Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice

Journal of Autoimmunity

Volumn 14, Issue 4, 2000, Pages 311-318

  Dittel, Bonnie N ^a,b   Urbania, Thomas H ^a,b   Janeway Jr , Charles A ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Haward Hughes Medica Institute   (United States)

Author keywords

Autoimmunity; B lymphocytes; Brain; Encephalomyelitis; Experimental autoimmune; Multiple sclerosis

Indexed keywords

CD4 ANTIGEN; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; IMMUNOREACTIVITY; LYMPHOCYTE PROLIFERATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RELAPSE; REMISSION; T LYMPHOCYTE ACTIVATION;

EID: 0033857977     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2000.0371     Document Type: Article

References (35)

1. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
2. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice
3. Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein
4. Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteoplipid protein
5. The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis
6. Epitope spreading: The role of self peptides and autoantigen processing by B lymphocytes
7. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
8. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
9. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
10. Do B cells drive the diversification of immune responses?
11. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants
12. Induction of autoreactive B cells allows priming of autoreactive T cells
13. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
14. Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis
15. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
16. Epitope spreading occurs in active but not passive EAE induced by myelin basic protein
17. Relapsing and remitting experimental allergic encephalomyelitis: A focused response to the encephalitogenic peptide rather than epitope spread
18. Myelin oligodendrocyte glycoprotein: A novel candidate autoantigen in multiple sclerosis
19. The role of lymphocyte subpopulations in the transfer of rat EAE
20. Cutting edge: B cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
21. Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis
22. + T cells that promptly produce interleukin 4
23. CD4(pos), NK1.1(pos) T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
24. +T cell from T cell receptor transgenic mice
25. + T cells in a Th2 response and in immunoglobulin E production
26. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis
27. + T-cell subsets in autoimmunity
28. Cytokin-induced immune deviation as a therapy for inflammatory autoimmune disease
29. Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis
30. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
31. A T helper cell 2 (Th2) immune response against non-self antigens modifies the cytokine profile of autoimmune T cells and protects against experimental allergic encephalomyelitis
32. Fas and FasL in the homeostatic regulation of immune responses
33. Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis
34. Experimental autoimmune encephalomyehtis in IL-4-deficient mice
35. A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice