Compromised late-stage motion processing in schizophrenia

Biological Psychiatry

Volumn 55, Issue 8, 2004, Pages 834-841

  Chen, Yue ^a,c   Levy, Deborah L ^a   Sheremata, Summer ^a   Holzman, Philip S ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Mailman Research Center   (United States)

Author keywords

Contrast; Psychiatry; Velocity discrimination; Visual system

Indexed keywords

ADULT; ARTICLE; BRAIN INJURY; CEREBELLUM CORTEX; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; GENICULATE BODY; HUMAN; IMAGE PROCESSING; INTERMETHOD COMPARISON; MALE; NEUROPHYSIOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA; VISUAL DISCRIMINATION; VISUAL THRESHOLD;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CONTRAST SENSITIVITY; DIFFERENTIAL THRESHOLD; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTION PERCEPTION; NEUROPSYCHOLOGICAL TESTS; PERCEPTUAL DISORDERS; PHOTIC STIMULATION; SCHIZOPHRENIA; SENSORY THRESHOLDS; STATISTICS; TIME FACTORS;

EID: 1842420624     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2003.12.024     Document Type: Article

References (43)

1. Albright T.D., Stoner G.R. Visual motion perception. Proc Natl Acad Sci U S A. 92:1995;2433-2440.
2. Bleuler E. Dementia praecox or the group of schizophrenias. 1950;International Universities Press, New York. (trans. H. Zinkin; original work published 1911).
3. Chen Y., Bedell H.E., Frishman L.J., Levi D.M. Stimulus uncertainty affects velocity discrimination. Vision Res. 38:1998;1265-1272.
4. Chen Y., Levy D.L., Matthysse S., Holzman P.S., Nakayama K. Contrast detection in schizophrenia A reply. Arch Gen Psychiatry. 57:2000;996-997.
5. Chen Y., Levy D.L., Nakayama K., Matthysse S., Palafox G., Holzman P.S. Dependence of impaired eye tracking on deficient velocity discrimination in schizophrenia. Arch Gen Psychiatry. 56:1999;155-161.
6. Chen Y., Levy D.L., Nakayama K., Matthysse S., Sheremata S., Holzman P.S. Effects of typical, atypical and no antipsychotic drugs on contrast detection of schizophrenia. Am J Psychiatry. 160:2003;1795-1801.
7. Chen Y., Nakayama K., Levy D.L., Matthysse S., Holzman P.S. Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit. Proc Natl Acad Sci U S A. 96:1999;4724-4729.
8. Chen Y., Nakayama K., Levy D.L., Matthysse S., Sheremata S., Holzman P.S. Processing of global, but not local, motion direction is deficient in schizophrenia. Schizophr Res. 61:2003;215-227.
9. Chen Y., Palafox G., Nakayama K., Levy D., Matthysse S., Holzman P. Motion perception in schizophrenia. Arch Gen Psychiatry. 56:1999;149-154.
10. Clementz B.A. Saccades to moving targets in schizophrenia Evidence for normal posterior cortex functioning. Psychophysiology. 33:1996;650-654.
11. Clementz BA, McDowell JE (1994): Smooth pursuit in schizophrenia: Abnormalities of open- and close-loop responses. Psychophysiology 31:79-86.
12. Clementz B.A., Sweeney J.A. Is eye movement dysfunction a biological marker for schizophrenia? A methodological review. Psychol Bull. 108:1990;77-92.
13. Doniger G.M., Silipo G., Rabinowicz E.F., Snodgrass J.G., Javitt D.C. Impaired sensory processing as a basis for object-recognition deficits in schizophrenia. Am J Psychiatry. 158:2001;1818-1826.
14. Friedman L., Jesberger J.A., Siever L.J., Thompson P., Mohs R., Meltzer H.Y. Smooth pursuit performance in patients with affective disorders or schizophrenia and normal control subjects Analysis with specific oculomotor measures, RMS error and qualitative ratings. Psychol Med. 25:1995;387-403.
15. Hollingshead A.B. Two factor index of social position. 1965;Yale Station, New Haven, CT.
16. Holzman P.S., Proctor L.R., Hughes D.W. Eye-tracking patterns in schizophrenia. Science. 181:1973;179-181.
17. Holzman P.S., Proctor L.R., Levy D.L., Yasillo N.J., Meltzer H.Y., Hurt S.W. Eye tracking dysfunctions in schizophrenic patients and their relatives. Arch Gen Psychiatry. 31:1974;143-151.
18. Iacono W.G., Koenig W.G. Features that distinguish the smooth-pursuit eye-tracking performance of schizophrenic, affective-disorder, and normal individuals. J Abnorm Psychol. 92:1983;29-41.
19. Keller E.L., Heinen S.J. Generation of smooth-pursuit eye movements Neuronal mechanisms and pathways. Neurosci Res. 11:1991;79-107.
20. Kendler K. Structured Interview for Schizotypy (SIS) (SISS, version 1.5). 1989;Department of Psychiatry, Medical College of Virginia, Richmond.
21. Keri S., Antal A., Benedek G., Janka Z. Contrast detection in schizophrenia. Arch Gen Psychiatry. 57:2000;995-996.
22. Kraepelin E (1919): Dementia Praecox and Paraphernalia [Barclay RM, trans.]. Chicago, IL: Chicago Medical Books.
23. Levin S., Luebke A., Zee D.S., Hain T.C., Robinson D.A., Holzman P.S. Smooth pursuit eye movements in schizophrenics Quantitative measurements with the search-coil technique. J Psychiatr Res. 22:1988;195-206.
24. Levy D.L., Holzman P.S., Matthysse S., Mendell N.R. Eye tracking dysfunction and schizophrenia A critical perspective. Schizophr Bull. 19:1993;461-536.
25. Lisberger S.G., Morris E.J., Tychsen L. Visual motion processing and sensory-motor integration for smooth pursuit eye movements. Annu Rev Neurosci. 10:1987;97-129.
26. Lisberger S.G., Movshon J.A. Visual motion analysis for pursuit eye movements in area MT of macaque monkeys. J Neurosci. 19:1999;2224-2246.
27. McKee S.P., Silverman G.H., Nakayama K. Precise velocity discrimination despite random variations in temporal frequency and contrast. Vision Res. 26:1986;609-619.
28. Merigan W.H., Byrne C.E., Maunsell J.H. Does primate motion perception depend on the magnocellular pathway? J Neurosci. 11:1991;3422-3429.
29. Newsome W.T., Wurtz R.H., Komatsu H. Relation of cortical areas MT and MST to pursuit eye movements. II. Differentiation of retinal from extraretinal inputs. J Neurophysiol. 60:1988;604-620.
30. O'Donnell B.F., Swearer J.M., Smith L.T., Nestor P.G., Shenton M.E., McCarley R.W. Selective deficits in visual perception and recognition in schizophrenia. Am J Psychiatry. 153:1996;687-692.
31. Park S., Holzman P.S. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry. 49:1992;975-982.
32. Pasternak T. Discrimination of differences in velocity and flicker rate depends on directionally selective mechanisms. Vision Res. 30:1987;625-660.
33. Pasternak T., Horn K.M., Maunsell J.H. Deficits in speed discrimination following lesions of the lateral suprasylvian cortex in the cat. Vis Neurosci. 3:1989;365-375.
34. Pasternak T., Merigan W.H. Motion perception following lesions of the superior temporal sulcus in the monkey. Cereb Cortex. 4:1994;247-259.
35. Plant G.T., Nakayama K. The characteristics of residual motion percep-tion in the hemifield contralateral to lateral occipital lesions in humans. Brain. 116:1993;1337-1353.
36. Sclar G., Maunsell J.H., Lennie P. Coding of image contrast in central visual pathways of the macaque monkey. Vision Res. 30:1990;1-10.
37. Slaghuis W.L. Contrast sensitivity for stationary and drifting spatial frequency gratings in positive- and negative-symptom schizophrenia. J Abnorm Psychol. 107:1998;49-62.
38. Stuve T.A., Friedman L., Jesberger J.A., Gilmore G.C., Strauss M.E., Meltzer H.Y. The relationship between smooth pursuit performance, motion perception and sustained visual attention in patients with schizophrenia and normal control subjects. Psychol Med. 27:1997;143-152.
39. Super H., Spekreijse H., Lamme V.A.F. A neural correlate of working memory in the monkey primary visual cortex. Science. 293:2001;120-124.
40. Sweeney J.A., Luna B., Srinivasagam N.M., Keshavan M.S., Schooler N.R., Haas G.L., Carl J.R. Eye tracking abnormalities in schizophrenia Evidence for dysfunction in the frontal eye fields. Biol Psychiatry. 44:1998;698-708.
41. Tanaka M., Lisberger S.G. Regulation of the gain of visually guided smooth-pursuit eye movements by frontal cortex. Nature. 409:2001;191-194.
42. Thaker G.K., Ross D.E., Cassady S.L., Adami H.M., LaPorte D., Medoff D.R., Lahti A. Smooth pursuit eye movements to extraretinal motion signals Deficits in relatives of patients with schizophrenia. Arch Gen Psychiatry. 55:1998;830-836.
43. Wechsler D. WAIS-R Manual. 1981;Psychological Corporation, New York.