cross A.H., and Trotter J.L. Oligoclonal band number as a marker for prognosis in multiple sclerosis. Arch Neurol 58 (2001) 2044-2045
4. Olsson J.E., and Link H. Immunoglobulin abnormalities in multiple sclerosis: relation to clinical parameters: exacerbations and remission. Arch Neurol 28 (1973) 392-399
5. Zeman A.Z.J., Kidd D., McLean B.N., Kelly M.A., Francis D.A., Miller D.H., et al. A study of oligoclonal band negative multiple sclerosis. J Neurol Neurosurg Psychiatry 60 (1996) 27-30
6. Genain C.P., Cannella B., Hauser S.L., and Raine C.S. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 5 (1999) 170-175
7. Raine C.S., Cannella B., Hauser S.L., and Genain C.P. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation. Ann Neurol 46 (1999) 144-160
8. Gausas J., Paterson P.Y., Day E.D., and Dal Canto M.C. Intact B-cell activity is essential for complete expression of experimental allergic encephalomyelitis in Lewis rats. Cell Immunol 72 (1982) 360-366
9. Willenborg D.O., and Prowse S.J. Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis. J Neuroimmunol 5 (1983) 99-109
10. Willenborg D.O., Sjollema P., and Danta G. Immunoglobulin deficient rats as donors and recipients of effector cells of allergic encephalomyelitis. J Neuroimmunol 11 (1986) 93-103
11. Myers K.J., Sprent J., Dougherty J.P., and Ron Y. Synergy between encephalitogenic T cells and myelin basic protein-specific antibodies in the induction of experimental autoimmune encephalomyelitis. J Neuroimmunol 41 (1992) 1-8
12. Wolf S.D., Dittel B.N., Hardarottir F., and Janeway Jr. C.A. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 184 (1996) 2271-2278
13. Hjelmstrom P., Juedes A.E., Fjell J., and Ruddle N.H. B cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J Immunol 161 (1998) 4480-4483
14. Dittel B.N., Urbania T.H., and Janeway C.A.J. Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice. J Autoimmun 14 (2000) 311-318
15. Lyons J.-A., Ramsbottom M.J., and Cross A.H. Critical role of antigen-specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoprotein. Eur J Immunol 32 (2002) 1905-1913
16. Lyons J.-A., San M., Happ M.P., and Cross A.H. B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide. Eur J Immunol 29 (1999) 3432-3439
17. Bernard C.C.A. Experimental autoimmune encephalomyelitis in mice: genetic control of susceptibility. J Immunogen 3 (1976) 263-274
18. Fallis R.J., Powers M.L., Sy M.-S., and Weiner H.L. Adoptive transfer of murine chronic-relapsing autoimmune encephalomyelitis: analysis of basic-protein reactive cells in lymphoid organs and nervous system of donor and recipient animals. J Neuroimmunol 14 (1987) 205-219
19. Lyons J.-A., Ramsbottom M.J., Trotter J.L., and Cross A.H. Identification of the encephalitogenic epitopes of CNS proteolipid protein in BALB/c mice. J Autoimmun 19 (2002) 195-201
20. Chen J., Trounstine M., Alt F.W., Young F., Kurahara C., Loring J.F., et al. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol 5 (1993) 647-656
21. Cross A.H., Misko T.P., Lin R.F., Hickey W.F., Trotter J.L., and Tilton R.G. Aminoguanidine an inhibitor of inducible nitric oxide synthase ameliorates experimental autoimmune encephalomyelitis in SJL mice. J Clin Invest 93 (1994) 2684-2690
22. Prineas J.W., and Connell F. The fine structure of chronically active multiple sclerosis plaques. Neurology 28 (1978) 68-75
23. Lucchinetti C.F., Bruck W., Rodriguez M., and Lassmann H. Distinct patterns of multiple sclerosis pathology indicate heterogeneity in pathogenesis. Brain Pathol 6 (1996) 259-274
24. Lucchinetti C.F., Bruck W., Parisi J., Scheithauer B., Rodriguez M., and Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47 (2000) 707-717
25. Kennedy M.K., Torrance D.S., Picha K.S., and Mohler K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol 149 (1992) 2496-2505
26. Fillatreau S., Sweenie C., McGeachy M., Gray D., and Anderton S. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 3 (2002) 944-950
27. Mann M., Maresz K., Shriver L., Tan Y., and Dittel B.N. B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis. J Immunol 178 (2007) 3447-3456
28. Schneider S.C., and Sercarz E.E. Antigen processing differences among APC. Hum Immunol 54 (1997) 148-158
29. Day M.J., Tse A.G.D., Puklavec M., Simmonds S.J., and Mason D.W. Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats. J Exp Med 175 (1992) 655-659
30. Saoudi A., Simmonds S., Huitinga I., and Mason D. Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells. J Exp Med 182 (1995) 335-344
31. Stockinger B., Zal T., Zal A., and Gray D. B cells solicit their own help from T cells. J Exp Med 183 (1996) 891-899
32. Shirota H., Sano K., Hirasawa N., Terui T., Ohuchi K., Hattori T., et al. B cells capturing antigen conjugated with CpG oligodeoxynucleotides induce Th1 cells by elaborating IL-12. J Immunol 169 (2002) 787-794
33. Pasare C., Morafo V., Entringer M., Bansal P., George A., Bal V., et al. Presence of activated antigen-binding B cells during immunization enhances relative levels of IFN-gamma in T cell responses. J Immunol 160 (1998) 778-787
34. Deng J., DeKruyff R.H., Freeman G.J., Umetsu D.T., and Levy S. Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses. Int Immunol 14 (2002) 513-523
35. Vijayakrishnan L., Manivel V., and Rao K.V.S. B cell responses to a peptide epitope. VI. The kinetics of antigen recognition mediates B cell-mediated recruitment of T helper sets. J Immunol 161 (1998) 4661-4670
36. Linington C., and Lassman H. Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titers to the myelin/oligodendrocyte glycoprotein (MOG). J Neuroimmunol 17 (1987) 61-69
37. Litzenburger T., Fassler R., Bauer J., Lassman H., Linington C., Wekerle H., et al. B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. J Exp Med 188 (1998) 169-180
38. Genain C.P., Nguyen M.-H., Letvin N.L., Pearl R., Davis R.L., Adelman M., et al. Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate. J Clin Invest 96 (1995) 2966-2974
39. Sun J., Link H., Olsson T., Xiao B.-G., Andersson G., Ekre H.-P., et al. T and B cell responses to myelin oligodendrocyte glycoprotein in multiple sclerosis. J Immunol 146 (1991) 1490-1495
40. Antoniou A.N., and Watts C. Antibody modulation of antigen presentation: positive and negative effects on presentation of the tetanus toxin antigen via the murine B cell isoform of FcgammaRII. Eur J Immunol 32 (2002) 530-540
41. Watts C., Antoniou A., Manoury B., Hewitt E.W., McKay L.M., Grayson L., et al. Modulation by epitope-specific antibodies of class II MHC-restricted presentation of the tetanus toxin antigen. Immunol Rev 164 (1998) 11-16
42. Guermonprez P., Lo-Man R., Sedlik C., Rojas M.J., Poljak R.J., and Leclerc C. mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells. Int Immunol 11 (1999) 1863-1872
43. Davidson H.W., and Watts C. Epitope-directed processing of specific antigen by B lymphocytes. J. Cell Biol 109 (1989) 85-92
44. Simitsek P.D., Campbell D.G., Lanzavecchia A., Fairweather N., and Watts C. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J Exp Med 181 (1995) 1957-1963 (see comment)
45. Watts C., and Lanzavecchia A. Suppressive effect of antibody on processing of T cell epitopes. J Exp Med 178 (1993) 1459-1463
46. Fournier P., Ammerlaan W., Ziegler D., Giminez C., Rabourdin-Combe C., Fleckenstein B.T., et al. Differential activation of T cells by antibody-modulated processing of the flanking sequences of class II-restricted peptides. Int Immunol 8 (1996) 1441-1451
47. Jaume J.C., Parry S.L., Madec A.M., Sonderstrup G., and Baekkeskov S. Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope. J Immunol 169 (2002) 665-672
48. Dai Y., Carayanniotis K.A., Eliades P., Lymberi P., Shepherd P., Kong Y., et al. Enhancing or suppressive effects of antibodies on processing of a pathogenic T cell epitope in thyroglobulin. J Immunol 62 (1999) 6987-6992
49. Dai Y.D., Eliades P., Carayanniotis K.A., McCormick D.J., Kong Y.C., Magafa V., et al. Thyroxine-binding antibodies inhibit T cell recognition of a pathogenic thyroglobulin epitope. J Immunol 174 (2005) 3105-3110
50. Trotter J.L., Pelfrey C.M., Trotter A.L., Selvidge J.A., Gushleff K.C., Mohanakumar T., et al. T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects. J Neuroimmunol 84 (1998) 172-178
51. Trotter J.L., Damico C.A., Cross A.H., Pelfrey C.M., Karr R.W., Fu X.-T., et al. HPRT mutant T-cells from multiple sclerosis patients recognize myelin proteolipid protein peptides. J Neuroimmunol 75 (1997) 95-103
52. Trotter J.L., Hickey W.F., Van der Veen R.C., and Sulze L. Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides. J Neuroimmunol 33 (1991) 55-62