Magnocellular pathway impairment in schizophrenia: Evidence from functional magnetic resonance imaging

Journal of Neuroscience

Volumn 28, Issue 30, 2008, Pages 7492-7500

  Martínez, Antígona ^a   Hillyard, Steven A ^b   Dias, Elisa C ^a   Hagler Jr, Donald J ^b   Butler, Pamela D ^a   Guilfoyle, David N ^a   Jalbrzikowski, Maria ^a   Silipo, Gail ^a   Javitt, Daniel C ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

fMRI; Magnocellular; Retinotopy; Schizophrenia; Spatial frequency; Visual processing

Indexed keywords

ADULT; ARTICLE; ATTENTION; BRAIN MAPPING; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GIANT CELL; HEMODYNAMICS; HUMAN; MALE; NERVE CELL; NEUROIMAGING; NEUROPHYSIOLOGY; OCCIPITAL LOBE; PARIETAL LOBE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA; SENSORY CORTEX; SPATIAL FREQUENCY DISCRIMINATION; TEMPORAL LOBE; VISION; VISUAL CORTEX; VISUAL SYSTEM; WORKING MEMORY; ANALYSIS OF VARIANCE; BLOOD; CONTRAST SENSITIVITY; IMAGE PROCESSING; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; RETINA; SPECTROSCOPY; VASCULARIZATION;

OXYGEN;

ADULT; ANALYSIS OF VARIANCE; BRAIN MAPPING; CONTRAST SENSITIVITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OXYGEN; PHOTIC STIMULATION; RETINA; SCHIZOPHRENIA; SPECTRUM ANALYSIS; VISUAL CORTEX; VISUAL PATHWAYS;

EID: 50549097074     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1852-08.2008     Document Type: Article

References (58)

1. Achim AM, Bertrand MC, Sutton H, Montoya A, Czechowska Y, Malla AK, Joober R, Pruessner JC, Lepage M (2007) Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis. Arch Gen Psychiatry 64:999-1014.
2. Ammons R, Ammons C (1962) The Quick Test (QT): provisional manual. Psychol Rep 11:111-162.
3. Bar M, Kassam KS, Ghuman AS, Boshyan J, Schmid AM, Dale AM, Hämäläinen MS, Marinkovic K, Schacter DL, Rosen BR, Halgren E (2006) Top-down facilitation of visual recognition. Proc Natl Acad Sci U S A 103:449-454.
4. Barch DM, Mathews JR, Buckner RL, Maccotta L, Csernansky JG, Snyder AZ (2003) Hemodynamic responses in visual, motor, and somatosensory cortices in schizophrenia. Neuroimage 20:1884-1893.
5. Booth JR, Burman DD, Van Santen FW, Harasaki Y, Gitelman DR, Parrish TB, Marsel Mesulam MM (2001) The development of specialized brain systems in reading and oral-language. Child Neuropsychol 7:119-141.
6. Braff DL (1981) Impaired speed of information processing in nonmedicated schizotypal patients. Schizophr Bull 7:499-508.
7. Braff DL, Saccuzzo DP (1982) Effect of antipsychotic medication on speed of information processing in schizophrenic patients. Am J Psychiatry 139:1127-1130.
8. Braus DF, Weber-Fahr W, Tost H, Ruf M, Henn FA (2002) Sensory information processing in neuroleptic-naive first-episode schizophrenic patients: a functional magnetic resonance imaging study. Arch Gen Psychiatry 59:696-701.
9. Brody D, Saccuzzo DP, Braff DL (1980) Information processing for masked and unmasked stimuli in schizophrenia and old age. J Abnorm Psychol 89:617-622.
10. Butler PD, Javitt DC (2005) Early-stage visual processing deficits in schizophrenia. Curr Opin Psychiatry 18:151-157.
11. Butler PD, Harkavy-Friedman JM, Amador XF, Gorman JM (1996) Backward masking in schizophrenia: relationship to medication status, neuropsychological functioning, and dopamine metabolism. Biol Psychiatry 40:295-298.
12. Butler PD, Schechter I, Zemon V, Schwartz SG, Greenstein VC, Gordon J, Schroeder CE, Javitt DC (2001) Dysfunction of early-stage visual processing in schizophrenia. Am J Psychiatry 158:1126-1133.
13. Butler PD, DeSanti LA, Maddox J, Harkavy-Friedman JM, Amador XF, Goetz RR, Javitt DC, Gorman JM (2003) Visual backward-masking deficits in schizophrenia: relationship to visual pathway function and symptomatology. Schizophr Res 59:199-209.
14. Butler PD, Zemon V, Schechter I, Saperstein AM, Hoptman MJ, Lim KO, Revheim N, Silipo G, Javitt DC (2005) Early-stage visual processing and cortical amplification deficits in schizophrenia. Arch Gen Psychiatry 62:495-504.
15. Butler PD, Martinez A, Foxe JJ, Kim D, Zemon V, Silipo G, Mahoney J, Shpaner M, Jalbrzikowski M, Javitt DC (2007) Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments. Brain 130:417-430.
16. Chen Y, Levy DL, Sheremata S, Holzman PS (2004) Compromised late-stage motion processing in schizophrenia. Biol Psychiatry 55:834-841.
17. Chen Y, Palafox GP, Nakayama K, Levy DL, Matthysse S, Holzman PS (1999a) Motion perception in schizophrenia. Arch Gen Psychiatry 56:149-154.
18. Chen Y, Nakayama K, Levy DL, Matthysse S, Holzman PS (1999b) Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit. Proc Natl Acad Sci U S A 96:4724-4729.
19. Cohen JD, Servan-Schreiber D (1992) Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychol Rev 99:45-77.
20. Cox RW (1996) AFNI - software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29:162-173.
21. Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis I: segmentation and surface reconstruction. Neuroimage 9:179-194.
22. Doniger GM, Silipo G, Rabinowicz EF, Snodgrass JG, Javitt DC (2001) Impaired sensory processing as a basis for object-recognition deficits in schizophrenia. Am J Psychiatry 158:1818-1826.
23. Doniger GM, Foxe JJ, Murray MM, Higgins BA, Javitt DC (2002) Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia. Arch Gen Psychiatry 59:1011-1020.
24. First MB, Spitzer RL, Gibbon M, Williams JBW (1997) Structured clinical interview for DSM-IV axis I disorders - patient edition. New York: New York State Psychiatric Institute.
25. Fischl B, Sereno MI, Tootell RB, Dale AM (1999) High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp 8:272-284.
26. Green MF, Nuechterlein KH, Breitmeyer B (1997) Backward masking performance in unaffected siblings of schizophrenic patients. Evidence for a vulnerability indicator. Arch Gen Psychiatry 54:465-472.
27. Harvey PD, Keefe RS, Moskowitz J, Putnam KM, Mohs RC, Davis KL (1990) Attentional markers of vulnerability to schizophrenia: performance of medicated and unmedicated patients and normals. Psychiatry Res 33:179-188.
28. Herrmann MJ, Ellgring H, Fallgatter AJ (2004) Early-stage face processing dysfunction in patients with schizophrenia. Am J Psychiatry 161:915-917.
29. Javitt DC (2007) Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions. Int Rev Neurobiol 78:69-108.
30. Johnston PJ, Stojanov W, Devir H, Schall U (2005) Functional MRI of facial emotion recognition deficits in schizophrenia and their electrophysiological correlates. Eur J Neurosci 22:1221-1232.
31. Kaplan E (1991) The receptive field structure of retinal ganglion cells in cat and monkey. In: Vision and visual dysfunction (Leventhal AG, ed), pp 10-40. Boston: CRC.
32. Kéri S, Janka Z (2004) Critical evaluation of cognitive dysfunctions as endophenotypes of schizophrenia. Acta Psychiatr Scand 110:83-91.
33. Kéri S, Kelemen O, Janka Z, Benedek G (2005) Visual-perceptual dysfunctions are possible endophenotypes of schizophrenia: evidence from the psychophysical investigation of magnocellular and parvocellular pathways. Neuropsychology 19:649-656.
34. Kveraga K, Boshyan J, Bar M (2007) Magnocellular projections as the trigger of top-down facilitation in recognition. J Neurosci 27:13232-13240.
35. Kwon YH, Nelson SB, Toth LJ, Sur M (1992) Effect of stimulus contrast and size on NMDA receptor activity in cat lateral geniculate nucleus. J Neurophysiol 68:182-196.
36. Manor BR, Gordon E, Williams LM, Rennie CJ, Bahramali H, Latimer CR, Barry RJ, Meares RA (1999) Eye movements reflect impaired face processing in patients with schizophrenia. Biol Psychiatry 46:963-969.
37. Merigan W, Maunsell J (1993) How parallel are the primate visual pathways? Annu Rev Neurosci 5:347-352.
38. Narumoto J, Yamada H, Iidaka T, Sadato N, Fukui K, Itoh H, Yonekura Y (2000) Brain regions involved in verbal or non-verbal aspects of facial emotion recognition. Neuroreport 11:2571-2576.
39. O'Donnell BF, Swearer JM, Smith LT, Nestor PG, Shenton ME, McCarley RW (1996) Selective deficits in visual perception and recognition in schizophrenia. Am J Psychiatry 153:687-692.
40. Puce A, Allison T, Gore JC, McCarthy G (1995) Face-sensitive regions in human extrastriate cortex studied by functional MRI. J Neurophysiol 74:1192-1199.
41. Pugh KR, Shaywitz BA, Shaywitz SE, Constable RT, Skudlarski P, Fulbright RK, Bronen RA, Shankweiler DP, Katz L, Fletcher JM, Gore JC (1996) Cerebral organization of component processes in reading. Brain 119:1221-1238.
42. Renshaw PF, Yurgelun-Todd DA, Cohen BM (1994) Greater hemodynamic response to photic stimulation in schizophrenic patients: an echo planar MRI study. Am J Psychiatry 151:1493-1495.
43. Revheim N, Butler PD, Schechter I, Jalbrzikowski M, Silipo G, Javitt DC (2006) Reading impairment and visual processing deficits in schizophrenia. Schizophr Res 87:238-245.
44. Saad ZS, Ropella KM, Cox RW, DeYoe EA (2001) Analysis and use of FMRI response delays. Hum Brain Mapp 13:74-93.
45. Saad ZS, DeYoe EA, Ropella KM (2003) Estimation of FMRI response delays. Neuroimage 18:494-504.
46. Saccuzzo DP, Braff DL (1981) Early information processing deficit in schizophrenia. New findings using schizophrenic subgroups and manic control subjects. Arch Gen Psychiatry 38:175-179.
47. Schechter I, Butler PD, Zemon VM, Revheim N, Saperstein AM, Jalbrzikowski M, Pasternak R, Silipo G, Javitt DC (2005) Impairments in generation of early-stage transient visual evoked potentials to magno- and parvocellular-selective stimuli in schizophrenia. Clin Neurophysiol 116:2204-2215.
48. Schroeder CE, Mehta AD, Givre SJ (1998) A spatiotemporal profile of visual system activation revealed by current source density analysis in the awake macaque. Cereb Cortex 8:575-592.
49. Sereno MI, McDonald CT, Allman JM (1994) Analysis of retinotopic maps in extrastriate cortex. Cereb Cortex 4:601-620.
50. Sereno MI, Dale AM, Reppas JB, Kwong KK, Belliveau JW, Brady TJ, Rosen BR, Tootell RB (1995) Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging. Science 268:889-893.
51. Slaghuis WL (2004) Spatio-temporal luminance contrast sensitivity and visual backward masking in schizophrenia. Exp Brain Res 156:196-211.
52. Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: an approach to cerebral imaging. New York: Thieme.
53. Tootell RB, Reppas JB, Kwong KK, Malach R, Born RT, Brady TJ, Rosen BR, Belliveau JW (1995) Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging. J Neurosci 15:3215-3230.
54. Turetsky BI, Kohler CG, Indersmitten T, Bhati MT, Charbonnier D, Gur RC (2007) Facial emotion recognition in schizophrenia: when and why does it go awry? Schizophr Res 94:253-263.
55. Vidyasagar TR (1999) A neuronal model of attentional spotlight: parietal guiding the temporal. Brain Res Brain Res Rev 30:66-76.
56. Wetherill GB, Levitt H (1965) Sequential estimation of points on a psychometric function. Br J Math Stat Psychol 18:1-10.
57. Whalley HC, Simonotto E, Moorhead W, McIntosh A, Marshall I, Ebmeier KP, Owens DG, Goddard NH, Johnstone EC, Lawrie SM (2006) Functional imaging as a predictor of schizophrenia. Biol Psychiatry 60:454-462.
58. Yeap S, Kelly SP, Sehatpour P, Magno E, Javitt DC, Garavan H, Thakore JH, Foxe JJ (2006) Early visual sensory deficits as endophenotypes for schizophrenia: high-density electrical mapping in clinically unaffected first-degree relatives. Arch Gen Psychiatry 63:1180-1188.