Introduction of NS5A mutations enables subgenomic HCV replicon derived from chimpanzee-infectious HC-J4 isolate to replicate efficiently in Huh-7 cells

Journal of Viral Hepatitis

Volumn 11, Issue 5, 2004, Pages 394-403

  Maekawa, S ^a   Enomoto, Nobuyuki ^a   Sakamoto, N ^a   Kurosaki, M ^a   Ueda, E ^a   Kohashi, T ^a   Watanabe, H ^a   Chen, C H ^a   Yamashiro, T ^a   Tanabe, Y ^a   Kanazawa, N ^a   Nakagawa, M ^a   Sato, C ^a   Watanabe, M ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Adaptive mutations; Cell culture system; Interferon sensitivity determining region; Serine cluster region

Indexed keywords

AMINO ACID; ISOLEUCINE; KANAMYCIN KINASE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5A; PROLINE; PROTEIN NS5B; SERINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; ARTICLE; CELL STRAIN HUH 7; CHIMPANZEE; COMPLEMENTARITY DETERMINING REGION; ENCEPHALOMYOCARDITIS VIRUS; GENETIC TRANSFECTION; GENETIC VARIABILITY; HEPATITIS C VIRUS; HEPATITIS C VIRUS CON1; HEPATITIS C VIRUS HC J4; HEPATOMA CELL; HUMAN; HUMAN CELL; INTERFERON SENSITIVITY DETERMINING REGION; INTERNAL RIBOSOME ENTRY SITE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; REPLICON; SIGNAL TRANSDUCTION; VIRUS MUTANT; VIRUS REPLICATION; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; GENOME, VIRAL; HEPACIVIRUS; HUMANS; INTERFERON-ALPHA; MOLECULAR SEQUENCE DATA; MUTATION; PAN TROGLODYTES; REPLICON; TUMOR CELLS, CULTURED; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 5044222992     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2004.00525.x     Document Type: Article

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