A common "hot spot" confers hERG blockade activity to α-scorpion toxins affecting K+ channels

Biochemical Pharmacology

Volumn 76, Issue 6, 2008, Pages 805-815

  Abdel Mottaleb, Yousra ^a   Corzo, Gerardo ^b   Martin Eauclaire, Marie France ^c   Satake, Honoo ^d   Céard, Brigitte ^c   Peigneur, Steve ^a   Nambaru, Praveen ^a   Bougis, Pierre Edouard ^c   Possani, Lourival D ^b   Tytgat, Jan ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^c AIX MARSEILLE UNIVERSITY   (France)

^d SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

KTx; KTxs; hERG channels; K+ channels; Scorpion toxins

Indexed keywords

POTASSIUM CHANNEL HERG; SCORPION VENOM;

ANIMAL CELL; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYCLIZATION; MEMBRANE ELECTROPHYSIOLOGY; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PURIFICATION;

AMINO ACID SEQUENCE; ANIMALS; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POTASSIUM CHANNEL BLOCKERS; SCORPION VENOMS; SCORPIONS; XENOPUS LAEVIS;

EID: 50549089703     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.07.008     Document Type: Article

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