Antigenic polymorphism of the 'short' scorpion toxins able to block K + channels

Toxicon

Volumn 43, Issue 4, 2004, Pages 447-453

  Vacher, Hélène ^a   Martin Eauclaire, Marie France ^a  

^a CNRS   (France)

Author keywords

Antibodies; Potassium channel blockers; Scorpion

Indexed keywords

POTASSIUM CHANNEL; SCORPION VENOM; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRAIN SYNAPTOSOME; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORPUS STRIATUM; CROSS REACTION; GENE DELETION; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; RABBIT; RADIOIMMUNOASSAY; SCORPION;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CHARYBDOTOXIN; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNE SERA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RADIOIMMUNOASSAY; SCORPION VENOMS; SCORPIONS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; VARIATION (GENETICS);

BUTHUS; MESOBUTHUS MARTENSII; ORYCTOLAGUS CUNICULUS; SCORPIONES;

EID: 1642544179     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.02.016     Document Type: Article

References (28)

1. Aiyar J., Withka J.M., Rizzi J.P., Singleton D.H., Andrews G.C., Lin W., Boyd J., Hanson D.C., Simon M., Dethlefs B., et al. Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins. Neuron. 15:1995;1169-1181.
2. Auguste P., Hugues M., Mourre C., Moinier D., Tartar A., Lazdunski M. Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites. Biochemistry. 31:1992;648-654.
3. Bednarek M.A., Bugianesi R.M., Leonard R.J., Felix J.P. Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytes. Biochem. Biophys. Res. Commun. 28:1994;619-625.
4. Bontems F., Roumestand C., Boyot P., Quilquin B., Doljansky Y., Menez A., Toma F. Three-dimensional structure of natural charybdotoxin in aqueous solution by 1H-NMR. Charybdotoxin possesses a structural motif found in other scorpion toxins. Eur. J. Biochem. 196:1991;19-28.
5. Dauplais M., Lecoq A., Song J., Cotton J., Jamin N., Gilquin B., Roumestand C., Vita C., de Medeiros C.L., Rowan E.G., Harvey A.L., Menez A. On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J. Biol. Chem. 14:1997;4302-4309.
6. El Ayeb M., Delori P., Rochat H. Immunochemistry of scorpion alpha-toxins: antigenic homologies checked with radioimmunoassays (RIA). Toxicon. 21:1983;709-716.
7. Gazarian T., Selisko B., Herion P., Gazarian K. Isolation and structure-functional characterization of phage display library-derived mimotopes of noxiustoxin, a neurotoxin of the scorpion Centruroides noxius Hoffmann. Mol. Immunol. 37:2000;755-766.
8. Goldstein S.A.N., Pheasant D.J., Miller C. The Charybdotoxin receptor of the Shaker K+ channel/ peptide and channel residues mediating molecular recognition. Neuron. 12:1994;1377-1388.
9. Granier C., Novotny J., Fontecilla-Camps J.C., Fourquet P., El Ayeb M., Bahraoui E. The antigenic structure of a scorpion toxin. Mol. Immunol. 26:1989;503-513.
10. Guex N., Diemand A., Peitsch M.C. Protein modelling for all. Trends. Biochem. Sci. 24:1999;364-367.
11. Hernandez R., Gazarian T., Hérion P.S., Gazarian K.G. Molecular localization and crossreactivity of two epitopes of noxiustoxin from scorpion Centruroides noxius, identified by a panel of monoclonal antibodies and peptide mimotopes. Immunol. Lett. 80:2002;97-103.
12. Kelley L.A., Gardner S.P., Sutcliffe M.J. An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies. Protein Engng. 9:1996;1063-1065.
13. Laraba-Djebari F., Legros C., Crest M., Céard B., Romi R., Mansuelle P., Jacquet G., Van Rietschtoten J., Gola M., Rochat H., Bougis P.E., Martin-Eauclaire M.-F. J. Biol. Chem. 269:1994;32835-32843.
14. Laskowski R.A., Moss D.S., Thornton J.M. Main-chain bond lengths and bond angles in protein structures. J. Mol. Biol. 231:1993;1049-1067.
15. Martin-Eauclaire M.-F., Couraud F. Scorpion neurotoxins: effects and mechanisms. Chang L.W., Dyer E.S. Handbook of Neurotoxicology. 1995;683-716 Marcel Dekker, New-York.
16. Morris A.L., MacArthur M.W., Hutchinson E.G., Thornton J.M. Stereochemical quality of protein structure coordinates. Proteins. 12:1992;345-364.
17. Naharashi T. Chemicals as tools in the study of excitable membranes. Physiol. Rev. 54:1974;813-889.
18. + channel blocking peptide, purified from the the venom of the scorpion Centruroides noxius Hoffman. Carlsberg. Res. Commun. 47:1982;285-289.
19. Romi R., Crest M., Gola M., Sampieri F., Jacquet G., Zerrouk H., Mansuelle P., Sorokine O., Van Dorsselaer A., Rochat H., et al. Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition? J. Biol. Chem. 268:1993;26302-26309.
20. Romi-Lebrun R., Lebrun B., Martin-Eauclaire M.F., Ishiguro M., Escoubas P., Wu F.Q., Hisada M., Pongs O., Nakajima T. Purification, characterisation, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels. Biochemistry. 36:1997;13473-13482.
21. Schetz J.A., Anderson P.A. Pharmacology of the high-affinity apamin receptor in rabbit heart. Cardiovasc. Res. 30:1995;755-762.
22. Schwede T., Kopp J., Guex N., Peitsch M.C. SWISS-MODEL: an automated protein homology-modeling server. Nucl. Acids Res. 31:2003;3381-3385.
23. Tam J.P. Synthetic peptide vaccine design: synthesis and properties of a high density multiple antigenic peptide system. Proc. Natl Acad. Sci. USA. 85:1988;5409-5413.
24. Thompson J.D., Higgins D.G., Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucl. Acids Res. 22:1994;4673-4680.
25. Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.F., van der Walt J.J., Possani L.D. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTX molecular subfamilies. Trends Pharmacol. Sci. 20:1999;444-447.
26. Vacher H., Romi-Lebrun R., Mourre C., Lebrun B., Kourrich S., Masmejean F., Nakajima T., Legros C., Crest M., Bougis P.E., Martin-Eauclaire M.F. A new class of scorpion toxin binding sites related to an A-type K+ channel: pharmacological characterization and localization in rat brain. FEBS Lett. 501:2001;31-36.
27. Vacher H., Alami M., Crest M., Possani L.D., Bougis P.E., Martin-Eauclaire M. Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur. J. Biochem. 269:2002;6037-6041.
28. Vacher H., Romi-Lebrun R., Crest M., Bougis P.E., Darbon H., Martin-Eauclaire M.F. Functional consequence of the deletion of the two C-terminal residues in the scorpion toxin BMTX3. Biochim. Biophys. Acta, Proteins Proteomics. 1646:2003;152-156.