Targeting the proteasome as a therapeutic strategy against haematological malignancies

Expert Opinion on Investigational Drugs

Volumn 15, Issue 2, 2006, Pages 117-130

  Orlowski, Robert Z ^a,b   Zeger, Erik L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Bortezomib; Multiple myeloma; Non Hodgkin's lymphoma; Proteasome; Proteasome inhibitor

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; ALKYLATING AGENT; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BORTEZOMIB; CISPLATIN; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; HEAT SHOCK PROTEIN 90 INHIBITOR; IMMUNOMODULATING AGENT; LENALIDOMIDE; MELPHALAN; PROTEASOME; PROTEASOME INHIBITOR; STEROID; THALIDOMIDE;

ABDOMINAL PAIN; ANEMIA; ANOREXIA; APOPTOSIS; ARTHRALGIA; BLOOD TOXICITY; BONE PAIN; CELL CYCLE ARREST; CHICKENPOX; CLINICAL TRIAL; CONSTIPATION; COUGHING; DEEP VEIN THROMBOSIS; DEHYDRATION; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG ELIMINATION; DRUG ERUPTION; DRUG HALF LIFE; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; DRUG TARGETING; DYSPNEA; EDEMA; ENZYME INHIBITION; FATIGUE; FEBRILE NEUTROPENIA; FEVER; FLUID RETENTION; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; HEADACHE; HEART ATRIUM FIBRILLATION; HEMATOLOGIC MALIGNANCY; HERPES ZOSTER; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOKALEMIA; HYPONATREMIA; HYPOTENSION; INSOMNIA; INTESTINE OBSTRUCTION; LIMB PAIN; MALAISE; MAXIMUM TOLERATED DOSE; MULTIPLE MYELOMA; MUSCLE CRAMP; MUSCLE WEAKNESS; MYALGIA; NAUSEA; NEUTROPENIA; NONHODGKIN LYMPHOMA; NONHUMAN; ORTHOSTATIC HYPOTENSION; PARESTHESIA; PERIPHERAL NEUROPATHY; PLASMA CELL DYSCRASIA; PNEUMONIA; PROTEIN METABOLISM; PRURITUS; RESPIRATORY TRACT DISEASE; REVIEW; SENSORY NEUROPATHY; SIDE EFFECT; SINUSITIS; SKIN MANIFESTATION; SKIN TOXICITY; SYNCOPE; THROMBOCYTOPENIA; TUMOR LYSIS SYNDROME; UBIQUITINATION; VOMITING;

ANIMALS; ANTINEOPLASTIC AGENTS; BORONIC ACIDS; DRUG DELIVERY SYSTEMS; HEMATOLOGIC NEOPLASMS; HUMANS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRAZINES;

EID: 32844455767     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.15.2.117     Document Type: Review

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