A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K+ channels responsible for the IA currents in cerebellum granular cells

Biochimica et Biophysica Acta - General Subjects

Volumn 1780, Issue 4, 2008, Pages 750-755

  Romeo, Stefania ^a   Corzo, Gerardo ^b   Vasile, Attilio ^a   Satake, Honoo ^c   Prestipino, Gianfranco ^a   Possani, Lourival D ^b  

^a CNR   (Italy)

^b INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^c SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

A currents; Discrepin; K+ channel; Scorpion toxin; Structure function

Indexed keywords

AMINO ACID; ARGININE; ASPARTIC ACID; DISCREPIN; ISOLEUCINE; LYSINE; PEPTIDE; POTASSIUM CHANNEL; PROTEIN ALPHA KTX15; PROTEIN BMTX3; PYROGLUTAMIC ACID; SCORPION VENOM; THREONINE; UNCLASSIFIED DRUG; VALINE; VOLTAGE GATED POTASSIUM CHANNEL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BUTHUS MARTENSI; CEREBELLUM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GRANULAR CELL; MUTATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RAT; SCORPION; TITYUS DISCREPAN;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; RATS; RATS, WISTAR; SCORPION VENOMS;

BUTHIDA; MESOBUTHUS MARTENSII; RATTUS; SCORPIONES; TITYUS DISCREPANS;

EID: 40949157490     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2008.01.012     Document Type: Article

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