Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels

European Journal of Biochemistry

Volumn 270, Issue 17, 2003, Pages 3583-3592

  M'Barek, Sarrah ^a   Mosbah, Amor ^a   Sandoz, Guillaume ^b   Fajloun, Ziad ^a   Olamendi Portugal, Timoteo ^c   Rochat, Hervé ^a   Sampieri, François ^a   Guijarro, J Iñaki ^d   Mansuelle, Pascal ^a   Delepierre, Muriel ^d   De Waard, Michel ^b   Sabatier, Jean Marc ^a,d  

^a AIX MARSEILLE UNIVERSITY   (France)

^b CEA GRENOBLE   (France)

^c INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^d CNRS   (France)

Author keywords

Half cystine pairings; K+ channels; Molecular docking; Pi4; Scorpion toxin

Indexed keywords

APAMIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; MAUROTOXIN; SCORPION VENOM; TOXIN HSTX1; TOXIN PI1; TOXIN PI4; TOXIN PI7; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN SYNAPTOSOME; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; ENZYME DEGRADATION; IN VIVO STUDY; INHIBITION KINETICS; ISOTOPE LABELING; MOLECULAR MODEL; NEUROTOXICITY; NONHUMAN; PANDINUS IMPERATOR; PHYSICAL CHEMISTRY; POROSITY; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SCORPION; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; TOXIN ANALYSIS; TOXIN SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; APAMIN; CALCIUM; CYSTEINE; DISULFIDES; ELECTROPHYSIOLOGY; LETHAL DOSE 50; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PROTEIN BINDING; RATS; SCORPION VENOMS; SEQUENCE HOMOLOGY, AMINO ACID; SYNAPTOSOMES; XENOPUS LAEVIS;

ANIMALIA; CHACTIDAE; PANDINUS; PANDINUS IMPERATOR; SCORPIONES; XENOPUS LAEVIS;

EID: 0042679493     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03743.x     Document Type: Article

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